Article
Oncology
Nathalie Belpame, Marijke C. Kars, Eva Deslypere, Peter Rober, Ann Van Hecke, Sofie Verhaeghe
Summary: This study explores five coping strategies employed by AYA survivors of childhood cancer to deal with the long-term consequences of their cancer experience, emphasizing the effort required to cope with being a childhood cancer survivor even long after treatment ends. It highlights the importance of individual frame of reference as the starting point for psychosocial support.
Article
Oncology
Hazel B. Nichols, Chris D. Baggett, Stephanie M. Engel, Darios Getahun, Chelsea Anderson, Nancy T. Cannizzaro, Laura Green, Parul Gupta, Cecile A. Laurent, Paul C. Lin, Clare Meernik, Lisa M. Moy, Ethan Wantman, Lanfang Xu, Marilyn L. Kwan, Jennifer E. Mersereau, Chun R. Chao, Lawrence H. Kushi
Summary: The AYA Horizon study aims to provide high-quality, contemporary evidence on reproductive outcomes for female cancer survivors in the United States. The study found that active response to the survey component was low overall, especially among minority groups.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Review
Oncology
Silvie H. M. Janssen, Winette T. A. van der Graaf, Daniel J. van der Meer, Eveliene Manten-Horst, Olga Husson
Summary: Adolescent and young adult (AYA) cancer patients, aged 15-39 years old, face unique challenges in their disease trajectory. Although the number of AYA cancer survivors has increased, they are at risk of long-term and late effects. Research efforts are needed to inform survivorship care for this growing population.
Article
Oncology
Pengcheng Yang, Lei Zhang, Xiaohua Hou
Summary: This study found that adolescent and young adult cancer patients in the US have a suicide rate over 20% higher than the general population, with the majority of suicides occurring within the first 5 years following diagnosis. Risk factors associated with a higher risk of suicide include male sex, white race, unmarried state, distant tumor stage, and single primary tumor.
CANCER CELL INTERNATIONAL
(2021)
Review
Pediatrics
Laura Reinman, Helen L. Coons, Jenna Sopfe, Robert Casey
Summary: In order to best support the diverse needs of adolescent and young adult cancer survivors, healthcare providers should assess and support them using a biopsychosocial and contextual framework. Building a trusting relationship with patients to openly discuss the physical and psychosocial aspects of sexual health is key to providing optimal care and outcomes.
Article
Oncology
Neige Marie Yvanne Journy, Wael Salem Zrafi, Stephanie Bolle, Brice Fresneau, Claire Alapetite, Rodrigue Setcheou Allodji, Delphine Berchery, Nadia Haddy, Isao Kobayashi, Martine Labbe, Helene Pacquement, Claire Pluchart, Boris Schwartz, Vincent Souchard, Cecile Thomas-Teinturier, Cristina Veres, Giao Vu-Bezin, Ibrahima Diallo, Florent de Vathaire
Summary: Childhood or adolescent cancer survivors undergoing cranial irradiation are at increased risk of developing subsequent primary neoplasms of the central nervous system (CNS), particularly meningiomas, and the risk is significantly associated with radiation dose. Monitoring patients with cranial irradiation should continue for at least 30 years post-treatment to ensure early detection and intervention. Identified risk factors, such as radiation dose and cumulative alkylating agents, can help inform long-term surveillance strategies for this population.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Jason J. Liu, Immaculata De Vivo, Chun-Ying Wu, Edward Giovannucci
Summary: This study found that childhood and adolescent cancer survivors have a higher risk of subsequent urogenital and kidney cancers, with females being more susceptible. Females also have a higher risk of specific reproductive system cancers.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Oncology
Silvie H. M. Janssen, Carla Vlooswijk, Eveliene Manten-Horst, Sophia H. E. Sleeman, Rhode M. Bijlsma, Suzanne E. J. Kaal, Jan Martijn Kerst, Jacqueline M. Tromp, Monique E. M. M. Bos, Tom van Der Hulle, Roy I. Lalisang, Janine Nuver, Mathilde C. M. Kouwenhoven, Winette T. A. van Der Graaf, Olga Husson
Summary: Despite growing awareness of age-specific care for adolescent and young adult cancer patients, it is not always provided or accepted as standard care. A study in the Netherlands found that a significant proportion of long-term survivors had missed age-specific care, particularly female survivors who were diagnosed at a younger age and received certain treatments. These survivors had a variety of needs, including disease and treatment information, emotional support, support from friends and family, fertility and pregnancy, work and reintegration, as well as comprehensive care and overall well-being. Improving age-specific care services for these survivors is necessary.
