Article
Biology
Iffat Imran, Saima Saleem, Abid Azhar, Sitwat Zehra
Summary: Pyrethroid (PYR) is a commonly used pesticide in agricultural fields in Sanghar, Pakistan. This study investigated the genetic variations of CYP1A1 and GSTP1 in individuals exposed to PYR, finding a potential risk association between mutant allele G of CYP1A1 and PYR toxicity, as well as a significant association between G allele of GSTP1 and PYR toxicity. This research contributes to understanding the hazardous effects of pesticides.
Article
Cardiac & Cardiovascular Systems
Astrid Elisabeth Lammers, Gerhard-Paul Diller, Rieke Lober, Mareike Moellers, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Joachim Gerss, Dominic Enders, Helmut Baumgartner
Summary: This population-based study reveals a reassuringly low maternal mortality rate in a highly developed healthcare system. However, maternal and neonatal morbidity/mortality were significantly increased in women with adult congenital heart disease (ACHD) and their offspring compared to non-ACHD controls, highlighting the importance of specialized care and pre-pregnancy counseling.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Astrid Elisabeth Lammers, Gerhard-Paul Diller, Rieke Lober, Mareike Moellers, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Joachim Gerss, Dominic Enders, Helmut Baumgartner
Summary: This population-based study revealed a reassuringly low maternal mortality rate in a highly developed healthcare system. However, maternal morbidity and neonatal morbidity/mortality were significantly increased in women with ACHD and their offspring compared to non-ACHD controls, highlighting the need for specialized care and pre-pregnancy counselling.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Xuelian Yuan, Fengchao Liang, Jun Zhu, Keyong Huang, Li Dai, Xiaohong Li, Yanping Wang, Qi Li, Xiangfeng Lu, Jianfeng Huang, Lihui Liao, Yang Liu, Dongfeng Gu, Hanmin Liu, Fangchao Liu
Summary: This study investigated the association between maternal exposure to fine particulate matter (PM2.5) and fetal congenital heart defects (CHDs) in China. The results showed that higher maternal PM2.5 exposure, especially during the preconception period, increased the risk of certain types of CHDs in offspring. The findings highlight the importance of improving air quality in China and other highly polluted regions for CHD prevention.
Review
Environmental Sciences
Xiaoyu Wan, Sixuan Wei, Yaqi Wang, Jun Jiang, Xinyao Lian, Zhiyong Zou, Jing Li
Summary: Previous studies on the association between maternal exposure to ambient air pollution and congenital anomalies in newborns have yielded ambiguous results. To address this knowledge gap, a systematic review and meta-analysis of existing literature were conducted. Our findings highlight potential evidence for the association between maternal air pollution exposure and congenital heart diseases.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Frida Richter, Stine Kloster, Kirstine Wodschow, Birgitte Hansen, Jorg Schullehner, Soren Munch Kristiansen, Mette Mains Petersen, Katrine Strandberg-Larsen, Annette Kjaer Ersboll
Summary: The study found that maternal exposure to arsenic in drinking water, even at low concentrations (0.5-0.9 micrograms per liter), increased the risk of congenital heart disease in offspring.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Bo-Yi Yang, Yanji Qu, Yuming Guo, Iana Markevych, Joachim Heinrich, Michael S. Bloom, Zhipeng Bai, Luke C. Knibbs, Shanshan Li, Gongbo Chen, Bin Jalaludin, Lidia Morawska, Meng Gao, Bin Han, Yunjiang Yu, Xiao-Xuan Liu, Yanqiu Ou, Jinzhuang Mai, Xiangmin Gao, Yong Wu, Zhiqiang Nie, Xiao-Wen Zeng, Li-Wen Hu, Xubo Shen, Yuanzhong Zhou, Shao Lin, Xiaoqing Liu, Guang-Hui Dong
Summary: The study found that maternal exposure to air pollution during pregnancy, particularly in the first trimester, is associated with an increased risk of CHD in offspring. No significant associations were observed for exposure to air pollutants during the second and third trimesters. The associations between air pollutants and different CHD subtypes varied.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Mengting Sun, Tingting Wang, Peng Huang, Jingyi Diao, Senmao Zhang, Jinqi Li, Liu Luo, Yihuan Li, Letao Chen, Yiping Liu, Jianhui Wei, Xinli Song, Xiaoqi Sheng, Jiabi Qin
