Journal
PATHOLOGY RESEARCH AND PRACTICE
Volume 206, Issue 7, Pages 511-513Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.prp.2010.01.008
Keywords
Low-grade adenosquamous carcinoma; Pathology; Immunohistochemistry; Breast; BRCA1
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Breast cancers occurring in women with germline BRCA1 mutations tend to fall into the category of triple-negative or basal-like phenotypes, such as metaplastic carcinoma. Low-grade adenosquamous carcinoma of the breast is a rare variant of metaplastic carcinoma We present the case of a 49-year-old woman with a past medical history of invasive ductal breast carcinoma 13 years ago, and who was recently diagnosed as having a low-grade adenosquamous carcinoma in the same breast Genetic analysis of blood DNA revealed a BRCA1 mutation To our knowledge, BRCA1 mutation in association with a low-grade adenosquamous carcinoma of the breast has not yet been reported. Thus, it may be important to consider the possibility of an association, but supplemental studies are needed (C) 2010 Elsevier GmbH All rights reserved
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