Article
Developmental Biology
A. Arias, J. A. Schander, M. Bariani, F. Correa, A. P. Dominguez Rubio, M. Cella, C. B. Cymeryng, M. L. Wolfson, A. M. Franchi, J. Aisemberg
Summary: Maternal dexamethasone administration during late gestation results in fetal and placental growth restriction, potentially due to altered placental angiogenesis.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Developmental Biology
Jeffery A. Goldstein, Ramin Nateghi, Ismail Irmakci, Lee A. D. Cooper
Summary: In this study, a machine learning model was used to identify and classify placental parenchymal lesions. The overall balanced accuracy was 0.86, and the three lesions were successfully recognized. Attention maps were used to gain further insight into the model's function.
Article
Obstetrics & Gynecology
Laura D. Brown, Claire Palmer, Lucas Teynor, Brit H. Boehmer, Jane Stremming, Eileen Chang, Alicia White, Amanda K. Jones, Sarah N. Cilvik, Stephanie R. Wesolowski, Paul J. Rozance
Summary: The study found that fetal sex does not have a widespread impact on experimental insults, with most outcomes showing no gender-based differences. The only exceptions were higher hormone concentrations in female fetuses.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Da Som Jeong, Ji-Yeon Lee, Myoung Hee Kim, Ji Hoon Oh
Summary: Our study investigated the effects of maternal LPS exposure on sex-specific placental adaptation. We found that LPS exposure induced placental inflammation in both sexes at GD 17.5. Prenatal infection resulted in growth retardation in both sexes of embryos, with males being more affected. Sex-specific impairments in placental development were observed, with LPS 400 μg/kg reducing the percentage area of the labyrinth in females and junctional zone in males. RNA sequencing revealed widespread sexually dimorphic transcriptional changes in placenta, particularly in processes such as trophoblast differentiation, nutrient/ion transport, pregnancy, and the immune system.
MOLECULAR MEDICINE
(2023)
Article
Pathology
Fang Zhou, Alan Marcus
Summary: This article presents the first two case reports of recanalization-like neovascularization within placental hematomas, suggesting that this phenomenon may not be as rare as previously thought. Further studies are needed to better understand the mechanisms and potential treatments for this phenomenon.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Pediatrics
Cristina Ramos-Navarro, Elena Maderuelo-Rodriguez, Ana Concheiro-Guisan, Santiago Perez-Tarazona, Santiago Rueda-Esteban, Ana Sanchez-Torres, Manuel Sanchez-Solis, Ester Sanz-Lopez, Manuel Sanchez-Luna
Summary: GEIDIS is a national-based research-net registry for patients with bronchopulmonary dysplasia (BPD) in Spanish hospitals, aiming to provide data on clinical characterization and follow-up. The study found that the main risk factor for BPD severity is the duration of mechanical ventilation, with male gender, oligohydramnios, and intrauterine growth restriction as independent prenatal risk factors.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Xing-Xing Gao, Shuai Lin, Pei-Ying Jiang, Meng-Ying Ye, Wei Chen, Chuan-Xiang Hu, Yuan-Hua Chen
Summary: This study revealed that gestational cholestasis induces apoptosis of trophoblast cells in the placenta, leading to placental insufficiency and IUGR. Furthermore, the activation of the IRE1α pathway was found in cholestasis cases.
