Review
Pediatrics
Colin J. Crilly, Sebastien Haneuse, Jonathan S. Litt
Summary: This article provides an in-depth review of risk prediction models for preterm neonates predicting functional outcomes, highlighting the focus on predicting poor neurodevelopmental outcomes. It suggests future models should aim for consistent outcomes definitions, standardized assessment schedules and measurement tools, and consider risks beyond physiologic antecedents. This review reveals areas for improvement in developing risk prediction tools for this population.
PEDIATRIC RESEARCH
(2021)
Article
Psychiatry
Amelie Stern-Delfils, Isabelle Leray, Laurence Caeymaex, Odile Dicky, Madeleine Akrich, Audrey Reynaud, Charlotte Bouvard, Anne Evrard, Jacques Sizun, Charlotte Tscherning, Pierre Kuhn
Summary: This study aimed to evaluate fathers' perceptions and care involvement for their very premature infants and their views of the hospitalization period. The results showed that most fathers were present at the births of their infants, but fewer fathers were near the mother. Less than two thirds of fathers accompanied their infants to the NICU. Fathers and mothers had similar perceptions regarding relationships with caregivers and skin-to-skin contact with their infants. However, fathers felt more welcome in the NICU and were more involved in their infants' care compared to mothers. Fathers and mothers significantly differed in the caring procedures they performed and their preferences for performing or not performing certain procedures.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Nursing
Qiuxia Dong, Mary Steen, Dianne Wepa, Amye Eden
Summary: Father-infant Kangaroo Care has positive effects on the emotional connection and attachment between fathers and infants in the NICU, although it also presents challenges. Further research and modifications to policies and facilities are needed to integrate father-infant Kangaroo Care into neonatal care, which is clinically significant.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Pediatrics
Erin Swieter, Jessica M. Gross, Julia Stephen, Kristi Watterberg, Jessie R. Maxwell
Summary: This study aimed to analyze the effects of skin-to-skin care on heart rate variability (HRV) in preterm infants receiving respiratory support. The results showed that skin-to-skin care led to decreased HRV, indicating physiological benefits for the infants.
FRONTIERS IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Ermias Sisay Chanie, Sahlu Mitku Shiferaw, Dejen Getaneh Feleke, Berihun Bantie, Natnael Moges, Sheganew Feten Tasew, Tikuneh Yetneberk Alemayehu, Assefa Agegnehu Teshome, Gebrie Kassaw Yirga, Ayenew Berhan, Abraham Tsedalu Amare, Mebratu Libanos, Wondosen Addis Emrie, Sewnet Sisay Chanie
Summary: This study aimed to assess the proportion of hypoglycemia and associated factors among preterm neonates admitted to the neonatal intensive care unit at Debre Tabor Comprehensive Specialized Hospital in Ethiopia. The study found that 23.59% of the preterm neonates developed hypoglycemia. Several factors, including hypothermia, birth asphyxia, seizure, and neonates born to diabetic mothers, were significantly associated with the occurrence of hypoglycemia.
SCIENTIFIC REPORTS
(2023)
Review
Pediatrics
Arvind Mohan, Ganga Gokulakrishnan, Ahmed El-Saie, Alix Brickley, Joseph Hagan, Mohan Pammi
Summary: The study shows that music therapy has a positive impact on physiological parameters and reducing maternal anxiety in preterm infants in the NICU in the short-term, but long-term safety and neurodevelopmental outcomes were not reported.