Article
Public, Environmental & Occupational Health
Eric Adjei Boakye, Katherine M. Polednik, Teresa L. Deshields, Arun Sharma, Yamile Molina, Lidia Schapira, Justin M. Barnes, Nosayaba Osazuwa-Peters
Summary: This study examined emotional distress in cancer survivors diagnosed as adolescents or young adults compared to survivors diagnosed as middle/older adults and the general population without a history of cancer. The findings showed that emotional distress was more prevalent among young adult cancer survivors than middle/older adult survivors. However, there was no difference in emotional distress between young adult cancer survivors and the general population without cancer.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Oncology
Renee L. Mulder, Anna Font-Gonzalez, Melissa M. Hudson, Hanneke M. van Santen, Erik A. H. Loeffen, Karen C. Burns, Gwendolyn P. Quinn, Eline van Dulmen-den Broeder, Julianne Byrne, Riccardo Haupt, W. Hamish Wallace, Marry M. van den Heuvel-Eibrink, Antoinette Anazodo, Richard A. Anderson, Anke Barnbrock, Joern D. Beck, Annelies M. E. Bos, Isabelle Demeestere, Christian Denzer, Natascia Di Iorgi, Holly R. Hoefgen, Rejin Kebudi, Cornelis Lambalk, Thorsten Langer, Lillian R. Meacham, Kenny Rodriguez-Wallberg, Catharyn Stern, Eveline Stutz-Grunder, Wendy van Dorp, Margreet Veening, Saskia Veldkamp, Eline van der Meulen, Louis S. Constine, Lisa B. Kenney, Marianne D. van de Wetering, Leontien C. M. Kremer, Jennifer Levine, Wim J. E. Tissing
Summary: This study aims to develop clinical practice guidelines for fertility preservation in female patients diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger. By utilizing the Grading of Recommendations Assessment, Development and Evaluation methodology, transparent recommendations were formed to facilitate the care of high-risk female patients. Collaboration led to a comprehensive review of existing evidence, transparent reporting, and achievement of global interdisciplinary consensus.
Article
Oncology
Smita Bhatia, Alberto S. Pappo, Melissa Acquazzino, Wendy A. Allen-Rhoades, Marie Barnett, Scott C. Borinstein, Robert Casey, Sun Choo, Rashmi Chugh, Shira Dinner, Ralph Ermoian, Douglas Fair, Noah Federman, Jeanelle Folbrecht, Shipra Gandhi, Julie Germann, Robert Goldsby, Robert Hayashi, Alex Y. Huang, Mary S. Huang, Linda A. Jacobs, Cathy Lee-Miller, Michael P. Link, John A. Livingston, Maryam Lustberg, Marcio Malogolowkin, Kevin C. Oeffinger, Christine A. Pratilas, Damon Reed, Jodi Skiles, Margaret von Mehren, Nicholas Yeager, Sarah Montgomery, Lisa Hang
Summary: This article discusses considerations for the comprehensive care of adolescent and young adult (AYA) patients with cancer, based on the NCCN Guidelines for AYA Oncology. AYA patients have unique needs in terms of treatment, fertility counseling, psychosocial and behavioral issues, and supportive care services compared to older adults with cancer.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Oncology
Renee L. Mulder, Anna Font-Gonzalez, Daniel M. Green, Erik A. H. Loeffen, Melissa M. Hudson Jacqueline, Jacqueline Loonen, Richard Yu, Jill P. Ginsberg, Rod T. Mitchell, Julianne Byrne, Roderick Skinner, Antoinette Anazodo, Louis S. Constine, Andrica de Vries, Kirsi Jahnukainen, Armando Lorenzo, Andreas Meissner, Leena Nahata, Marij Dinkelman-Smit, Herman Tournaye, Riccardo Haupt, Marry M. van den Heuvel-Eibrink, Hanneke M. van Santen, Ans M. M. van Pelt, Uta Dirksen, Jaap den Hartogh, Eline van Dulmen-den Broeder, W. Hamish Wallace, Jennifer Levine, Wim J. E. Tissing, Leontien C. M. Kremer, Lisa B. Kenney, Marianne D. van de Wetering
Summary: This clinical practice guideline provides guidance on risk assessment and fertility preservation methods for male patients diagnosed with childhood, adolescent, and young adult cancer at age 25 or younger. By rigorously evaluating existing evidence, transparent and easy-to-use recommendations are developed to facilitate the care of male patients at high risk of fertility impairment.
