Article
Medicine, General & Internal
Ana M. Calinescu, Anne-Laure Rougemont, Mehrak Anooshiravani, Nathalie M. Rock, Valerie A. McLin, Barbara E. Wildhaber
Summary: This study aimed to analyze the histopathology of liver nodules in patients with biliary atresia and correlate it with pretransplant radiological features. The results showed that different types of nodules were identified in the explants, including malignant and premalignant nodules. The occurrence of liver nodules in the explants was associated with patient age, time from surgery, and type of surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Kalyani R. Patel, Sadhna Dhingra, John Goss
Summary: This study investigated the explant pathology of adult biliary atresia (BA) patients, focusing on portal venous abnormalities. The study found fibromyxoid intimal hyperplasia of the portal vein and hepatoportal sclerosis in all three cases, with two cases showing recurrent cholangitis and one case without biliary cirrhosis. These findings are important for the proper evaluation of liver pathology in adult BA patients.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Engineering, Biomedical
Katsuhiro Tomofuji, Ken Fukumitsu, Jumpei Kondo, Hiroshi Horie, Kenta Makino, Satoshi Wakama, Takashi Ito, Yu Oshima, Satoshi Ogiso, Takamichi Ishii, Masahiro Inoue, Etsuro Hatano
Summary: In this study, researchers reconstructed intrahepatic bile ducts in a rat decellularized liver graft using organoid technology. Through an ex vivo perfusion culture system, they successfully demonstrated the biliary characteristics of repopulated liver organoids and reconstructed biliary tree-like networks with luminal structures. They also established a method to mimic the appropriate cell distribution in the native liver and demonstrated reconstructed bile ducts in human organoids.
Article
Pediatrics
Anh-Hoa Pham Nguyen, Yen Hai T. Pham, Giap H. Vu, My Ha Nguyen, Thach Ngoc Hoang, AiXuan Holterman
Summary: The study identified advanced histologic findings of portal plate bile duct size <150μm and severe hepatocellular damage as predictors of poor post-Kasai jaundice clearance and short-term survival outcomes.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Medicine, General & Internal
Miriam Cortes-Cerisuelo, Christina Boumpoureka, Noel Cassar, Deepak Joshi, Marianne Samyn, Michael Heneghan, Krishna Menon, Andreas Prachalias, Parthi Srinivasan, Wayel Jassem, Hector Vilca-Melendez, Anil Dhawan, Nigel D. Heaton
Summary: Good outcomes can be achieved after liver transplant for biliary atresia in young patients with careful donor selection and surgery. Identification of anatomical variants and shunting are helpful in guiding attitude at the time of transplant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Ioannis A. Ziogas, Fei Ye, Zhiguo Zhao, Shu Cao, Muhammad A. Rauf, Manhal Izzy, Lea K. Matsuoka, Lynette A. Gillis, Sophoclis P. Alexopoulos
Summary: The study identified factors such as increasing bilirubin level, portal vein thrombosis, and ventilator dependence at listing associated with higher risk of waitlist mortality, while weight >= 10 kg at listing associated with lower risk. Ascites at listing was also found to be associated with a higher risk for the composite outcome.
JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Caroline P. Lemoine, John P. LeShock, Katherine A. Brandt, Riccardo Superina
Summary: This study compared transplant outcomes in children with biliary atresia who underwent primary liver transplant (pLT) with or without a prior Kasai portoenterostomy (KPE). The results showed comparable patient and graft survival between the pLT and failed KPE groups. The study suggests that pLT may be a beneficial option for patients predicted to have early failure of KPE.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Wei Song, Li-Ying Sun, Zhi-Jun Zhu, Lin Wei, Wei Qu, Zhi-Gui Zeng, Yun-Sheng Yang
Summary: The study analyzed the changes in gut microbiota (GM) before and after liver transplantation (LT) in patients with biliary atresia (BA), finding that LT partially improved the dysbiosis of GM by reducing certain bacteria and increasing the levels of short chain fatty acid (SCFA)-producing bacteria, though not fully restoring to normal levels.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Nobuhiro Takahashi, Daigo Ochiai, Yohei Yamada, Masumi Tamagawa, Hiroki Kanamori, Mototoshi Kato, Satoru Ikenoue, Yoshifumi Kasuga, Tatsuo Kuroda, Mamoru Tanaka
Summary: This study investigated the relationship between liver function, perinatal outcomes, and prognosis in pregnant biliary atresia (BA) patients with native liver. Lower serum ChE levels, lower platelet counts, and higher MELD scores were associated with unfavorable perinatal outcomes. Special attention is needed for pregnant patients with BA, with serum ChE levels, platelet counts, and MELD scores being important markers for predicting perinatal prognosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Jiaxu Zhang, Yi Luo, Mingxuan Feng, Qiang Xia
Summary: Biliary atresia is strongly associated with immune response, with differentially expressed immune-related genes and cell types identified in the liver. Further correlation analysis suggests potential markers for fibrosis and inflammation in BA liver.
FRONTIERS IN PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Ahmad Anouti, Madhukar S. Patel, Lisa B. VanWagner, William M. Lee, John J. Fung, George Cholankeril, Christine S. Hwang, Arjmand R. Mufti, Shannan Tujios, Thomas Kerr, Nicole E. Rich, Jeremy Louissaint, Dev M. Desai, Parsia A. Vagefi, Steven Hanish, Jigesh Shah, Amit G. Singal, Thomas G. Cotter
Summary: Biliary atresia (BA) is the leading indication for pediatric liver transplantation worldwide, but it is uncommon for older liver transplant recipients. The impact of recent donor allocation changes, organ shortage, and evolving transplantation practices on the BA liver transplant population is unknown. The study found that liver transplant outcomes in BA patients are excellent, and optimal graft outcomes are associated with living-donor liver transplantation (LDLT) and higher transplant center volume.
LIVER INTERNATIONAL
(2023)
Article
Cell & Tissue Engineering
Soichiro Sonoda, Koichiro Yoshimaru, Haruyoshi Yamaza, Ratih Yuniartha, Toshiharu Matsuura, Erika Yamauchi-Tomoda, Sara Murata, Kento Nishida, Yoshinao Oda, Shouichi Ohga, Tasturo Tajiri, Tomoaki Taguchi, Takayoshi Yamaza
Summary: The study found that BA-specific post-natal stem cells are not suitable as a source for treatment, possibly due to epigenetic modifications in the prenatal and perinatal BA environments. Additionally, these studies may help in understanding the molecular mechanisms underlying BA development.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Surgery
Shunsuke Watanabe, Tatsuya Suzuki, Tomonori Tsuchiya, Yasuhiro Kondo
Summary: This study aimed to investigate spleen enlargement as a marker for complications of portal hypertension and its relationship with long-term native liver fibrosis in patients with biliary atresia. The results showed that total bile acids, hyaluronic acid, type IV collagen, and APRi increased in patients with spleen enlargement at 25 years. Spleen volume and type IV collagen were correlated with long-term native liver fibrosis.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Pediatrics
Fei Liu, Xiaogang Xu, Zijian Liang, Boyuan Tao, Menglong Lan, Jixiao Zeng
Summary: In children without cholangitis after KPE, early bile drainage has a positive impact on outcomes, and recurrent cholangitis is an important factor affecting native liver survival (NLS).
FRONTIERS IN PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Shengqiao Zhao, Zhixin Zhang, Zhuyuan Si, Chong Dong, Chao Sun, Kai Wang, Wei Zhang, Weiping Zheng, Xinzhe Wei, Wei Gao, Zhongyang Shen
Summary: Biliary stricture (BS) is a significant complication after pediatric living donor liver transplantation (LDLT) for biliary atresia (BA). This study found that longer arterial ischemia time (AIT) was the only independent risk factor for the development of BS. AIT ≥40 minutes increased the 5-year cumulative risk of BS, highlighting the importance of minimizing AIT to reduce BS.
LIVER TRANSPLANTATION
(2023)