Article
Immunology
Ulrika Snygg-Martin, Kok Wai Giang, Mikael Dellborg, Josefina Robertson, Zacharias Mandalenakis
Summary: Patients with congenital heart disease have a higher cumulative incidence of infective endocarditis compared to controls, and this incidence increases with age. The incidence of infective endocarditis varies by age but not by birth year.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Environmental Sciences
Xiaoyu Wan, Sixuan Wei, Yaqi Wang, Jun Jiang, Xinyao Lian, Zhiyong Zou, Jing Li
Summary: Previous studies on the association between maternal exposure to ambient air pollution and congenital anomalies in newborns have yielded ambiguous results. To address this knowledge gap, a systematic review and meta-analysis of existing literature were conducted. Our findings highlight potential evidence for the association between maternal air pollution exposure and congenital heart diseases.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Eva Havers-Borgersen, Jawad H. Butt, Lauge ostergaard, Jeppe K. Petersen, Christian Torp-Pedersen, Lars Kober, Emil L. Fosbol
Summary: Patients with congenital heart disease (CHD) have a higher risk of infective endocarditis (IE) compared to the general population. This observational cohort study in Denmark found that the risk of IE varied among different types of CHD. Factors associated with IE in CHD patients included male sex, cyanosis, cardiac prostheses, chronic kidney disease, and cardiac implantable electronic devices. This highlights the importance of implementing preventive measures for CHD patients.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Eva Havers-Borgersen, Jawad H. Butt, Morten Smerup, Gunnar H. Gislason, Christian Torp-Pedersen, Mathis Groning, Michael Rahbek Schmidt, Lars Sondergaard, Lars Kober, Emil L. Fosbol
Summary: Patients with tetralogy of Fallot (ToF) are at increased risk of infective endocarditis (IE), particularly those who undergo pulmonary valve replacement (PVR). Limited data exist on the long-term risk of IE, but the study confirms an association between PVR and increased incidence of IE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Pediatrics
Abeer A. Hasan, Naser Aldain A. Abu Lehyah, Moath K. Al Tarawneh, Mahmoud Y. Abbad, Areen G. Fraijat, Razan A. Al-Jammal, Dania M. Moamar, Qasem A. Shersheer, Scott O. Guthrie, Joseph R. Starnes
Summary: This study investigated the epidemiology and identification methods of CHD in Jordan. The results showed a high incidence of CHD in Jordan, and prenatal and perinatal screening could facilitate early detection.
FRONTIERS IN PEDIATRICS
(2023)
Article
Public, Environmental & Occupational Health
Z. Yu, D. Li, L. Sun, X. Zhao, H. Chang, L. Cui, H. Zhang, X. Liu, X. Lao, Z. Wan, X. Zhang
Summary: The study investigated the incidence and trends of congenital anomalies in Central China's Henan Province from 1997 to 2019. The overall incidence increased over time, with higher rates in urban areas and among males. The incidence of neural tube defects decreased, while congenital heart disease incidence rose, making it the most common anomaly post-2013.
Article
Cardiac & Cardiovascular Systems
Shabnam Peyvandi, Duan Xu, James Barkovich, Dawn Gano, Vann Chau, V. Mohan Reddy, Thiviya Selvanathan, Ting Guo, J. William Gaynor, Mike Seed, Steven P. Miller, Patrick McQuillen
Summary: This study examined the rate and changes in preoperative and postoperative brain injury among neonates with complex congenital heart disease. The results showed no significant change in preoperative white matter injury and stroke rates, but a decrease in postoperative white matter injury rate. Higher postoperative blood pressures may explain this decline.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Valtteri Muroke, Mikko Jalanko, Jari Haukka, Juha Sinisalo
Summary: This study aimed to evaluate the long-term mortality and cause-specific mortality of patients with atrial septal defect (ASD) in a nationwide cohort. The results showed that patients with ASD had higher overall mortality, with increased cause-specific mortality in congenital malformations, stroke, and heart diseases.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Environmental Sciences
Daniela Dibello, Lucio Torelli, Valentina Di Carlo, Adamo Pio d'Adamo, Flavio Faletra, Alessandro Mangogna, Giulia Colin
Summary: This study uses the Certificate of Delivery Care Registry database from the Italian Ministry of Health to conduct a descriptive study on the incidence of clubfoot in Italy and calls for a reevaluation of the existing data. The study aims to provide a framework for future epidemiological research.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Behavioral Sciences
Johan Zelano, Mikael Dellborg, Peter Eriksson, Zacharias Mandalenakis
Summary: This study from Sweden found that patients with congenital heart disease (CHD) have a nearly fourfold increased risk of epilepsy compared to controls, although the absolute risk is low. Among patients with CHD, several brain comorbidities, including intellectual disability and stroke, as well as having undergone more than two cardiac interventions, were significantly associated with epilepsy.
