Article
Allergy
Felix Forster, Markus Johannes Ege, Jessica Gerlich, Tobias Weinmann, Sylvia Kreissl, Gudrun Weinmayr, Jon Genuneit, Dennis Nowak, Erika von Mutius, Christian Vogelberg, Katja Radon
Summary: Distinct trajectories of asthma and allergy symptoms establish from childhood through adolescence and stabilize during early adulthood. Wheeze-related latent classes showed the strongest positive associations with environmental exposures in adolescence/young adulthood, indicating that not only childhood but also adolescence is relevant for disease development.
Article
Pediatrics
Ian Henderson, Siobhan Quenby
Summary: Gestational hypertension was weakly positively associated with childhood asthma, partly mediated by earlier delivery. Only a small proportion of early childhood asthma was attributable to gestational hypertensive disease in this representative UK-based birth cohort.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Environmental Sciences
Margarete Arrais, Ofelia Lulua, Francisca Quifica, Jose Rosado-Pinto, Jorge M. R. Gama, Philip J. Cooper, Luis Taborda-Barata, Miguel Brito
Summary: This study in Angolan schoolchildren found no consistent associations between intestinal helminth infections and asthma, allergic diseases, or atopy, except for Ascaris lumbricoides, which was inversely associated with rhinoconjunctivitis and directly associated with aeroallergen-specific IgE.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Dermatology
A. M. Andersson, A. S. Halling, N. Loft, L. Skov, A. Koch, E. Guttman-Yassky, J. P. Thyssen
Summary: AD prevalence varies in the Arctic region, with indigenous children having slightly lower risk. The dominant phenotype is mild to moderate flexural dermatitis with facial involvement, and common comorbidities include asthma and allergic rhinitis. Further research is needed to confirm these findings and explore potential behavioral or genetic explanations.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Clinical Neurology
Hee-Kyung Joh, Hyuktae Kwon, Ki Young Son, Jae Moon Yun, Su Hwan Cho, Kyungdo Han, Jin-Ho Park, Belong Cho
Summary: This study examines the association between the allergic triad (asthma, allergic rhinitis, atopic dermatitis) and the risk of dementia. The results indicate that allergic diseases are positively associated with dementia risk, and the severity of allergic diseases has a dose-effect relationship with dementia risk.
ANNALS OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper-Emil T. Pedersen, Ilya Petoukhov, Judith M. Vonk, Ulrike Gehring, Marijn Berg, Marnix Buegel, Orestes A. Carpaij, Erick Forno, Andreanne Morin, Anders U. Eliasen, Yale Jiang, Maarten Van den Berge, Martijn C. Nawijn, Yang Li, Wei Chen, Louis J. Bont, Klaus Bonnelykke, Juan C. Celedon, Gerard H. Koppelman, Cheng-Jian Xu
Summary: The study demonstrates that nasal DNA methylation is the most accurate predictor for diagnosing childhood allergic diseases, identifying multimorbidity and IgE sensitization, with findings replicated in children of different ages and ethnicities.
NATURE COMMUNICATIONS
(2022)
Article
Pediatrics
Alexandros N. Zounas, Ioannis Giannakopoulos, Panagiotis Lampropoulos, Aggeliki Vervenioti, Eleana-Georgia Koliofoti, Styliani Malliori, Kostas N. Priftis, Gabriel Dimitriou, Michael B. Anthracopoulos, Sotirios Fouzas
Summary: The prevalence of childhood wheeze/asthma has significantly decreased over the past decade in Greece. The persistent and noncurrent wheeze/asthma groups followed the overall trend, while the recent-onset wheeze/asthma prevalence remained unchanged. Physicians and parents' changing perceptions of asthma may have contributed to this reversing trend, especially in younger children with troublesome respiratory symptoms.
