Article
Medicine, General & Internal
Taira Hada, Morikazu Miyamoto, Hiroki Ishibashi, Hiroko Matsuura, Takahiro Sakamoto, Soichiro Kakimoto, Hideki Iwahashi, Rie Suzuki, Kimiya Sato, Hitoshi Tsuda, Masashi Takano
Summary: This study found that ovarian mucinous carcinoma (MC) with expansile invasion and ovarian mucinous borderline tumor (MBT) share similar histopathological features and clinical outcomes. MC cases were more likely to be diagnosed at advanced FIGO stages and receive adjuvant chemotherapy compared to MBT cases. However, there was no significant difference in recurrence rate between MC with expansile invasion and MBT. Progression-free survival was worse for MC cases, but it was not an independent prognostic factor in multivariate analysis. The prognostic outcomes of MC with expansile invasion may resemble those of MBT, suggesting that treatment strategies for ovarian borderline tumors could be applied to MC.
Article
Oncology
Yi Yu, Tao Wang, Zhen Yuan, Wei Lin, Jiaxin Yang, Dongyan Cao
Summary: This study compared the pre- and intraoperative characteristics of misdiagnosed appendiceal mucinous neoplasms (AMNs) and primary ovarian mucinous tumors (POMTs). The findings showed significant differences in age, menopausal status, CEA levels, tumor size, presence of multiple nodules, presence of mucinous ascites, bilateral ovarian involvement, peritoneal dissemination, and appendiceal appearance between the two groups. A prediction model was developed to differentiate AMNs from pelvic mucinous tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seo-Youn Choi, Ji Hye Min, Jung Hoon Kim, Hyun Jeong Park, Yeun-Yoon Kim, Yeo Eun Han, Sung Hwan Bae, Jeong Hyun Lee, Yoon-Hyeong Choi, Ji Eun Moon
Summary: This study evaluated the interobserver agreement and diagnostic performance of MRI assessment in predicting the malignant potential of pancreatic IPMN according to radiologists' experience. The results showed substantial agreement among radiologists for high-risk stigmata and better agreement among more-experienced reviewers. The diagnostic performance of MRI assessment for predicting malignant IPMN was good.
Article
Reproductive Biology
Mengqi Huang, Qian Lv, Jingyan Xie
Summary: Bilateral ovarian epithelial neoplasms in adolescents are rare, especially with borderline mucinous neoplasms and mural nodules. We present a case of a 17-year-old female diagnosed with a left ovarian tumor accompanied by mural nodules. The surgical removal of the right ovarian cyst, left ovary, and fallopian tube revealed the presence of bilateral ovarian tumor with mural nodules, consisting of sarcomatoid transformation, anaplastic carcinoma, and sarcoma. Post-operation, the patient received chemotherapy and ovarian function protection. Regular follow-up confirmed no recurrence.
JOURNAL OF OVARIAN RESEARCH
(2022)
Editorial Material
Obstetrics & Gynecology
Mohamed Laban, Xi Chen, Bing Guo
Summary: This study compared two subtypes of BOT and identified significant differences in their clinical pathological features, providing insights for improved diagnosis and treatment strategies.
REPRODUCTIVE SCIENCES
(2023)
Article
Oncology
Jeongmin Hong, Aya Shiba-Ishii, Yunjung Kim, Masayuki Noguchi, Noriaki Sakamoto
Summary: OCIAD2 is highly expressed in lung adenocarcinoma and its suppression affects mitochondrial structure and number, leading to decreased cellular growth, proliferation, migration, and invasion, as well as promoting mitochondria-related apoptosis. It may serve as a potential target for lung adenocarcinoma treatment.
Article
Medicine, General & Internal
Jie Zhang, Yuling Dong, Xiaoqiu Zhou, Brian S. Finkelman, Deyin Xing
Summary: This study reports a new case of ovarian mucinous borderline tumor co-existing with mesonephric-like proliferation. The findings suggest a possible new origin for some ovarian mucinous neoplasms.
