Article
Urology & Nephrology
Gholam Ali Jafari, Reza Fotouhi Ardakani, Mohsen Akhavan Sepahi, Jamileh Nowroozi, Mohammad Soleiman Soltanpour
Summary: This study evaluated the relationship between the load of Oxalobacter formigenes and the formation of calcium oxalate urolithiasis, finding a significant negative association between the presence of the bacterium and kidney stone disease in patients. Additionally, the presence of Oxalobacter formigenes was shown to highly inhibit the formation of calcium oxalate urolithiasis.
IRANIAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Multidisciplinary Sciences
Yogita Mehra, Pragasam Viswanathan
Summary: Lactobacillus paragasseri, identified as a novel sister taxon of L. gasseri in 2018, was found to possess probiotic properties and exhibit a high efficiency in degrading oxalate according to genome analysis.
Article
Biochemistry & Molecular Biology
Michael Zahn, Gerhard Konig, Huy Viet Cuong Pham, Barbara Seroka, Ryszard Lazny, Guangli Yang, Ouathek Ouerfelli, Zenon Lotowski, Thore Rohwerder
Summary: This study determined the crystal structures of Actinobacterial 2-hydroxyacyl-CoA lyase, shedding light on its substrate binding and reaction mechanism. The catalytic cycle of the enzyme was structurally portrayed, and the role of residue E493 in the catalytic process was confirmed through mutations. Water molecules were also found to potentially contribute to proton transfer. The unique feature of a large C-terminal lid domain in this enzyme restricts substrate size. Overall, these findings provide important insights for biotechnological applications.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Fatemeh Kahaki, Seyed Dehnavi
Summary: This study achieved high-level expression of oxalyl-CoA decarboxylase in Escherichia coli by optimizing the expression conditions. The optimal expression conditions resulted in one of the highest reported rates of oxalyl-CoA decarboxylase production.
ADVANCED BIOMEDICAL RESEARCH
(2022)
Article
Allergy
Linnea Reinert-Hartwall, Heli Siljander, Taina Harkonen, Tommi Vatanen, Jorma Ilonen, Onni Niemela, Kristiina Luopajarvi, Natalya Dorshakova, Sergei Mokurov, Aleksandr Peet, Vallo Tillmann, Raivo Uibo, Mikael Knip, Outi Vaarala, Jarno Honkanen
Summary: The study revealed that T helper cell signature cytokines are upregulated during the first 12 months of life, reflecting the natural development of adaptive immune responses; under normal circumstances, children have higher circulating levels of epidermal growth factor (EGF), which may play a protective role for children without IgE sensitization responses.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Inna Starskaia, Essi Laajala, Toni Gronroos, Taina Harkonen, Sini Junttila, Roosa Kattelus, Henna Kallionpaa, Asta Laiho, Veronika Suni, Vallo Tillmann, Riikka Lund, Laura L. Elo, Harri Lahdesmaki, Mikael Knip, Ubaid Ullah Kalim, Riitta Lahesmaa
Summary: This study used RRBS technology to investigate early-stage DNA methylation changes in type 1 diabetes, identifying differentially methylated regions associated with the disease and confirming some of the results. These preliminary results provide novel insights into the cell type-specific epigenetic regulation of genes, contributing to our understanding of type 1 diabetes pathogenesis at an early stage.
