Article
Cardiac & Cardiovascular Systems
Alicia Jeanette Fischer, Dominic Enders, Kristina Wasmer, Ursula Marschall, Helmut Baumgartner, Gerhard-Paul Diller
Summary: Limited data exist on the impact of gender and specialized care on the requirement of repeat treatment of supraventricular tachycardia (SVT) in adult patients with congenital heart disease (ACHDs). The study found that gender, age, the complexity of cardiovascular diseases, chronic kidney disease, and atrial fibrillation were independent predictors of repeat treatment in adult patients with congenital heart disease. Additionally, female ACHD patients treated at specialized centers had a lower risk of requiring retreatment.
Article
Cardiac & Cardiovascular Systems
Jeremy P. Moore, Austin Burrows, Roberto G. Gallotti, Kevin M. Shannon
Summary: This study aimed to identify the electrophysiological characteristics of atrial tachycardia (AT) recurrence in adults with congenital heart disease (ACHD). The results showed that repeat ATs in ACHD patients were more frequently focal, required isoproterenol administration, or involved intra-atrial reentrant tachycardia within the pulmonary venous atrium or atrial septum. Partial success, index pulmonary venous atrium substrate, and a remote history of atrial fibrillation were negative factors associated with AT/AF recurrence.
Article
Cardiac & Cardiovascular Systems
Jeremy P. Moore, Roberto G. Gallotti, Kevin M. Shannon, Benjamin A. Blais, Elizabeth S. DeWitt, Shuenn-Nan Chiu, David S. Spar, Frank A. Fish, Maully J. Shah, Sabine Ernst, Paul Khairy, Ronald J. Kanter, Philip M. Chang, Thomas Pilcher, Ian H. Law, Eric S. Silver, Mei-Hwan Wu
Summary: This study describes the electrophysiological properties and outcomes of catheter ablation for atrioventricular reciprocating tachycardia via twin atrioventricular nodes (T-AVRT). Although catheter ablation has been established for T-AVRT, there is limited data on its electrophysiological properties and outcomes.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Patryk Leczycki, Maciej Banach, Marek Maciejewski, Agata Bielecka-Dabrowa
Summary: In recent decades, there has been a significant increase in the number of adults with congenital heart diseases (ACHD), necessitating thorough evaluation of their current condition. There is currently a lack of universal parameters or scales to easily assess the deterioration of ACHD patients' condition, emphasizing the need to identify widely available, cost-effective, and user-friendly factors. Studies have shown potential prognostic factors including echocardiography and magnetic resonance imaging, cardiopulmonary exercise testing, and biomarkers. However, further research is needed to create a specific assessment panel for patients with specific congenital heart diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Kristina Wasmer, Lars Eckardt, Helmut Baumgartner, Julia Koebe
Summary: Arrhythmias are common complications in adults with congenital heart disease, leading to debilitating symptoms and life-threatening risks. Differences in substrates and risks for arrhythmias exist among different congenital defects, influenced by changes in surgical repair techniques. This article summarizes the prevalence, mechanisms, treatment options, and outcomes of specific arrhythmias in ACHD patients.
CARDIOVASCULAR DIAGNOSIS AND THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas Bonnin, Pierre Roumegou, Soumaya Sridi, Saagar Mahida, Aurelien Bustin, Josselin Duchateau, Romain Tixier, Nicolas Derval, Thomas Pambrun, Ghassen Chniti, Takamitsu Takagi, Tsukasa Kamakura, Philipp Krisai, Clementine Andre, Remi Chauvel, Meleze Hocini, Michel Haissaguerre, Pierre Jais, Hubert Cochet, Frederic Sacher
Summary: This study assessed the prevalence, risk factors, and management of intra-cardiac thrombus in patients referred for scar-related VT ablation. The results showed that 11% of patients had cardiac thrombi, highlighting the importance of systematic thrombus screening to minimize the risk of embolism.