Article
Gastroenterology & Hepatology
Jason J. Liu, Chuan-Yu Chen, Edward Giovannucci, Chun-Ying Wu
Summary: The study found that survivors of childhood and adolescent cancers diagnosed from 1975 to 2015 have significantly elevated risks of developing digestive system cancers compared to the general population in the US. Among the 41,249 cancer survivors, 133 developed subsequent primary digestive system cancer, with bone cancer, lymphoma, and neuroblastoma survivors having the highest risks. The findings suggest the need for surveillance recommendations for childhood and adolescent cancer survivors and further studies to understand the mechanisms behind the increased risks of digestive system cancers.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Emily Haines, Sarah Asad, Lauren Lux, Hilary Gan, Kara Noskoff, Bindu Kumar, Betty Roggenkamp, John M. Salsman, Sarah Birken
Summary: This study used an implementation science framework to identify barriers and generate practical guidance for implementing specialized AYA cancer care, contributing to the body of evidence available for future implementation efforts.
JCO ONCOLOGY PRACTICE
(2022)
Article
Oncology
Renee L. Mulder, Anna Font-Gonzalez, Eline van Dulmen-den Broeder, Gwendolyn P. Quinn, Jill P. Ginsberg, Erik A. H. Loeffen, Melissa M. Hudson, Karen C. Burns, Hanneke M. van Santen, Claire Berger, Tamara Diesch, Uta Dirksen, Aleksander Giwercman, Clarisa Gracia, Sarah E. Hunter, Joanne F. Kelvin, James L. Klosky, Joop S. E. Laven, Barbara A. Lockart, Sebastian J. C. M. M. Neggers, Michelle Peate, Bob Phillips, Damon R. Reed, Eva Maria E. Tinner, Julianne Byrne, Margreet Veening, Marleen van de Berg, Chris M. Verhaak, Antoinette Anazodo, Kenny Rodriguez-Wallberg, Marry M. van den Heuvel-Eibrink, Ogechukwu A. Asogwa, Alexandra Brownsdon, W. Hamish Wallace, Daniel M. Green, Roderick Skinner, Riccardo Haupt, Lisa B. Kenney, Jennifer Levine, Marianne D. van de Wetering, Wim J. E. Tissing, Norbert W. Paul, Leontien C. M. Kremer, Julia Inthorn
Summary: Patients with childhood, adolescent, and young adult cancer treated with gonadotoxic therapies are at higher risk for infertility and may desire fertility preservation. A clinical practice guideline offers recommendations for ongoing communication to facilitate effective dialogue between patients and their families.