Article
Obstetrics & Gynecology
Selen Yaman, Meryem Ceyhan, Necati Hancerliogullari, Esin Merve Koc, Tuba Candar, Aytekin Tokmak
Summary: This study aimed to detect serum KYN levels and investigate their relationship with obstetric complications (FGR and oligohydramnios). The study found that pregnant women with FGR and oligohydramnios had lower serum KYN levels compared to normal pregnancies.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Environmental Sciences
Alison G. Paquette, James MacDonald, Samantha Lapehn, Theo Bammler, Laken Kruger, Drew B. Day, Nathan D. Price, Christine Loftus, Kurunthachalam Kannan, Carmen Marsit, W. Alex Mason, Nicole R. Bush, Kaja Z. LeWinn, Daniel A. Enquobahrie, Bhagwat Prasad, Catherine J. Karr, Sheela Sathyanarayana
Summary: This study examined the relationship between prenatal phthalate exposure and the placental transcriptome at birth, identifying numerous genes and lncRNAs associated with prenatal phthalate exposure. The findings provide insight into the biological pathways affected by phthalate exposure, contributing to a better understanding of the mechanisms of action during fetal development.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Biology
Tina Napso, Xiaohui Zhao, Marta Ibanez Lligona, Ionel Sandovici, Richard G. Kay, Amy L. George, Fiona M. Gribble, Frank Reimann, Claire L. Meek, Russell S. Hamilton, Amanda N. Sferruzzi-Perri
Summary: The study characterized secretory output of mouse placental endocrine cells and found that proteins secreted from the placenta are involved in metabolic, immune and growth modulation. These placental proteins could serve as new biomarkers for pregnancy complications, as demonstrated by increased levels of certain protein ratios in women prior to diagnosis of gestational diabetes.
COMMUNICATIONS BIOLOGY
(2021)
Article
Reproductive Biology
C. Bertholdt, M. Dap, R. Pillot, P. Chavatte-Palmer, O. Morel, M. Beaumont
Summary: The study aimed to quantitatively characterize placental perfusion using contrast-enhanced ultrasound in pregnant rabbits and qualitatively assess the placental perfusion. The results showed that placental vascularization became gradually homogeneous as pregnancy progressed, and the wash-in and wash-out rates significantly increased. Contrast-enhanced ultrasound is feasible for qualitative and quantitative analysis of placental vascularization during pregnancy in animal models.
Article
Biochemistry & Molecular Biology
Oriane Tasta, Audrey Swiader, Marie-Helene Grazide, Myriam Rouahi, Olivier Parant, Christophe Vayssiere, Emmanuel Bujold, Robert Salvayre, Paul Guerby, Anne Negre-Salvayre
Summary: The study reveals that lipid peroxidation-derived 4-hydroxy-2-nonenal (HNE) may contribute to premature placental senescence in conditions like preeclampsia and intrauterine growth restriction by inducing DNA breaks, presence of lipofuscin granules, and protein accumulation. These findings emphasize the significant role of HNE and lipid peroxidation-derived aldehydes in pathological pregnancies such as PE and IUGR.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, General & Internal
Yao-Lung Chang, Chin-Chieh Hsu, An-Shine Chao, Shuenn-Dyh Chang, Po-Jen Cheng, Wen-Fang Li
Summary: This study investigates the fetal growth pattern after fetoscopic laser photocoagulation (FLP) in twin-twin transfusion syndrome (TTTS) and the effect of FLP on placental perfusion and intrauterine growth restriction (IUGR) incidence. The results suggest that FLP can decrease body weight discordance (BWD), improve the prognosis of TTTS, and reduce the incidence of IUGR in donor twins.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Ana Heras-Molina, Natalia Yeste, Jose Luis Pesantez-Pacheco, Susana Astiz, Marta Vazquez-Gomez, Arianna Bettiga, Francesco Trevisani, Consolacion Garcia-Contreras, Sergio Luis-Lima, Anna Bassols, Esteban Porrini, Antonio Gonzalez-Bulnes
Summary: The study explores the adult phenotype of offspring with low birth weight induced by maternal malnutrition or placental insufficiency, using a swine model. The findings suggest that low birth weight offspring can achieve similar obesity in adulthood as normal birth weight offspring when exposed to a fattening diet and glucose metabolism is more compromised in obese low birth weight pigs than obese normal birth weight pigs.
Article
Biochemistry & Molecular Biology
Rebecca Swanson, Zully Contreras-Correa, Thu Dinh, Heath King, Darcie Sidelinger, Derris Burnett, Caleb Lemley
Summary: Melatonin rescues the effects of nutrient restriction on uterine blood flow and fetal body weight in a seasonal dependent manner within a bovine model. It has been found to regulate maternal and fetal amino acids and placental nutrient transporters.
