Article
Oncology
Antonio G. P. Bastos, Bruno Carvalho, Roberto Silva, Dina Leitao, Paulo Linhares, Rui Vaz, Jorge Lima
Summary: This study suggests that higher MVD-CD105 expression in recurrent GBM patients is associated with worse PFS-2 and OS. This highlights the importance of tracking the molecular evolution of the tumor during the course of the disease.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Pingping Wang, Hai Li, Yu Hu, Xiaojing Peng, Xinhua Ye, Di Xu, Ao Li
Summary: This study found a moderate correlation between vascular density grade and Ki-67 LI in soft tissue sarcoma, with other ultrasound features showing no correlation. The optimal cut-off point for distinguishing low and high proliferation groups was determined to be grade II. The area under the ROC curve was 0.74, with a sensitivity of 60.6% and specificity of 78.6%.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Giovanni Centonze, Patrick Maisonneuve, Michele Simbolo, Vincenzo Lagano, Federica Grillo, Alessandra Fabbri, Natalie Prinzi, Giovanna Garzone, Martina Filugelli, Carlotta Pardo, Alessia Mietta, Sara Pusceddu, Giovanna Sabella, Luisa Bercich, Alessandro Mangogna, Luigi Rolli, Salvatore Grisanti, Mauro Roberto Benvenuti, Ugo Pastorino, Luca Roz, Aldo Scarpa, Alfredo Berruti, Carlo Capella, Massimo Milione
Summary: This study investigated the expression of Ki-67 and morphological factors in lung carcinoid tumors (LCTs) and found that Ki-67 >= 3% potentially plays a key role in predicting disease-free survival (DFS) in LCTs.
Article
Medicine, General & Internal
Cristina Secosan, Andrea Pasquini, Delia Zahoi, Andrei Motoc, Diana Lungeanu, Oana Balint, Aurora Ilian, Ligia Balulescu, Dorin Grigoras, Laurentiu Pirtea
Summary: The study conducted HPV genotyping and dual-staining for p16/Ki-67 in patients undergoing LEEP for evaluating sensitivity and specificity in diagnosing CIN2+ in patients under 30 years old. The findings indicated that dual-staining p16/Ki-67 alone or in combination with HR-HPV and/or colposcopy showed higher specificity for diagnosing biopsy-confirmed CIN2+ in patients under 30 years old.
Article
Oncology
Mariam Oladejo, Hong-My Nguyen, Hannah Seah, Arani Datta, Laurence M. Wood
Summary: CD105 is a transmembrane protein highly expressed on endothelial cells, and contributes to tumor angiogenesis and progression. It is also expressed by tumor cells in certain cancers, such as renal cell carcinoma, where it is associated with stem cell-like properties. However, the role of tumor-expressed CD105 in the anti-tumor immune response and tumor microenvironment is still unclear.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Pathology
Daniella Serafin Couto Vieira, Sandro Wopereis, Laura Otto Walter, Lisandra de Oliveira Silva, Amanda Abdalla Biasi Ribeiro, Renato Salerno Wilkens, Braulio Leal Fernandes, Manoela Lira Reis, Lisleia Golfetto, Maria Claudia Santos-Silva
Summary: Ki-67 antigen has been proven to be a prognostic marker in various neoplasms, including breast cancer (BC). This study compared Ki-67 expression in BC samples using flow cytometry (FC) with immunohistochemical (IHC) examination, finding that FC provides results equivalent to IHC analysis and may allow for simultaneous analysis of more cells.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Pathology
Eliane Pedra Dias, Nathalia Silva Carlos Oliveira, Amanda Oliveira Serra-Campos, Anna Karoline Fausto da Silva, Licinio Esmeraldo da Silva, Karin Soares Cunha
Summary: This study aimed to classify the patterns of Ki-67-positive nuclei, investigate its expression and localization throughout the cell cycle, and develop a protocol for application. Results showed that the immunohistochemical patterns of Ki-67 are similar in tumoral and non-tumoral epithelium and were classified without difficulty. The proposed new evaluation method for Ki-67 may have implications for cancer prognosis and personalized therapy.
