Article
Hematology
Yue Peng, Qijian Yi
Summary: This study aimed to determine the incidence, timing, and risk factors of coronary thrombosis in Kawasaki disease (KD) patients with giant coronary artery aneurysm (GCAA). The study found that male gender, involvement of the left anterior descending artery (LAD), and coronary absolute diameter ≥ 8 mm were associated with a higher risk of coronary thrombosis. These findings provide important insights for the thromboprophylaxis management of KD patients with GCAA.
THROMBOSIS RESEARCH
(2023)
Article
Immunology
Jie Liu, Piaoliu Yuan, Yusheng Pang, Danyan Su
Summary: This study investigated the relationship between the ITPKC polymorphism (rs7251246) and the severity and susceptibility to Kawasaki disease (KD) in the Han Chinese population in Southern China. The results showed that the ITPKC rs7251246 polymorphism was significantly associated with the risk of coronary artery aneurysm (CAA) in children with KD. It was also found that male children with the rs7251246 CT/TT genotype had a lower risk of thrombosis. Moreover, the study observed downregulated ITPKC mRNA levels in children with KD, especially those with CAA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Yutaro Koyama, Masaru Miura, Tohru Kobayashi, Tatsunori Hokosaki, Eisuke Suganuma, Fujito Numano, Kenji Furuno, Junko Shiono, Ryota Ebata, Shigeto Fuse, Ryuji Fukazawa, Yoshihide Mitani
Summary: This multicenter registry study aimed to investigate the long-term prognosis and associated factors of patients with Kawasaki disease complicated by coronary artery aneurysms. The study found that the presence of large coronary artery aneurysms is an important factor for coronary events in these patients.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
I-Hsin Tai, Kai-Sheng Hsieh, Ho-Chang Kuo
Summary: Kawasaki disease (KD) is a febrile systemic vasculitis that mainly affects children aged under five years old. The formation of coronary aneurysm is the most common complication after KD.
Review
Pediatrics
Wenyan Jiao, Li Wei, Fuyong Jiao, Dorina Pjetraj, Jianying Feng, Jvyan Wang, Carlo Catassi, Simona Gatti
Summary: This case report describes a 3-month infant with Kawasaki disease who developed coronary artery aneurysm and thrombosis after only 3 days of fever, highlighting the importance of individualized diagnostic criteria and treatment indications in young infants with KD.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhongqin Zhou, Dongmei Wei, Shiganmo Azhe, Chuan Fu, Xiaoyue Zhou, Jing An, Davide Piccini, Jessica Bastiaansen, Yingkun Guo, Lingyi Wen
Summary: Self-navigated coronary MR angiography (SN-CMRA) can be used to evaluate coronary aneurysms (CAA) in patients with Kawasaki disease without increasing radiation. It has reliable diagnostic performance and application value, offering a simplified scanning procedure, shorter scan time, and comparable image quality and diagnostic accuracy compared to other imaging methods.
EUROPEAN RADIOLOGY
(2023)
Article
Pediatrics
Haobo Weng, Yue Peng, Qiongfei Pei, Fengchuan Jing, Maoling Yang, Qijian Yi
Summary: The study found that serum ANXA1 levels were significantly decreased in Kawasaki disease patients, especially those with coronary artery aneurysms. ANXA1 may be involved in the pathogenesis of Kawasaki disease and its downregulation could contribute to hypercoagulability. This highlights ANXA1 as a potential therapeutic target for Kawasaki disease patients.
PEDIATRIC RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Ho-Chang Kuo
Summary: This report describes a Kawasaki disease patient with a regressed coronary artery aneurysm after hydrogen inhalation therapy. This finding suggests hydrogen gas inhalation as a potential treatment for Kawasaki disease, but further research is needed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Rheumatology
Shivaprasad Pannasamudra Mohankumar, Samannay Das, P. Likitha, Priyanka Naranje, Manisha Jana, Saurabh Kumar Gupta, Narendra Kumar Bagri
Summary: Polyarteritis nodosa (PAN) is a medium-vessel vasculitis with cutaneous and multisystem involvement. Coronary artery involvement, a characteristic feature of Kawasaki disease, is rarely reported in PAN. This manuscript presents 2 cases of PAN involving coronaries mimicking Kawasaki disease, emphasizing the importance of differentiation due to differences in treatment and outcome.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Alireza Asadbeygi, Simon Lee, John Kovalchin, Hoda Hatoum
Summary: This study simulates the effects of beta blockers on the hemodynamics and thrombotic risk of coronary artery aneurysms in Kawasaki disease. Computational fluid dynamics was used to simulate coronary blood flow in patient-specific aneurysm models. Two possible responses to beta blockers were evaluated: preserved coronary flow and reduced coronary flow at lower heart rates. The results showed that reduced coronary flow led to a potential increase in thrombotic risk, while preserved coronary flow at lower heart rates had minimal effect on local aneurysm hemodynamics.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yue Peng, Zhenli Cheng, Qijian Yi
Summary: This study aimed to develop and validate a model for predicting coronary thrombosis in Kawasaki disease (KD) patients with medium or large coronary artery aneurysm (CAA). The results showed that male gender, large CAA, and no use of high-dose aspirin prior to intravenous immunoglobulin (IVIG) treatment were significantly associated with coronary thrombosis. The nomogram based on these factors exhibited good diagnostic performance and clinical utility.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Taichi Kato, Masaru Miura, Tohru Kobayashi, Tetsuji Kaneko, Naoya Fukushima, Kenji Suda, Jun Maeda, Shinya Shimoyama, Junko Shiono, Keiichi Hirono, Kazuyuki Ikeda, Seiichi Sato, Fujito Numano, Yoshihide Mitani, Kenji Waki, Mamoru Ayusawa, Ryuji Fukazawa, Shigeto Fuse
Summary: This study is a retrospective study of 1006 patients in Japan, which found that small aneurysms, recent onset, and diagnosis under the age of 1 year contribute to the regression of aneurysms, even giant aneurysms could regress. These data may contribute to the long-term management of coronary aneurysms.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Pediatrics
Ching-Ying Huang, Nan-Chang Chiu, Fu-Yuan Huang, Yen-Chun Chao, Hsin Chi
Summary: The study suggests that a Zmax >= 2.0 of coronary arteries on baseline echocardiography in children may predict a high risk of late CAAs and allow for targeted early intensification therapy.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Toshiyuki Kitoh, Tsuyoshi Ohara, Taichiro Muto, Akihisa Okumura, Reizo Baba, Yusuke Koizumi, Yuka Yamagishi, Hiroshige Mikamo, Kenji Daigo, Takao Hamakubo
Summary: PTX3 is a reliable biomarker for predicting IVIG resistance and subsequent CAL formation in patients with KD, with a specificity of 88.5% and a sensitivity of 94.4%.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Laura Gellis, Daniel A. Castellanos, Rebecca Oduor, Kimberlee Gauvreau, Audrey Dionne, Jane Newburger, Kevin G. Friedman
Summary: CCT and echocardiography show high agreement in measuring the absolute dimensions of proximal coronary artery segments, but there is greater discrepancy in measuring distal coronary artery segments.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2022)