Article
Biochemistry & Molecular Biology
Lan Yang, Xingyun Liu, Yalan Chen, Bairong Shen
Summary: The CHDGKB was established in 2020 to provide comprehensive knowledge about the genetics and pathogenesis of NS-CHD, integrating genetic and non-genetic risk factors. The updated CHDGKB, named CHD-RF-KB, is a vital tool for evaluating the recurrence risk and prognosis of NS-CHD, guiding treatment, and emphasizing precautions. Systematic understanding of the heterogeneous relationship between risk factors and NS-CHD phenotypes can be achieved through extensive functional analyses of the data in CHD-RF-KB.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Pediatrics
Ayako Chida-Nagai, Hiroki Sato, Itsumi Sato, Masahiro Shiraishi, Daisuke Sasaki, Gaku Izumi, Hirokuni Yamazawa, Kazutoshi Cho, Atsushi Manabe, Atsuhito Takeda
Summary: Despite the use of palivizumab, preterm birth, bronchopulmonary dysplasia, trisomy 21, and hemodynamically significant congenital heart disease were identified as risk factors for severe RSV infection requiring hospitalization. High-risk infants should be closely monitored, and prolonged use of palivizumab should be considered.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Daniel Cromb, Alexandra F. Bonthrone, Alessandra Maggioni, Paul Cawley, Ralica Dimitrova, Christopher J. Kelly, Lucilio Cordero-Grande, Olivia Carney, Alexia Egloff, Emer Hughes, Joseph V. Hajnal, John Simpson, Kuberan Pushparajah, Mary A. Rutherford, A. David Edwards, Jonathan O'Muircheartaigh, Serena J. Counsell
Summary: Infants with congenital heart disease (CHD) are at risk of impaired brain growth, especially in the immediate postoperative period. The duration of postoperative intensive care stay is associated with the degree of impaired brain growth. Clinical risk factors, such as higher preoperative creatinine levels and longer cardiopulmonary bypass duration, are also associated with impaired brain growth.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Heather M. M. Giacone, Henry Chubb, Anne M. M. Dubin, Kara S. S. Motonaga, Scott R. R. Ceresnak, William R. R. Goodyer, Debra Hanisch, Anthony V. V. Trela, Nicole Boramanand, Erin Lencioni, Derek Boothroyd, Anna Graber-Naidich, Gail Wright, Christiane Haeffele, Seth A. A. Hollander, Doff B. B. McElhinney, Michael Ma, Frank L. L. Hanley, Sharon Chen
Summary: This study assessed the incidence of ventricular arrhythmias (VAs) in Fontan patients and their implications on transplant-free survival. The results showed that 11% of patients were diagnosed with VA, and VA was highly associated with the risk of transplant or death. Older age at Fontan and a history of right ventricular to pulmonary artery conduit were risk factors for VA. A diagnosis of VA in Fontan patients should lead to increased clinical surveillance.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Guglielmo Capponi, Gilda Belli, Mattia Giovannini, Giulia Remaschi, Alice Brambilla, Francesca Vannuccini, Silvia Favilli, Giulio Porcedda, Luciano De Simone
Summary: The combination of flecainide and beta-blockers showed high effectiveness in maintaining sinus rhythm in patients with supraventricular tachycardias under 1 year of age, whether they were re-entry or automatic tachycardias.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Charlotte Brouwer, Joachim Hebe, Peter Lukac, Jan-Hendrik Nurnberg, Jens Cosedis Nielsen, Marta de Riva Silva, Nico Blom, Mark Hazekamp, Katja Zeppenfeld
Summary: In contemporary patients with congenital heart disease, the outcome after atrial tachycardia (AT) ablation is associated with the presence of prior atrial surgery and the achievement of predefined procedural endpoints, rather than the complexity of the heart disease. Techniques to improve lesion durability are likely to further improve long-term outcomes.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Article
Pediatrics
Margot Mignot, Helena Huguet, Gilles Cambonie, Sophie Guillaumont, Marie Vincenti, Julie Blanc, Caroline Ovaert, Marie-Christine Picot, Clement Karsenty, Pascal Amedro, Laura Kollen, Arthur Gavotto
Summary: This retrospective longitudinal multicenter study aimed to identify the risk factors of early occurrence of malnutrition in infants with severe congenital heart disease (CHD) during their first year of life. The study found that malnutrition was observed in a high proportion of infants, with the highest prevalence in infants with increased pulmonary blood flow. Low birthweight, CHD with increased pulmonary blood flow, heart failure, and the number of hospitalizations were associated with malnutrition.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan Uniat, Allison C. C. Hill, Mark Shwayder, Michael J. J. Silka, Yaniv Bar-Cohen
Summary: This retrospective study analyzed the risk factors and outcomes of ectopic atrial tachycardia (EAT) in infants undergoing congenital heart disease (CHD) surgery from 2007 to 2020. The results showed that total anomalous venous connection (TAPVC) repair, DiGeorge syndrome, longer and more complex surgeries, and longer cardiopulmonary bypass times were independent risk factors for EAT. EAT typically occurred around 9 days after CHD surgery.
