Article
Multidisciplinary Sciences
Qi Zhang, Xiao-Min Lu, Min Zhang, Chen-Ying Yang, Si-Yuan Lv, Shi-Fen Li, Cai-Yun Zhong, Shan-Shan Geng
Summary: The study found that three iron supplements improved hematological parameters in both mother and offspring rats, increased serum iron, transferrin saturation and serum ferritin levels, raised ferritin light chain levels in liver and spleen, enhanced the number of born alive per litter, and promoted physical growth and neurodevelopment of offspring rats. Iron supplementation also improved the expression of ferritin light chain and synaptic growth associated proteins in the brain and hippocampus.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Adedotun J. Owolabi, Idowu O. Senbanjo, Kazeem A. Oshikoya, Jos Boekhorst, Robyn T. Eijlander, Guus A. M. Kortman, Jeske H. J. Hageman, Folake Samuel, Alida Melse-Boonstra, Anne Schaafsma
Summary: The study successfully reduced the prevalence of anaemia among Nigerian toddlers using a multi-nutrient fortified dairy-based drink, without significant effects on iron deficiency and iron deficiency anaemia. Additionally, the drink did not significantly impact the composition of gut microbiota.
Review
Medicine, General & Internal
Hye Won Shin, Doo Yeon Go, Suk Woo Lee, Yoon Ji Choi, Eun Ji Ko, Hae Sun You, Yoo Kyung Jang
Summary: This systematic review compared the efficacy and safety of ferric carboxymaltose (FCM) and iron sucrose (IS) in treating iron deficiency anemia (IDA) in obstetric and gynecologic patients. The results showed that FCM was more effective in increasing Hb and ferritin levels compared to IS, with a more favorable safety profile.
Article
Oncology
Jie Jin, Zhihua Ran, Emanuele Noseda, Bernard Roubert, Matthieu Marty, Anna Mezzacasa, Udo Michael Goring
Summary: Ferric carboxymaltose (FCM) and iron sucrose (IS) have similar effects in treating iron deficiency anemia (IDA), but FCM shows a faster hemoglobin response and correction of iron deficiency.
FRONTIERS OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Rhona C. F. Sinclair, Sean Nadaraja, Nicholas A. Kennedy, Mai Wakatsuki, Sunil Bhandari
Summary: This retrospective multicenter observational study provides pragmatic information about the safety and clinical responses of Ferric derisomaltose (FDI; Monofer) in real-world clinical practice. The study demonstrates the low risk of adverse reactions with FDI treatment across diverse patient populations and the improvement in hemoglobin and ferritin levels.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Zhenglin Dong, Lan Li, Yiming Zhang, Liu Guo, Xin Wu, Yulong Yin, Dan Wan
Summary: Circadian iron administration affected iron absorption and storage in pigs. Evening iron supplementation may be a more effective pattern for iron utilization. The rhythmic system in the intestine, driven by the time, played an important role in this process.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Surgery
Michael Auerbach, Maureen M. Achebe, Lars L. Thomsen, Richard J. Derman
Summary: This post hoc analysis compared the efficacy and safety of ferric derisomaltose (FDI) and iron sucrose (IS) in treating iron deficiency anemia following bariatric surgery. The results showed that FDI produced a faster and more pronounced response in hemoglobin levels compared to IS, and both treatments were well tolerated.
Article
Cardiac & Cardiovascular Systems
Bomee Chung, Yong Wang, Marleen Thiel, Fatemeh Rostami, Anika Rogoll, Valentin G. Hirsch, Zulaikha Malik, Anne Buehrke, Christian Baer, Michael Klintschar, Jan D. Schmitto, Carla Vogt, Christopher Werlein, Danny Jonigk, Johann Bauersachs, Kai C. Wollert, Tibor Kempf
Summary: This study aims to investigate the functional importance of cardiac iron status after myocardial infarction (MI) and the potential of pre-emptive iron supplementation in preventing cardiac iron deficiency (ID) and attenuating left ventricular (LV) remodelling. The results showed that cardiac iron status was dynamically regulated after MI, and iron supplementation could maintain cardiac iron content and attenuate adverse remodeling. These findings suggest that cardiac iron deficiency is a novel disease mechanism and therapeutic target in post-infarction LV remodeling and HF.
CARDIOVASCULAR RESEARCH
(2023)
Article
Oncology
Laura Butragueno-Laiseca, Sara de la Mata Navazo, Amelia Caridad Sanchez Galindo, Maria Jose Santiago Lozano
Summary: This study is the first evaluation of intravenous iron therapy in pediatric critical care, providing preliminary evidence of the safety and efficacy of IV iron sucrose. The 7 mg/kg dose regimen showed higher iron deficit replacement in a shorter time, which could be beneficial for critically ill children.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Nutrition & Dietetics
Chih-Wei Tsao, Yuan-Ru Liao, Ting-Chia Chang, Yih-Fong Liew, Chin-Yu Liu
Summary: This study aimed to investigate the effects of iron supplementation on spermatogenesis and testicular functions in iron-deficient rats. The results showed that iron deficiency resulted in poorer spermatogenesis and testis dysfunction, while iron supplementation reversed the impairment and improved antioxidant levels.
Article
Agriculture, Multidisciplinary
Xiaoyang Liu, Xuening Yu, Shijie Dou, Fawen Yin, Deyang Li, Dayong Zhou
Summary: This study successfully formed a complex of oyster-protein hydrolysates and ferrous chloride, which showed better iron absorption than ferrous sulfate and had better protective effects against iron-deficiency anemia. Three representative peptides that were absorbed intact were identified.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Hematology
Tomasz Jasinski, Andrzej Breborowicz
Summary: Iron supplementation drugs have detrimental effects on peritoneal mesothelial cells, but these effects are reversible in an iron-free medium.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Chukwuma A. Chukwu, Helen Gilbody, Olivia Wickens, Craig Carroll, Sunil Bhandari, Philip A. Kalra
Summary: This study aimed to investigate the factors affecting the erythropoietic response to parenteral iron in iron-deficient anaemic patients. It found that the nature of iron deficiency, rather than the severity of CKD, has a greater impact on Hb response to intravenous iron, with a diminished response seen in patients with functional iron deficiency regardless of the degree of renal impairment.
Article
Nutrition & Dietetics
Vito Leonardo Miniello, Maria Carmen Verga, Andrea Miniello, Cristina Di Mauro, Lucia Diaferio, Ruggiero Francavilla
Summary: The complementary feeding period between 6 and 24 months is crucial for infant nutrition and development, especially in addressing iron deficiency and anemia. Healthcare providers should follow guidelines to ensure adequate iron intake and address iron deficiency in infants during this critical period.
Article
Obstetrics & Gynecology
Rebecca F. Hamm, Christine Blauvelt, Eileen Y. Wang, Sindhu K. Srinivas
Summary: The study shows that antepartum intravenous iron sucrose infusion effectively increases hemoglobin levels from the third trimester to delivery, with the best results seen when administered 2-12 weeks before delivery. Early administration and increasing number of doses both have a positive impact on treatment outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)