Article
Allergy
Magnus Lindqvist, Katja Biering Leth-Moller, Allan Linneberg, Inger Kull, Anna Bergstrom, Antonios Georgellis, Magnus P. Borres, Agneta Ekebom, Marianne van Hage, Erik Melen, Marit Westman
Summary: Patients with pollen-induced allergic rhinitis face a high risk of persistent disease for at least 20 years, with childhood to adolescence being the most critical period for disease progression. The study findings underscore the close relationship between sensitization, allergic rhinitis, and asthma.
Article
Food Science & Technology
Chia-Jung Li, Ling-Sai Chang, Mindy Ming-Huey Guo, Liang-Jen Wang, Ho-Chang Kuo
Summary: This study aimed to investigate the role of vitamin D in children with coexisting allergic diseases, particularly in terms of sex differences, and to explore the behavioral profiles of these patients. The study found that males with two or more allergic diseases had significantly lower levels of vitamin D, while the levels of IgE were negatively correlated with vitamin D in females. Additionally, serum IgE was significantly correlated with children's adaptive skills, and different sexes were associated with different aspects of adaptive skills. Therefore, vitamin D has a protective role in the development of one allergic disease against the coexistence of allergic diseases in males, and the study extends the evidence for sex differences in immunity.
FOOD SCIENCE & NUTRITION
(2023)
Article
Multidisciplinary Sciences
Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper-Emil T. Pedersen, Ilya Petoukhov, Judith M. Vonk, Ulrike Gehring, Marijn Berg, Marnix Buegel, Orestes A. Carpaij, Erick Forno, Andreanne Morin, Anders U. Eliasen, Yale Jiang, Maarten Van den Berge, Martijn C. Nawijn, Yang Li, Wei Chen, Louis J. Bont, Klaus Bonnelykke, Juan C. Celedon, Gerard H. Koppelman, Cheng-Jian Xu
Summary: The study demonstrates that nasal DNA methylation is the most accurate predictor for diagnosing childhood allergic diseases, identifying multimorbidity and IgE sensitization, with findings replicated in children of different ages and ethnicities.
NATURE COMMUNICATIONS
(2022)
Article
Pediatrics
Prapasri Kulalert, Paskorn Sritipsukho, Sira Nanthapisal, Orapan Poachanukoon
Summary: In children with allergic respiratory diseases, there is moderate agreement in SPT response between house dust mite and cockroach, as well as dog and cat allergens. This may be due to cross-reactivity, suggesting the need for component-resolved diagnosis in cases of co-sensitization to these allergen pairs.
Article
Allergy
Jo A. Douglass, Caroline Lodge, Samantha Chan, Alice Doherty, Ju Ann Tan, Celina Jin, Alastair Stewart, Anne M. Southcott, Andrew Gillman, Joy Lee, Danny Csutoros, Liam Hannan, Laurence Ruane, Sara Barnes, Lou Irving, Nur-Shirin Harun, Phillipe Lachapelle, Kymble Spriggs, Michael Sutherland, Katharine See, Christine F. McDonald, Matthew Conron, Naghmeh Radhakrishna, Christopher Worsnop, Fay H. Johnston, Janet M. Davies, Vanessa Bryant, Linda Iles, David Ranson, Paresa Spanos, Don Vicendese, Adrian Lowe, Edward J. Newbigin, Philip Bardin, Shyamali Dharmage
Summary: This study found that low FEV1 value, high Asthma Control Questionnaire score, and elevated levels of RGP-sp IgE concentration, eosinophil counts, and fractional exhaled nitric oxide were associated with the risk of thunderstorm asthma among individuals with seasonal allergic rhinitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Otorhinolaryngology
Michael S. Benninger, Claudia Cabrera, Eulalia M. Amador, Kevin Grafmiller, Raj Sindwani
Summary: This study explores the relationship between specific allergen sensitization and asthma severity. It found that positive tests for cat dander, dog dander, certain fungi, and house dust were associated with more severe asthma.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2022)
Review
Pharmacology & Pharmacy
Yasuhiro Gon, Shuichiro Maruoka, Kenji Mizumura
Summary: Omalizumab is a therapeutic agent for severe bronchial asthma. It improves symptoms, reduces exacerbation risk, and enhances quality of life. However, it is associated with high treatment costs and lacks clear methods to identify responders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Zhan Zhao, Yuqin Deng, Lei Xiang, Jin Chen, Jing Wan, Jinli Sun, Yonggang Kong, Qingquan Hua
Summary: This study aimed to evaluate the clinical efficacy of omalizumab in patients with allergic rhinitis by analyzing the ratio of total IgE level at week 16 to baseline. Retrospective analysis of 62 patients showed that 48 patients demonstrated significant improvement after 16 weeks of treatment, while 14 patients did not show significant improvements. The ratio of total IgE levels at week 16 to baseline was higher in responders compared to non-responders. In conclusion, the ratio of total IgE level at week 16 to baseline correlated with the clinical response to omalizumab in moderate to severe allergic rhinitis patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Allergy
Manon Belhassen, Marjorie Berard, Gilles Devouassoux, Faustine Dalon, Jean Bousquet, Eric Van Ganse
Summary: This study investigated the prescription patterns and medication adherence in patients with perennial allergic rhinitis (PAR) and asthma. The findings showed that despite regular healthcare visits and medication prescriptions, allergic patients only partly and selectively refilled their treatments, preferring less effective therapy, in a context of poor control of asthma symptoms.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Clinical Neurology
Hee-Kyung Joh, Hyuktae Kwon, Ki Young Son, Jae Moon Yun, Su Hwan Cho, Kyungdo Han, Jin-Ho Park, Belong Cho
Summary: This study examines the association between the allergic triad (asthma, allergic rhinitis, atopic dermatitis) and the risk of dementia. The results indicate that allergic diseases are positively associated with dementia risk, and the severity of allergic diseases has a dose-effect relationship with dementia risk.