BRAIN AND BEHAVIOR
(2022)
Article
Cardiac & Cardiovascular Systems
Scott J. Weinreb, Oluwatimilehin Okunowo, Heather Griffis, Victoria Vetter
Summary: In this study, 23% of the 114 subjects with CCHB reached the composite outcome of cardiac morbidity and mortality, with no significant association found between age at diagnosis, fetal diagnosis, and maternal antibody status with composite cardiac morbidity and mortality. However, fetal diagnosis had a higher associated hazard of heart failure and/or cardiomyopathy.
Article
Cardiac & Cardiovascular Systems
Sreehari M. Nair, Bistra Zheleva, Adriana Dobrzycka, Peter Hesslein, Rajeev Sadanandan, R. Krishna Kumar
Summary: This study reports the early results of a population health program for Congenital Heart Disease (CHD) in Kerala, India, showing that through innovative measures, including a web-based application for real-time registration, referral, and tracking of CHD cases, improvements in early identification, referral, and treatment of infants with CHD have been achieved.
Article
Pediatrics
Alba Perez-Perez, Sara Vigil-Vazquez, Ana Gutierrez-Velez, Gonzalo Solis-Garcia, Maria Lopez-Blazquez, Jose Luis Zunzunegui Martinez, Constancio Medrano Lopez, Juan Miguel Gil-Jaurena, Juan Carlos de Agustin-Asensio, Manuel Sanchez-Luna
Summary: The aim of this study was to analyze the occurrence and risk factors of chylothorax in neonatal patients after congenital heart disease surgery. A retrospective and observational study was conducted on neonates who underwent surgery between January 2014 and December 2019. The results showed a high incidence of chylothorax after surgery, leading to longer hospital stays and increased morbidity and mortality.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Kok Wai Giang, Zacharias Mandalenakis, Maria Fedchenko, Peter Eriksson, Annika Rosengren, Mikael Norman, Katarina Hanseus, Mikael Dellborg
Summary: The study assessed the birth prevalence of congenital heart disease (CHD) in Sweden over a half-century and found a significant increase in the number of cases, with the largest increase observed among patients with simple defects. Overall, cardiac interventions decreased, but interventions for the most complex CHD groups increased.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Qun Miao, Sandra Dunn, Shi Wu Wen, Jane Lougheed, Cynthia Maxwell, Jessica Reszel, Kaamel Hafizi, Mark Walker
Summary: This study investigates the interrelationships between maternal socioeconomic status, race, and congenital heart diseases (CHD) among infants. The results suggest that infants born to mothers living in lower-income neighborhoods and neighborhoods with fewer individuals with a university degree have a higher likelihood of developing CHD. Additionally, black mothers have a higher odds of giving birth to a child with CHD. Further research is needed to examine the impact of racial variation on CHD.
Article
Cardiac & Cardiovascular Systems
Daphney Kernizan, Shubhika Srivastava, Priya Nigam, Elaine M. Geary, Carissa Baker-Smith
Summary: This study retrospectively assessed the application of appropriate use criteria (AUC) for outpatient transthoracic echocardiography following telehealth visits. The findings indicate that most echocardiograms requested after telehealth visits were appropriate and no abnormal findings were detected in rarely appropriate cases.
PEDIATRIC CARDIOLOGY
(2023)
Review
Pediatrics
T. Michael O'Shea, Monica McGrath, Judy L. Aschner, Barry Lester, Hudson P. Santos, Carmen Marsit, Annemarie Stroustrup, Crisma Emmanuel, Mark Hudak, Elisabeth McGowan, Simran Patel, Rebecca C. Fry
Summary: The National Institutes of Health's ECHO Program conducts research on the links between children's environment and health, with a focus on very preterm infants. The program utilizes data from three cohorts to study the effects of environmental factors on the health outcomes of preterm infants.
