Article
Medicine, General & Internal
Weixi Liu, Zhicheng Yang, Yan Chen, Haoyu Yang, Xiaoxian Wan, Xindie Zhou, Ruiping Liu, Yunkun Zhang
Summary: The study found that the CTLA-4 rs231775 gene polymorphism decreased the risk of RA, while the CTLA-4 rs16840252 and CD86 rs17281995 gene polymorphisms were not associated with RA susceptibility. Stratification analyses revealed significant associations for CTLA-4 rs231775 and rs16840252 gene polymorphisms in RF-positive and RF-negative groups. The meta-analysis of CTLA-4 gene polymorphisms indicated that CTLA-4 rs231775 and rs3087243 gene polymorphisms decreased the risk of RA. Additional clinical cases should be investigated in further studies to confirm these findings.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Chuankun Zhou, Shutao Gao, Xi Yuan, Zixing Shu, Song Li, Xuying Sun, Jun Xiao, Hui Liu
Summary: CTLA-4 gene polymorphisms may be associated with the risk of Rheumatoid arthritis (RA), with rs3087243 and rs231775 polymorphisms showing significant associations, while rs5742909 polymorphism is not associated with RA risk. Meta-analysis confirms the relationship between CTLA-4 gene polymorphisms and RA risk in different populations.
Article
Rheumatology
Irina Gessl, Claudia A. Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S. Smolen, Daniel Aletaha, Peter Mandl
Summary: The study aimed to assess the predictive value of tenderness in non-swollen joints for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), taking into consideration other potential risk factors. Clinical and sonographic examination of hand joints were performed on patients with RA and PsA. The results showed that tenderness in non-swollen joints was associated with radiographic progression in RA, while the impact was weaker in PsA. Other risk factors such as sonographic signs for synovitis and baseline radiographic damage also had an effect on subsequent structural damage in both diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Multidisciplinary Sciences
Ah-Ram Kim, Eunhye Ji, Sahmin Lee, Seokchan Hong, Dae-Hee Kim, Jong-Min Song, Duk-Hyun Kang, Jae-Kwan Song
Summary: Despite the lack of biomarkers for disease activity in aortic stenosis (AS), this study investigated the association between anti-cyclic citrullinated peptide (CCP) antibodies and AS. The results showed that a high positive anti-CCP antibody result is associated with aortic valve (AV) degeneration and may be an independent factor for AS progression. Immunohistochemistry and Western blotting also revealed increased citrullination in diseased AV tissue compared to normal tissue.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Megan M. Y. Hong, Saman Maleki Vareki
Summary: Immunotherapy has revolutionized the treatment of advanced cancers by utilizing the immune system to target tumor cells. CTLA-4-targeting agents can release the brakes on the immune system to promote anti-tumor immune responses. While anti-CTLA-4 therapy can confer long-lasting clinical benefits, patient response rates remain relatively low.
Article
Rheumatology
Jonathan Aldridge, Kerstin Andersson, Inger Gjertsson, Anna-Karin Hultgard Ekwall, Magnus Hallstrom, Ronald van Vollenhoven, Anna-Carin Lundell, Anna Rudin
Summary: This study found that the proportions of PD-1(+)TFh and CTLA-4(+) conventional CD4(+) T cells in circulation at baseline may serve as predictive biomarkers for remission in early RA after CTLA-4Ig treatment.
Article
Rheumatology
Theresa Burkard, Enriqueta Vallejo-Yague, Kim Lauper, Axel Finckh, Thomas Hugle, Andrea M. Burden
Summary: The study found that an increase in BMI may not result in changes in DAS28-esr in patients receiving infliximab, but may lead to a decrease in joint erosions.
