Letter
Dermatology
William Fostier, Georgie Holt, James Sampson, Neil Rajan
Summary: Cutaneous leiomyosarcoma (cLMS) is a rare soft tissue sarcoma with unclear genetic drivers. The presence of cLMS in Birt-Hogg-Dube (BHD) syndrome suggests that FLCN loss may be involved in cLMS pathogenesis. This report provides novel genetic evidence of FLCN loss in BHD cLMS, indicating that cLMS is a sporadic but recurring element of the BHD phenotype.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Medicine, General & Internal
Florica Sandru, Razvan-Cosmin Petca, Monica Costescu, Mihai Cristian Dumitrascu, Adelina Popa, Aida Petca, Raluca-Gabriela Miulescu
Summary: Mastocytosis is a systemic pathology characterized by increased accumulation and clonal proliferation of mast cells in the skin and/or different organs. It is classified into cutaneous mastocytosis and systemic mastocytosis. In children, cutaneous mastocytosis is the most frequent form.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Michael J. Carr, James Sun, William A. Adams, Michelle M. Dugan, Syeda M. H. Naqvi, Youngchul Kim, Jane L. Messina, Ricardo J. Gonzalez, Jonathan S. Zager, John E. Mullinax
Summary: This study evaluates the recurrence and survival of primary cutaneous leiomyosarcoma (cLMS) patients through analyzing their clinicopathologic and treatment characteristics. The results show that primary tumor resection provides excellent local control for low-grade tumors, while patients with intermediate- to high-grade tumors may experience local recurrence, distant metastasis, and death.
Editorial Material
Critical Care Medicine
Christina Triantafyllidou, Petros Effraimidis, Mirjam Schimanke, Simone Ignatova, Anders Ringman, Susann Skoog, Farkas Vanky, Miklos Boros, Karin Cederquist
Summary: A 26-year-old male patient with a history of asthma and smoking presented with a 2-week history of productive cough and a 1-year history of effort-related dyspnea.
Review
Dermatology
Sophie Stoneham, Alys Hunter, Mina Raahimi, Amy Livesey, Charles D. Mitchell, Stephen Keohane
Summary: Cutaneous sarcomas are rare but potentially fatal tumors originating from mesenchymal cells in the skin. Guidelines for management exist for soft-tissue sarcomas, but not for cutaneous sarcomas. This review summarizes the available literature on management of seven different types of cutaneous sarcomas and aims to provide practical recommendations for their recognition, management, and follow-up. The goal is to support clinicians in providing the best evidence-based care for these rare but important tumors.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
A. Torrelo, L. Vergara-de-la-Campa, J. M. Azana, S. Greenberger, J. M. Lam, L. P. Lawley, M. -A. Morren, J. V. Schaffer, I. Garcia-Doval, A. Matito, I. Alvarez-Twose
Summary: The study found that there was a higher level of agreement among experts in classifying childhood MPCM into monomorphic and polymorphic types, while general dermatologists showed lower agreement levels, failing to validate the classification system effectively.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Oncology
Jomjit Chantharasamee, Karlton Wong, Pasathorn Potivongsajarn, Amir Qorbani, Neda Motamed, Sandra Brackert, Joshua Cohen, Bartosz Chmielowski, Anusha Kalbasi, Jianyu Rao, Scott Nelson, Arun Singh
Summary: There is currently no standard adjuvant treatment protocol for localized uterine leiomyosarcoma (uLMS). This study aims to determine the benefit of adjuvant chemotherapy for uLMS. The results showed that patients who received any form of adjuvant therapy had a slightly longer disease-free survival, but the difference was not significant. Tumor size and mitotic rate were identified as independent prognostic factors for worse outcomes. Therefore, the need for adjuvant therapy for resected uLMS remains in question.
Review
Dermatology
Bhavya Swarnkar, Rashmi Sarkar
Summary: Cutaneous mastocytosis is a neoplasm characterized by the proliferation and accumulation of mast cells in the skin. It can affect other organ systems as well. Symptoms range from various skin manifestations to systemic reactions. Treatment includes avoiding triggers, medication, and in some cases, more aggressive therapies like stem cell transplantation. This article aims to review the English literature on childhood cutaneous mastocytosis.