PEDIATRIC RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Jun Yasuhara, Kaihei Masuda, Kae Watanabe, Takuro Shirasu, Hisato Takagi, Naokata Sumitomo, Simon Lee, Toshiki Kuno
Summary: This study investigated the longitudinal cardiovascular outcomes in children with multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. It found that the majority of cases showed resolution of left ventricular systolic dysfunction within 3 months. However, coronary abnormalities and mitral regurgitation persisted in a subset of patients at mid-term follow-up.
PEDIATRIC CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kristian C. Becker, Jennifer Cohen, Jon D. Nyce, Jen Lie Yau, Santosh C. Uppu, Partho P. Sengupta, Shubhika Srivastava
Summary: Left ventricular vortex formation plays an important role in optimizing blood transport and minimizing energy loss. This study examined vortex patterns and energy loss in children, especially those under 1 year old. The findings suggest that the growing heart undergoes a transition to adult vortex flow patterns over the first 2 years of life, with an acute increase in diastolic energy loss during the 2-month to 2-year period. These findings provide insight into the dynamic changes of left ventricular flow patterns in pediatric patients.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Obstetrics & Gynecology
Steven J. Ondersma, Amii M. Kress, Annemarie Stroustrup, Robert D. Annett, Lyndsay A. Avalos, Maria Talavera-Barber, Patricia A. Brennan, Carlos A. Camargo, Elisabeth Conradt, Anne L. Dunlop, Amy J. Elliott, Monique M. Hedderson, Ximin Li, Monica McGrath, Ruby H. N. Nguyen, Grier P. Page, Sheela Sathyanarayana, Barry Lester
JOURNAL OF PERINATOLOGY
(2023)
Letter
Medicine, General & Internal
Brian W. McCrindle, Ashraf S. Harahsheh, Ryan Handoko, Geetha Raghuveer, Michael A. Portman, Michael Khoury, Jane W. Newburger, Simon Lee, Supriya S. Jain, Manaswitha Khare, Nagib Dahdah, Cedric Manlhiot
Summary: The severity of multisystem inflammatory syndrome in children (MIS-C) has decreased with each subsequent SARS-CoV-2 variant, but critical illness remains prevalent in hospitalized patients with MIS-C.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jerin Jose, Elif Seda Selamet Tierney, Ashraf S. Harahsheh, Nagib Dahdah, Geetha Raghuveer, Kevin G. Friedman, Michael Khoury, Mark D. Hicar, Shae A. Merves, Frederic Dallaire, Pedrom Farid, Cedric Manlhiot, Kyle Runeckles, Nilanjana Misra, Michael Portman, Jean A. Ballweg, Simon Lee, Supriya S. Jain, Tyler H. Harris, Jacqueline R. Szmuszkovicz, William Orr, Guillermo Larios, Brian W. McCrindle
Summary: This study compares the clinical differences in children with complete Kawasaki disease (KD) with and without prior SARS-CoV-2 infection. The results show that patients with prior SARS-CoV-2 infection are older and have more severe symptoms and cardiac involvement. Patients without prior SARS-CoV-2 infection are more likely to have coronary artery aneurysms.
PEDIATRIC CARDIOLOGY
(2023)
Article
Pediatrics
Marie Camerota, Elisabeth C. McGowan, Judy Aschner, Annemarie Stroustrup, Margaret R. Karagas, Elisabeth Conradt, Sheila E. Crowell, Patricia A. Brennan, Brian S. Carter, Jennifer Check, Lynne M. Dansereau, Sheri A. DellaGrotta, Todd M. Everson, Jennifer B. Helderman, Julie A. Hofheimer, Jordan R. Kuiper, Cynthia M. Loncar, Carmen J. Marsit, Charles R. Neal, Thomas Michael O'Shea, Steven L. Pastyrnak, Stephen J. Sheinkopf, Lynne M. Smith, Xueying Zhang, Barry M. Lester
Summary: A multi-cohort study of preterm and term-born infants revealed two dysregulated neurobehavioral profiles with distinct perinatal antecedents. Factors such as gender, maternal age, and emotional state were predictive of neurobehavioral profiles. Further understanding of these factors could inform interventions for positive developmental outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Immunology
Guliz Erdem, Clifford L. L. Cua, Amrita Basu, Simon Lee, Amy Leber, Roshini S. S. Abraham
Summary: We present a case of an asymptomatic child with heterotaxy syndrome who repeatedly tested positive for SARS-CoV-2 polymerase chain reaction. An unusual subset of lymphocytes expressing CD19, CD16, and CD56 was identified, and phenotyping revealed atypical natural killer cells. The role of this subset in protection against severe disease or reinfection remains unclear.
