Article
Physiology
Aravind Natarajan, Hao-Wei Su, Conor Heneghan
Summary: This study shows that Resting Heart Rate is modified for several weeks following a COVID-19 infection, with three phases of elevation, decrease, and subsequent increase. The extent of these changes varies with disease severity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Baowei Zhang, Chunjiang Zhou, Jinqiu Liu, Jinlin Zhang, Chenyang Jiang, Min Tang, Jiaxi Xie, Yizhang Wu, Xin Xie, Xiaorong Li, Jinbo Yu, Xuecheng Wang, Dian Cheng, Jian Zhou, Zijun Chen, Fenghua Fan, Xiujuan Zhou, Aibin Tao, Bing Yang
Summary: This study shows that cardiac sympathetic nerve system activity is impaired in arrhythmogenic cardiomyopathy (ACM) patients. Heart rate variability (HRV) can be used to assess and predict the risk of sustained ventricular tachycardia (sVT) in ACM patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Ana Carolina M. Omoto, Renata M. Lataro, Thais M. Silva, Helio Cesar Salgado, Rubens Fazan Jr, Luiz Eduardo Virgilio Silva
Summary: The study found that myocardial infarction increases heart rate fragmentation, leading to reduced cardiac function, further emphasizing the importance of using this method to explore pathophysiological conditions.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2021)
Review
Cardiac & Cardiovascular Systems
Taylor Schultz, Frank J. Raucci, Fadi N. Salloum
Summary: Duchenne muscular dystrophy (DMD) is a rare and devastating disease, affecting approximately 1 in every 3,500 male births worldwide. Cardiomyopathy has become the most common cause of death in DMD patients. Current research aims to identify therapeutic targets for treating DMD cardiomyopathy.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, General & Internal
Huanhuan Zhang, Meng Zhang, Yanru Du, Jinhua He, Jianli Li
Summary: This study reported a case of a 41-year-old female patient diagnosed with gallbladder polyps who underwent laparoscopic cholecystectomy under general anesthesia. During the operation, sudden bradycardia occurred and atropine was administered intravenously, which resulted in ventricular tachycardia and acute heart failure. Immediate treatment was provided and the patient experienced no complications after 6 months of follow-up.
Article
Endocrinology & Metabolism
Wenjing Wang, Shuchen Zhang, Longjiang Xu, Yu Feng, Xiaoguang Wu, Mengyao Zhang, Zongliang Yu, Xiang Zhou
Summary: The study revealed that knockdown of circHIPK3 attenuated myocardial fibrosis and enhanced cardiac function in DCM mice, and could suppress proliferation of cardiac fibroblasts treated with angiotensin II. Furthermore, RNA immunoprecipitation and luciferase reporter assay demonstrated a circHIPK3-miR-29b-3p-Col1a1-Col3a1 regulatory network in the pathogenesis of myocardial fibrosis.
Article
Rheumatology
Keita Ninagawa, Masaru Kato, Satonori Tsuneta, Suguru Ishizaka, Hideyuki Ujiie, Ryo Hisada, Michihito Kono, Yuichiro Fujieda, Yoichi M. Ito, Tatsuya Atsumi
Summary: Nintedanib has beneficial effects on cardiomyopathy associated with SSc, suggesting its anti-fibrotic effect may not be limited to the lungs.
Article
Engineering, Biomedical
Jesse D. Parreira, Yekanth R. Chalumuri, Azin S. Mousavi, Mihir Modak, Yuanyuan Zhou, Jesus Antonio Sanchez-Perez, Asim H. Gazi, Anna B. Harrison, Omer T. Inan, Jin- Oh Hahn
Summary: In this study, we investigated how various cardiorespiratory parameters respond to acute mental stress by utilizing multi-modal physiological signals and wearable-based sensing platforms. The results showed that the cross-integration of these signals can provide effective signatures to elucidate the collective physiological changes during acute mental stress. This work demonstrates the proof-of-concept of tracking acute mental stress through physiology-inspired signatures derived from multi-modal physiological signals, paving the way for future research in quantifying stress responses in real-world settings.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Computer Science, Information Systems
Jian Zhang, Yuan Wu, Yanjiao Chen, Tong Chen
Summary: Myocardial infarction (MI) is a serious heart muscle injury caused by continuous ischemia and hypoxia of the coronary arteries. Early detection of MI is crucial for symptom relief and improvement in daily activities. In this paper, a contactless and non-intrusive MI detection method based on wireless sensing is introduced, which monitors abnormalities in heartbeats for early detection.