Article
Multidisciplinary Sciences
Gdiom Gebreheat, Hirut Teame
Summary: This study assessed the predictors of preterm neonatal survival in a neonatal intensive care unit (NICU). The results showed a significant decrement in survival probability of preterm neonates during the first week of life. Fetal presentation, gestational age, birth weight, 1-min APGAR score, perinatal asphyxia, and respiratory distress syndrome were identified as independent predictors of preterm neonatal mortality.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Sarah Coutts, Alix Woldring, Ann Pederson, Julie De Salaberry, Horacio Osiovich, Lori A. Brotto
Summary: The study identified four main themes as barriers and enablers to Kangaroo Care (KC) implementation by healthcare providers in NICUs: the NICU physical environment, healthcare provider beliefs about KC, clinical practice variation, and parent presence. A 'one size fits all' approach cannot be applied to guide KC implementation as each NICU presents unique barriers and enablers to its uptake. Support for improving parental presence, shifting healthcare provider beliefs, and developing a provincial guideline for KC may help reduce barriers to KC for healthcare providers, families, and administrators.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Psychology, Multidisciplinary
Maria Di Chiara, Gianluigi Laccetta, Sara Gangi, Benedetta De Santis, Caterina Spiriti, Martina Attenni, Laura Bertolaso, Giovanni Boscarino, Maria Chiara De Nardo, Gianluca Ciambra, Pasquale Parisi, Gianluca Terrin
Summary: Preterm birth and admission to NICU can lead to PTSD. The gestational age of newborns, parental stressor scale visual and auditory scores, and early Kangaroo Care (KC) play important roles in the occurrence of PTSD.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Pediatrics
Ashraf Kharrat, Patrick J. McNamara, Dany E. Weisz, Edmond Kelly, Edith Masse, Amit Mukerji, Deepak Louis, Jehier Afifi, Xiang Y. Ye, Prakesh S. Shah, Amish Jain
Summary: This retrospective cohort study aimed to study the clinical burden associated with cardio-pulmonary critical decompensations (CPCDs) in preterm neonates and factors associated with mortality. The study found clustering effects in CPCD-associated mortality among Canadian NICUs, with higher incidence units showing lower mortality.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Maria Grazia Monaci, Maya Gratier, Colwyn Trevarthen, Didier Grandjean, Pierre Kuhn, Manuela Filippa
Summary: The study found that mothers' speaking and singing to preterm infants in incubators can effectively enhance communication between them, with mothers feeling progressively more at ease and effective in this interaction. Nurses and medical staff should support and promote this form of parent-infant interaction, while individual musical experience also influences the effectiveness of communication with infants after premature birth.
Article
Pediatrics
Viral G. Jain, Christy Kessler, Linda Lacina, Greg A. Szumlas, Clare Crosh, John S. Hutton, Robert Needlman, Thomas G. Dewitt
Summary: The study aimed to evaluate the impact of a program designed to promote reading to infants in the NICU on parental reading behaviors, and found that the program helped increase parental reading frequency in the NICU, especially for high-risk parents who do not enjoy reading.
JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Juan D. Rios, Prakesh S. Shah, Marc Beltempo, Deepak Louis, Amit Mukerji, Shahirose Premji, Vibhuti Shah, Shoo K. Lee, Petros Pechlivanoglou
Summary: The study developed and validated an itemized costing algorithm for in-patient neonatal intensive care unit (NICU) costs for prematurely born infants. Results showed that NICU costs for preterm infants increase as gestational age decreases and length of stay increases. The cost estimates provided are easily accessible, transparent, and consistent with previous estimates.
JOURNAL OF PEDIATRICS
(2021)
Article
Environmental Sciences
Delia Cristobal Canadas, Tesifon Parron Carreno, Cristina Sanchez Borja, Antonio Bonillo Perales
Summary: Kangaroo mother care (KMC) has a positive effect on the stress of preterm infants and their mothers, reducing cortisol levels, promoting infant weight gain, and reducing postpartum depression in mothers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Endalkachew Worku Mengesha, Desalegne Amare, Likawunt Samuel Asfaw, Mulugeta Tesfa, Mitiku B. Debela, Fentie Ambaw Getahun
Summary: This study explored the experiences of parents in neonatal intensive care units in Ethiopia. The findings revealed that parents faced psychological and emotional problems, as well as challenges in accessing adequate healthcare services.
ANNALS OF MEDICINE
(2022)
Article
Pediatrics
Katrine Kure Pollstergaard, Rikke Wiingreen, Rasmus Gregersen, Rene Mathiasen, Bo Molholm Hansen, Gorm Greisen
Summary: The study shows that very low birth weight has negative effects on the socioeconomic outcomes of young adults, although the relative disadvantages are smaller compared to childhood.