Letter
Oncology
Francesco Gavazzi, Jamie L. Fraser, Miriam Bloom, Laura Tochen, Jullie Rhee, Megan Kwan, Teresa Victoria, David T. Teachey, Cheng-Ying Ho, Adeline Vanderver, Rebecca L. Linn
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Theodore Vougiouklakis, Kelsey Zhu, Varshini Vasudevaraja, Jonathan Serrano, Guomiao Shen, Rebecca L. Linn, Xiaojun Feng, Sarah Chiang, Julieta E. Barroeta, Kristen M. Thomas, Lauren E. Schwartz, Pratibha S. Shukla, Anais Malpica, Esther Oliva, Paolo Cotzia, Deborah F. DeLair, Matija Snuderl, George Jour
Summary: This study is the largest comprehensive molecular study of juvenile granulosa cell tumors, revealing putative oncogenic drivers and TERT rearrangements, offering insights into possible targeted therapies for this rare entity.
CLINICAL CANCER RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Alexa A. Freedman, Britney P. Smart, Lauren S. Keenan-Devlin, Ann Borders, Linda M. Ernst, Gregory E. Miller
Summary: The study shows that individuals living in areas with higher eviction rates are more likely to experience adverse pregnancy outcomes, especially for those with low neighborhood and individual socioeconomic status who are likely to be renters and affected by local eviction policies.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Microbiology
Kofi K. Acheampong, Dylan L. Schaff, Benjamin L. Emert, Jonathan Lake, Sam Reffsin, Emily K. Shea, Courtney E. Comar, Leslie A. Litzky, Nigar A. Khurram, Rebecca L. Linn, Michael Feldman, Susan R. Weiss, Kathleen T. Montone, Sara Cherry, Sydney M. Shaffer
Summary: We developed an in situ RNA detection assay for RNA generated by the SARS-CoV-2 virus. We found viral RNA in lung, lymph node, and placenta samples from pathology specimens from COVID patients. Using high-magnification microscopy, we can visualize the subcellular distribution of these RNA in single cells.
Article
Medicine, Research & Experimental
Abhineet M. Sharma, Robert Birkett, Erika T. Lin, Linda M. Ernst, William A. Grobman, Suchitra Swaminathan, Hiam Abdala-Valencia, Alexander Misharin, Elizabeth T. Bartom, Karen K. Mestan
Summary: Placental lesions are associated with unique changes in gene expression in fetal monocytes and monocyte subsets. Fetal monocytes exposed to acute placental inflammation upregulate biological processes related to monocyte activation, monocyte chemotaxis, and platelet function, while monocytes exposed to maternal vascular malperfusion lesions downregulate these processes. Intermediate monocytes might be a source of mitogens implicated in different outcomes related to prematurity.
Article
Obstetrics & Gynecology
Sunitha C. Suresh, Alexa A. Freedman, Emmet Hirsch, Linda M. Ernst
Summary: This study analyzed the placental pathology histologic types in preterm births and found that high-grade chronic placental inflammation was associated with recurrent preterm birth. Low-grade maternal vascular malperfusion was associated with recurrent preterm birth only in early preterm births.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Raymond W. Redline, Drucilla J. Roberts, Mana M. Parast, Linda M. Ernst, Terry K. Morgan, Michael F. Greene, Cynthia Gyamfi-Bannerman, Judette M. Louis, Emin Maltepe, Karen K. Mestan, Roberto Romero, Joanne Stone
Summary: The importance of a fully functioning placenta for a good pregnancy outcome is unquestioned. Placental pathology has advanced the science and practice of obstetrics and neonatal-perinatal medicine. However, obstacles in incorporating placental findings into clinical studies and practice have existed. Nonetheless, the potential use of placental pathology for phenotypic classification, understanding adverse pregnancy outcomes, and developing treatment and prevention has never been greater. This review reexamines the role of placental pathology, explains current concepts and terminology, emphasizes the usefulness of specific diagnoses, and suggests future improvements.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Engineering, Biomedical
Lin Wang, Jeffrey M. Cochran, Tiffany Ko, Wesley B. Baker, Kenneth Abramson, Lian He, David R. Busch, Venki Kavuri, Rebecca L. Linn, Samuel Parry, Arjun G. Yodh, Nadav Schwartz
