Article
Cardiac & Cardiovascular Systems
Adrienne H. Kovacs, Gerald Lebovic, Stavroula Raptis, Samuel Blais, Christopher A. Caldarone, Nagib Dahdah, Frederic Dallaire, Christian Drolet, Jasmine Grewal, Camille L. Hancock Friesen, Edward Hickey, Gauri Rani Karur, Paul Khairy, Benedetta Leonardi, Michelle Keir, Brian W. McCrindle, Syed Najaf Nadeem, Ming-Yen Ng, Ashish H. Shah, Edythe B. Tham, Judith Therrien, Andrew E. Warren, Isabelle F. Vonder Muhll, Alexander Van de Bruaene, Kenichiro Yamamura, Michael E. Farkouh, Rachel M. Wald
Summary: This study explored the relationship between pulmonary regurgitation and quality of life and health status in adults with Tetralogy of Fallot (TOF), and found that with advancing age, patients reported more problems in mobility and pain or discomfort. Factors associated with superior patient-reported outcomes include race, syndrome, employment, and left ventricular function, while being asymptomatic was found to have the greatest impact on quality of life and health status.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wan-Chen Shen, Chun-An Chen, Chung-I Chang, Yih-Sharng Chen, Shu-Chien Huang, Mei-Hwan Wu, Jou-Kou Wang
Summary: The study found associations between RVOT and PA geometries with RV remodeling and exercise capacity in patients with repaired tetralogy of Fallot (rTOF). Patients with different RVOT shapes and bilateral PA size discrepancy may require further intervention for optimal outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Pediatrics
Mingwen Yang, Yuting Liu, Siyu Ma, Shujie Wang, Mingcui Fu, Meijiao Zhu, Yaping Li, Shuting Cheng, Zhangzhi Feng, Ming Yang, Xuming Mo
Summary: This study aimed to investigate the structural brain alterations of preschool-aged children with tetralogy of Fallot and its correlation with neurodevelopmental outcome. The results showed cortical morphological differences between groups and their association with neurocognitive abilities and perioperative variables. The study also suggested that cortical morphology can serve as an early potential biomarker for capturing relevant brain abnormalities.
PEDIATRIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Benedetta Leonardi, Federica Gentili, Marco Alfonso Perrone, Fabrizio Sollazzo, Lucia Cocomello, Stefani Silva Kikina, Rachel M. Wald, Vincenzo Palmieri, Aurelio Secinaro, Maria Giulia Gagliardi, Attilio Parisi, Attilio Turchetta, Lorenzo Galletti, Massimiliano Bianco, Fabrizio Drago
Summary: The study aimed to assess the association between CPET values, IPAQ measures, and MRI parameters in patients with repaired Tetralogy of Fallot (rToF). The results showed that reduced exercise capacity in rToF patients was associated with biventricular stroke volumes and left ventricular end-diastolic volume index, and parameters such as oxygen uptake efficiency slope and peak O-2 pulse were also associated with biventricular stroke volumes. Additionally, physical activity level was correlated with peak VO2/kg.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Review
Health Care Sciences & Services
Mahim Malik, Zaiba Shafik Dawood, Mahin Janjua, Sardar Shahmir Babar Chauhan, Laila Akbar Ladak
Summary: Through a systematic review and meta-analysis of 16 studies, it was found that repaired ToF patients scored significantly lower in the physical domain of HRQOL compared to healthy controls, but scored significantly higher in bodily pain and social functioning domains. There was no significant difference in other domains of HRQOL between the two groups.