Review
Pediatrics
Mohamed El-Dib, Nicholas S. J. Abend, Topun Austin, Geraldine Boylan, Valerie Chock, M. Roberta Cilio, Gorm Greisen, Lena Hellstroem-Westas, Petra Lemmers, Adelina Pellicer, Ronit Pressler, Arnold Sansevere, Tammy Tsuchida, Sampsa Vanhatalo, Courtney J. Wusthoff
Summary: The development of neonatal neurocritical care in the past decade has shown significant progress in neuromonitoring and neuroprotection. Commonly used brain monitoring tools in the neonatal intensive care unit (NICU) include amplitude integrated EEG (aEEG), full multichannel continuous EEG (cEEG), and near-infrared spectroscopy (NIRS). However, there is no consensus on the consistent and efficient use of these modalities in common NICU scenarios. This review summarizes current evidence for the best utilization of neuromonitoring modalities in neonates with encephalopathy or possible seizures.
PEDIATRIC RESEARCH
(2023)
Review
Pediatrics
Mohamed El-Dib, Nicholas S. Abend, Topun Austin, Geraldine Boylan, Valerie Chock, M. Roberta Cilio, Gorm Greisen, Lena Hellstrom-Westas, Petra Lemmers, Adelina Pellicer, Ronit M. Pressler, Arnold Sansevere, Eniko Szakmar, Tammy Tsuchida, Sampsa Vanhatalo, Courtney J. Wusthoff
Summary: Neonatal intensive care has shifted focus from cardiorespiratory care to a holistic approach that emphasizes brain health. The most commonly used tools in the neonatal intensive care unit (NICU) to monitor brain function and physiology are amplitude-integrated EEG, full multichannel continuous EEG, and near-infrared spectroscopy. Each of these tools has unique characteristics and functions, but there is no consensus on the optimal approach to neuromonitoring in the NICU. This review examines current evidence to guide the use of these neuromonitoring tools for neuroprotective care in extremely premature infants and critically ill neonates.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Catherine Gire, Ninon Fournier, Johanna Pirrello, Stephane Marret, Hugues Patural, Cyril Flamant, Veronique Pierrat, Monique Kaminski, Pierre-Yves Ancel, Barthelemy Tosello, Julie Berbis
Summary: This study examined the relationship between hemoglobin levels in very preterm infants within the first 24 hours of birth and the neurodevelopment outcomes at 24 months of corrected age. The results showed that early low hemoglobin levels were associated with major neonatal morbidities but not with neurodevelopment outcomes at two years of age, except in male infants born at gestational age of more than 26 weeks.
Article
Medicine, General & Internal
Mathias L. Hansen, Adelina Pellicer, Simon Hyttel-Srensen, Ebru Ergenekon, Tomasz Szczapa, Cornelia Hagmann, Gunnar Naulaers, Jonathan Mintzer, Monica Fumagalli, Gabriel Dimitriou, Eugene Dempsey, Jakub Tkaczyk, Guoqiang Cheng, Siv Fredly, Anne M. Heuchan, Gerhard Pichler, Hans Fuchs, Saudamini Nesargi, Gitte H. Hahn, Salvador Piris-Borregas, Jan Sirc, Miguel Alsina-Casanova, Martin Stocker, Hilal Ozkan, Kosmas Sarafidis, Andrew O. Hopper, Tanja Karen, Beata Rzepecka-Weglarz, Serife S. Oguz, Luis Arruza, Asli C. Memisoglu, Ruth del Rio Florentino, Mariana Baserga, Pierre Maton, Anita C. Truttmann, Isabel de las Cuevas, Peter Agergaard, Pamela Zafra, Lars Bender, Ryszard Lauterbach, Chantal Lecart, Julie de Buyst, Afif El-Khuffash, Anna Curley, Olalla O. Vaccarello, Jan Miletin, Evangelia Papathoma, Zachary Vesoulis, Giovanni Vento, Luc Cornette, Laura S. Lopez, Beril Yasa, Anja Klamer, Massimo Agosti, Olivier Baud, Emmanuele Mastretta, Merih Cetinkaya, Karen McCall, Shujuan Zeng, Eleftheria Hatzidaki, Agata Bargiel, Sylwia Marciniak, Xiaoyan Gao, Lin Huijia, Lina Chalak, Ling Yang, Shashidhar A. Rao, Xin Xu, Begona L. Gonzalez, Maria Wilinska, Zhaoqing Yin, Iwona Sadowska-Krawczenko, Itziar Serrano-Vinuales, Barbara Krolak-Olejnik, Marta M. Ybarra, Catalina Morales-Betancourt, Peter Korcek, Marta Teresa-Palacio, Fabio Mosca, Anja Hergenhan, Nilgun Koksal, Konstantia Tsoni, Munaf M. Kadri, Claudia Knoepfli, Elzbieta Rafinska-Wazny, Mustafa S. Akin, Tone Nordvik, Zhang Peng, Sinem G. Kersin, Liesbeth Thewissen, Ana Alarcon, David Healy, Berndt Urlesberger, Muenevver Bas, Jana Baumgartner, Eleni Skylogianni, Veronika Karadyova, Eva Valverde, Elena Bergon-Sendin, Jachym Kucera, Silvia Pisoni, Le Wang, Anne Smits, Rebeca Sanchez-Salmador, Marie I. Rasmussen, Markus H. Olsen, Aksel K. Jensen, Christian Gluud, Janus C. Jakobsen, Gorm Greisen
