Article
Cardiac & Cardiovascular Systems
Christopher J. Petit, Andrew C. Glatz, Andrew B. Goldstone, Mark A. Law, Jennifer C. Romano, Shiraz A. Maskatia, Paul J. Chai, Jeffrey D. Zampi, Jeffery J. Meadows, George T. Nicholson, Shabana Shahanavaz, Athar M. Qureshi, Courtney E. Mccracken, Christopher E. Mascio, Sarosh P. Batlivala, Ivor B. Asztalos, Steven J. Healan, Justin D. Smith, Joelle A. Pettus, Asaad Beshish, James E. B. Raulston, Krissie M. Hock, Amy L. Pajk, Bryan H. Goldstein
Summary: This study aimed to quantify the impact of hypoplastic pulmonary arteries (hPA) on outcomes in neonates with symptomatic tetralogy of Fallot (sTOF), and measure the impact of management strategy on pulmonary artery (PA) growth. The study included 542 neonates and found that the presence of hPA did not increase the hazard of mortality or reintervention after definitive repair, and the hPA cohort showed superior PA growth.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Aditya Sengupta, Ji M. Lee, Kimberlee Gauvreau, Steven D. Colan, Pedro J. del Nido, John E. Mayer Jr, Meena Nathan
Summary: This study aims to characterize the natural history of aortic root dilation and aortic regurgitation in tetralogy of Fallot (TOF). The findings indicate that patients with TOF-variant are at a greater risk of pathologic root dilation, requiring closer longitudinal follow-up.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Engineering, Biomedical
Alessia Di Nardo, Leslie Louvelle, David A. Romero, Matthew Doyle, Thomas L. Forbes, Cristina H. Amon
Summary: Tetralogy of Fallot (ToF), a congenital heart disease, can be alleviated through surgical application of a biocompatible vessel patch. This study used computational simulations to compare the mechanical performance of four patch materials at different stenosis locations. Biological patch materials showed higher stress levels compared to synthetic patch materials, regardless of stenosis location or patient anatomy.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Medicine, General & Internal
Christopher DeZorzi, Anais Marenco, Anne Marie Valente
Summary: Tricuspid regurgitation is a significant finding in patients who have undergone repair for tetralogy of Fallot, and it can have primary or secondary causes. Moderate or severe tricuspid regurgitation is associated with a higher occurrence of atrial tachyarrhythmias in these patients. The optimal timing for tricuspid valve intervention during pulmonary valve replacement in repaired tetralogy of Fallot patients remains uncertain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Veterinary Sciences
Valentina Vitale, Gaby Van Galen, Malene Laurberg, Bridgette Young, Victoria Mciver, Marta Wereszka, Marina Gimeno
Summary: This case report presents a rare case of tetralogy of Fallot in a horse, complicated by a large ascending aortic aneurysm. The mare exhibited sustained tachycardia, mild intermittent colic, depression, inappetence, and weight loss, and was euthanized due to poor prognosis. Post-mortem examination revealed factors contributing to the development of aortic haematoma, highlighting the importance of considering cardiac issues in cases with sustained tachycardia.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Pediatrics
Julia Moosmann, Ariawan Purbojo, Susanne Eder, Sven Dittrich
Summary: Primary surgical repair is the traditional treatment for critical duct-dependent coarctation of the aorta, but balloon angioplasty can serve as a rescue strategy for high-risk infants. This case demonstrates the feasibility of palliative balloon angioplasty and rescue stent implantation through an alternative antegrade right-axillary artery approach.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medical Laboratory Technology
Wei Wang, Hao Cui, Gao Ran, Chuhao Du, Xiao Chen, Shuo Dong, Siyuan Huang, Jun Yan, Junmin Chu, Jiangping Song
Summary: This study investigated the plasma metabolic profiles to identify key metabolites for early diagnosis of Tetralogy of Fallot (TOF), a common congenital heart disease. The researchers found significant metabolic differences between TOF patients and normal controls, specifically in nicotinamide and purine metabolism pathways. The study suggests that plasma FAD could serve as a highly valuable biomarker for differentiating TOF from normal. These findings contribute to the development of reliable biomarkers and improving early screening for TOF.
