Journal
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
Volume 11, Issue 3, Pages 239-244Publisher
SAGE PUBLICATIONS INC
DOI: 10.2350/07-06-0296.1
Keywords
cytogenetics; Ewing sarcoma; primitive round cell sarcoma
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We report the 4th case of a primitive round cell sarcoma with the translocation (4;19)(q35;q13.1) as the primary cytogenetic abnormality. This undifferentiated sarcoma shows some features of Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), including a diffuse reactivity for FLI1, but it shows only focal and weak reactivity for CD99 and is negative for a rearrangement of EWS, the molecular signature of ES/PNET. Recognition of the histopathologic and cytogenetic features of this entity is necessary to avoid its misdiagnosis as ES/PNET, especially in small biopsy samples.
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