QUALITY OF LIFE RESEARCH
(2021)
Article
Medicine, General & Internal
Christopher DeZorzi, Anais Marenco, Anne Marie Valente
Summary: Tricuspid regurgitation is a significant finding in patients who have undergone repair for tetralogy of Fallot, and it can have primary or secondary causes. Moderate or severe tricuspid regurgitation is associated with a higher occurrence of atrial tachyarrhythmias in these patients. The optimal timing for tricuspid valve intervention during pulmonary valve replacement in repaired tetralogy of Fallot patients remains uncertain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Christopher J. Petit, Andrew C. Glatz, Andrew B. Goldstone, Mark A. Law, Jennifer C. Romano, Shiraz A. Maskatia, Paul J. Chai, Jeffrey D. Zampi, Jeffery J. Meadows, George T. Nicholson, Shabana Shahanavaz, Athar M. Qureshi, Courtney E. Mccracken, Christopher E. Mascio, Sarosh P. Batlivala, Ivor B. Asztalos, Steven J. Healan, Justin D. Smith, Joelle A. Pettus, Asaad Beshish, James E. B. Raulston, Krissie M. Hock, Amy L. Pajk, Bryan H. Goldstein
Summary: This study aimed to quantify the impact of hypoplastic pulmonary arteries (hPA) on outcomes in neonates with symptomatic tetralogy of Fallot (sTOF), and measure the impact of management strategy on pulmonary artery (PA) growth. The study included 542 neonates and found that the presence of hPA did not increase the hazard of mortality or reintervention after definitive repair, and the hPA cohort showed superior PA growth.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Physiology
Nouf J. Althali, Kathryn E. Hentges
Summary: Congenital heart defects refer to structural abnormalities of the heart or blood vessels present at birth, affecting approximately 1% of newborns worldwide. Tetralogy of Fallot is the most common cyanotic congenital heart abnormality, accounting for 5-10% of all congenital cardiac defects. While some cases of TOF are associated with known diseases or chromosomal abnormalities, the majority are non-syndromic and have unknown causes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medical Laboratory Technology
Wei Wang, Hao Cui, Gao Ran, Chuhao Du, Xiao Chen, Shuo Dong, Siyuan Huang, Jun Yan, Junmin Chu, Jiangping Song
Summary: This study investigated the plasma metabolic profiles to identify key metabolites for early diagnosis of Tetralogy of Fallot (TOF), a common congenital heart disease. The researchers found significant metabolic differences between TOF patients and normal controls, specifically in nicotinamide and purine metabolism pathways. The study suggests that plasma FAD could serve as a highly valuable biomarker for differentiating TOF from normal. These findings contribute to the development of reliable biomarkers and improving early screening for TOF.
CLINICA CHIMICA ACTA
(2023)
Review
Cardiac & Cardiovascular Systems
Stephan von Haehling, Michael Arzt, Wolfram Doehner, Frank Edelmann, Ruben Evertz, Nicole Ebner, Christoph Herrmann-Lingen, Tania Garfias Macedo, Michael Koziolek, Michel Noutsias, P. Christian Schulze, Rolf Wachter, Gerd Hasenfuss, Ulrich Laufs
Summary: The focus of large-scale trials in chronic heart failure has been on evaluating treatments in terms of hospitalizations and mortality, but improving exercise capacity and quality of life for patients with heart failure is also important. Current evidence shows limited effects of treatments on exercise capacity and quality of life, with further studies needed to better understand the effectiveness of these interventions.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Xianchao Jiang, Bo Peng, Jinyang Liu, Heng Zhang, Shoujun Li, Jun Yan, Qiang Wang
Summary: The study results indicate that increased surgeon experience is associated with improved risk-adjusted outcomes, which have important implications for the quality and results of complete repair for TOF.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Bryan H. Goldstein, Christopher J. Petit, Athar M. Qureshi, Courtney E. McCracken, Michael S. Kelleman, George T. Nicholson, Mark A. Law, Jeffery J. Meadows, Jeffrey D. Zampi, Shabana Shahanavaz, Christopher E. Mascio, Paul J. Chai, Jennifer C. Romano, Sarosh P. Batlivala, Shiraz A. Maskatia, Ivor B. Asztalos, Alicia M. Kamsheh, Steven J. Healan, Justin D. Smith, R. Allen Ligon, Joelle A. Pettus, Sarina Juma, James E. B. Raulston, Krissie M. Hock, Amy L. Pajk, Lindsay F. Eilers, Hala Q. Khan, Taylor C. Merritt, Matthew Canter, Stephan Juergensen, Fatuma-Ayaan Rinderknecht, Holly Bauser-Heaton, Andrew C. Glatz
Summary: In this multicenter comparison of staged repair (SR) and primary repair (PR) for neonates with symptomatic tetralogy of Fallot (sTOF), early mortality and neonatal morbidity were lower in the SR group, while cumulative morbidity and reinterventions favored the PR group, suggesting potential benefits to each strategy.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jouke P. Bokma, Tal Geva, Lynn A. Sleeper, Ji Hae Lee, Minmin Lu, Tehila Sompolinsky, Sonya V. Babu-Narayan, Rachel M. Wald, Barbara J. M. Mulder, Anne Marie Valente
Summary: The study aimed to determine whether pulmonary valve replacement (PVR) is associated with improved survival and freedom from sustained ventricular tachycardia (VT) in patients with repaired tetralogy of Fallot (rTOF). The results showed that patients who received PVR had a lower risk of death or sustained VT compared to those who did not receive PVR.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Physiology