Article
Oncology
Yufei Liang, Chunying Li, Yingying Liu, Liang Tian, Dongliang Yang
Summary: This study aimed to explore the correlation between CD74, CD10, Ki-67 and clinicopathological parameters, and identify independent prognostic factors of diffuse malignant peritoneal mesothelioma (DMPM). Results showed that CD74, Ki-67, TNM stage, ECOG PS and treatment were independent factors affecting the prognosis of DMPM. Reasonable chemotherapy treatment may improve patient prognosis. The proposed nomogram was an effective visual tool for predicting overall survival of DMPM patients.
Review
Oncology
Claudia Ollauri-Ibanez, Blanca Ayuso-inigo, Miguel Pericacho
Summary: The composition of the tumor microenvironment (TME) plays a crucial role in prognosis and response to immunotherapy. Cold tumors, with cells and molecules that inhibit antitumor response, have poor prognosis, while hot tumors, rich in antitumor cells, respond well to immunotherapy. Endoglin (CD105) is involved in angiogenesis, inflammation, and cancer-associated fibroblast (CAF) accumulation, making it a potential target for converting cold tumors into hot tumors.
Review
Health Care Sciences & Services
Camelia Liana Buhas, Andrei Pascalau, Claudia Teodora Judea-Pusta, Ovidiu Laurean Pop, Adrian Sorin Judea, Bianca-Maria Negrutiu, Lavinia Marcut, Bogdan Adrian Buhas, Daniela Gheorghita, Alin Danut Bodog
Summary: This is a rare case of epidermoid cyst in the uterine cervix of a female patient. The patient underwent biopsy and uterine curettage, followed by total hysterectomy. The histopathologic analysis and immunohistochemical assay confirmed the cervical epidermoid cyst. High-risk HPV was only detected in the cervical mucosa. The exact etiopathogenesis is unknown, but implantation of embryonic tissue after childbirth could be involved in the development of these lesions.
Article
Oncology
Mariam Oladejo, Hong-My Nguyen, Laurence Wood
Summary: Molecular biomarkers interacting with vascular and immune compartments have a significant role in the progression of solid malignancies. CD105, a component of the TGF-β signaling cascade, has been extensively studied for its angiogenic role in various cancers. However, in renal cell carcinoma (RCC), CD105 has a diverse expression profile and multiple functions on tumor cells, tumor vasculature, and immune system components. This review summarizes the recent evidence and findings of the multifunctional roles of CD105 in angiogenesis and immunomodulation in different subtypes of RCC, with a specific emphasis on clear cell RCC. The review also provides an update on the preclinical and clinical applications of CD105 as a therapeutic platform in RCC.
Article
Biochemistry & Molecular Biology
Aneta Popiel-Kopaczyk, Jedrzej Grzegrzolka, Aleksandra Piotrowska, Mateusz Olbromski, Beata Smolarz, Hanna Romanowicz, Agnieszka Rusak, Monika Mrozowska, Piotr Dziegiel, Marzenna Podhorska-Okolow, Christopher Kobierzycki
Summary: The study aimed to assess the immunohistochemical expression of testin in cervical cancer and its correlation with clinical data, as well as the expression of Ki-67 antigen and p16 protein. The results showed that testin expression was inversely correlated with p16 and Ki-67 expression, and weaker testin expression was observed in cancer cases. This study suggests that the combined assessment of testin, Ki-67, and p16 expression may enhance cervical cancer diagnostics.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Eduardo Listik, Ben Horst, Alex Seok Choi, Nam. Y. Lee, Balazs Gyorffy, Karthikeyan Mythreye
Summary: Inhibins play important roles in a subset of cancers, particularly in p53 mutated breast and ovarian cancers, and lung adenocarcinomas. INHA, INHBA, TGFBR3, and ENG are also significant in predicting patients' response to anthracycline and taxane therapy in breast cancer patients.