Article
Endocrinology & Metabolism
Aili Tagoma, Kadri Haller-Kikkatalo, Astrid Oras, Kristine Roos, Anne Kirss, Raivo Uibo
Summary: This study found that plasma adiponectin and CCL2 concentrations can distinguish women with GDM, and IL-27 and IL-22 levels may be associated with autoimmune reactions.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Correction
Multidisciplinary Sciences
Jelena Stsepetova, Kart Simre, Aili Tagoma, Oivi Uibo, Aleksandr Peet, Heli Siljander, Vallo Tillmann, Mikael Knip, Reet Mandar, Raivo Uibo
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jelena Stsepetova, Kart Simre, Aili Tagoma, Oivi Uibo, Aleksandr Peet, Heli Siljander, Vallo Tillmann, Mikael Knip, Reet Mandar, Raivo Uibo
Summary: This study compared the microbiota composition and immune markers concentration in breast milk from mothers of children with genetic predisposition to celiac disease (CD) and mothers of unaffected children. The breast milk of mothers with genetically predisposed offspring who developed CD showed higher bacterial phylotype abundance and diversity, as well as a different bacterial composition. The immune markers were associated with specific bacterial genera and species, and may influence the risk for development of CD beyond early childhood.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Mari Lukka, Vallo Tillmann, Aleksandr Peet
Summary: The use of dual-wave boluses for evening meals based solely on the carbohydrate count did not improve time in range (TIR) in children with type 1 diabetes (T1D). However, it enabled significantly less correction boluses to achieve normal blood glucose levels in the morning compared to standard boluses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Liisa Saare, Aleksandr Peet, Vallo Tillmann
Summary: The incidence of type 1 diabetes (T1D) is increasing worldwide. Our study found that children at genetic risk for T1D who were taller had a lower IGF-1/IGFBP-3 molar ratio, and children with diabetes-associated auto-antibodies (DAAB) tended to be taller and have a higher body mass index. The accelerator hypothesis for the increasing incidence of T1D may not solely be dependent on environmental factors, but could be partially genetically determined.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biotechnology & Applied Microbiology
Kristi Alnek, Ija Talja, Brita Laht, Kaja Metskuela, Maire Mandel, Ingrid Reppo, Maire Lubi, Raivo Uibo
Summary: This study found a significant association between enterovirus antibodies and type 1 diabetes in both children and young adults, suggesting that enterovirus infections may be an important disease-promoting factor. However, further virological studies are needed to confirm this association.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Efe Ergur, Ege Ergur, Kristi Alnek, Kaja Metskula, Aleksandr Peet, Maire Lubi, Kaire Heilman, Raivo Uibo
Summary: The distribution of TCF7L2 polymorphism was assessed and associations between TCF7L2 and characteristics of type 1 diabetes were explored. The study found that TCF7L2 polymorphism is associated with zinc transporter 8 and islet antigen-2 autoantibodies and C-peptide levels in patients with type 1 diabetes.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Eva Mengel, Reeli Tamme, Liina Remmel, Priit Purge, Evelin Maestu, Jaak Jurimae, Vallo Tillmann
Summary: Increased insulin resistance during puberty may have a negative effect on the accumulation of lumbar spine bone mineral density independently of body composition parameters, potentially challenging adult bone quality.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Astrid Oras, Henna Kallionpa, Tomi Suomi, Satu Koskinen, Asta Laiho, Laura L. Elo, Mikael Knip, Riitta Lahesmaa, Alar Aints, Raivo Uibo
Summary: A study on the gene expression in B-cells from children developing CoD early in life revealed gene expression changes associated with CoD development, indicating the important role of B-cells in CoD development.
Article
Pediatrics
Marit Salus, Vallo Tillmann, Liina Remmel, Eve Unt, Evelin Mäestu, Ulle Parm, Agnes Mägi, Maie Tali, Jaak Jürimäe
Summary: The aim of this study was to investigate the effects of supervised cycling sprint interval training on serum osteocalcin, lipocalin-2 and sclerostin levels, and bone mineral characteristics among obese adolescent boys. After a 12-week intervention, there were significant improvements in bone mineral content and density in the SIT group. However, no significant differences were found in osteocalcin, lipocalin-2, and sclerostin levels between the two groups.
Meeting Abstract
Endocrinology & Metabolism
Mari Lukka, Vallo Tillmann, Aleksandr Peet
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Eva Mengel, Reeli Tamme, Liina Remmel, Priit Purge, Evelin Maestu, Jaak Jurimae, Vallo Tillmann
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Reeli Tamme, Jaak Jurimae, Evelin Maestu, Liina Remmel, Priit Purge, Eva Mengel, Vallo Tillmann
Summary: The study found a negative association between leptin to adiponectin ratio (LAR) in puberty and lumbar spine bone mineral density (BMD) and bone mineral apparent density (BMAD) at the age of 18.