Guangming Zhang, Yujie Mao, Mingliang Li, Li Peng, Yunfei Ling, Xiaobo Zhou
Summary: A new method based on Generative Adversarial Networks (GANs) was proposed to optimize patch size, shape, and location in patients with Tetralogy of Fallot (TOF), achieving a high accuracy in patch prediction through fivefold cross-validation (CV) and improving the clinical outcomes, suggesting the potential of reducing misjudgment rate during surgery.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Oncology
Aylin Tanriverdi, Buse Ozcan Kahraman, Gulbin Ergin, Didem Karadibak, Sema Savci
Summary: The purpose of this study is to examine the effects of exercise intervention on exercise capacity, physical function, and patient-reported outcome measures in adults with cancer receiving palliative care. A systematic review and meta-analysis of 14 studies and 1034 adults with cancer receiving palliative care showed that exercise interventions significantly improved exercise capacity, pain, fatigue, and quality of life.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Cardiac & Cardiovascular Systems
Janez Vodiskar, Takashi Kido, Martina Strbad, Julie Cleuziou, Alfred Hager, Peter Ewert, Juergen Hoerer, Masamichi Ono
Summary: This study retrospectively analyzed the clinical data of patients with heterotaxy born between 2001 and 2019, and found that restrictive pulmonary blood flow and greater than mild atrioventricular valve regurgitation are independent risk factors for mortality.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Benedikt Mayr, Melchior Burri, Martina Strbad, Julie Cleuziou, Alfred Hager, Peter Ewert, Juergen Hoerer, Ruediger Lange, Masamichi Ono
Summary: A common atrioventricular valve (CAVV) in patients with functional single ventricle (FSV) is considered a risk factor for early and late deaths. CAVV surgery is challenging and associated with high mortality and reoperation rates.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Takashi Kido, Melchior Burri, Benedikt Mayr, Martina Strbad, Julie Cleuziou, Alfred Hager, Juergen Hoerer, Masamichi Ono
Summary: This study aimed to assess the impact of high mean pulmonary artery pressure before bidirectional cavopulmonary shunt on late adverse events in low pulmonary artery pressure patients before total cavopulmonary connection (TCPC). Results showed that high mean pulmonary artery pressure remained a significant risk factor for adverse events after TCPC, even if the pressure decreased below 10mmHg before TCPC. Various factors such as previous atrial septectomy and pulmonary artery banding were associated with different pressure levels before TCPC.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Takashi Kido, Masamichi Ono, Lisa Anderl, Melchior Burri, Martina Strbad, Gunter Balling, Julie Cleuziou, Alfred Hager, Peter Ewert, Juergen Hoerer
Summary: Reduced ventricular function was significantly associated with death during the ICU stay, prolonged ICU stay and a dominant right ventricle increased the risk of death, and an ICU stay longer than 19 days was a significant risk factor for mortality. High pulmonary artery pressure at BCPS was also a significant risk factor for prolonged ICU stay.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Masamichi Ono, Takashi Kido, Marie Wallner, Melchior Burri, Julia Lemmer, Peter Ewert, Martina Strbad, Julie Cleuziou, Alfred Hager, Juergen Hoerer
Summary: A retrospective analysis of 322 neonates undergoing the Norwood procedure for HLHS or its variants identified low birth weight, restrictive atrial septum, and extracardiac anomalies as risk factors for inter-stage mortality. The study concluded that different risk factors affected inter-stage mortality at each stage of the procedure.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Masamichi Ono, Takashi Kido, Marie Wallner, Melchior Burri, Julia Lemmer, Peter Ewert, Martina Strbad, Julie Cleuziou, Alfred Hager, Jurgen Hoerer
Summary: This study evaluated the outcomes of neonates undergoing the Norwood procedure with modified Blalock-Taussig shunt (MBTS) or right ventricular-pulmonary artery conduit (RVPAC). The results showed no significant difference in early mortality, inter-stage attritions, or overall survival between the two types of shunts during a maximum follow-up period of 18.8 years.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Benedikt Mayr, Takashi Kido, Samantha Holder, Marie Wallner, Janez Vodiskar, Martina Strbad, Bettina Ruf, Alfred Hager, Peter Ewert, Jurgen Hoerer, Rudiger Lange, Masamichi Ono
Summary: This study reviewed the cases of patients who underwent the Norwood procedure and found that moderate or greater atrioventricular valve regurgitation is an independent risk factor for mechanical support. Mechanical support is associated with high in-hospital mortality, but successful Fontan completion was achieved in some patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Takashi Kido, Caecilia Euringer, Melchior Burri, Janez Vodiskar, Martina Strbad, Julie Cleuziou, Bettina Ruf, Peter Ewert, Alfred Hager, Juergen Hoerer, Masamichi Ono
Summary: Low arterial oxygen saturation in the early postoperative period has a significant impact on mortality after bidirectional cavopulmonary shunt (BCPS).