Article
Biochemistry & Molecular Biology
Sai Krishna Srimadh Bhagavatham, Sujith Kumar Pulukool, Sai Sanwid Pradhan, R. Saiswaroop, Ashwin Ashok Naik, Datta V. M. Darshan, Venketesh Sivaramakrishnan
Summary: Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. This study aimed to identify the critical pathways involved in RA pathophysiology through the analysis of transcriptomics, proteomics, and metabolomics datasets. The analysis revealed that SNPs associated with RA were categorized into pathways driving immune response and cytokine production. Further analysis identified gene expression and metabolic pathways with potential implications for RA.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Rheumatology
Robert Landewe, Luna Sun, Yun-Fei Chen, Daojun Mo, Desiree van der Heijde
Summary: Demonstrating the inhibition of joint damage in rheumatoid arthritis trials is commonly achieved through statistically significant differences in radiographic progression measured by the mTSS. The frequently used ANCOVA+LE method for handling missing data may not be ideal for long-term extension or paediatric studies. The RC model shows better performance in terms of bias, RMSE, power and type I error rate, making it a more sensitive and precise alternative for analysing mTSS in studies with missing data.
Article
Orthopedics
Edit Vegh, Janos Gaal, Pal Geher, Edina Goemoeri, Attila Kovacs, Laszlo Kovacs, Katalin Nagy, Edit Feketene Posta, Laszlo Tamasi, Edit Toth, Eszter Varga, Andrea Domjan, Zoltan Szekanecz, Gabriella Szucs
Summary: In this Hungarian study, 18% of RA patients were found to have a high risk of RRP. These patients showed differences in various parameters compared to others. RRP was associated with non-response to MTX.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Manon Peran, Edem Allado, Eliane Albuisson, Marion Couderc, Paul Ornetti, Camille Roux, Julien Grosse, Isabelle Chary-Valckenaere, Damien Loeuille
Summary: Ultrasonography is a highly reproducible method for detecting bone erosion progression in patients with rheumatoid arthritis, with significant findings at the joint level in early RA patients.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Review
Allergy
Jocelyn R. Farmer, Gulbu Uzel
Summary: There is a growing recognition of the clinical overlap between primary immune deficiency and autoimmunity; detailed profiling of family history is crucial in the diagnostic process. Genetic and functional diagnostic approaches are complementary methods for identifying inborn errors of immunity, and extended immune phenotyping of family members can provide insight into disease inheritance and modifiers.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Medicine, General & Internal
Natalia Mena-Vazquez, Marta Rojas-Gimenez, Carmen Maria Romero-Barco, Sara Manrique-Arija, Ana Hidalgo Conde, Rocio Arnedo Diez de los Rios, Eva Cabrera Cesar, Rafaela Ortega-Castro, Francisco Espildora, Maria Carmen Aguilar-Hurtado, Isabel Anon-Onate, Lorena Perez-Albaladejo, Manuel Abarca-Costalago, Inmaculada Urena-Garnica, Maria Luisa Velloso-Feijoo, Rocio Redondo-Rodriguez, Antonio Fernandez-Nebro
Summary: The study found that about half of patients with interstitial lung disease associated with systemic autoimmune disease stabilize or improve after a median of 5 years, but over one-third of patients die. Rheumatoid arthritis is associated with higher rates of disease progression and hospitalization in ILD, while usual interstitial pneumonia pattern, FVC%, and smoking are independent predictors for worsening of ILD-SAI.
Article
Immunology
Tae Sung M. Kim, Lakmali Silva, Vasileios Ionas Theofilou, Teresa Greenwell-Wild, Lu Li, Drake Winslow Williams, Tomoko Ikeuchi, Laurie H. Brenchley, Thomas I. Bugge, Patricia J. Diaz, Mariana Kaplan, Carmelo M. Carmona-Rivera, Niki Moutsopoulos
Summary: Neutrophil extracellular traps (NETs) are early triggers of pathogenic inflammation in periodontitis, a prevalent oral inflammatory disease. NETs promote IL-17/Th17 immune response and contribute to bone destruction. Human findings support the role of NET-mediated pathology in periodontitis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Engineering, Biomedical
Ruqi Huang, Caiyi Zhang, Yeyang Bu, Zheng Li, Xin Zheng, Shang Qiu, Jeremiah Ong'achwa Machuki, Lijie Zhang, Yun Yang, Kaijin Guo, Fenglei Gao
Summary: The study designed a metal/semiconductor composite for combination therapy of rheumatoid arthritis, aiming to remove hyperplasia of the synovium using photothermal therapy, photodynamic therapy, and chemotherapy. The findings showed that this composite nanomaterial may provide a potential treatment option for rheumatoid arthritis.