Summary: Our study revealed genetic polymorphisms of maternal MTHFR gene were significantly associated with the risk of fetal CHD in the Chinese population, with significant interactions among different SNPs. Further research in different ethnic populations with larger sample sizes is needed to confirm these findings and understand how these SNPs impact fetal heart development.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Obstetrics & Gynecology
Jing Li, Yujiao Du, Yini Liu, Jiaoyang Du, Ruo Zhang, Pengfei Qu, Hong Yan, Duolao Wang, Shaonong Dang
Summary: The study suggests that maternal exposure to negative life events during pregnancy may increase the risk of congenital heart disease in offspring, while experiencing positive events may have a potential protective role.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Luis D. Pacheco, George Saade, Vineet Shrivastava, Raj Shree, Uri Elkayam
Summary: Pregnancy in individuals with a mechanical heart valve is classified as very high risk, requiring special anticoagulation management to prevent complications and mortality. Adjustments to anticoagulation regimens may be made based on valve type, trimester, individual risk tolerance, and timing of delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Environmental Sciences
Huanhuan Zhang, Xiaoan Zhang, Xin Zhao, Guomei Cheng, Hui Chang, Xiaofang Ye, Jingzhe Wang, Zengli Yu, Qiong Wang, Cunrui Huang
Summary: In Henan, China, exposure to CO in the first and second trimester was associated with an increased risk of overall CHDs. Additionally, NO2 and CO in the first trimester, PM2.5 and PM10 in the second trimester were linked to a higher risk of ASD, with susceptible windows occurring mainly in the 1st-6th gestational weeks. No positive association was found between air pollution and tetralogy of Fallot.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Public, Environmental & Occupational Health
Die Li, Weize Xu, Yunxiang Qiu, Feixia Pan, Hongliang Lou, Jing Li, Yueqin Jin, Ting Wu, Lulu Pan, Jing An, Junqiu Xu, Wei Cheng, Linghua Tao, Yongliang Lei, Chengyin Huang, Fei Yin, Qiang Shu
Summary: This study aimed to examine the association between air pollution and neonatal congenital heart disease (CHD) and evaluate the cumulative burden of CHD attributed to high levels of ambient air pollution exposure. The results showed that increased exposure to air pollutants was associated with a higher risk of CHD, and this association was more significant in cities with higher average education levels and in babies conceived during the cold season.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Beatriz Alvarez-Gonzalez, Patricia Porras-Quesada, Veronica Arenas-Rodriguez, Alba Tamayo-Gomez, Fernando Vazquez-Alonso, Luis Javier Martinez-Gonzalez, Antonio F. Hernandez, Maria Jesus Alvarez-Cubero
Summary: The development and progression of prostate cancer are influenced by the interaction between genetic, environmental, and dietary factors. Chemical exposures and genetic polymorphisms in genes encoding xenobiotic metabolizing enzymes, antioxidant enzymes, and DNA repair enzymes play a major role in cancer development. Understanding the causal risk factors for prostate cancer can help identify high-risk individuals and develop effective detection and prevention methods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Chengrong Wang, Xin Pi, Shengju Yin, Mengyuan Liu, Tian Tian, Lei Jin, Jufen Liu, Zhiwen Li, Linlin Wang, Zhengwei Yuan, Yu Wang, Aiguo Ren
Summary: Prenatal exposure to specific heavy metals, especially mercury and lead, is significantly associated with an increased risk for CHDs. The risk of CHDs increases with the levels of a combination of metals, with mercury being the most important contributor to the mixture effect.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Pengfei Qu, Doudou Zhao, Mingxin Yan, Danmeng Liu, Ruo Zhang, Shanshan Li, Leilei Pei, Hong Yan, Lingxia Zeng, Shaonong Dang
Summary: This study aimed to investigate the association between maternal exposure to housing renovation during the periconceptional period and isolated congenital heart disease (CHD) in infants. A multi-hospitals case-control study was conducted, and it was found that maternal exposure to home improvement projects was associated with an increased risk of isolated CHD in offspring.
