Article
Gastroenterology & Hepatology
Yosuke Okada, Hideki Nakasone, Yuhei Nakamura, Masakatsu Kawamura, Shunto Kawamura, Junko Takeshita, Nozomu Yoshino, Yukiko Misaki, Kazuki Yoshimura, Shimpei Matsumi, Ayumi Gomyo, Aki Tanihara, Masaharu Tamaki, Machiko Kusuda, Kazuaki Kameda, Shun-Ichi Kimura, Shinichi Kako, Noriko Oyama-Manabe, Yoshinobu Kanda
Summary: Pancreatic atrophy is associated with chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation. The recovery of pancreatic thickness plays a crucial role in body weight recovery, but pancreatic atrophy may have a negative impact on prognosis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Immunology
Jonathan Bordat, Sebastien Maury, Mathieu Leclerc
Summary: Allo-HSCT recipients are highly vulnerable to COVID-19 due to immunodeficiency, and changes in clinical practice have been implemented to reduce the risk. mRNA vaccines have shown effectiveness in preventing severe forms of the disease, but Allo-HSCT recipients may have a poor response to vaccination. Challenges include adapting vaccine protection to emerging variants.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Sanam Shahid, Nicholas Ceglia, Jean-Benoit Le Luduec, Andrew Mcpherson, Barbara Spitzer, Theodota Kontopoulos, Viktoria Bojilova, M. Kazim Panjwani, Mikhail Roshal, Sohrab P. Shah, Omar Abdel-Wahab, Benjamin Greenbaum, Katharine C. Hsu
Summary: This study investigated the effects of allo-HCT on AML cells using a novel single-cell proteogenomic approach. The results demonstrated immune-related transcriptional signatures in posttransplant relapses, revealing dysfunction in activated natural killer cells and CD8+ T-cell subsets, as well as an expansion of dysfunctional T cells.
Review
Immunology
Natalie Kohler, Dietrich Alexander Ruess, Rebecca Kesselring, Robert Zeiser
Summary: Immune checkpoint molecules play a crucial role in relapse and treatment after allo-HCT by inhibiting the graft-versus-leukemia effect, allowing tumor cells to escape. The activation of inhibitory receptors on T cell surfaces by immune checkpoint molecules facilitates immune escape. Research shows that immune checkpoint blockade holds potential value in improving the immunotherapeutic effect of relapse after allo-HCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jintao Xia, Xuejie Li, Genyong Gui, Jian Wu, Shengnan Gong, Yuxin Shang, Jun Fan
Summary: This study evaluated the early immune response of recipients with disparate HCMV outcomes and found that HCMV-specific IFN-gamma secreting cells, HCMV IgG, and absolute lymphocyte count could represent the humoral and cellular immune response. Early monitoring of these immune markers could enable prediction of HCMV outcomes posttransplant and assessment of the severity of HCMV DNAemia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Jiayu Wang, Meng Yuan, Guanghua Zhu, Runhui Wu, Chenguang Jia, Bin Wang, Jie Zheng, Jie Ma, Maoquan Qin, Sidan Li
Summary: This study analyzed the immune reconstitution of pediatric patients with aplastic anemia after hematopoietic stem-cell transplantation (HSCT) and found that early rapid immune reconstitution is a good predictor of clinical prognosis in children with AA.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Immunology
Richard J. Lin, Harold K. Elias, Marcel R. M. van den Brink
Summary: Older patients with hematologic malignancies are increasingly undergoing allogeneic hematopoietic cell transplantation, with aging-related thymic dysfunction and other aging hallmarks potentially impacting immune reconstitution post-transplantation. Mechanism-based therapeutic interventions are being discussed to address these issues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Mathieu Leclerc, Rabah Redjoul, Anne Le Bouter, Florence Beckerich, Christine Robin, Vincent Parinet, Cecile Pautas, Dehbia Menouche, Selwa Bouledroua, Lydia Roy, Ludovic Cabanne, Yakout Nait-Sidenas, Slim Fourati, Sebastien Maury