Article
Medicine, Research & Experimental
LaQuita M. Jones, Katelyn Melgar, Lyndsey Bolanos, Kathleen Hueneman, Morgan M. Walker, Jian-Kang Jiang, Kelli M. Wilson, Xiaohu Zhang, Jian Shen, Fan Jiang, Patrick Sutter, Amy Wang, Xin Xu, Gregory J. Tawa, Scott B. Hoyt, Mark Wunderlich, Eric O'Brien, John P. Perentesis, Daniel T. Starczynowski, Craig J. Thomas
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Oncology
Nicole J. Ullrich, Sanjay P. Prabhu, Alyssa T. Reddy, Michael J. Fisher, Roger Packer, Stewart Goldman, Nathan J. Robison, David H. Gutmann, David H. Viskochil, Jeffrey C. Allen, Bruce Korf, Alan Cantor, Gary Cutter, Coretta Thomas, John P. Perentesis, Tomoyuki Mizuno, Alexander A. Vinks, Peter E. Manley, Susan N. Chi, Mark W. Kieran
Article
Oncology
Erin H. Breese, Christa Krupski, Adam S. Nelson, John P. Perentesis, Christine L. Phillips
Summary: CAR T-cell therapy was used in an infant with chemotherapy-refractory KMT2A-rearranged ALL, showing feasibility in T-cell collection and expansion, achieving minimal residual disease negative remission with good quality of life, and delaying hematopoietic stem cell transplantation.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2021)
Article
Oncology
Mathieu Sertorio, Ali Nowrouzi, Mahdi Akbarpour, Kashish Chetal, Nathan Salomonis, Stephan Brons, Anthony Mascia, Dan Ionascu, Shelby McCauley, Taylor Kupneski, Andreas Kothe, Juergen Debus, John P. Perentesis, Amir Abdollahi, Yi Zheng, Susanne I. Wells
Summary: This study identified specific transcriptional regulation of a subset of genes in lymphoma cells following proton therapy compared to X-ray radiation, leading to decreased protein translation and diminished unfolded protein response activation possibly due to oxidative stress. Inhibition of PPARgamma was found to sensitize lymphoma cells to proton therapy, suggesting it as a potential strategy for sensitizing lymphoma to PT.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Nicole J. Ullrich, Sanjay P. Prabhu, Roger J. Packer, Stewart Goldman, Nathan J. Robison, Jeffrey C. Allen, David H. Viskochil, David H. Gutmann, John P. Perentesis, Bruce R. Korf, Michael J. Fisher, Mark W. Kieran
Summary: In children with neurofibromatosis type 1-associated optic pathway gliomas (NF1-OPGs), visual acuity tends to stabilize or improve after treatment with everolimus, although there may be discrepancies between visual and radiologic outcomes.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Shannon Cunningham, Shelby McCauley, Kanimozhi Vairamani, Joseph Speth, Swati Girdhani, Eric Abel, Ricky A. Sharma, John P. Perentesis, Susanne I. Wells, Anthony Mascia, Mathieu Sertorio
Summary: This study validated the reduction of normal tissue damage with FLASH radiotherapy compared to conventional treatment, and demonstrated the potential of PBS FLASH radiotherapy using proton pencil beam scanning technology in mice. The results support the role of FLASH radiotherapy in improving treatment outcomes and provide valuable data for further research.
Article
Oncology
Mark Wunderlich, Nicole Manning, Christina Sexton, Eric O'Brien, Luke Byerly, Cody Stillwell, John P. Perentesis, James C. Mulloy, Benjamin Mizukawa
Summary: Immune therapies such as blinatumomab have shown significant improvements in outcomes for relapsed B-ALL, but up to half of patients do not respond completely. Testing the combination of blinatumomab with pembrolizumab in UCB-humanized NRGS mice engrafted with PDX cells from patients with treatment resistance or relapse demonstrated improved disease burden reduction and long-term survival rates compared to single agent therapy. The results suggest that UCB-humanized PDX leukemia models can be valuable in preclinical studies evaluating immune therapies in B-ALL.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Y. Zhang, Z. Ding, J. P. Perentesis, D. Khuntia, S. X. Pfister, R. A. Sharma
Summary: FLASH radiotherapy delivers radiation treatment at an ultra-high dose rate and has shown normal tissue sparing effects and equivalent antitumour activity in preclinical studies. Research suggests that FLASH irradiation may be a rational partner to combine with immune modulating drugs to improve clinical outcomes.
Article
Oncology
Madeline Niederkorn, Chiharu Ishikawa, Kathleen M. Hueneman, James Bartram, Emily Stepanchick, Joshua R. Bennett, Ashley E. Culver-Cochran, Lyndsey C. Bolanos, Emma Uible, Kwangmin Choi, Mark Wunderlich, John P. Perentesis, Timothy M. Chlon, Marie-Dominique Filippi, Daniel T. Starczynowski
Summary: USP15 is overexpressed in AML, correlating with KEAP1 protein and NRF2 suppression. Inhibition of USP15 leads to activation of NRF2 and impaired AML cell function. Targeting USP15 catalytic function may selectively impair leukemic progenitor cells while sparing normal hematopoiesis.