Summary: A multicenter, randomized trial found that treatment guided by cerebral oximetry monitoring for the first 72 hours after birth did not reduce the risk of death or severe brain injury at 36 weeks' postmenstrual age in extremely preterm infants.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Andreas Jensen, Gorm Greisen, Thomas Hjuler, Lone Graff Stensballe
Summary: This study aimed to assess the utilization of surgery in Danish children aged 0-5 years from 1999 to 2018. The results showed that the overall incidence of surgical procedures did not increase during this period. It was also found that boys underwent more surgery than girls, and the rate of surgery decreased in public hospitals but increased in private specialist practices among children with severe chronic disease.
Article
Pediatrics
Rikke Wiingreen, Gorm Greisen, Ellen C. L. Lokkegaard, Christian Torp-Pedersen, Kathrine K. Sorensen, Mikkel P. Andersen, Bo M. Hansen
Summary: This study investigated the association between gestational age and grade point averages in language and mathematics at the end of lower secondary education. The findings showed that decreasing gestational age was associated with lower grades in mathematics, but there were only minor differences in grades in language. Children with shorter gestational age were also more likely to have mathematical difficulties.
Editorial Material
Pediatrics
Petra S. Huppi, Manuela Filippa
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Charlotte Carina Holm-Hansen, Stine Lund, Tine Bruhn Skytte, Jil Molenaar, Christina Nadia Steensgaard, Ulfat Amour Mohd, Said Mzee, Said Mouhammed Ali, Jesper Kjaergaard, Gorm Greisen, Jette Led Sorensen, Anja Poulsen
Summary: The aim of this study was to assess risk factors for neonatal mortality, quality of neonatal resuscitation, and identify areas for improvement. The study found significant deviations from guidelines in the quality of care for neonatal resuscitation, despite 87.5% of health workers being trained in this area. The videos provided direct evidence of gaps in care and highlighted the need for future education in effective positive pressure ventilation.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Anne Mette Plomgaard, Nathan Stevenson, James A. Roberts, Tue Hvass Petersen, Sampsa Vanhatalo, Gorm Greisen, SafeBoosC-II study group
Summary: Automated computational measures of EEG in extremely preterm infants were found to be predictive of neurodevelopmental impairment at 2 years of age. The association between EEG measures and neurodevelopment in childhood was confirmed in this study, and the measure appears to be robust to differences in electrodes, amplifiers, and filters.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, Research & Experimental
Maria Linander Vestager, Mathias Luehr Hansen, Marie Isabel Rasmussen, Gitte Holst Hahn, Simon Hyttel-Sorensen, Adelina Pellicer, Anne Marie Heuchan, Cornelia Hagmann, Eugene Dempsey, Gabriel Dimitriou, Gerhard Pichler, Gunnar Naulaers, Hans Fuchs, Jakub Tkaczyk, Jonathan Mintzer, Monica Fumagalli, Saudamini Nesargi, Siv Fredly, Tomasz Szczapa, Christian Gluud, Janus Christian Jakobsen, Gorm Greisen
Summary: The SafeBoosC-IIIv trial aims to evaluate the benefits and harms of cerebral oximetry added to usual care versus usual care in mechanically ventilated newborns. This randomized clinical trial, involving 3000 participants from multiple countries, will assess outcomes such as mortality rate and neurodevelopmental disabilities. The findings from this study will provide important guidance for neonatal intensive care and treatment of brain injuries.