ANNALS OF NEUROLOGY
(2023)
Review
Allergy
Birgit Pfaller, Sarah Bendien, Agnes Ditisheim, Thomas Eiwegger
Summary: Managing allergic diseases during pregnancy presents challenges and potential risks for mother and child, especially with limited safety data on anti-allergic drugs during pregnancy.
Article
Health Care Sciences & Services
Serafeim Chrysovalantis Kotoulas, Ioanna Tsiouprou, Eva Fouka, Athanasia Pataka, Despoina Papakosta, Konstantinos Porpodis
Summary: This review summarizes the knowledge of almost two decades of use of omalizumab in patients with severe allergic asthma. Evidence suggests that omalizumab improves asthma control and reduces the incidence and frequency of exacerbations. It is also effective in reducing corticosteroid use and healthcare utilization.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Meng-Ru Ding, Qi-Lin Liang, Huan-Ge Xu, Xiang-Dan Li, Kuo Zhang, Zi-Jin Wei, Yong-Hong Gao, Qing-Shi Zhang, Rui Huang, Huai Yang, Lei Wang, Hao Wang
Summary: This study introduces a Smart PeptIde defeNse (SPIN) web technique that can trap IgE to prevent allergic rhinitis (AR) and other allergic reactions. The technique shows promising results in reducing the symptoms of rhinitis and inflammatory factors, surpassing a first-line clinical drug in efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Allergy
Sawako Masuda, Mizuho Nagao, Satoko Usui, Kazutaka Nogami, Yuji Tohda, Takao Fujisawa
Summary: This study prospectively investigated the development process of allergic rhinitis (AR) in high-risk children and found that the prevalence of HDM-related AR-like phenotype significantly increased during infancy and was associated with high-risk recurrent wheeze.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Tomoko Tajiri, Motohiko Suzuki, Takeo Kutsuna, Hirono Nishiyama, Keima Ito, Norihisa Takeda, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Satoshi Fukuda, Takehiro Umemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Kosho Yoshikawa, Akio Niimi
Summary: This study aimed to assess whether pretreatment specific IgE response could predict responsiveness to omalizumab in patients with severe allergic asthma sensitized to perennial allergens. The results showed that sensitization to pollen was independently associated with the effectiveness of omalizumab.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Editorial Material
Allergy
Esra Birben, Omer Kalayci, Philippe A. Eigenmann
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Editorial Material
Allergy
Erik Melen, Omer Kalayci, Philippe Eigenmann
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Yvan Vandenplas, Katerina Bajerova, Christophe Dupont, Philippe Eigenmann, Mikael Kuitunen, Rosan Meyer, Carmen Ribes-Koninckx, Silvia Salvatore, Raanan Shamir, Hania Szajewska
Summary: CoMiSS was developed 7 years ago as a tool to increase awareness among healthcare professionals about the possibility of infant symptoms being related to cow's milk. Based on extensive research, an updated CoMiSS with lowered required cutoff and adaptation for non-toilet trained children has been proposed. However, further studies are needed to evaluate its effectiveness and regional differences. It is important to note that CoMiSS is an awareness tool and not a diagnostic test.
Editorial Material
Allergy
Alexandra F. Santos, Philippe A. Eigenmann
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Editorial Material
Allergy
Motohiro Ebisawa, Philippe Eigenmann
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Editorial Material
Allergy
Fabio Candotti, Philippe Eigenmann
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Editorial Material
Allergy
Victoria X. X. Soriano, Philippe Eigenmann, Rachel L. L. Peters
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Editorial Material
Allergy
Beatriz Moya, Carmen Riggioni, Omer Kalayci, Philippe Eigenmann
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Editorial Material
Allergy
Agnes Sze-yin Leung, Philippe Eigenmann
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Editorial Material
Allergy
Laura Polloni, Omer Kalayci, Philippe Eigenmann
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Editorial Material
Allergy
Dermot Ryan, Omer Kalayci, Philippe Eigenmann
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Editorial Material
Allergy
Philippe Eigenmann, Alexandra Santos
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Editorial Material
Allergy
Marina Labella Alvarez, Philippe Eigenmann, Jean-Christoph Caubet, Marina Atanaskovic Markovic
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Editorial Material
Allergy
Philippe Eigenmann, Ayobami Akenroye, Marina Atanaskovic Markovic, Fabio Candotti, Motohiro Ebisawa, Jon Genuneit, Oemer Kalayci, Doris Kollmann, Agnes Sze Yin Leung, Rachel L. Peters, Carmen Riggioni
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Meeting Abstract
Medicine, General & Internal
A. Piletta-Zanin, A. Scherl, T. Harr, H. Nigolian, S. Manzano, S. Grosgurin, Tonson A. la Tour, G. Braendle, H. Soechbach, J. C. Caubet, J. P. Pahud, D. Ortelli, P. EEdder, P. Eigenmann
SWISS MEDICAL WEEKLY
(2022)