Journal
PEDIATRIC BLOOD & CANCER
Volume 53, Issue 3, Pages 472-474Publisher
WILEY
DOI: 10.1002/pbc.22058
Keywords
heparin induced thrombocytopenia; paroxysmal nocturnal hemoglobinuria; spleen; thrombosis
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We describe a patient with paroxysmal nocturnal hemoglobinuria (PNH) and no previous history of thrombosis who presented with hepatic venous thromboses and subsequently developed splenic infarction and rupture requiring splenectomy while on anticoagulation therapy for the hepatic thromboses. The patient's anticoagulation was complicated by heparin-induced thrombocytopenia (HIT) highlighting the unique management challenge presented by PNH in combination with HIT. Pediatr Blood Cancer 2009;53: 472-474. (C) 2009 Wiley-Liss, Inc.
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