Summary: Hematopoietic stem cell transplant recipients show lower immune response to BNT162b2 mRNA vaccine after 6 months, with peak antibody levels predicting persistent protection. Immunosuppressive drugs and low lymphocyte counts correlate with lower antibody levels.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Hematology
Oriana Miltiadous, Nicholas R. Waters, Hana Andrlova, Anqi Dai, Chi L. Nguyen, Marina Burgos da Silva, Sarah Lindner, John Slingerland, Paul Giardina, Annelie Clurman, Gabriel K. Armijo, Antonio L. C. Gomes, Madhavi Lakkaraja, Peter Maslak, Michael Scordo, Roni Shouval, Anna Staffas, Richard O'Reilly, Ying Taur, Susan Prockop, Jaap Jan Boelens, Sergio Giralt, Miguel-Angel Perales, Sean M. Devlin, Jonathan U. Peled, Kate A. Markey, Marcel R. M. van den Brink
Summary: This study analyzed stool samples and peripheral blood samples from patients undergoing allogeneic hematopoietic cell transplantation, and found that the diversity of intestinal microbiota and the relative abundance of specific bacterial genera were associated with the recovery of immune cells.
Article
Oncology
Linda Victoria Eriksson, Katarina Holmberg, Carina Lundh Hagelin, Yvonne Wengstrom, Karin Bergkvist, Jeanette Winterling
Summary: This study aimed to investigate patient-reported symptom burden in the first year after allo-HSCT and examine whether a high symptom burden 4 months after allo-HSCT predicts recovery, including general health and sick leave, 1 year after transplantation.
Article
Immunology
Dina Leth Moller, Katrine Kielsen, Claus Henrik Nielsen, Henrik Sengelov, Anders Elm Pedersen, Lars Peter Ryder, Klaus Muller
Summary: This study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Immunology
Vera Portillo, Stavroula Masouridi-Levrat, Lena Royston, Sabine Yerly, Manuel Schibler, Maria Mappoura, Sarah Morin, Federica Giannotti, Anne-Claire Mamez, Christian van Delden, Yves Chalandon, Dionysios Neofytos
Summary: Positive CMV serology in allogeneic hematopoietic cell transplant recipients (allo-HCTRs) may be false-positive due to transfusion-associated passive immunity. Reclassifying CMV status can help accurately assess the risk of CMV infection in these patients.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Anna Soderstrom, Sofie Vonlanthen, Kerstin Jonsson-Videsater, Stephan Mielke, Hannes Lindahl, Johan Torlen, Michael Uhlin
Summary: This study found that measuring TREC levels can predict the prognosis of adult AML patients after bone marrow transplantation, especially overall survival. Lower TREC levels were associated with viral infections and CMV reactivation. KREC levels were not associated with clinical outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sun Yao, Chen Jianlin, Qiao Zhuoqing, Li Yuhang, Hu Jiangwei, Hu Guoliang, Ning Hongmei, Zhang Bin, Hu Liangding
Summary: This case report describes a patient with treated secondary AML who received tislelizumab in combination with azacitidine. While the patient achieved complete remission, they also experienced serious immune-related adverse events and graft vs. host disease, ultimately leading to death. This highlights the safety concerns of combining anti-PD-1 antibodies with azacitidine after allo-HSCT, particularly the risk of GVHD.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Riccardo Masetti, Daniele Zama, Davide Leardini, Edoardo Muratore, Silvia Turroni, Patrizia Brigidi, Andrea Pession