PEDIATRIC CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Chieh-Ching Yen, Shou-Yen Chen, Chung-Hsien Chaou, Chih-Kai Wang, Hsin-Tzu Yeh, Chip-Jin Ng
Summary: This study analyzed the elevation of cTnI in pediatric patients with acute SVT episodes, and observed the correlation between cTnI and SVT recurrence within 30 days. The results showed that the cTnI-positive group had more adverse symptoms and a higher rate of ICU admissions. The independent predictor for recurrent SVT within 30 days was initial hypotension.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Jacob K. Kresovich, Yong-Moon Mark Park, Jean A. Keller, Dale P. Sandler, Jack A. Taylor
Summary: This study found that healthy eating is inversely associated with methylation-based measures of biological age. Improving diet has the most benefits in lowering biological age among women with lower levels of physical activity.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Mary V. Diaz-Santana, Katie M. O'Brien, Yong-Moon Mark Park, Dale P. Sandler, Clarice R. Weinberg
Summary: Gestational diabetes mellitus is strongly associated with an increased risk of type 2 diabetes, and this risk persists for over 35 years. The risk of type 2 diabetes is higher with each additional pregnancy affected by gestational diabetes mellitus, and the association weakens over time.
Review
Nutrition & Dietetics
Jiali Zheng, Tianren Zhu, Guanghuan Yang, Longgang Zhao, Fangyu Li, Yong-Moon Park, Fred K. Tabung, Susan E. Steck, Xiaoguang Li, Hui Wang
Summary: Isocaloric substitution of plant-based protein for animal-based protein may have beneficial effects on preventing all-cause and cardiovascular disease-specific mortality, especially when substituting red and processed meat protein. However, more studies are needed, particularly regarding cancer incidence and other specific aging-related diseases.
Article
Nutrition & Dietetics
Yong-Moon Mark Park, Jenna Lilyquist, Thomas J. Van't Erve, Katie M. O'Brien, Hazel B. Nichols, Ginger L. Milne, Clarice R. Weinberg, Dale P. Sandler
Summary: Plasma carotenoids, as well as supplemental beta-carotene, were found to be associated with lower concentrations of 8-iso-PGF(2 alpha) metabolite. These associations may reflect antioxidant effects.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
Seung Hoon Kim, Yong-Moon Park, Kyungdo Han, Seung Hyun Ko, Shin Young Kim, So Hyang Song, Chi Hong Kim, Kyu Yeon Hur, Sung Kyoung Kim
Summary: This study finds that smoking is a risk factor for tuberculosis (TB), and maintaining weight after quitting smoking may reduce the risk of TB development. However, individuals who lose weight after quitting smoking still have a higher risk of developing TB.