Article
Oncology
Jeremy D. Rubinstein, Rachana Shah, Erin H. Breese, Karen C. Burns, Jennifer L. Mangino, Robin E. Norris, Lynn Lee, Benjamin Mizukawa, Maureen M. O'Brien, Christine L. Phillips, John P. Perentesis, Lauren Pommert, Michael J. Absalon
Summary: A retrospective study showed that the use of SC-EPOCH regimen can achieve good treatment outcomes with manageable toxicities and high survival rates in pediatric or young adult patients with high-risk PTLD.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Shailaja Hegde, Anjelika Gasilina, Mark Wunderlich, Yuan Lin, Marcel Buchholzer, Oliver H. F. Krumbach, Mohammad Akbarzadeh, Mohammad Reza Ahmadian, William Seibel, Yi Zheng, John P. Perentesis, Benjamin E. Mizukawa, Lisa Privette Vinnedge, Jose A. Cancelas, Nicolas N. Nassar
Summary: The small-molecule inhibitor IODVA1 targeting VAV3 effectively inhibits RAC activation and signaling, leading to increased pro-apoptotic activity in BCR-ABL1-transformed cells. In difficult-to-treat pediatric Ph+ and TKI-resistant Ph+ B-ALL patient-derived xenograft models, IODVA1 outperforms dasatinib or ponatinib and provides a more durable response after treatment withdrawal.
Editorial Material
Oncology
Alexandra Power-Hays, Christopher E. Dandoy, Angela Lorts, John P. Perentesis, Ndidi Unaka, Russell E. Ware, Patrick T. McGann
PEDIATRIC BLOOD & CANCER
(2022)
Article
Cell Biology
Laura Barreyro, Avery M. Sampson, Chiharu Ishikawa, Kathleen M. Hueneman, Kwangmin Choi, Mario A. Pujato, Somchai Chutipongtanate, Michael Wyder, Wendy D. Haffey, Eric O'Brien, Mark Wunderlich, Vighnesh Ramesh, Ellen M. Kolb, Cem Meydan, Yaseswini Neelamraju, Lyndsey C. Bolanos, Susanne Christie, Molly A. Smith, Madeline Niederkorn, Tomoya Muto, Santosh Kesari, Francine E. Garrett-Bakelman, Boris Bartholdy, Britta Will, Matthew T. Weirauch, James C. Mulloy, Zartash Gul, Stephen Medlin, Rhett A. Kovall, Ari M. Melnick, John P. Perentesis, Kenneth D. Greis, Elmar Nurmemmedov, William L. Seibel, Daniel T. Starczynowski
Summary: This study found that dysregulation of immune signaling pathways is associated with oncogenic immune signaling states in acute myeloid leukemia (AML) hematopoietic stem and progenitor cells. Inhibition of the ubiquitin-conjugating enzyme UBE2N disrupted oncogenic immune signaling and promoted cell death in AML cells while sparing normal cells. These findings highlight the potential of interfering with UBE2N function as a therapeutic strategy for AML.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Letter
Oncology
John Breneman, John P. Perentesis, Jeffrey Bradley, Anthony Mascia, Eric Abel, Agam Sharda, Deepak Khuntia, Ricky A. Sharma, Charles B. Simone
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Karen D. Wright, Xiaopan Yao, Wendy B. London, Pei-Chi Kao, Lia Gore, Stephen Hunger, Russ Geyer, Kenneth J. Cohen, Jeffrey C. Allen, Howard M. Katzenstein, Amy Smith, Jessica Boklan, Kellie Nazemi, Tanya Trippett, Matthias Karajannis, Cynthia Herzog, Joseph Destefano, Jennifer Direnzo, Jay Pietrantonio, Lianne Greenspan, Danielle Cassidy, Debra Schissel, John Perentesis, Mitali Basu, Tomoyuki Mizuno, Alexander A. Vinks, Sanjay P. Prabhu, Susan N. Chi, Mark W. Kieran
Summary: Everolimus shows efficacy as an alternative treatment for pediatric patients with radiographically progressive low-grade glioma, with a well-tolerated profile. Some patients experienced toxicities, but overall survival rates were relatively high.
PEDIATRIC BLOOD & CANCER
(2021)
