Article
Multidisciplinary Sciences
Fahad M. Aldakheel, Bader H. Alali, Shatha A. Alduraywish, Ayesha Mateen, Rabbani Syed
Summary: Alloantibodies, formed against various blood components, are commonly associated with transfusions. This study examined the clinical factors related to red blood cell transfusion and the impact of Rh-Kell antigen matching on alloimmunization in sickle cell anemia patients. The results indicated that advancing age and multiple transfusion episodes were associated with an increased risk of alloantibody development after transfusion in SCA patients.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Hematology
Jorn Gerritsma, Vera Bongaerts, Corien Eckhardt, Harriet Heijboer, Erfan Nur, Bart Biemond, Ellen van der Schoot, Karin Fijnvandraat
Summary: Delayed haemolytic transfusion reaction (DHTR) is a potentially life-threatening complication of red blood cell (RBC) transfusions in sickle cell disease (SCD), with a high incidence rate despite extended donor RBC matching. Early diagnosis is crucial for improving outcomes.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
Kaoru Takasaki, David F. Friedman, Stacey Uter, Sunitha Vege, Connie M. Westhoff, Stella T. T. Chou
Summary: RH diversity contributes to Rh immunization despite serologic Rh-matched transfusions. Anti-D can occur in D+ patients with RHD variants encoding partial D antigens. In sickle cell disease patients, anti-D formed more frequently in individuals with partial D antigens, occurred after fewer D+ transfusions, and persisted longer. Prophylactic RH genotype-matched transfusions may benefit patients with partial D antigens, while future studies should explore the use of RH genotype-matched transfusions to reduce D immunization and transfusion of D- units to D+ individuals with conventional RHD or DAU0 alleles.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Medicine, General & Internal
Fahd A. Kuriri
Summary: This article provides an overview of current, new, and future treatment options for sickle cell disease (SCD). Current treatments include hydroxyurea and voxelotor, which increase fetal hemoglobin levels and selectively bind hemoglobin, respectively. Potential side effects and the need for new treatments are discussed, along with the promise of gene therapy as a future treatment option for SCD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yuhong Zhao, Jianping Cao, Yan Lv, Dawei Cui, Jue Xie
Summary: This study aims to investigate the roles of human platelet antigens (HPAs) in platelet transfusion refractoriness (PTR). Genotyping of HPA 1-6, 15 systems was performed, and the effects of matched platelet transfusion were analyzed. The study found that allele b of HPA-3 had the highest frequency, 0.51, and HPA-15 had the highest heterozygosity, 0.33. The results showed that the corrected count increment (CCI) in the antigen match-compatible transfusion group was significantly better than the random donor transfusion group. Establishment of a local database of platelet genes is recommended to provide compatible platelet products to alloimmunized patients and improve the safety and efficacy of platelet transfusion.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Medicine, General & Internal
Jing-Cheng Zhang, Li-Hong Ni, Yan Tu, Hui-Xian Hu
Summary: This study compared the hemostatic effect of platelets donated by relatives and unrelated donors. The results showed that platelets donated by relatives had a significantly better hemostatic effect and could prevent bleeding without increasing adverse transfusion reactions. This may be a better transfusion strategy for platelet refractoriness patients in emergency situations.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Pilar Solves, Javier Marco-Ayala, Miguel Angel Sanz, Ines Gomez-Segui, Aitana Balaguer-Rosello, Ana Facal, Marta Villalba, Juan Montoro, Guillermo Sanz, Javier de la Rubia, Jaime Sanz
Summary: This study compares the transfusion requirements of patients undergoing different modalities of hematopoietic stem cell transplantation (HSCT) over a twelve-year period. The results show that transfusion requirements have significantly increased for matched related donor HSCT, while there were no significant changes for matched unrelated donor and haploidentical transplant HSCT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Dorsa Zarrabian, Mirette Hanna
Summary: This retrospective study reviewed the clinical and transfusion records of 92 pediatric transfusion-dependent thalassemia patients and found that 9% of patients developed clinically significant alloantibodies. Blood matching for ABO, RhD, and K antigens can reduce the frequency of alloimmunization.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Medical Laboratory Technology
Raed Felimban, Ahmed Alsharyufi, Jasem Aljehani, Ahmed Sahlool, Hamead Aljabri, Talal Qadah
Summary: This study aimed to determine the prevalence of RBC alloimmunization and frequency of Rhesus (Rh) and Kell (K) antigens among SCA and beta-thalassemia patients in Al-Madinah region of Saudi Arabia. The results showed a low rate of RBC alloimmunization compared to other studies, with anti-K being the most frequent alloantibody. Further attention is required to reduce the risk of alloimmunization and improve the efficiency of blood transfusions.
