Article
Transplantation
Bernd Hoppe, Patricia A. Pellikka, Bastian Dehmel, Ana Banos, Elisabeth Lindner, Ulrike Herberg
Summary: In PH1 ESRD patients, long-term administration of OC5 was found to significantly reduce Pox concentrations, improve or stabilize cardiac function and clinical status, without increasing dialysis frequency. OC5 was safe and well-tolerated, showing promising results for potential clinical impact.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Didier Ducloux, Mathieu Legendre, Jamal Bamoulid, Philippe Saas, Cecile Courivaud, Thomas Crepin
Summary: ESRD patients exhibit clinical features of premature ageing such as frailty, cardiovascular disease, and muscle wasting, with immune system aging and chronic inflammation also being key factors. Preventing or reversing immune senescence/inflammation is a major goal to improve clinical outcomes for ESRD patients.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Pranjal Kashiv, Shubham Dubey, Kapil N. Sejpal, Sunny Malde, Prasad Gurjar, Amit Pasari, Manish Balwani
Summary: This case report presents a 26-year-old male with primary hyperoxaluria type 2 (PH2) who experienced recurrent nephrolithiasis since childhood, leading to end-stage renal disease. Genetic testing confirmed the diagnosis of PH2, highlighting the importance of early detection and genetic testing in managing this condition.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Lan Huang, Ya-Juan Zhao, Qiao-Rong Dong, Gui-Cai Hu
Summary: PMN is the most common cause of idiopathic nephrotic syndrome progressing to ESRD, with approximately 75-80% of cases having autoantibodies present. Previous research suggests a correlation between elevated serum calcium levels in IgG4-RD and PMN patients, as well as an increase in intracellular calcium levels during PMN. Additionally, disrupted calcium signaling may play a crucial role in the progression of PMN to ESRD.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Orthopedics
Scott J. Douglas, Sahir S. Pervaiz, Oliver C. Sax, Nequesha S. Mohamed, Ronald E. Delanois, Aaron J. Johnson
Summary: ESRD dialysis patients had higher rates of readmissions, mechanical complications, and revision surgery after THA compared to RTRs. Additionally, they incurred higher costs, suggesting that joint surgeons may consider delaying THA in suitable patients until after renal transplantation.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Clinical Neurology
Chang Min Heo, Won Ho Lee, Bong Soo Park, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Dong Ah Lee, Byeong Cheol Yoo, Kang Min Park
Summary: This study compares glymphatic dysfunction between patients with end-stage renal disease (ESRD) and healthy controls, and reveals the presence of glymphatic dysfunction in patients with ESRD as demonstrated by the DTI-ALPS index. Additionally, a significant positive correlation is found between the DTI-ALPS index and serum parathyroid hormone levels in ESRD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Deepika Shrestha, Sally Picciotto, Michael P. LaValley, Sa Liu, S. Katharine Hammond, Daniel E. Weiner, Ellen A. Eisen, Katie M. Applebaum
Summary: Despite increasing prevalence of end-stage renal disease, this study found no overall association between metalworking fluids (MWF) and ESRD. However, there were modest associations between MWF and ESRD classification of glomerulonephritis and diabetic nephropathy. Differences by race suggest that black males may have higher disease rates following MWF exposure, indicating a need for further examination of this relationship.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Hui-Teng Cheng, Xiaoqi Xu, Paik Seong Lim, Kuan-Yu Hung
Summary: The study compared the incidence of diabetes-related end-stage renal disease globally from 2000 to 2015, finding significant geographic variation in the risk of diabetic patients reaching ESRD in different regions during the study period.
Article
Primary Health Care
Noah Wouk
Summary: End-stage renal disease (ESRD) treatment options include kidney transplantation, dialysis, and palliative care. Prior to dialysis, optimal disease management is essential and initiation should be decided through shared decision-making. Vaccination, blood pressure control, salt restriction, and adequate dialysis are recommended for ESRD patients to optimize treatment outcomes.
AMERICAN FAMILY PHYSICIAN
(2021)
Article
Biotechnology & Applied Microbiology
Jen-Shih Lee, Lian-Pin Lee
Summary: The study found that factors such as plasma protein concentration, restitution volume, and plasma volume change during hemodialysis. The filtration coefficient KSo plays a key role in facilitating the restitution of fluid to compensate for the loss of plasma volume due to extraction.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yinghui Wang, Lu Gao
Summary: Chronic kidney disease and cardiac insufficiency often co-exist, especially in uremic patients on hemodialysis. Impaired renal function is often indicative of poor prognosis in patients with cardiac insufficiency. Inflammation plays a significant role in the development of cardiovascular complications in patients with chronic kidney disease and is indicative of prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Takahide Ito, Kanako Akamatsu
Summary: End-stage renal disease (ESRD) is a clinical condition associated with high morbidity and mortality. It is characterized by myocardial hypertrophy, heart failure, valvular calcification, and pericardial effusion. Multiple factors contribute to these abnormalities, including pressure/volume overload, oxidative stress, and neurohormonal imbalances.