CLINICA CHIMICA ACTA
(2023)
Article
Cardiac & Cardiovascular Systems
Drayton C. Harvey, Riya Verma, Brandon Sedaghat, Brooke E. Hjelm, Sarah U. Morton, Jon G. Seidman, S. Ram Kumar
Summary: The study identified key genes and biological processes involved in the pathogenesis of non-syndromic TOF, highlighting the importance of molecular defects in cardiac progenitor cells and genes related to their viability and function. The findings have implications for personalized clinical care of TOF patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Bryan H. Goldstein, Christopher J. Petit, Athar M. Qureshi, Courtney E. McCracken, Michael S. Kelleman, George T. Nicholson, Mark A. Law, Jeffery J. Meadows, Jeffrey D. Zampi, Shabana Shahanavaz, Christopher E. Mascio, Paul J. Chai, Jennifer C. Romano, Sarosh P. Batlivala, Shiraz A. Maskatia, Ivor B. Asztalos, Alicia M. Kamsheh, Steven J. Healan, Justin D. Smith, R. Allen Ligon, Joelle A. Pettus, Sarina Juma, James E. B. Raulston, Krissie M. Hock, Amy L. Pajk, Lindsay F. Eilers, Hala Q. Khan, Taylor C. Merritt, Matthew Canter, Stephan Juergensen, Fatuma-Ayaan Rinderknecht, Holly Bauser-Heaton, Andrew C. Glatz
Summary: In this multicenter comparison of staged repair (SR) and primary repair (PR) for neonates with symptomatic tetralogy of Fallot (sTOF), early mortality and neonatal morbidity were lower in the SR group, while cumulative morbidity and reinterventions favored the PR group, suggesting potential benefits to each strategy.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jennifer A. Faerber, Jing Huang, Xuemei Zhang, Lihai Song, Grace DeCost, Christopher E. Mascio, Chitra Ravishankar, Michael L. O'Byrne, Maryam Y. Naim, Steven M. Kawut, Elizabeth Goldmuntz, Laura Mercer-Rosa
Summary: Repair of Tetralogy of Fallot (TOF) is associated with high operative survival rates, but a subset of patients experience post-operative complications. By using machine learning, this study identified predictors for these complications, including prolonged cardiopulmonary bypass, gestational age, pre-operative right ventricular remodeling, and post-operative arterial oxygen level. These findings suggest opportunities to optimize surgical repair for TOF and reduce post-operative complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Physiology
Nouf J. Althali, Kathryn E. Hentges
Summary: Congenital heart defects refer to structural abnormalities of the heart or blood vessels present at birth, affecting approximately 1% of newborns worldwide. Tetralogy of Fallot is the most common cyanotic congenital heart abnormality, accounting for 5-10% of all congenital cardiac defects. While some cases of TOF are associated with known diseases or chromosomal abnormalities, the majority are non-syndromic and have unknown causes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Juemin Yu, Qiushi Ren, Xiaobing Liu, Tianyu Chen, Rong Liufu, Shusheng Wen, Jimei Chen, Jianzheng Cen, Jian Zhuang
Summary: The use of concomitant mitral valve repair in ALCAPA patients with MR remains controversial, with favorable outcomes seen in long-term ALCAPA repair and suggestion of concomitant mitral valve repair for moderate to severe MR.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Zsofia Kakucs, Erhard Heidenhoffer, Marian Pop
Summary: The prevalence of coronary artery and aortic arch anomalies in TOF patients was determined using CT angiography. The study found that CT angiography is a powerful tool for evaluating congenital cardiovascular anomalies, and the prevalence of these anomalies detected was consistent with anatomical specimens.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
James E. Davies, Gagandip Singh, Panos N. Vardas
Summary: This case report presents a 32-year-old male with ALCAPA, ischemic cardiomyopathy, and an anomalous left main coronary artery. A posterior re-implantation was performed using a modified Cabrol technique and a polytetrafluoroethylene graft, with excellent outcomes for this rare and challenging clinical entity.
