Journal
PEDIATRIC BLOOD & CANCER
Volume 59, Issue 7, Pages 1310-1312Publisher
WILEY PERIODICALS, INC
DOI: 10.1002/pbc.24246
Keywords
apoptosis; Down syndrome; immunology; lymphocytes
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Down syndrome (DS) resembles immunodeficiency with increased infections, auto-immune diseases, and hematological malignancies. Until now, immunological studies in DS mainly focused on T-lymphocytes. We recently described a profound B-lymphocytopenia in children with DS. This could be caused by increased apoptosis. Therefore, we determined expression of flowcytometric markers for apoptosis [Annexin-V (AV) and propidium iodide (PI)] on peripheral lymphocytes in 72 children with DS and 32 age-matched controls (AMC). Within the total lymphocyte compartment, apoptosis was more pronounced in DS; it increased with age. Moreover, apoptosis was highest within the B-lymphocyte compartment which may be a contributing factor to the B-lymphocytopenia found in DS. Pediatr Blood Cancer 2012; 59: 13101312.(C) 2012 Wiley Periodicals, Inc.
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