ENVIRONMENTAL HEALTH
(2023)
Article
Oncology
Antonello Russo, Maria Blettner, Hiltrud Merzenich, Daniel Wollschlaeger, Friederike Erdmann, Emilio Gianicolo
Summary: This study investigated the incidence of childhood leukemia near nuclear power plants and found a slight decrease in leukemia incidence rate ratios after the shutdown of nuclear reactors in 2011.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Pediatrics
Tatjana Tamara Koenig, Maria-Christina Stefanescu, Melanie Wildermuth, Luisa Maria Frankenbach, Oliver J. Muensterer, Emilio Gianicolo
Summary: This study aimed to calculate specific percentiles for body weight and height in children with esophageal atresia born between 2001 and 2021, accounting for prematurity and congenital heart disease (CHD). The results showed that children with esophageal atresia had lower bodyweight and height compared to the general population. Specific percentile curves are helpful for evaluating their growth and development.
Article
Oncology
Christina Gerlach, Miriam Baus, Emilio Gianicolo, Oliver Bayer, Dagny Faksvag Haugen, Martin Weber, Catriona Mayland, ERANet LAC CODE Core Sci Grp
Summary: This study conducted an international survey to assess and improve the quality of care for bereaved relatives of cancer patients. The findings from free-text comments highlighted the importance of human interaction and personal meaningful interactions in healthcare.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Dermatology
Ilenia Foffa, Agata Janowska, Marco Fabbri, Paola Losi, Elena Ciabatti, Sabrina Gabbriellini, Francesco Faita, Laura De Rosa, Valentina Dini, Alessandro Mazzoni, Marco Romanelli, Giorgio Soldani
Summary: This study evaluated the safety and efficacy of using umbilical cord blood platelet gel combined with a hydrogel dressing in the treatment of chronic venous ulcers. After 4 weeks of treatment, patients showed significant reduction in wound size and improvement in WBS, NRS, and EQ-5D index score. This suggests that umbilical CBPG combined with a hydrogel dressing has the potential to accelerate the healing of chronic lesions.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Health Care Sciences & Services
Renate Stemmer, Britta Buechler, Matthias Buettner, Christina Dera-Stroehm, Joachim Klein, Emilio Gianicolo
Summary: This study aims to examine the integration of advanced practice nurses (APNs) in primary care for multimorbid patients in Germany and its impact on optimizing care for the target group and reducing the workload of general practitioners (GPs). The study uses a nonrandomized controlled trial design and collects data through quantitative and qualitative research methods. The evaluation outcomes include emergency contacts and GP visits, treatment costs, patient health status, and stakeholder satisfaction.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maria Grazia Andreassi, Nadia Haddy, Mats Harms-Ringdahl, Jonica Campolo, Andrea Borghini, Francois Chevalier, Jochen M. Schwenk, Brice Fresneau, Stephanie Bolle, Manuel Fuentes, Siamak Haghdoost
Summary: The Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy (photon and proton) in Pediatrics (HARMONIC) is a five-year project funded by the European Commission with the aim of improving understanding of long-term ionizing radiation risks for pediatric patients. This paper provides a detailed overview of the project's rationale, design, and methods for the biological aspect, with objectives to understand the molecular pathways and identify potential biomarkers involved in long-term health risks. Biological samples will be collected at three time points, and state-of-the-art analytical methods will be used to assess biomarker levels and explore proteomics and miRNA transcriptomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Aida Cavallo, Tamer Al Kayal, Angelica Mero, Andrea Mezzetta, Anissa Pisani, Ilenia Foffa, Cecilia Vecoli, Marianna Buscemi, Lorenzo Guazzelli, Giorgio Soldani, Paola Losi
Summary: Marine collagen, derived from marine organisms, is an abundant and eco-friendly source of collagen that possesses several advantages over mammalian collagen such as easy extraction, water solubility, avoidance of transmissible diseases, and antibacterial activity. This study investigated the use of collagen extracted from basa fish skin for the development of a bioink for 3D bioprinting of a bilayered skin model. The bioink was successfully formulated and showed good printability, supporting cell viability and proliferation of fibroblasts and keratinocytes.