CARDIOTHORACIC SURGEON
(2022)
Article
Cardiac & Cardiovascular Systems
Jouke P. Bokma, Tal Geva, Lynn A. Sleeper, Ji Hae Lee, Minmin Lu, Tehila Sompolinsky, Sonya V. Babu-Narayan, Rachel M. Wald, Barbara J. M. Mulder, Anne Marie Valente
Summary: The study aimed to determine whether pulmonary valve replacement (PVR) is associated with improved survival and freedom from sustained ventricular tachycardia (VT) in patients with repaired tetralogy of Fallot (rTOF). The results showed that patients who received PVR had a lower risk of death or sustained VT compared to those who did not receive PVR.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Anatomy & Morphology
Meriem Mostefa Kara, Lucile Houyel, Damien Bonnet
JOURNAL OF ANATOMY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. Blondiaux, G. Autret, F. Dhombres, M. Gonzales, E. Audureau, O. Clement, J. -M. Jouannic, L. Houyel
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2019)
Article
Cardiac & Cardiovascular Systems
Sebastien Hascoet, Suzanne Borrhomee, Nabil Tahhan, Jerome Petit, Angele Boet, Lucile Houyel, Emmanuel Lebret, Mohammed Ly, Regine Roussin, Emre Belli, Virginie Lambert, Daniela Laux
ARCHIVES OF CARDIOVASCULAR DISEASES
(2019)
Review
Cardiac & Cardiovascular Systems
Anne Moreau de Bellaing, Lucile Houyel, Damien Bonnet
CARDIOLOGY IN THE YOUNG
(2019)
Article
Cardiac & Cardiovascular Systems
Margaux Pontailler, Moussa Haidar, Mathilde Meot, Anne Moreau de Bellaing, Regis Gaudin, Lucile Houyel, Olivier Metton, Pamela Moceri, Damien Bonnet, Pascal Vouhe, Olivier Raisky
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2019)
Article
Cell Biology
Audrey Desgrange, Johanna Lokmer, Carmen Marchiol, Lucile Houyel, Sigolene M. Meilhac
DISEASE MODELS & MECHANISMS
(2019)
Article
Cardiac & Cardiovascular Systems
Said Bichali, Romulus Cristian Grigorescu, Mathilde Lefebvre, Charlotte Oriot, Ferdinand Dhombres, Damien Bonnet, Lucile Houyel
CARDIOLOGY IN THE YOUNG
(2019)
Article
Anatomy & Morphology
Nicolas Arribard, Meriem Mostefa Kara, Sebastien Hascoet, Bettina Bessieres, Damien Bonnet, Lucile Houyel
JOURNAL OF ANATOMY
(2020)
Article
Cardiac & Cardiovascular Systems
Zahra Belhadjer, Mathilde Meot, Fanny Bajolle, Diala Khraiche, Antoine Legendre, Samya Abakka, Johanne Auriau, Marion Grimaud, Mehdi Oualha, Maurice Beghetti, Julie Wacker, Caroline Ovaert, Sebastien Hascoet, Maelle Selegny, Sophie Malekzadeh-Milani, Alice Maltret, Gilles Bosser, Nathan Giroux, Laurent Bonnemains, Jeanne Bordet, Sylvie Di Filippo, Pierre Mauran, Sylvie Falcon-Eicher, Jean-Benoit Thambo, Bruno Lefort, Pamela Moceri, Lucile Houyel, Sylvain Renolleau, Damien Bonnet
Letter
Cardiac & Cardiovascular Systems
Zahra Belhadjer, Johanne Auriau, Mathilde Meot, Mehdi Oualha, Sylvain Renolleau, Lucile Houyel, Damien Bonnet
Article
Anatomy & Morphology
Lucile Houyel, Laurence Cohen, Patrick Burlot, Anne Heitzmann, Damien Bonnet
Summary: The anomalous connection of the inferior caval vein to the left atrium is extremely rare and has been considered impossible by some authors. This study demonstrates the existence of this rare malformation for the first time, diagnosed prenatally and confirmed post-mortem in a 24-week gestational age fetus, in association with a common arterial trunk.
JOURNAL OF ANATOMY
(2021)
Letter
Cardiac & Cardiovascular Systems
Lucile Houyel, Anne Moreau de Bellaing, Damien Bonnet
Summary: The IPCCC defines visceral heterotaxy as abnormal arrangement of internal organs, distinct from traditional heterotaxy syndrome, requiring detailed description of cardiac and other organ relationships and arrangements, with particular attention to venoatrial connections.
CARDIOLOGY IN THE YOUNG
(2021)
Article
Cardiac & Cardiovascular Systems
Asma Tajouri, Clement Batteux, Reaksmei Ly, Lucile Houyel, Sebastien Hascoet
Summary: This article reports a case of pulmonary arterial hypertension related to a rare congenital heart disease, characterized by inferior sinus venosus defect associated with left hepatic vein drainage to the coronary sinus. Accurate anatomical description was necessary for planning heart-lung transplantation in this case.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Cardiac & Cardiovascular Systems
Gregory T. Adamson, Lucile Houyel, Doff B. McElhinney, Shiraz A. Maskatia, Michael Ma, Frank L. Hanley, Leo Lopez
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Karim Tararbit, Nathalie Lelong, Francois Goffinet, Babak Khoshnood, Damien Bonnet, Johanna Calderon, Drina Candilis, Anne-Lise Delezoide, Catherine De Vigan, Lucile Houyel, Jean-Marie Jouannic, Suzel Magnier, Jean-Francois Magny, Caroline Rambaud, Dominique Salomon, Veronique Vodovar, Anne-Claire Thieulin, Thibaut Andrieu, Maggy Chausson, Anissa Brinis, Laure Faure, Maryline Delattre, Jean-Marc Treluyer, Gerard Breart, Dominique Cabrol, Alain Serraf, Daniel Sidi, Marcel Voyer