IEEE TRANSACTIONS ON MOBILE COMPUTING
(2022)
Article
Cardiac & Cardiovascular Systems
Daniele Muser, Gaetano Nucifora, Simon A. Castro, Andres Enriquez, C. Anwar A. Chahal, Silvia Magnani, Ramanan Kumareswaran, Jeffrey Arkles, Gregory Supple, Robert Schaller, Matthew Hyman, Sanjay Dixit, David Lin, Erica S. Zado, Cory Tschabrunn, David J. Callans, Saman Nazarian, David S. Frankel, Francis E. Marchlinski, Pasquale Santangeli
Summary: The study aimed to characterize the relationship between DF, EAM substrate, and outcomes of catheter ablation of VT in NICM patients. It found that DF estimated using post-contrast T-1 mapping correlates with voltage abnormality at EAM and likely impacts post-ablation outcomes.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Shiran Yu, Xuefei Dong, Min Yang, Qingtao Yu, Jie Xiong, Jing Chen, Bo Dong, Qing Su
Summary: The PRR-YAP pathway is believed to play a crucial role in the pathogenesis of DCM by promoting pathological injuries through triggering oxidative stress and myocardial fibrosis, as revealed in experiments involving Wistar rats and neonatal rat cardiac fibroblasts in vivo and in vitro.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Aleksandra Karabinowska-Malocha, Ewa Dziewiecka, Pawel Banys, Malgorzata Urbanczyk-Zawadzka, Maciej Krupinski, Malgorzata Mielnik, Jacek Lach, Aleksandra Budkiewicz, Piotr Podolec, Lukasz Zydzik, Sylwia Wisniowska-Smialek, Katarzyna Holcman, Magdalena Kostkiewicz, Pawel Rubis
Summary: This study aimed to evaluate the relationship between interstitial fibrosis on cardiac magnetic resonance (CMR) and non-sustained ventricular tachycardia (nsVT) in hypertrophic cardiomyopathy (HCM). The study found that the presence of late gadolinium enhancement (LGE) alone is not enough to determine the occurrence of nsVT in HCM patients, but rather the actual extent of LGE is important, while the role of interstitial fibrosis remains unclear.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zsofia Onodi, Petra Lujza Szabo, Daniel Kucsera, Peter Pokreisz, Christopher Dostal, Karlheinz Hilber, Gavin Y. Oudit, Bruno K. Podesser, Peter Ferdinandy, Zoltan V. Varga, Attila Kiss
Summary: Duchenne muscular dystrophy (DMD) is a muscle wasting disease characterized by difficulty moving and premature death, mainly due to heart failure. Inflammation is thought to play a role in the disease progression, but the specific mechanisms are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Ikutaro Nakajima, Ryohsuke Narui, Asad A. Aboud, Oluwaseun Adeola, Julia McHugh, Benjamin Holmes, Ricardo Lugo, Travis D. Richardson, Jay Montgomery, Sharon Shen, Arvindh Kanagasundram, Gregory F. Michaud, William G. Stevenson
Summary: In patients without heart disease, the 5th percentile of endocardial voltage for increasing distance from the aortic valve ring was determined. Among NICM patients, periaortic VTs were associated with similar periaortic bipolar voltage but lower UVs, and could be divided into left bundle branch block and right bundle branch block types with different ablation outcomes and risks. Adjusting voltage parameters based on distance from the aortic valve may improve definition of left ventricular outflow tract arrhythmia substrate.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Thijs P. Kerstens, Wouter M. van Everdingen, Jesse Habets, Arie P. J. van Dijk, Willem A. Helbing, Dick H. J. Thijssen, Floris E. A. Udink ten Cate
Summary: In pediatric patients with Duchenne muscular dystrophy (DMD), lower global strain is associated with the presence and extent of left ventricular (LV) myocardial fibrosis, while segmental strain does not seem to correspond to the location of fibrosis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tomoyuki Mizuno, Katja M. Gist, Zhiqian Gao, Michael F. Wempe, Jeffrey Alten, David S. Cooper, Stuart L. Goldstein, Alexander A. Vinks
CLINICAL PHARMACOKINETICS
(2019)
Article
Cardiac & Cardiovascular Systems
Catherine C. Allen, Regina Keller, Krystle C. Barnard, Zhiqian Gao, Eileen C. King, Erik C. Michelfelder
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2019)
Article
Cardiac & Cardiovascular Systems
Samuel G. Wittekind, Thomas D. Ryan, Zhiqian Gao, Farhan Zafar, Richard J. Czosek, Clifford W. Chin, John L. Jefferies
PEDIATRIC CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Katherine E. Bates, Nicolas L. Madsen, Lara Khadr, Zhiqian Gao, Kari Crawford, Michael Gaies, Margaret Graupe, Samuel P. Hanke, Anthony M. Hlavacek, Evonne Morell, Sara K. Pasquali, Jennifer L. Russell, Susan K. Schachtner, Ronn E. Tanel, Adam L. Ware, Alaina K. Kipps
ANNALS OF THORACIC SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Justin R. Ryder, Elise Northrop, Kyle D. Rudser, Aaron S. Kelly, Zhiqian Gao, Philip R. Khoury, Thomas R. Kimball, Lawrence M. Dolan, Elaine M. Urbina
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Cardiac & Cardiovascular Systems
Andrea Girnius, Dominica Zentner, Anne Marie Valente, Petronella G. Pieper, Katherine E. Economy, Magalie Ladouceur, Jolien W. Roos-Hesselink, Carri Warshak, Sara L. Partington, Zhiqian Gao, Nicholas Ollberding, Michelle Faust, Saulius Girnius, Harald Kaemmerer, Nicole Nagdyman, Scott Cohen, Mary Canobbio, Teiji Akagi, Jasmine Grewal, Elisa Bradley, Yonathan Buber, Joseph Palumbo, Niki Walker, Jamil Aboulhosn, Erwin Oechslin, Helmut Baumgartner, Wesam Kurdi, Wendy M. Book, Barbara J. M. Mulder, Gruschen R. Veldtman
Summary: This study evaluated thrombosis and bleeding risk in pregnant women with Fontan. Current antithrombotic strategies effectively attenuate thrombotic risk, but come with a high (>30%) bleeding risk, especially 13% being severe. Achieving haemostatic balance is challenging in pregnant women with Fontan.