CLINICAL LABORATORY
(2021)
Article
Medicine, General & Internal
Salome Conrath, Vincent Vantilcke, Mickael Parisot, Francoise Maire, Pierre Selles, Narcisse Elenga
Summary: This study aimed to describe the prevalence of alloimmunization in patients with sickle cell disease who were monitored at Cayenne Hospital in 2016. It found that 23% of the patients had detectable RBC alloantibodies, and 19% of those patients developed a delayed hemolytic transfusion reaction. Differences between donors from France vs. recipients from French Guiana may explain the high prevalence of alloimmunization and further reduction strategies are needed.
FRONTIERS IN MEDICINE
(2021)
Review
Multidisciplinary Sciences
Jeanne Boudreaux
Summary: This article provides an overview of the current challenges and recommendations regarding transfusion management for thalassemia patients. It also discusses the components of blood safety and blood product modification for specific populations. The article describes adverse transfusion reactions and explores newer technologies to minimize the risk of transfusion-associated pathogens. Finally, the article briefly discusses research in blood storage and manufactured blood.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Medicine, General & Internal
Amr J. Halawani, Abdullah A. Mobarki, Ali H. Arjan, Muhammad Saboor, Hassan A. Hamali, Gasim Dobie, Khalaf F. Alsharif
Summary: This study examined the rates of alloimmunization and autoimmunization in patients with sickle cell disease (SCD) and thalassemia in Jazan Province, Saudi Arabia. The results highlight the importance of extended phenotyping in the screening panel to ensure better transfusion practices.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Hematology
Alice Tang, Ana Nicolle Strat, Mahmudur Rahman, Helen Zhang, Weili Bao, Yunfeng Liu, David Shi, Xiuli An, Deepa Manwani, Patricia Shi, Karina Yazdanbakhsh, Avital Mendelson
Summary: Studies have found that murine SCD MSCs exhibit altered gene signatures, reduced stem cell properties, and increased oxidative stress, leading to decreased HSC maintenance ability. The activation of Toll-like receptor-4 through p65 in MSCs further exacerbates MSC dysfunction in SCD.
Review
Hematology
Sherif M. Badawy, Usman Beg, Robert Liem, Sonali Chaudhury, Alexis A. Thompson
Summary: There is increasing interest in curative therapies for patients with sickle cell disease (SCD) and thalassemia, including hematopoietic stem cell transplant (HSCT) and gene therapy. Research shows that HSCT has a positive impact on HRQOL, with potential for improvement in HRQOL outcomes following gene therapy in patients with SCD and thalassemia.
Article
Hematology
Brian D. Adkins, Ajay Mehta, Margaret Selesky, Stephany Vittitow, Mark E. Smolkin, Sarah J. Ratcliffe, Chance J. Luckey
Summary: This study aimed to investigate the predisposition of MDS patients to antibody formation and found a relative enrichment of JAK2 positivity among patients with RBC alloantibodies. The results of the investigation on patients' immune response to red blood cells are consistent with recent literature.
Article
Oncology
Hallie Coltin, Adam Rapoport, Nancy N. Baxter, Chenthila Nagamuthu, Paul C. Nathan, Jason D. Pole, Franco Momoli, Sumit Gupta
Summary: Adolescents and young adults with cancer may receive high-intensity end-of-life care, with pediatric care and rural residence associated with higher odds of ICU death.
Article
Oncology
Yichen Zhang, Anita Katharina Wagner, Haoxin Du, Taisen Han, Sumit Gupta, Avram E. Denburg, A. Lindsay Frazier, Xiaodong Guan, Luwen Shi
Summary: Compared to less developed countries, the United States has a higher cure rate for childhood cancers with traditional chemotherapy as the main treatment and newer targeted medications being introduced. The numbers and types of cancer drugs approved for children differ between China and the United States, with a higher correlation between indications and disease burden in the US. China has more traditional chemotherapy drugs approved, while the US has a stronger presence in targeted childhood anticancer medications.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Hematology
Sumit Gupta, Sarah Alexander, Jason D. Pole, Rinku Sutradhar, Michael Crump, Chenthila Nagamuthu, Nancy N. Baxter, Paul C. Nathan
Summary: The study found that AYA aged 15-21 diagnosed with B-NHL had better event-free and overall survival rates when treated at pediatric centers compared to adult centers. Adjusted for factors like histology and stage, the disparities in survival rates remained significant, indicating potential benefits of pediatric protocols for AYA with B-NHL.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Letter
Oncology
Sumit Gupta, Paul C. Nathan, David Hodgson
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Caitlin W. Elgarten, Joel C. Thompson, Anne Angiolillo, Zhiguo Chen, Susan Conway, Meenakshi Devidas, Sumit Gupta, John A. Kairalla, Jennifer L. McNeer, Maureen M. O'Brien, Karen R. Rabin, Rachel E. Rau, Susan R. Rheingold, Cindy Wang, Charlotte Wood, Elizabeth A. Raetz, Mignon L. Loh, Sarah Alexander, Tamara P. Miller
Summary: This article discusses key processes implemented in two ongoing Children's Oncology Group ALL trials to improve reporting of infectious AEs. Preliminary assessment suggests improved reporting and opportunities for further improvement.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Hallie Coltin, Priscila Pequeno, Ning Liu, Derek S. Tsang, Sumit Gupta, Michael D. Taylor, Eric Bouffet, Paul C. Nathan, Vijay Ramaswamy
Summary: This study characterized the late effects of childhood medulloblastoma survivors using real-world health services data. The findings reveal significant long-term medical sequelae and increased mortality rates, emphasizing the need for a re-evaluation of current treatment approaches and prioritization of interventions targeting late effects.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Lindsay A. Jibb, Stephanie M. Nanos, Sarah Alexander, Carmine Malfitano, Anne Rydall, Sumit Gupta, Aaron D. Schimmer, Camilla Zimmermann, Sarah Hales, Rinat Nissim, Charles Marmar, Katharina Schultebraucks, Kenneth Mah, Gary Rodin
Summary: This study aims to determine the prevalence, severity, longitudinal course, and predictors of traumatic stress symptoms in family caregivers of patients with acute leukemia and to understand their lived experience of traumatic stress and support needs.