Article
Medicine, Research & Experimental
Marie Isabel Rasmussen, Mathias Luhr Hansen, Adelina Pellicer, Christian Gluud, Eugene Dempsey, Jonathan Mintzer, Simon Hyttel-Sorensen, Anne Marie Heuchan, Cornelia Hagmann, Ebru Ergenekon, Gabriel Dimitriou, Gerhard Pichler, Gunnar Naulaers, Guoqiang Cheng, Jakub Tkaczyk, Hans Fuchs, Monica Fumagalli, Saudamini Nesargi, Siv Fredly, Tomasz Szczapa, Anne Mette Plomgaard, Bo Molholm Hansen, Janus Christian Jakobsen, Gorm Greisen
Summary: The SafeBoosC-III follow-up study aims to assess mortality, neurodevelopmental disability, or any harm in trial participants at 2 years of corrected age. The lack of funding for trial-specific assessment local costs is a challenge that needs to be addressed.
Article
Oncology
Daniela Pierannunzio, Alice Maraschini, Tania Lopez, Serena Donati, Rosalba Amodio, Fortunato Bianconi, Rossella Bruni, Marine Castaing, Claudia Cirilli, Giovanna Fantaci, Linda Guarda, Silvia Iacovacci, Lucia Mangone, Guido Mazzoleni, Walter Mazzucco, Anna Melcarne, Elisabetta Merlo, Fabio Parazzini, Fedro Alessandro Peccatori, Massimo Rugge, Giuseppe Sampietro, Giovanni Scambia, Giovanna Scarfone, Ausilia Sferrazza, Fabrizio Stracci, Antonina Torrisi, Maria Francesca Vitale, Silvia Francisci
Summary: Concurrence of pregnancy and cancer diagnosis is becoming more common due to the trend of postponing childbearing. This study aims to describe the frequency and trend of pregnancy-associated cancer (PAC) in Italy. The study found that PAC has been increasing from 2003 to 2015, with breast cancer being the most frequent type. The findings provide guidance for clinicians in managing PAC.
Article
Medicine, General & Internal
Liv Borch-Johnsen, Caroline Gren, Stine Lund, Fredrik Folke, Morten Schroder, Marianne Sjolin Frederiksen, Freddy Lippert, Annette Kjaer Ersboll, Gorm Greisen, Dina Cortes
Summary: This study assessed the effectiveness and safety of video tutorials in caring for acutely ill children. The results showed that video tutorials significantly increased caregivers' self-efficacy, reduced the need for telephone triage, and resulted in fewer hospital assessments for children.
Article
Pediatrics
David G. Sweet, Virgilio P. Carnielli, Gorm Greisen, Mikko Hallman, Katrin Klebermass-Schrehof, Eren Ozek, Arjan te Pas, Richard Plavka, Charles C. Roehr, Ola D. Saugstad, Umberto Simeoni, Christian P. Speer, Maximo Vento, Gerry H. A. Visser, Henry L. Halliday
Summary: The sixth version of European Guidelines for the Management of RDS has been developed by a panel of experienced European neonatologists and an expert perinatal obstetrician based on available literature up to end of 2022. These updated guidelines aim to optimize outcomes for babies with RDS through various measures such as prediction of risk of preterm delivery, appropriate maternal transfer to a perinatal center, and evidence-based lung-protective management. The guidelines also address the importance of general care for infants with RDS, including cardiovascular support and judicious use of antibiotics. The guidelines have received endorsement from the European Society for Paediatric Research (ESPR) and the Union of European Neonatal and Perinatal Societies (UENPS). Rating: 7 out of 10.