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Laura Willinger, Leon Brudy, Anna-Luisa Haecker, Michael Meyer, Alfred Hager, Renate Oberhoffer-Fritz, Peter Ewert, Jan Mueller
Summary: This study investigated the predictive value of hs-TnT, NT-proBNP, and CRP in stable ACHD patients. The results showed that hs-TnT and NT-proBNP were independent predictors of death or cardiac-related events in stable ACHD, while the prognostic value of CRP vanished after multivariable adjustment.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Arthur Gavotto, Thibault Mura, Jonathan Rhodes, Suellen Moli Yin, Alfred Hager, Julia Hock, Sophie Guillaumont, Marie Vincenti, Gregoire De La Villeon, Anne Requirand, Marie-Christine Picot, Helena Huguet, Luc Souilla, Johan Moreau, Stefan Matecki, Pascal Amedro
Summary: This study aimed to establish reference Z-score values for paediatric cycloergometer VO2max, applicable to normal and extreme weights, using a logarithmic function of VO2max, height, and BMI. The study found that the mathematical model using natural logarithms of VO2max, height, and BMI was the best fit for the data and more reliable than the existing linear equations.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Veronika Hammer, Thibault Schaeffer, Helena Staehler, Paul Philipp Heinisch, Melchior Burri, Nicole Piber, Julia Lemmer, Alfred Hager, Peter Ewert, Juergen Hoerer, Masamichi Ono
Summary: This study evaluated the incidence, outcomes, and predictors of protein-losing enteropathy (PLE) and plastic bronchitis (PB) in a cohort of patients undergoing total cavopulmonary connection (TCPC). The results showed that 41 patients developed PLE/PB, and dominant right ventricle and prolonged pleural effusion after TCPC were independent risk factors. Surgical interventions were performed in 10 patients, and 9 of them achieved recovery from PLE.
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Vincent Dahmen, Paul Philipp Heinisch, Helena Staehler, Thibault Schaeffer, Melchior Burri, Christoph Roehlig, Frank Klawonn, Alfred Hager, Peter Ewert, Juergen Hoerer, Masamichi Ono
Summary: This study aimed to determine the longitudinal change of systemic ventricular function and atrioventricular valve (AVV) regurgitation after total cavopulmonary connection (TCPC). In a retrospective evaluation of 4219 longitudinal echocardiographic examinations, it was found that there were no transplant-free survival difference and no difference in ventricular function between dominant right ventricle (RV) and dominant left ventricle (LV) for the first 10 years after TCPC. However, ventricular function in dominant RV was inferior to that in dominant LV thereafter, and AVV regurgitation was more frequent in dominant RV, positively associated with ventricular dysfunction.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Caecilia Euringer, Thibault Schaeffer, Paul Philipp Heinisch, Melchior Burri, Stanimir Georgiev, Julia Lemmer, Peter Ewert, Alfred Hager, Juergen Hoerer, Masamichi Ono
Summary: This study aimed to determine whether the size of the pulmonary artery (PA) affects survival and if an additional aortopulmonary shunt (APS) promotes left PA growth in patients with hypoplastic left heart syndrome who underwent bidirectional cavopulmonary shunt (BCPS). The study found that preoperative PA index did not affect mortality after BCPS, and the additional APS was unable to improve left PA size in patients with inadequate BCPS.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Lukas Klemm, Thibault Schaeffer, Paul Philipp Heinisch, Helena Staehler, Christoph Roehlig, Christian Meierhofer, Nicole Piber, Alfred Hager, Peter Ewert, Juergen Hoerer, Masamichi Ono
Summary: This study evaluates the clinical outcomes and hemodynamic variables of patients after the Bj & ouml; rk procedure, based on their pulmonary flow patterns. The results suggest that patients with pulsatile systolic pulmonary flow have better survival rates, higher cardiac index, larger right ventricle, and improved exercise capacity compared to those without pulsatile systolic pulmonary flow.
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Melvin Schmiel, Takashi Kido, Stanimir Georgiev, Melchior Burri, Paul Philipp Heinisch, Janez Vodiskar, Martina Strbad, Peter Ewert, Alfred Hager, Juergen Hoerer, Masamichi Ono
Summary: The incidence and associated factors of aortopulmonary collaterals (APCs) in patients with univentricular heart undergoing staged palliation were examined in this study. The presence of APCs before Glenn shunt was highly associated with hypoplastic left heart syndrome, while lower Nakata-Index and younger age at Glenn shunt were associated with the development of APCs before Fontan procedure. However, the presence of APCs or intervention for APCs did not affect intensive care unit stay or mortality after total cavopulmonary connection.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