Article
Oncology
Jenny Sprooten, Ann Vankerckhoven, Isaure Vanmeerbeek, Daniel M. Borras, Yani Berckmans, Roxanne Wouters, Raquel S. Laureano, Thais Baert, Louis Boon, Chiara Landolfo, Antonia Carla Testa, Daniela Fischerova, Caroline Van Holsbeke, Tom Bourne, Valentina Chiappa, Wouter Froyman, Dominique Schols, Patrizia Agostinis, Dirk Timmerman, Sabine Tejpar, Ignace Vergote, An Coosemans, Abhishek D. Garg
Summary: The study established a novel biomarker resource for serum screening in patients with ovarian cancer to evaluate peripheral immunodynamics, patient survival trends, malignancy risk, and preclinical chemo-immunotherapy strategies. The in silico data-driven framework predicted that analysis of myeloid NF kappa B signaling and interferon-stimulated genes' responses could capture patients' peripheral immunodynamics effectively. Multiparametric serum profiling of patients with ovarian cancer showed that the sFIS assay can decode peripheral immunology, estimate survival trends, and co-estimate malignancy risk.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Kyung-Hwa Shin, Hyung-Hoi Kim, Hyung Joon Yoon, Eun Taeg Kim, Dong Soo Suh, Ki Hyung Kim
Summary: This study evaluated the correlation between imaging and tumor markers in predicting the diagnosis of ovarian tumors. The findings showed discrepancies between the two methods, emphasizing the importance of understanding underlying diseases, benign conditions, and rare histopathologies. The study aims to reduce misidentification of tumors.
Article
Biochemistry & Molecular Biology
Lili Sun, Chen Yao, Xiaojiao Li, Yuxing Wang, Ru Wang, Molin Wang, Qiao Liu, Denise J. Montell, Changshun Shao, Yaoqin Gong, Gongping Sun
Summary: This study reveals that cells can survive executioner caspase activation through a process called anastasis, and these surviving cells have enhanced migration and pro-angiogenic capacity. The activation of p38 MAPK plays a crucial role in anastasis and is essential for the elevated migratory and angiogenic capacity in these cells.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Multidisciplinary Sciences
Shiyun Li, Jiaqi Liu, Yuanhuan Xiong, Peipei Pang, Pinggui Lei, Huachun Zou, Mei Zhang, Bing Fan, Puying Luo
Summary: This study developed a two-dimensional radiomics approach using computed tomography to differentiate between benign and malignant ovarian neoplasms. By extracting texture features, selecting the best features, and building a radiomics model, the method improved the classification and diagnosis of ovarian tumors effectively.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Arpita Suri, Vanamail Perumal, Prajwal Ammalli, Varsha Suryan, Sanjiv Kumar Bansal
Summary: The study compared the diagnostic accuracy of ROMA, HE-4, and CA125 in early diagnosis and screening of epithelial ovarian cancer. ROMA was found to be the best marker for differentiating EOC from benign ovarian masses in postmenopausal women, while HE4 showed promise as a diagnostic predictor in premenopausal women. Further research is needed to explore the full potential of HE4 in premenopausal women.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Taira Hada, Morikazu Miyamoto, Yuka Ohtsuka, Jin Suminokura, Tsubasa Ito, Naohisa Kishimoto, Soko Nishitani, Minori Takada, Akari Imauji, Risa Tanabe, Masashi Takano
Summary: This study found that mucinous carcinoma with infiltrative invasion has a worse prognosis compared to those with expansile invasion or mucinous borderline tumors. The infiltrative invasion group had a higher tumor mutation burden and higher risks of recurrence and death.
DIAGNOSTIC PATHOLOGY
(2023)
Article
Pharmacology & Pharmacy
A. Santoro, N. D'alessandris, A. Travaglino, D. Arciuolo, F. Inzani, G. Angelico, G. Scaglione, M. Valente, A. Raffone, G. F. Zannoni
Summary: This article describes a peculiar case of mucinous ovarian tumor with intestinal differentiation arising in a seromucinous lesion, which may represent a distinct entity.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Enora Dolivet, Leopold Gaichies, Corinne Jeanne, Celine Bazille, Melanie Briand, Megane Vernon, Florence Giffard, Frederic Lepretre, Laurent Poulain, Christophe Denoyelle, Nicolas Vigneron, Raffaele Fauvet
Summary: Mucinous ovarian carcinoma is a rare and aggressive form of ovarian cancer. This study identifies miRNAs as potential diagnostic biomarkers and shows that a combination of miRNA ratios can accurately distinguish between malignant and borderline tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
