Journal
PEDIATRIC BLOOD & CANCER
Volume 61, Issue 7, Pages 1329-1335Publisher
WILEY
DOI: 10.1002/pbc.25017
Keywords
allogeneic BMT; voriconazole; phototoxicity
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Funding
- Women's Auxiliary Millennium Chair in Haematology/Oncology
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We investigated the incidence of phototoxic skin reactions in pediatric BMT recipients treated with voriconazole. Nine out of 40 patients (22.5%), all Caucasian, developed skin lesions in sun-exposed distributions. Dermatologic findings included sunburn-like erythema, pseudo-porphyria, linear papulovesicular lesions, severe erosive cheilitis, dermatoheliosis and lentigines. Patients were treated with sun avoidance, high-potency sunscreens, and topical steroids with significant improvement in all cases. Prolonged voriconazole use requires close monitoring for chronic skin toxicities. Long-term risks including the risk of skin cancer need to be investigated. Pediatr Blood Cancer 2014;61:1325-1328. (c) 2014 Wiley Periodicals, Inc.
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