Article
Oncology
Adeleke Fowokan, Glenn Mbah Afungchwi, Lorna Renner, Piera Freccero, Sumit Gupta, Avram Denburg
Summary: This study evaluated the impact of an early childhood cancer training intervention on healthcare workers in Ghana. The findings suggest that the training improved knowledge, attitudes, and clinical practice among participants. However, challenges at both the patient and system levels need to be addressed for sustained impact.
JCO GLOBAL ONCOLOGY
(2022)
Article
Hematology
Angela Punnett, Nancy N. N. Baxter, David Hodgson, Rinku Sutradhar, Jason D. D. Pole, Cindy Lau, Paul C. C. Nathan, Sumit Gupta
Summary: We used population-based clinical and healthcare data to study the treatment patterns and long-term outcomes of adolescents and young adults (AYA) with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). We collected detailed clinical data of AYA aged 15-21 years at diagnosis with NLPHL in Ontario, Canada between 1992 and 2012. Additional events such as subsequent malignant neoplasms, relapses, and deaths were identified through linkage to healthcare databases. The study found that AYA with NLPHL have excellent long-term survival rates, and resection alone was associated with good outcomes, but strategies to avoid chemotherapy and radiation should be considered due to the risk of subsequent malignant neoplasms.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Oncology
Catherine Mark, Paul Gibson, Lucie Lafay-Cousin, Georgina Martin, Sapna Oberoi, Lucie Pecheux, Shahrad R. Rassekh, Alexandra Zorzi, Sarah Alexander, Sumit Gupta
Summary: This retrospective study investigated the outcomes of 86 children with cancer who were diagnosed with COVID-19. 41.9% of the patients required hospitalization, but only 11.6% of hospitalizations were attributed to the virus. There were no deaths directly caused by COVID-19, and the findings support minimizing the interruption of chemotherapy after infection.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2023)
Article
Oncology
Sumit Gupta, Qing Li, Paul C. Nathan, Norma D'Agostino, Nancy N. Baxter, Colleen Fox, Karine Chalifour, Natalie Coburn, Rinku Sutradhar
Summary: The symptom burden in adolescents and young adults with cancer in Canada is not well characterized and affects their quality of life. The study found that a significant proportion of these patients experience fatigue and anxiety. The severity of symptoms is closely related to the risk of death, highlighting the need for interventions to improve the quality of life in this population.
Editorial Material
Oncology
Junious Sichali, Avi Denburg, Harriet Khofi, Cecilia Mdoka, Deborah Nyirenda, Yamikani Chimalizeni, George Chagaluka, Elizabeth Molyneux, Marc Y. R. Henrion, Sumit Gupta, Trijn Israels
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Aditi Desai, Rinku Sutradhar, Cindy Lau, Kim Widger, Douglas S. S. Lee, Paul C. C. Nathan, Sumit Gupta
Summary: The impact of a child's cancer diagnosis on maternal physical health shows an increased risk of cancer for mothers, but no increased risk of other adverse physical outcomes. However, exposed mothers were more likely to engage in preventive healthcare practices. Bereaved mothers had an increased risk of subsequent cancer and death.
PEDIATRIC BLOOD & CANCER
(2023)
Review
Oncology
Han Yan, Veda Zabih, Ute Bartels, Sunit Das, Paul Nathan, Sumit Gupta
Summary: Prognostication and treatment of medulloblastoma in adolescents and young adults is limited by a lack of primary evidence and specificity. Lower disease burden, superior postoperative functional status, and higher doses and larger fields of radiation may be associated with improved survival.
NEURO-ONCOLOGY ADVANCES
(2022)
Article
Oncology
S. Ahuja, J. Sharma, S. Gupta, S. Bakhshi, R. Seth, A. Singh, P. Bagai, R. S. Arora
Summary: This study aimed to pilot a tool for tracking children with cancer in New Delhi, India, and estimate treatment abandonment rates. The results showed that only 3 out of 81 patients abandoned their treatment during the 12-week tracking period, with workers expressing satisfaction with the tool's usability.