Letter
Cardiac & Cardiovascular Systems
John L. Heyniger, Katarzyna E. Gil, Brett G. Klamer, Kan N. Hor, Lauren Ledingham, Simon Lee, Matthew S. Tong, Orlando P. Simonetti, Saurabh Rajpal
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Alireza Asadbeygi, Simon Lee, John Kovalchin, Hoda Hatoum
Summary: This study simulates the effects of beta blockers on the hemodynamics and thrombotic risk of coronary artery aneurysms in Kawasaki disease. Computational fluid dynamics was used to simulate coronary blood flow in patient-specific aneurysm models. Two possible responses to beta blockers were evaluated: preserved coronary flow and reduced coronary flow at lower heart rates. The results showed that reduced coronary flow led to a potential increase in thrombotic risk, while preserved coronary flow at lower heart rates had minimal effect on local aneurysm hemodynamics.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jennifer Cohen, Bhawna Arya, Richard Caplan, Mary T. Donofrio, Dina Ferdman, Jamie K. Harrington, Deborah Y. Ho, Whitnee Hogan, Lisa K. Hornberger, Simone Jhaveri, Stacy A. S. Killen, Christopher L. Lindblade, Erik Michelfelder, Anita J. Moon-Grady, Sheetal Patel, Emilio Quezada, Christina Ronai, Aura A. Sanchez Mejia, David N. Schidlow, Corey Stiver, Varsha Thakur, Shubhika Srivastava
Summary: In this retrospective study, we investigated the natural history, associated anomalies, and outcomes of fetal ccTGA. We found that associated cardiac defects and arrhythmias are common in fetal ccTGA, and functional changes frequently occur during gestation. Fetal tricuspid regurgitation (>= mild), any arrhythmia, pulmonary atresia, aortic obstruction, and worsening hemodynamics on serial echocardiograms are associated with worse outcomes. These findings can guide prenatal counseling and perinatal management planning.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Jason L. Williams, Hannah M. Jacobs, Simon Lee
Summary: Myocarditis is a condition caused by inflammation of the cardiac myocytes, leading to myocardial edema and injury. It can be caused by viruses, infections, and even the COVID-19 disease and vaccine. Diagnosis includes various tests such as laboratory testing and non-invasive imaging studies, with cardiac magnetic resonance being an important tool. Management is crucial, especially in children, as myocarditis can be life-threatening.
CARDIOLOGY AND THERAPY
(2023)
Article
Obstetrics & Gynecology
Bettina F. Cuneo, Jill P. Buyon, Lisa Sammaritano, Edgar Jaeggi, Bhawna Arya, Nicholas Behrendt, Julene Carvalho, Jennifer Cohen, Kristopher Cumbermack, Greggory DeVore, Tam Doan, Mary T. Donofrio, Lindsay Freud, Henry L. Galan, Melanie R. F. Gropler, Caitlin Haxel, Lisa K. Hornberger, Lisa W. Howley, Peter Izmirly, Stacy S. Killen, Michelle Kaplinski, Anita Krishnan, Stephanie Lavasseur, Christopher Lindblade, Jyothi Matta, Majd Makhoul, Jena Miller, Shaine Morris, Erin Paul, Erin Perrone, Colin Phoon, Nelangi Pinto, Jack Rychik, Gary Satou, Amit Saxena, Mark Sklansky, James Stranic, Janette F. Strasburger, Shubhika Srivastava, Sharda Srinivasan, Theresa Tacy, Wayne Tworetzky, Orhan Uzun, Simcha Yagel, Michael Zaretsky, Anita J. Moon-Grady
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea L. Jones, Brian R. White, Reena M. Ghosh, Antara Mondal, Steve Ampah, Deborah Y. Ho, Kevin Whitehead, Matthew A. Harris, David M. Biko, Sara Partington, Stephanie Fuller, Meryl S. Cohen, Mark A. Fogel
Summary: This study found that pre-operative cardiac MRI can predict the success rate of biventricular repair in patients with unbalanced common atrioventricular canal. Cardiac MRI combined with the left ventricle-right ventricle angle in diastole and the echocardiographic atrioventricular valve index can provide a more accurate prediction of success.
CARDIOLOGY IN THE YOUNG
(2023)