Article
Cell Biology
Rosa Patruno, Giuseppe Passantino, Carmelo Laface, Antonella Tinelli, Alfredo Zito, Roberta Ruggieri, Francesco Luposella, Pietro Gadaleta, Mariarita Laforgia, Luca Lacitignola, Michele Ammendola, Girolamo Ranieri, Nicola Zizzo
Summary: The study focused on the correlation among microvascular density (MVD), endothelial area (EA), and Ki-67 proliferative index in tissue samples from cats affected by post-injection fibrosarcomas, aiming to demonstrate that cats may be a useful animal model for studying human diseases.
Article
Ophthalmology
Mood Mahesh, Sanjeev K. Mittal, Sanjeev Kishore, Anupam Singh, Neeti Gupta, Rimpi Rana
Summary: This study found a positive correlation between p53 and Ki-67 expression with the severity and duration of pterygium, indicating that p53 expression increased with the duration and severity of pterygium. Ki-67 expression, on the other hand, increased with the duration of pterygium but not with the severity.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Oncology
Marius Raica, Amalia Raluca Ceausu, Anca Maria Cimpean, Serban Comsa, Simona Sarb
Summary: The study investigated the expression of CLIC1, Ecad, and Pcad in breast cancer, revealing their association with molecular subtypes and the ability to define new high-risk subgroups. This stratification may explain variations in treatment response and aggressiveness observed by different authors within the same molecular subtype.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Iulia Florentina Burcea, Valeria Nicoleta Nastase, Anca Maria Cimpean, Amalia Raluca Ceausu, Ionela Baciu, Cristina Capatina, Roxana Dusceac, Simona Galoiu, Dan Niculescu, Serban Radian, Raluca Trifanescu, Anda Dumitrascu, Laurentiu Catalin Cocosila, Marius Raica, Catalina Poiana
Summary: Among 32 acromegaly patients, 93.75% had macroadenomas; Ki-67 labelling index did not predict remission, while PIT-1 was positive in all specimens with weak expression in two; there was no correlation between GH serum levels and IHC expression.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Serban Comsa, Amalia-Raluca Ceausu, Roxana Popescu, Anca-Maria Cimpean, Simona Sarb, Marius Raica
Summary: This study aimed to analyze the patterns of tumor vasculogenesis by generating an in vivo breast cancer environment. Results showed that tumor and embryonic vasculogenesis share a common paradigm, with CD105, AC133, and Oct3/4 playing important roles in establishing the vasculogenic and hematopoietic stage.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Andrei Dan Radu-Cosnita, Alexandru Nesiu, Patricia Lorena Berzava, Simona Cerbu, Andrei Cosma, Serban Comsa, Simona Sarb, Adela Maria Ferician, Ovidiu Catalin Ferician, Anca Maria Cimpean
Summary: This study evaluated the effect of anti-CLIC1 antibodies on human cc-RCC xenografts in rabbit cornea and chick embryo CAM models. The results showed that the antibodies induced tumor necrosis and regression of tumor vasculature, suggesting a potential therapeutic strategy for RCC.
ANTICANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Ciprian Roi, Pusa Nela Gaje, Raluca Amalia Ceausu, Alexandra Roi, Laura Cristina Rusu, Eugen Radu Boia, Simina Boia, Ruxandra Elena Luca, Mircea Rivis
Summary: Gingivitis is a common oral disease that can progress to periodontitis if left untreated. Inflammation of the gingiva is associated with pathological angiogenesis and changes in blood vessel morphology. The severity of gingival lesions is correlated with increased microvessel density.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Rodica Elena Heredea, Eugen Melnic, Laura Elena Cirligeriu, Patricia Lorena Berzava, Maria Corina Stanciulescu, Calin Marius Popoiu, Anca Maria Cimpean
Summary: This study compared the gene expression profile of involuting and recurrent infantile hemangiomas, identifying several genes with differential expression. Further research is needed to accurately map the gene expression profile and establish a gene expression-based classification for hemangiomas.