Article
Cardiac & Cardiovascular Systems
Annamaria Mazzone, Serena Del Turco, Giuseppe Trianni, Paola Quadrelli, Marco Marotta, Luca Bastiani, Tommaso Gasbarri, Andreina D'Agostino, Massimiliano Mariani, Giuseppina Basta, Ilenia Foffa, Silverio Sbrana, Cristina Vassalle, Marcello Ravani, Marco Solinas, Sergio Berti
Summary: This study aimed to evaluate outcomes in older severe aortic valve stenosis patients and select treatment according to frailty levels. The results showed that patients with early frailty levels were the most suitable candidates for surgical or transcatheter aortic valve replacement, while advanced frailty would make each treatment futile or palliative.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maria Grazia Andreassi
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Public, Environmental & Occupational Health
Jannis Hansa, Hiltrud Merzenich, Lorena Cascant Ortolano, Stefanie J. Klug, Maria Blettner, Emilio Gianicolo
Summary: Titanium dioxide (TiO2) is an inorganic compound with various applications, but concerns about its safety and potential carcinogenicity to humans have been raised. This study provides a comprehensive overview of epidemiological studies on occupational health risks associated with TiO2 exposure. The results show that the associations between occupational TiO2 exposure and mortality are uncertain, although a significantly increased risk of lung cancer mortality was observed in a population from Europe.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Borghini, Antonella Mercuri, Jonica Campolo, Marina Parolini, Rudina Ndreu, Stefano Turchi, Maria Grazia Andreassi
Summary: A strong relationship between Chr9p21 rs1333049 variant and LTL was identified, and they interactively affect the risk of poor prognosis in CAD patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Letter
Public, Environmental & Occupational Health
Emilio Antonio Luca Gianicolo, Antonello Russo, Maurizio Portaluri
EPIDEMIOLOGIA & PREVENZIONE
(2023)
Article
Pediatrics
Tatjana Tamara Koenig, Maria-Luisa Frankenbach, Emilio Gianicolo, Anne-Sophie Holler, Christina Oetzmann von Sochaczewski, Lucas Wessel, Anke Widenmann, Leon Klos, Simon Kolb, Jannos Siaplaouras, Claudia Niessner
Summary: This study compares the physical activity levels of children and adolescents with and without oesophageal atresia (EA). The results show that children with EA are less active at higher intensities compared to controls, but there is no significant difference in the overall sports activity level. Physical activity is associated with medical factors such as weight, height, urogenital malformation, and anorectal malformation.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Jonica Campolo, Andrea Borghini, Marina Parolini, Antonella Mercuri, Stefano Turchi, Maria Grazia Andreassi
Summary: Clinical and epidemiological evidence suggests a link between coronary artery disease (CAD) and cancer. This study aimed to identify risk factors and biomarkers that could predict cancer incidence and death in CAD patients. The study found that age, smoking, obesity, and systemic inflammatory indexes were associated with cancer incidence, while age was a predictor of cancer death. Lung and gastrointestinal cancer patients had higher levels of a specific biomarker. The study suggests that reducing risk factors and suppressing chronic inflammation may help prevent cancer in CAD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
M. Riechmann-Wolf, J. Hegewald, S. Jankowiak, M. Prigge, K. Rossnagel, S. Droessler, M. Nuebling, Romero K. Starke, A. Seidler, A. Schulz, D. Zahn, T. Muenzel, N. Pfeiffer, P. S. Wild, M. E. Beutel, E. Gianicolo, K. J. Lackner, S. Letzel