Summary: This study developed a non-invasive method for real-time assessment of placental oxygenation, and improved the accuracy of assessment by combining it with ultrasound imaging and image reconstruction algorithms. In a pilot investigation, significant differences were found in the hemodynamic responses to maternal hyperoxia between normal and abnormal placentas. This study provides a potential non-invasive method for early detection of placenta-related adverse pregnancy outcomes and maternal vascular malperfusion.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Obstetrics & Gynecology
Drucilla J. Roberts, Rebecca N. Baergen, Theonia K. Boyd, Chrystalle Katte Carreon, Virginia E. Duncan, Linda M. Ernst, Ona M. Faye-Petersen, Ann K. Folkins, Jonathon L. Hecht, Amy Heerema-McKenney, Debra S. Heller, Rebecca L. Linn, Carolyn Polizzano, Sanjita Ravishankar, Raymond W. Redline, Carolyn M. Salafia, Vanda F. Torous, Eumenia C. Castro
Summary: Pathologic examination of the placenta can provide valuable information for understanding the causes of prenatal and intrapartum events, as well as for diagnosing and predicting outcomes for both the mother and infant. Prioritizing placentas for examination should be based on verified indications, such as maternal comorbidities or pregnancy complications, to improve clinical care and advance the field of obstetrics and neonatology.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Pathology
Linda M. Ernst, Alexa Freedman, Erica Price, Andrew Franklin
Summary: The tapering of the ductus arteriosus in stillborn fetuses is associated with fetal vascular blood flow obstruction and more prevalent in cases with umbilical cord accident/FVM-related cause of death.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2023)
Article
Pathology
Kiran Manjee, Erica Price, Linda M. Ernst
Summary: This study compares the autopsy findings of second trimester and third trimester stillbirths and finds that the most common cause of death is pathologic placental conditions, particularly those associated with umbilical cord obstruction. The study emphasizes the importance of placenta examination in determining the cause of death in both second and third trimester fetuses.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2023)
Article
Pathology
Alexa A. A. Freedman, Erica Price, Andrew Franklin, Linda M. Ernst
Summary: Placental maternal vascular malperfusion (MVM) is associated with fetal growth restriction (FGR). In autopsied stillbirths, it was found that stillbirths caused by MVM had relatively less impact on heart weight compared to body weight. Therefore, the effect of MVM on fetal cardiac structure is minimal and further research is needed in this area.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2023)
Article
Pathology
Michael K. Fritsch, Nina Gotteiner, Jamaal A. Rehman, Erica Price, Linda M. Ernst
Summary: This research identified that anomalies in the cardiac conduction system and thinning or discontinuity of the annulus fibrosus may lead to fetal atrioventricular reentrant tachycardia, resulting in refractory dysrhythmia.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2023)
Article
Pathology
Ansa Mehreen, Sunitha Suresh, Alexa A. Freedman, Linda M. Ernst
Summary: This study compared the histopathology and CD15 expression in large for gestational age (LGA) placentas with appropriate for gestational age (AGA) placentas. The results showed that LGA placentas had increased expression of CD15 in villous capillary endothelium and a higher prevalence of fetal vascular malperfusion, delayed villous maturation, and villous chorangiosis. Therefore, LGA placentas have high-risk features compared to AGA placentas.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2023)
Article
Microbiology
Kofi K. Acheampong, Dylan L. Schaff, Benjamin L. Emert, Jonathan Lake, Sam Reffsin, Emily K. Shea, Courtney E. Comar, Leslie A. Litzky, Nigar A. Khurram, Rebecca L. Linn, Michael Feldman, Susan R. Weiss, Kathleen T. Montone, Sara Cherry, Sydney M. Shaffer
Summary: This study developed an in situ RNA detection assay for RNA generated by the SARS-CoV-2 virus. Viral RNA was found in lung, lymph node, and placenta samples from pathology specimens from COVID patients, and the subcellular distribution of these RNA in single cells can be visualized using high-magnification microscopy.