PEDIATRIC PULMONOLOGY
(2021)
Article
Obstetrics & Gynecology
Kristen J. Polinski, Danielle R. Stevens, Pauline Mendola, Tzu-Chun Lin, Rajeshwari Sundaram, Erin Bell, Edwina H. Yeung
Summary: The study found that children conceived with infertility treatment have an increased risk of developing asthma and atopic conditions, even after adjusting for parental asthma and atopy. Further research is needed to clarify the mechanisms involved.
HUMAN REPRODUCTION
(2022)
Article
Allergy
Sigurveig T. Sigurdardottir, Kristjan Jonasson, Michael Clausen, Kristin Lilja Bjornsdottir, Sigridur Erla Sigurdardottir, Graham Roberts, Kate Grimshaw, Nikolaos G. Papadopoulos, Paraskevi Xepapadaki, Ana Fiandor, Santiago Quirce, Aline B. Sprikkelman, Lies Hulshof, Marek L. Kowalski, Marcin Kurowski, Ruta Dubakiene, Odilija Rudzeviciene, Johanna Bellach, Songul Yurek, Andreas Reich, Sina Maria Erhard, Philip Couch, Montserrat Fernandez Rivas, Ronald van Ree, Clare Mills, Linus Grabenhenrich, Kirsten Beyer, Thomas Keil
Summary: Allergic multimorbidity should be considered an important chronic childhood disease in Europe. Some early-life factors associated with it are modifiable and could be considered for prevention strategies.
Article
Environmental Sciences
So-Lun Lee, Yu-Lung Lau, Wilfred Hing-Sang Wong, Lin-Wei Tian
Summary: The study found an increase in the prevalence of wheezing, allergic rhinitis, and eczema among school-aged children across the surveys. The most important associated risk factor identified was the increased prevalence of a parental history of atopy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Immunology
Holly Steininger, Jacqueline Moltzau-Anderson, Susan V. Lynch
Summary: The rapid increase in atopy and asthma in industrialized nations has led to research on the influence of early life environmental factors, particularly on the human microbiome. Microbes play a crucial role in tuning and training host immunity, and their composition is influenced by various factors including those known to affect allergy and asthma risk. This review highlights the importance of studying the microbiome and its impact on childhood atopy and asthma, offering insights into microbial mediators of maladaptive immunity and chronic inflammatory disease in childhood.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Maryam Dastoorpoor, Narges Khodadadi, Farzan Madadizadeh, Hanieh Raji, Elham Shahidizadeh, Esmaeil Idani, Maryam Haddadzadeh Shoushtari
Summary: This study investigated the prevalence and severity of asthma, allergic rhinitis, and eczema among schoolchildren in Khuzestan Province, Iran. The results showed that allergic rhinitis, eczema, and gender were significantly associated with the prevalence and severity of asthma symptoms.
Article
Allergy
Brian Stone, Karen Rance, Douglas Waddell, Mark Aagren, Eva Hammerby, Joseph P. Tkacz
Summary: This study utilized claims data from AR patients in the United States to assess AIT use and outcomes. Patients who reached AIT maintenance had better outcomes and higher baseline comorbidity rates compared to the full AIT cohort and patients without AIT claims.
ALLERGY AND ASTHMA PROCEEDINGS
(2021)
Article
Dermatology
Tugba Naziroglu, Kurtulus Aksu
Summary: The study found that allergic diseases are less common in COVID-19 patients, but there is no clear association between atopic status and the severity of COVID-19 disease.
DERMATOLOGIC THERAPY
(2021)
Article
Respiratory System
Kathrine Pape, Whitney Cowell, Camilla Sandal Sejbaek, Niklas Worm Andersson, Cecilie Svanes, Henrik Albert Kolstad, Xiaoqin Liu, Karin Sorig Hougaard, Rosalind J. Wright, Vivi Schlunssen
Summary: In a study of 466,556 children born in Denmark, three childhood onset asthma phenotypes were identified, and early life ACEs were found to be associated with increased odds for each of these phenotypes among both girls and boys.