INDIAN JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Iris Wohlmuth-Wieser
Summary: Primary cutaneous lymphomas are extranodal non-Hodgkin lymphomas that predominantly affect older patients, but can occur in all age groups including children. Diagnosis requires collaboration between dermatologists, pediatric oncologists, and pathologists. Children with cutaneous lymphomas often present with early-stage disease and respond well to treatment with corticosteroids and phototherapy.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Review
Dermatology
Catarina Soares Queiros, Paulo Filipe, Luis Soares de Almeida
Summary: Cutaneous leiomyosarcoma is a rare malignant neoplasm of muscular origin, representing a small percentage of all cutaneous soft tissue sarcomas. This study analyzed 11 cases of cutaneous leiomyosarcoma over a 20-year period, with most cases occurring in men and primarily located in the head and neck region. Immunohistochemical staining played a crucial role in diagnosis and all cases were treated surgically, with a mean survival of 32.2 months.
ANAIS BRASILEIROS DE DERMATOLOGIA
(2021)
Article
Health Care Sciences & Services
Seth S. Tigchelaar, Christopher Frey, Dharshan Sivaraj, Nicole A. Segovia, David G. Mohler, Robert J. Steffner, Raffi S. Avedian
Summary: Truncal and peripheral extremity leiomyosarcomas (LMS) are aggressive tumors with high metastatic potential and mortality. Factors such as age, tumor characteristics, and differentiation scores are associated with metastases. PET imaging shows greater tumor detection frequency compared to CT imaging.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Oncology
Liyan Zhao, Yining Jiang, Yubo Wang, Yang Bai, Ying Sun, Yunqian Li
Summary: Leiomyosarcoma, especially primary intracranial leiomyosarcoma (PILMS), is rare and poorly researched. This study presents a case of PILMS secondary to glioblastoma, highlighting the importance of aggressive multimodal treatment with surgery and radiotherapy for PILMS. Further research, including systemic treatment options, is needed to address the unanswered questions surrounding PILMS.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Blair McNamara, Justin Harold, Diego Manavella, Stefania Bellone, Levent Mutlu, Tobias Max Philipp Hartwich, Margherita Zipponi, Yang Yang-Hartwich, Cem Demirkiran, Miguel Skyler Z. Verzosa, Kevin Yang, Jungmin Choi, Weilai Dong, Natalia Buza, Pei Hui, Gary Altwerger, Gloria S. Huang, Vaagn Andikyan, Mitchell Clark, Elena Ratner, Masoud Azodi, Peter E. Schwartz, Elizabeth A. Burton, Hiroaki Inagaki, Aaron Albers, Chao Zhang, Gideon Bollag, Joseph Schlessinger, Alessandro D. Santin
Summary: This study investigates the in vivo activity of a novel MAP2K4 inhibitor, PLX8725, against uLMS harboring MAP2K4 gene amplification. The results demonstrate that PLX8725 significantly inhibits tumor growth and prolongs survival in mice. PK studies also show that oral administration of PLX8725 provides extended exposure. Ex vivo experiments show that PLX8725 decreases levels of phosphorylated-ATR, JNK, and p38, and increases expression of apoptotic molecules.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Dermatology
David J. Rosenfeld, Mark A. Cappel, Stanislav N. Tolkachjov
Summary: Cutaneous mesenchymal tumors (CMT) are rare and heterogeneous, making it difficult to provide definitive treatment recommendations. However, recent literature suggests Mohs micrographic surgery (MMS) may be a useful and potentially superior option for primary cutaneous mesenchymal tumors.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Review
Veterinary Sciences
Niora J. Fabian, Michael Y. Esmail, Lauren Richey, Sureshkumar Muthupalani, Jennifer L. Haupt, Joanna Joy, Sebastian E. Carrasco
Summary: Cutaneous leiomyosarcomas, malignant mesenchymal tumors originating from smooth muscle, occasionally occur in avian species. This case report describes a 14-year-old White Carneau pigeon presenting with a cervical soft tissue mass, diagnosed as leiomyosarcoma based on histopathology and immunohistochemistry. Postoperative examination revealed metastatic foci in the lungs and liver, emphasizing the aggressive behavior of cutaneous LMS in avian species.