Article
Biochemistry & Molecular Biology
Cristina Stefania Dumitru, Amalia Raluca Ceausu, Nela Pusa Gaje, Cristian Silviu Suciu, Marius Raica
Summary: This study demonstrates the importance of double immunolabeling in assessing lymphangiogenesis and tumor proliferation in correlation with histopathological grades in HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dorin Novacescu, Talida Georgiana Cut, Alin Adrian Cumpanas, Felix Bratosin, Raluca Amalia Ceausu, Marius Raica
Summary: Despite advancements in RCC detection and molecular pathology, mortality rates are increasing and better clinical management tools are needed. The study found TD expression in RCC tissue and healthy renal parenchyma, with possible prognostic relevance. Further molecular analysis is required to fully understand the biological significance of this newly documented TD expression in RCC.
Article
Biochemistry & Molecular Biology
Ciprian Roi, Meda Lavinia Negrutiu, Alexandra Roi, Mircea Rivis, Ruxandra Elena Luca, Marius Raica, Raluca Amalia Ceausu, Alexandru Catalin Motofelea, Pusa Nela Gaje
Summary: This study aimed to quantify the existence of microvessel density, mast cell density, and the heterogeneity of blood vessels in patients with periapical odontogenic granulomas. The results showed a high number of mast cells, particularly in inflamed tissue, high heterogeneity of blood vessels, and increased microvessel density with positive CD34. The study concludes that mast cells play a key role in angiogenesis and the host's inflammatory response.
Article
Biochemistry & Molecular Biology
Amalia Raluca Ceausu, Alexandru Ciolofan, Alexandru Blidisel, Andrei Alexandru Cosma, Pusa Nela Gaje, Octavian Cretu
Summary: This study aimed to evaluate the relation between CLIC1 expression, growth patterns of liver metastasis, and angiogenesis. The study found a correlation between CLIC1 expression in primary tumors and the growth patterns and angiogenesis of metastatic tumors. The results suggest that the CLIC1 score may have prognostic and therapeutic value for liver metastasis with different growth patterns.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Oncology
Adela Maria Ferician, Ovidiu Catalin Ferician, Andrei Dragos Cumpanas, Patricia Lorena Berzava, Alexandru Nesiu, Ariana Barmayoun, Anca Maria Cimpean
Summary: This study identified three subgroups of renal cell carcinoma (RCC) with different vascular patterns and gene expression profiles. These findings may contribute to the development of personalized targeted therapies.
CANCER GENOMICS & PROTEOMICS
(2022)
Article
Medicine, Research & Experimental
Maria-Corina Stanciulescu, Marius-Calin Popoiu, Anca Maria Cimpean, Vlad-Laurentiu David, Rodica Heredea, Simona Cerbu, Eugen-Sorin Boia
Summary: This study demonstrates for the first time the heterogeneous expression of beta 1-AR among pediatric vascular malformations, supporting the need for beta 1-AR assessment to select cases with a robust response to beta 1-selective blockers. The assessment of beta 1-AR may have a significant impact on therapeutic refinement for pediatric vascular anomalies by selecting cases with a stronger response to beta-blockers.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. M. Cimpean, R. Taga
Article
Medicine, Research & Experimental
Raluca Amalia Ceausu, Alexandru Ciolofan, Alexandru Blidisel, Octavian Marius Cretu, Anca Maria Cimpean, Marius Raica
Summary: This study found that metastatic cells change their phenotype during the metastatic process, which may explain why not all metastases respond similarly to therapy.
Article
Medicine, Research & Experimental
Liliana Bordean, Monica Chis, Marius Raica, Ovidiu Simion Cotoi, Amalia Raluca Ceausu, Claudiu Avram, Anca Maria Cimpean
Summary: The study found that the expression of CLIC1 in the skin of patients with rheumatoid arthritis and psoriatic arthritis is closely related to the treatment plan, with methotrexate, leflunomide, and biological therapies significantly impacting CLIC1 expression. The results support CLIC1 as a potential marker of inflammation and a tool for predicting therapy response in rheumatoid arthritis.