Article
Cardiac & Cardiovascular Systems
Richard J. Czosek, Zhiqian Gao, Jeffrey B. Anderson, Timothy K. Knilans, Nicholas J. Ollberding, David S. Spar
Summary: This study aimed to evaluate patient and device characteristics associated with ventricular dysfunction in pediatric patients with chronic ventricular pacing. It found that QRS duration and changes in QRS duration over time were important factors associated with long-term ventricular dysfunction, highlighting the potential increased risk with prolonged ventricular pacing.
PEDIATRIC CARDIOLOGY
(2021)
Article
Critical Care Medicine
David Cooper, Ravi Thiagarajan, Brandon Michael Henry, Jonathan W. Byrnes, Andrew Misfeldt, Jason Frischer, Eileen King, Zhiqian Gao, Peter Rycus, Bradley S. Marino
Summary: This study found that the outcomes of multiple runs of ECMO remain poor. Survival decreases with each additional run. Patients requiring additional runs for pulmonary indications should be considered prime candidates. Renal complications on the first run significantly increase the risk of mortality on subsequent runs.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Mathias Possner, Anisa Chaudhry, Jonathan R. Dillman, Elaine M. Urbina, Zhiqian Gao, Connie McCoy, Michelle Faust, Harry B. Rossiter, Adam W. Powell, Wayne Mays, Gruschen Veldtman
Summary: Exercise acutely increased liver stiffness and venous pressures, but inhaled Treprostinil did not significantly impact these responses.
CARDIOLOGY IN THE YOUNG
(2021)
Article
Pediatrics
Stephanie Y. Tseng, Zhiqian Gao, Theodosia A. Kalfa, Nicholas J. Ollberding, Sammy Tabbah, Regina Keller, James F. Cnota
Summary: Term newborns with congenital heart disease demonstrated altered erythropoiesis at birth, characterized by decreased hemoglobin levels despite red blood cell indices consistent with stress erythropoiesis. These alterations were not associated with outcomes of fetal growth or Doppler patterns.
PEDIATRIC RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Fangfei Wang, Quan He, Zhiqian Gao, Andrew N. Redington
Summary: The study indicates that cardiac-specific Atg5 knockdown results in the development of age-related cardiomyopathy, and remote ischemic conditioning can reverse the molecular and structural phenotype both acutely and chronically.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhiqian Gao, Philip R. Khoury, Lawrence M. Dolan, Elaine M. Urbina
Summary: In high-risk youth, baseline obesity leads to increased blood pressure and glucose, accelerating the accumulation of carotid arterial injury. The prevention of obesity acquisition in youth is crucial in slowing the development of cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
David A. Katz, Zhiqian Gao, Joshua Freytag, Arjun Mahendran, Cassandra Szugye, Shalayna Woodly, T. Christine E. Alvarez, Adam M. Lubert, Tarek Alsaied, Stuart L. Goldstein, Alexander R. Opotowsky
Summary: In this study, it was found that using Cystatin C-estimated glomerular filtration rate (eGFR) can more frequently detect chronic kidney disease, and urine kidney injury biomarkers also increase with declining Fontan physiological features.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Kathleen Colman, Tarek Alsaied, Adam Lubert, Harry B. Rossiter, Wayne A. Mays, Adam W. Powell, Sandra Knecht, Danielle Poe, Nicholas Ollberding, Zhiqian Gao, Clifford Chin, Gruschen R. Veldtman
Summary: The study demonstrates a strong association between elevated peripheral venous pressure (PVP) during exercise and adverse outcomes in Fontan patients. Monitoring PVP during exercise could be a useful tool for identifying individuals at higher risk for Fontan-related morbidities.
Article
Cardiac & Cardiovascular Systems
James A. Reagor, Sean Clingan, Zhiqian Gao, David L. S. Morales, James S. Tweddell, Roosevelt Bryant, William Young, Jesse Cavanaugh, David S. Cooper
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2020)