Article
Health Care Sciences & Services
Laura Ioana Mazilescu, Isabel Bernheim, Juergen Treckmann, Sonia Radunz
Summary: This study found that female recipients and female surgeons are underrepresented in liver transplant surgery, and the survival rate of female recipients may be affected. Further research is needed to examine the societal factors influencing the outcome of female patients and take measures to possibly improve the prognosis of female liver transplant recipients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
S. Ali Husain, Kristen L. King, Navin Sanichar, R. John Crew, Jesse D. Schold, Sumit Mohan
Summary: The study found that living donor kidney transplants from donors biologically related to their recipients had higher rates of allograft failure than transplants from donors unrelated to their recipients after HLA matching was accounted for. This association was mainly observed in recipients without cystic kidney disease and transplants from African American donors. Further research is needed to explore the factors contributing to this finding.
Article
Immunology
Juan Hu, Yong-Wei Yu, Dong-Sheng Han, Xue-Jie Li, Yi-Qi Zhang, Hong-Liu Cai, Yong-Hong Xiao, Xia Zheng
Summary: This study describes a lung transplant recipient who developed EBV-associated PTLD, highlighting the importance of monitoring EBV-DNA load as a sensitive indicator for early diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Li Chen, Limin Yang, Yingyu Li, Tianrun Liu, Bolun Yang, Lei Liu, Rui Wu
Summary: The interaction between autophagy and inflammation plays a crucial role in viral infections, and understanding their regulatory roles can provide insights and theoretical foundations for disease prevention, treatment, and drug development.
Article
Immunology
Shehzad K. Niazi, Emily Brennan, Aaron Spaulding, Julia Crook, Shalmali Borkar, Andrew Keaveny, Adriana Vasquez, Melanie T. Gentry, Terry Schneekloth, C. Burcin Taner
Summary: This study examines the association between age at liver transplant and survival, taking into account other factors such as gender, disease status, etc. The results show a nonlinear relationship between age and survival, indicating that age alone should not be the determining factor for liver transplant candidacy.
Review
Cell Biology
Tong Chen, Shaoyu Tu, Ling Ding, Meilin Jin, Huanchun Chen, Hongbo Zhou
Summary: Autophagy is a cellular process that degrades virus particles and components during a viral infection. However, viruses have evolved various strategies to subvert autophagy and counteract cellular antiviral responses.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Surgery
Srijan Tandukar, Christine Wu, Sundaram Hariharan, Chethan Puttarajappa
Summary: Transplanting kidneys from shorter donors into taller recipients may result in suboptimal allograft survival. This study found that the height mismatch between the donor and recipient influences the outcomes of kidney transplant.
TRANSPLANT INTERNATIONAL
(2022)
Article
Immunology
Allison J. Kwong, W. Ray Kim, John Lake, Peter G. Stock, Connie J. Wang, James B. Wetmore, Marc L. Melcher, Andrew Wey, Nicholas Salkowski, Jon J. Snyder, Ajay K. Israni
Summary: A study found that livers with macrovesicular steatosis are less likely to be transplanted due to their higher risk of graft failure. To facilitate the use of these higher-risk organs, the SRTR now includes the variable of macrovesicular steatosis in their risk-adjustment models.
Article
Biochemistry & Molecular Biology
Abraham Shaked, Bao-Li Loza, Elisabet Van Loon, Kim M. Olthoff, Weihua Guan, Pamala A. Jacobson, Andrew Zhu, Claire E. Fishman, Hui Gao, William S. Oetting, Ajay K. Israni, Giuliano Testa, James Trotter, Goran Klintmalm, Maarten Naesens, Sumeet K. Asrani, Brendan J. Keating
Summary: T2D PRS can identify transplant candidates at high risk of PTDM, aiding in preemptive diabetes management and donor selection.
Article
Surgery
Hee-Yeon Jung, Yena Jeon, Kyu Ha Huh, Jae Berm Park, Cheol Woong Jung, Sik Lee, Seungyeup Han, Han Ro, Jaeseok Yang, Curie Ahn, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Chan-Duck Kim
Summary: The smoking status of kidney transplant recipients before transplantation is significantly associated with impaired graft survival, with a smoking history of more than 20 pack-years significantly increasing the risk of graft failure. No significant impact of donor smoking was found on graft survival.
TRANSPLANT INTERNATIONAL
(2021)
Article
Surgery
Abhishek Kumar, Levi N. Bonnell, Marios Prikis, Richard Solomon
Summary: The study found that receiving a younger heart had a protective effect for heart transplant recipients under 45 years old, while receiving a heart from an older donor was detrimental for recipients aged 25-35.
CLINICAL TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Yasbanoo Moayedi, Eduard Rodenas-Alesina, Brigitte Mueller, Chun-Po S. Fan, Wida S. Cherikh, Josef Stehlik, Jeffrey J. Teuteberg, Heather J. Ross, Kiran K. Khush
Summary: European heart transplantation centers are more likely to accept higher-risk donor hearts than North American centers. The acceptance of higher-risk donor hearts is associated with higher survival rates in European centers.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Raquel Lopez-Vilella, Francisco Gonzalez-Vilchez, Maria G. Crespo-Leiro, Javier Segovia-Cubero, Manuel Cobo, Juan Delgado-Jimenez, Jose Maria Arizon del Prado, Manuel Martinez-Selles, Jose Manuel Sobrino Marquez, Sonia Mirabet-Perez, Jose Gonzalez-Costello, Felix Perez-Villa, Jose Luis Lambert-Rodriguez, Gregorio Rabago-Aracil, Maria Teresa Blasco-Peiro, Luis de la Fuente-Galan, Iris Garrido-Bravo, Deborah Otero, Luis Almenar-Bonet
Summary: Analysis of heart transplant recipients and donors based on age combinations showed that age is a significant prognostic factor in transplant outcomes. The age combination of donor-recipient has implications on survival rates and should be considered during organ acceptance for transplant.
REVISTA ESPANOLA DE CARDIOLOGIA
(2021)
Article
Hematology
Antonio Jimenez Jimenez, Krishna Komanduri, Samantha Brown, Trent Wang, Denise Pereira, Mark Goodman, Amer Beitinjaneh, Lazaros Lekakis, Stephanie Chinapen, Sean Devlin, Doris Ponce, Craig Sauter, Miguel-Angel Perales, Brian C. Shaffer
Summary: This study compared the graft-versus-host disease-free, relapse-free survival (GRFS) in patients who underwent allogeneic hematopoietic cell transplantation from an HLA-mismatched unrelated donor using different prophylactic measures. The results showed that the use of posttransplant cyclophosphamide resulted in superior GRFS and overall survival after one year.
Article
Virology
Eun-Jin Choi, Wenzhe Wu, Xiaoyan Cong, Ke Zhang, Jiaqi Luo, Sha Ye, Pingyuan Wang, Adarsh Suresh, Uneeb Mohammad Ullah, Jia Zhou, Xiaoyong Bao
Summary: EPAC is a promising therapeutic target for regulating the replication and inflammation of respiratory syncytial virus (RSV) and other respiratory viral infections. This new finding may lead to the development of novel treatment strategies for these viruses.