Article
Rheumatology
Marta Waliszewska-Prosol, Agata Sebastian, Piotr Wiland, Slawomir Budrewicz, Edyta Dziadkowiak, Maria Ejma
Summary: This study found that auditory pathway disturbances could be present in pSS patients without clinical central nervous system impairment. Disorders of brain bioelectrical activity may be a consequence of ongoing autoimmune process.
CLINICAL RHEUMATOLOGY
(2021)
Meeting Abstract
Rheumatology
R. van Vollenhoven, T. Takeuchi, J. Aelion, N. Chavez, P. Mannucci Walter, A. Singhal, J. Swierkot, A. Friedman, N. Khan, Y. Li, X. Bu, J. Klaff, V. Strand
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
R. Fleischmann, E. Mysler, L. Bessette, C. Peterfy, P. Durez, Y. Tanaka, J. Swierkot, N. Khan, X. Bu, Y. Li, I. H. Song
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
J. M. Sanchez-Maldonado, R. Caliz Caliz, M. A. Lopez-Nevot, A. Moniz-Diez, A. J. Cabrera-Serrano, H. Canhao, R. Ter Horst, A. Escudero Contreras, S. Sorensen, M. L. Hetland, M. A. Ferrer Gonzalez, B. Glintborg, I. Filipescu, E. Perez-Pampin, P. Conesa-Zamora, J. Swierkot, A. Den Broeder, S. De Vita, S. E. Hove Jaconsen, L. Quartuccio, Y. Li, M. Netea, M. J. H. Coenen, V. Andersen, J. E. Fonseca, K. Bogunia-Kubik, E. Collantes Estevez, J. Sainz
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Anna Kulikowska de Nalecz, Lidia Ciszak, Lidia Usnarska-Zubkiewicz, Irena Frydecka, Edyta Pawlak, Magdalena Szmyrka, Agata Kosmaczewska
Summary: In patients with multiple myeloma, T cells show signs of immunosenescence and exhaustion, with a loss of checkpoint expression primarily at diagnosis and increased PD-1 distribution irrespective of disease phase. The inappropriate expression of immune checkpoints, especially PD-1, may contribute to sub-optimal clinical response to therapeutic checkpoint inhibitors in multiple myeloma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Daniel E. Furst, Janusz Jaworski, Rafal Wojciechowski, Piotr Wiland, Anna Dudek, Marek Krogulec, Slawomir Jeka, Agnieszka Zielinska, Jakub Trefler, Katarzyna Bartnicka-Maslowska, Magdalena Krajewska-Wlodarczyk, Piotr A. Klimiuk, Sang Joon Lee, Sung Hyun Kim, Yun Ju Bae, Go Eun Yang, Jae Kyoung Yoo, Jonathan Kay, Edward Keystone
Summary: The study found that the efficacy, pharmacokinetics, safety, and immunogenicity of CT-P17 and reference adalimumab were comparable after one year of treatment, including after switching from reference adalimumab to CT-P17.
Article
Rheumatology
Marek Frankowski, Jerzy Swierkot, Marek Gomulkiewicz, Lucyna Korman, Marta Skoczynska, Aleksandra Starba
Summary: The study found that levels of PIIINP in RA patients were correlated with body weight, RA activity, and diabetes mellitus, while the ELF-1 score was correlated with age, cumulative MTX dose, and RA activity. TE results were only correlated with BMI, and were significantly higher in patients with risk factors for liver fibrosis, suggesting TE is useful in assessing liver condition.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Agata Sebastian, Marta Madej, Maciej Sebastian, Anna Luczak, Pawel Gajdanowicz, Magdalena Zemelka-Wiacek, Piotr Wiland
Summary: The upregulation of IFN pathways and their stimulated genes is associated with primary Sjogren's syndrome (pSS). The study found that patients with positive IFN gamma were younger and had higher levels of RF and ESSDAI compared to patients without IFN gamma.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Lidia Karabon, Anna Andrzejczak, Lidia Ciszak, Anna Tomkiewicz, Aleksandra Szteblich, Agnieszka Bojarska-Junak, Jacek Rolinski, Dariusz Wolowiec, Tomasz Wrobel, Agata Kosmaczewska
Summary: Our study reveals that miR-155-5p is involved in BTLA deficiency, affecting the proliferation of CLL B cells, which may be one of the mechanisms responsible for CLL pathogenesis.