HEART FAILURE REVIEWS
(2023)
Article
Cell Biology
Zaipul I. Md Dom, Eiichiro Satake, Jan Skupien, Bozena Krolewski, Kristina O'Neil, Jill A. Willency, Simon T. Dillon, Jonathan M. Wilson, Hiroki Kobayashi, Katsuhito Ihara, Towia A. Libermann, Marlon Pragnell, Kevin L. Duffin, Andrzej S. Krolewski
Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Malgorzata Maraj, Paulina Hetwer, Beata Kusnierz-Cabala, Barbara Maziarz, Paulina Dumnicka, Marek Kuzniewski, Piotr Ceranowicz
Summary: In hemodialyzed patients, serum AGP is weakly associated with the dietary intake of several nutrients, emphasizing the importance of patients consuming adequate nutrients for their overall health.
Article
Immunology
Emrah Gunay, Tugba Celebi, Sait Sen, Gulay Asci, Banu Sarsik Kumbaraci, Cenk Gokalp, Mumtaz Yilmaz, Huseyin Toz
TRANSPLANTATION PROCEEDINGS
(2019)
Article
Immunology
Emrah Gunay, Aysin Zeytinoglu, Sait Sen, Mumtaz Yilmaz, Gokhan Atay, Gulay Asci, Taylan Ozgur Sezer, Huseyin Toz
TRANSPLANTATION PROCEEDINGS
(2019)
Article
Cardiac & Cardiovascular Systems
Cenk Gokalp, Merve Guner Oytun, Emrah Gunay, Mustafa Dogdus, Meltem Sezis Demirci, Sait Sen, Sadik Tamsel, Taylan Ozgur Sezer, Huseyin Toz
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2020)
Article
Urology & Nephrology
Aygul Celtik, Sait Sen, Fatma Keklik, Guray Saydam, Gulay Asci, Banu Sarsik, Mehmet Ozkahya, Huseyin Toz
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2020)
Article
Immunology
Cenk Gokalp, Merve Guner Oytun, Emrah Gunay, Sadik Tamsel, Sait Sen, Taylan Ozgur Sezer, Huseyin Toz
TRANSPLANTATION PROCEEDINGS
(2020)
Article
Dermatology
Banu Yaman, Banu Sarsik Kumbarac, Claudia A. Gomez Gonzalez, Taner Akalin, Sait Sen
Summary: This study demonstrated the utility of C4d staining in detecting amyloid deposits in cutaneous amyloidosis (CA). C4d immunohistochemistry showed high sensitivity and specificity, making it a potential alternative diagnostic marker. It is a more rapid and convenient method compared to Congo red evaluation.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Rheumatology
Fatih Tastekin, Duygu Kerim, Sait Sen, Yasemin Kabasakal
Summary: There are few reported cases on the coexistence of Sjogren's syndrome and pulmonary nodular amyloidosis being treated with rituximab. However, it is important to consider amyloid lung when nodules with central calcification and cystic lesions are seen on computed tomography. Biopsy is recommended to differentiate it from malignancies. In this article, we present a case of a 66-year-old female patient with Sjogren's syndrome who had multiple cystic lesions with central calcification in the lung, confirmed as amyloid nodule through biopsy and stable under rituximab treatment. The rarity of pulmonary nodular amyloidosis in Sjogren patients and the limited use of rituximab for treatment make this case important for guiding clinicians.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Fatih Tastekin, Duygu Kerim, Sait Sen, Yasemin Kabasakal
Summary: This case report presents a rare association between systemic AA amyloidosis and jugular paraganglioma. The patient was successfully treated with the interleukin-1 inhibitor anakinra.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Meeting Abstract
Pathology
S. Sen, C. A. Gomez Gonzalez, A. Celtik, G. Asci, B. Sarsik Kumbaraci, H. Toz
Article
Urology & Nephrology
Aygul Celtik, Sait Sen, Fatma Keklik Karadag, Guray Saydam, Gulay Asci, Banu Sarsik Kumbaraci, Mehmet Ozkahya, Huseyin Toz
Summary: This study found a relationship between the grading of amyloid deposition and renal function and prognosis in patients with non-AA renal amyloidosis. However, the grading did not significantly affect patient survival.
TURKISH JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Ilknur Girisgen, Secil Conkar, Ipek Kaplan Bulut, Sait Sen, Sevgi Mir
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2019)
Article
Oncology
Fuat Kizilay, Adnan Simsir, Emir Akincioglu, Serdar Kalemci, Sait Sen, Banu Sarsik, Cag Cal, Ibrahim Cureklibatir
UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY
(2019)
Article
Urology & Nephrology
Fuat Kizilay, Serdar Kalemei, Adnan Simsir, Hamed Jafarzadeh Andabil, Banu Sarsik, Sait Sen, Cag Cal, Ibrahim Cureklibatir
JOURNAL OF UROLOGICAL SURGERY
(2019)
Article
Urology & Nephrology
Yesim Ceylan, Sevil Tatlidil, Sait Sen, Banu Sarsik, Zehra Ozcan
JOURNAL OF UROLOGICAL SURGERY
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Y. Ceylan, S. Tatlidil, S. Sen, B. Sarsik, Z. Ozcan
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2018)