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2021)
Article
Dermatology
Evelyne De Vuyst, Severine Giltaire, Catherine Lambert de Rouvroit, Jeremy Malaisse, Abdallah Mound, Maureen Bourtembourg, Yves Poumay, Arjen F. Nikkels, Aline Chretien, Michel Salmon
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Dermatology
R. N. Werner, A. F. Nikkels, B. Marinovic, M. Schaefer, M. Czarnecka-Operacz, A. M. Agius, Z. Bata-Csorgo, J. Breuer, G. Girolomoni, G. E. Gross, S. Langan, R. Lapid-Gortzak, T. H. Lesser, U. Pleyer, J. Sellner, G. M. Verjans, P. Wutzler, C. Dressler, R. Erdmann, S. Rosumeck, A. Nast
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2017)
Article
Dermatology
R. N. Werner, A. F. Nikkels, B. MarinoviC, M. Schaefer, M. Czarnecka-Operacz, A. M. Agius, Z. Bata-Csorgo, J. Breuer, G. Girolomoni, G. E. Gross, S. Langan, R. Lapid-Gortzak, T. H. Lesser, U. Pleyer, J. Sellner, G. M. Verjans, P. Wutzler, C. Dressler, R. Erdmann, S. Rosumeck, A. Nast
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2017)
Article
Mycology
F. Libon, N. Nikkels-Tassoudji, B. Dezfoulian, J. E. Arrese, A. F. Nikkels
Article
Dermatology
L. El Hayderi, A. Ruebben, A. F. Nikkels
Article
Dermatology
L. El Hayderi, A. Ruebben, A. F. Nikkels
Letter
Dermatology
Florence Libon, Justine Courtois, Caroline Le Goff, Pierre Lukas, Neus Fabregat-Cabello, Laurence Seidel, Etienne Cavalier, Arjen F. Nikkels
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2017)
Article
Endocrinology & Metabolism
Florence Libon, Justine Courtois, Caroline Le Goff, Pierre Lukas, Neus Fabregat-Cabello, Laurence Seidel, Etienne Cavalier, Arjen F. Nikkels
ARCHIVES OF OSTEOPOROSIS
(2017)
Article
Dermatology
Guy Shalom, Luigi Naldi, Mark Lebwohl, Arjen Nikkels, Elke M. G. J. de Jong, Steven Fakharzadeh, Kavitha G. Goyal, Bhaskar Srivastava, Wayne Langholff, Claudia Galindo, Arnon D. Cohen
JOURNAL OF DERMATOLOGICAL TREATMENT
(2019)
Article
Oncology
Mariana Orduz Robledo, Eve Lebas, Marie-Annick Reginster, Mahmoud Baghaie, Sabine Groves, Arjen F. Nikkels
Article
Dermatology
Eve Lebas, Cesar Chian, Nazli Nikkels-Tassoudji, Jorge E. Arrese, Arjen F. Nikkels
CASE REPORTS IN DERMATOLOGY
(2017)
Article
Obstetrics & Gynecology
A. Detrixhe, A. F. Nikkels, B. Dezfoulian
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2017)
Article
Oncology
J. De Smedt, S. Van Kelst, V. Boecxstaens, M. Stas, K. Bogaerts, D. Vanderschueren, C. Aura, K. Vandenberghe, D. Lambrechts, P. Wolter, O. Bechter, A. Nikkels, T. Strobbe, G. Emri, V. Marasigan, M. Garmyn
Article
Dermatology
F. Sampogna, L. Puig, P. Spuls, G. Girolomoni, M. A. Radtke, B. Kirby, M. Brunori, P. Bergmans, P. Smirnov, J. Rundle, F. Lavie, C. Paul
BRITISH JOURNAL OF DERMATOLOGY
(2017)
Article
Dermatology
Eve Lebas, Pascale Quatresooz, Jorge E. Arrese, Arjen F. Nikkels
CASE REPORTS IN DERMATOLOGY
(2017)
