Journal
PATHOLOGY RESEARCH AND PRACTICE
Volume 204, Issue 2, Pages 129-132Publisher
ELSEVIER GMBH
DOI: 10.1016/j.prp.2007.09.001
Keywords
leukemic transformation; diffuse osteolyses; TNF-alpha; LDH; myelofibrosis
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Myelofibrosis is a clonal myeloproliferative disorder characterized by splenomegaly, abnormal deposition of collagen in the bone marrow, extramedullary hematopoiesis, dacriocytosis, and leukoerythroblastic blood smear. Development and maintenance or fibrosis are mediated by a complex network of several cytokines, including tumor necrosis factor-alpha (TNF-alpha). Osteosclerosis is the most frequently observed bone change in myelofibrosis. Based on this, we present an atypical case of leukemic transformation in myelofibrosis associated with diffuse osteolytic lesions and extremely elevated TNF-alpha and lactate dehydrogenase (LDH). Parathormone was not disturbed. (C) 2007 Elsevier GmbH. All rights reserved.
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