Article
Medicine, Research & Experimental
Marta Madej, Agata Sebastian, Ewa Morgiel, Lucyna Korman, Magdalena Szmyrka, Renata Sokolik, Maria Chodyra, Malgorzata Walas-Antoszek, Iga Andrasiak, Jerzy Swierkot
Summary: This study assessed the risk of COVID-19 infection and disease progression in medical staff of COVID-only and non-COVID hospitals. The results showed that medical staff of COVID-only hospitals had a higher risk of infection. Gender and BMI were confirmed as factors influencing the risk of infection. Influenza vaccination was found to have a beneficial effect in patients with COVID-19 infection.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Environmental Sciences
Iwona Markiewicz-Gorka, Malgorzata Chowaniec, Helena Martynowicz, Anna Wojakowska, Aleksandra Jaremkow, Grzegorz Mazur, Piotr Wiland, Krystyna Pawlas, Rafal Poreba, Pawel Gac
Summary: This study found an association between cadmium exposure and the risk of developing or exacerbating symptoms of inflammatory arthritis (IA). High levels of blood cadmium were linked to an increased risk of IA, as well as elevated levels of oxidative damage marker and cyclooxygenase-2, and frequent consumption of offal. Cadmium exposure was also related to disease symptoms onset in IA patients, decreased levels of anti-inflammatory interleukin 10, and increased disease activity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Bartosz Bugaj, Joanna Wielinska, Jerzy Swierkot, Katarzyna Bogunia-Kubik, Katarzyna Gorna
Summary: The study found that single nucleotide polymorphisms in the vitamin D receptor gene are related to disease activity in patients with axial spondyloarthritis undergoing anti-TNF therapy. Different genotypes were associated with gender, improvement in CRP levels, and changes in BASDAI scores.
Article
Medicine, General & Internal
Agata Sebastian, Marta Madej, Pawel Gajdanowicz, Maciej Sebastian, Anna Luczak, Magdalena Zemelka-Wiacek, Marek Jutel, Piotr Wiland
Summary: Primary Sjogren syndrome (pSS) is a complex multifactorial disease, involving various cytokines including interferon. This study aimed to quantify specific cytokines involved in the pathomechanism of pSS and determine their clinical correlation. Results showed that IFN gamma was the most frequently detected cytokine, and was present along with other specific cytokines in most patients. However, no clinical correlation was observed among the three most common cytokines, IL6, IFN gamma, and TNF alpha. These preliminary research findings suggest the possibility of exploring new treatments for pSS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Virology
Jerzy Swierkot, Marta Madej, Magdalena Szmyrka, Lucyna Korman, Renata Sokolik, Iga Andrasiak, Ewa Morgiel, Agata Sebastian
Summary: This study evaluated the prevalence of autoimmune antibodies before and after SARS-CoV-2 mRNA vaccination in healthcare professionals. The findings showed no significant increase in the prevalence of certain antibodies or autoimmune diseases after vaccination. However, there was an association between the severity of vaccine adverse events and ANA titre.
Review
Rheumatology
Krzysztof Proc, Marta Madej, Piotr Wiland, Agata Sebastian
Summary: Felty's syndrome can be treated with classic synthetic and biological disease-modifying anti-rheumatic drugs (DMARDs), but these drugs may cause clinical complications. It is important to know and prevent neutropenia-related issues for the treatment of Felty's syndrome.