Article
Pediatrics
Kimberly Fan, Caitlin Hurley, Michael J. McNeil, Asya Agulnik, Sara Federico, Amr Qudeimat, Arun Saini, Jennifer McArthur, Ronald Ray Morrison, Hitesh Sandhu, Samir Shah, Saad Ghafoor
Summary: Diffuse alveolar hemorrhage (DAH) is an early pulmonary complication of hematopoietic cell transplantation (HCT) associated with severe hypoxemic respiratory failure and high mortality. This study reports two cases of DAH following HCT successfully supported with ECMO despite refractory hypoxemic respiratory failure, suggesting that ECMO support may be considered for DAH patients.
FRONTIERS IN PEDIATRICS
(2021)
Article
Critical Care Medicine
Zhenmei Zhang, Can Wang, Steve G. Peters, William J. Hogan, Shahrukh K. Hashmi, Mark R. Litzow, Mrinal S. Patnaik, Alexander S. Niven, Hemang Yadav
Summary: DAH after HCT has a low incidence rate but high mortality rate, requiring attention. Multiple factors may influence the incidence rate, mortality rate, and risk factors, including time of onset, platelet count, and the need for invasive mechanical ventilation. For treatment outcomes, lower doses of steroids may help improve patient survival.
Review
Engineering, Biomedical
Haritha G. Reddy, Elizabeth J. Maynes, Abhiraj Saxena, Melissa A. Austin, Thomas J. O'Malley, Marc N. Gadda, Nawar N. Al-Rawas, Michael Baram, Bharat K. Awsare, H. Todd Massey, Vakhtang Tchantchaleishvili
Summary: DAD/DAH predominantly affects a younger, female population and is commonly associated with systemic autoimmune processes. ECLS, regardless of type, seems to result in favorable short-term survival outcomes.
Article
Emergency Medicine
Lei Zhang, Lina Liu, Caiwei Lin, Xudong Wang
Summary: Diffuse alveolar hemorrhage (DAH) is a serious disease with main symptoms of hemoptysis and dyspnea, and ECMO can provide oxygenation support when mechanical ventilation fails. Early initiation of V-V ECMO can rescue patients' lives.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Alyssa M. Loecher, Kathleen West, Timothy D. Quinn, Aubrey A. Defayette
Summary: DAH is a critical complication that can occur in patients post-HSCT, with treatment options including corticosteroids, aminocaproic acid, and rFVIIa. Further research is needed to explore the efficacy of these treatments for improved outcomes.
Review
Immunology
Sabrina N. Copsel, Dietlinde Wolf, Brent Pfeiffer, Henry Barreras, Victor L. Perez, Robert B. Levy
Summary: Human and mouse CD4(+)FoxP3(+) T cells, as non-redundant regulatory compartments, play crucial roles in maintaining self-tolerance and have potential therapeutic applications in autoimmune disorders and transplants. Currently, the focus is on using donor-derived Tregs, but manipulating recipient Tregs after transplantation remains challenging. Researchers are exploring strategies to control recipient Tregs and improve post-transplant outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Lucas Hamrick, Seth J. Deskins, Saif Al-Qatarneh
Summary: A 15-year-old female patient presented with symptomatic anemia, fatigue, dyspnea, and weight loss, which were later diagnosed as systemic lupus erythematosus. She developed respiratory failure and bilateral pleural effusions during her hospital admission, but her symptoms improved with treatment.
PEDIATRIC PULMONOLOGY
(2023)
Review
Engineering, Biomedical
Anne Willers, Justyna Swol, Mariusz Kowalewski, Giuseppe Maria Raffa, Paolo Meani, Federica Jiritano, Matteo Matteucci, Dario Fina, Samuel Heuts, Elham Bidar, Ehsan Natour, Jan Willem Sels, Thijs Delnoij, Roberto Lorusso
Summary: The use of ECLS support in hemorrhagic conditions may improve patient outcomes, with hemodynamic support benefits outweighing the risk of bleeding. Further research is needed to better understand patient selection and ECLS management strategies.
Article
Immunology
Yotam Kolben, Fares Darawshy, Barhoum Barhoum, Avraham Abutbul, Rottem Kuint
Summary: G-CSF, commonly used in healthy adults prior to stem cell donation, can lead to rare but life-threatening pulmonary adverse events such as diffuse alveolar hemorrhage. Healthcare providers should be aware of this potential complication.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Zhongnan Yang, Lei Yan, Huixia Cao, Yue Gu, Pan Zhou, Mingyue Shi, Guodong Li, Xiaojing Jiao, Na Li, Xiangnan Li, Kai Sun, Fengmin Shao
Summary: The study showed that erythropoietin (EPO) can alleviate diffuse alveolar hemorrhage (DAH) by reducing macrophage recruitment and promoting phenotype switch, suggesting its potential as a therapeutic agent for DAH. Further research is needed to validate the direct target of miR-494-3p in regulating JAK2/STAT3 signaling transduction.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Pediatrics
Xinjuan Zhang, Yanping Yu
Summary: This case reports a severe pediatric mycoplasma pneumonia patient who rapidly deteriorated with severe lung lesions, pleural effusion, bleeding, and respiratory distress requiring ventilator and VV-ECMO support. The patient was successfully discharged after timely diagnosis and treatment.
FRONTIERS IN PEDIATRICS
(2023)
Article
Rheumatology
Xue Li, Yuxin Chen, Jianyu Zhang, Ting Li, Jian Chen, Yu Lu, Liu Yang
Summary: Diffuse alveolar hemorrhage (DAH) is a severe complication of systemic lupus erythematosus (SLE) with high mortality. This case report discusses a 28-year-old female patient with SLE complicated by DAH. By adjusting the treatment regimen, the patient's symptoms improved.
Review
Biochemistry & Molecular Biology
Jeong A. Park
Summary: Diffuse alveolar hemorrhage is a life-threatening pulmonary complication with unclear pathogenesis and controversial treatment options, including the off-label use of FVIIa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Matt S. Zinter, Jennifer McArthur, Christine Duncan, Roberta Adams, Erin Kreml, Heidi Dalton, Hisham Abdel-Azim, Courtney M. Rowan, Shira J. Gertz, Kris M. Mahadeo, Adrienne G. Randolph, Prakadeshwari Rajapreyar, Marie E. Steiner, Leslie Lehmann
Summary: This article describes the effectiveness and factors related to the use of extracorporeal life support in pediatric hematopoietic cell transplantation patients and proposes a framework to guide physicians' decision-making.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Review
Respiratory System
Biplab K. Saha, Woon H. Chong
Summary: Diffuse alveolar hemorrhage is a rare condition with diverse etiologies, where cardiac diseases are often underestimated causes, particularly heart failure and mitral valve diseases being the most common. DAH is typically caused by the stress failure of pulmonary capillaries due to pulmonary venous hypertension, with a contribution from the bronchial circulation.