Article
Endocrinology & Metabolism
Jae-Seung Yun, Kyungdo Han, Yong-Moon Park, Eugene Han, Yong-ho Lee, Seung-Hyun Ko
Summary: This study investigated the associations between lifestyle factors and changes to these factors with the risk of severe hypoglycemia in type 2 diabetes patients. The results showed that current smokers and heavy drinkers had an increased risk of severe hypoglycemia, while regular physical activity was associated with a reduced risk. Improvements in unhealthy lifestyle habits were also linked to a lower risk of severe hypoglycemia.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Health Care Sciences & Services
Ji Eun Lee, Kyungdo Han, Juhwan Yoo, Yohwan Yeo, In Young Cho, Belong Cho, Hyuktae Kwon, Dong Wook Shin, Jong Ho Cho, Yong-Moon Park
Summary: This study investigated the association between variability in metabolic parameters and esophageal cancer incidence using large nationally representative data. The results showed that a high variability of metabolic parameters was associated with an increased risk of esophageal cancer, and further studies are needed to replicate these findings in other populations.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Soyeon Kang, Yong-Moon Park, Dong Jin Kwon, Youn-Jee Chung, Jeong Namkung, Kyungdo Han, Seung-Hyun Ko
Summary: In postmenopausal women with type 2 diabetes, a longer reproductive life span is associated with a lower risk of severe hypoglycemia, and every 5-year increment in the reproductive life span reduces the risk of severe hypoglycemia. The use of hormone replacement therapy (HRT) is also associated with a lower risk of severe hypoglycemia.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Oncology
Ji Eun Lee, Kyungdo Han, Juhwan Yoo, Yohwan Yeo, In Young Cho, Belong Cho, Jin-Ho Park, Dong Wook Shin, Jong Ho Cho, Yong -Moon Park
Summary: MetS is associated with an increased risk of esophageal cancer, specifically ESCC. Further studies are needed to establish the relationship between MetS and esophageal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Nutrition & Dietetics
Moon Kyung Choi, Yong-Moon Mark Park, Nitin Shivappa, Oak-Kee Hong, Kyungdo Han, Susan E. Steck, James R. Hebert, Anwar T. Merchant, Dale P. Sandler, Seong-Su Lee
Summary: This study investigated the association between consuming a pro-inflammatory diet and mortality risk in adults with normal BMI but with central obesity. The results showed that a pro-inflammatory diet was associated with an increased risk of cardiovascular disease mortality in individuals with central obesity.
CLINICAL NUTRITION
(2023)
Article
Medicine, General & Internal
Gene Huh, Kyoung Do Han, Yong-Moon Park, Chan-Soon Park, Kyu-na Lee, Eun Young Lee, Jung-Hae Cho
Summary: This study investigated the prevalence, associated factors, and comorbidities of high-risk obstructive sleep apnea (OSA) in a Korean adult population. The results showed that high-risk OSA was more common in males and was associated with chronic metabolic diseases such as diabetes, hypertension, and obesity. Active screening and management for OSA may help improve health outcomes in these populations.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Dojoon Park, Yong-Moon Park, Seung-Hyun Ko, Youn-Ho Choi, Dong-Uk Min, Jae-Hyun Ahn, Bongseong Kim, Hae-Seok Koh, Kyungdo Han
Summary: The study aimed to investigate the association between knee osteoarthritis (OA) and cardiovascular disease (CVD) risk and all-cause death, and assess whether exercise behavior impacts this association. Using the Korea National Health Insurance Service (KNHIS) database, the study included 201,466 participants (7572 with knee OA) who underwent health screening from 2009 to 2015. Cox proportional hazard models were used to evaluate the association, and stratification analysis was performed to determine the effect of exercise behavior. The study found that knee OA was independently associated with increased risks of CVD, myocardial infarction (MI), and stroke. Lack of exercise might have a synergistic adverse effect on the association between knee OA and CVD.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Brittany Crawford, Susan E. Steck, Dale P. Sandler, Hazel B. Nichols, Ginger L. Milne, Yong-Moon Mark Park
Summary: Healthy dietary patterns were found to be inversely associated with oxidative stress levels. The associations were stronger among younger women, those with lower income, and those with higher BMI. Among postmenopausal women, only the continuous DASH and aHEI models showed significant results.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Oncology
Young Hyo Choi, Yong-Moon Park, Kyung Jae Hur, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim, Kyungdo Han, Seung Hyun Ko, Yong Hyun Park
Summary: The study suggests that the duration of diabetes mellitus is associated with an increased risk of kidney and bladder cancer. Individuals with impaired fasting glucose and longer duration of diabetes have a higher likelihood of developing these cancers compared to those without diabetes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Endocrinology & Metabolism
Mary Diaz-Santana, Katie M. O'Brien, Yong-Moon Mark Park, Dale P. Sandler, Clarice R. Weinberg
Summary: This study found that a history of gestational diabetes mellitus, whether occurring once or multiple times, significantly increases the risk of developing type 2 diabetes. The risk increases steeply with each additional affected pregnancy, and although it attenuates over time after the affected pregnancies, it remains elevated for >35 years.