Summary: The gut microbiome plays a significant role in hematopoietic stem cell transplantation, with its metabolites mediating interactions between intestinal microbial communities and the host. New data offer a fresh perspective on the role of microbiome-derived metabolites in transplant settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Correction
Biophysics
Johannes Schetelig, Patrice Chevallier, Michel van Gelder, Jennifer Hoek, Olivier Hermine, Ronjon Chakraverty, Paul Browne, Noel Milpied, Michele Malagola, Gerard Socie, Julio Delgado, Eric Deconinck, Ghandi Damaj, Sebastian Maury, Dietrich Beelen, Stephanie Nguyen Quoc, Paneesha Shankara, Arne Brecht, Jiri Mayer, Mathilde Hunault-Berger, Jorg Bittenbring, Catherine Thieblemont, Stephane Lepretre, Henning Baldauf, Liesbeth C. de Wreede, Olivier Tournilhac, Ibrahim Yakoub-Agha, Nicolaus Kroger, Peter Dreger
BONE MARROW TRANSPLANTATION
(2022)
Article
Hematology
Graciela Rabadan Moraes, Florence Pasquier, Christophe Marzac, Eric Deconinck, Carlotta Caterina Damanti, Gwendoline Leroy, Mira El-Khoury, Wassim El Nemer, Jean-Jacques Kiladjian, Hana Raslova, Albert Najman, William Vainchenker, Caroline Marty, Christine Bellanne-Chantelot, Isabelle Plo
Summary: This study identified an EPOR variant in a large family with JAK2-positive MPN, indicating the importance of inherited-risk alleles affecting the JAK2/STAT pathway in MPN. The findings suggest potential implications for risk assessment and treatment of MPN.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Immunology
Emilie Gaiffe, Dewi Vernerey, Laurent Bardiaux, Franck Leroux, Aurelia Meurisse, Jamal Bamoulid, Cecile Courivaud, Philippe Saas, Pierre Tiberghien, Didier Ducloux
Summary: Early red blood cell transfusion after kidney transplantation is associated with increased transplant failure.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Caroline Laheurte, Evan Seffar, Eleonore Gravelin, Julie Lecuelle, Adeline Renaudin, Laura Boullerot, Marine Malfroy, Amelie Marguier, Benoit Lecoester, Beatrice Gaugler, Philippe Saas, Caroline Truntzer, Francois Ghiringhelli, Olivier Adotevi
Summary: Plasmacytoid dendritic cells (pDCs) in non-small cell lung cancer patients have been shown to have an ambivalent role in cancer immunity. Higher levels of circulating pDCs are associated with improved overall survival (OS) in NSCLC, especially in early-stage patients, and a high pDC signature in the tumor microenvironment predicts better efficacy of immune checkpoint inhibitors in these patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Hematology
Nico Gagelmann, Dirk-Jan Eikema, Linda Koster, Tanja Netelenbos, Andrew McDonald, Anne-Marie Stoppa, Roland Fenk, Achilles Anagnostopoulos, Gwendolyn van Gorkom, Eric Deconinck, Claude-Eric Bulabois, Michel Delforge, Donald Bunjes, William Arcese, Peter Remenyi, Maija Itala-Remes, Lorenz Thurner, Ali Zahit Bolaman, Yafour Nabil, Johan Lund, Helene Labussiere-Wallet, Patrick J. Hayden, Meral Beksac, Stefan Schoenland, Ibrahim Yakoub-Agha
Summary: This study investigated the impact of extramedullary disease (EMD) in patients with multiple myeloma (MM) after autograft and maintenance therapy. It was found that organ involvement was a significant risk factor for worse outcome. Thalidomide had no significant effect on disease progression during maintenance therapy, while lenalidomide and bortezomib improved patients' survival specifically in EMD.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Dermatology
Yasmin El Mahi, Alexis Varin, Mathieu Vetter, Ludivine Dal Zuffo, Loic Mazzeo, Jean-Paul Pais De Barros, Francois Aubin, Philippe Saas, Irene Gallais Serezal
Summary: The relapses of psoriasis are related to T cells that reside in the skin, with the fatty acid intake capacity of tissue-resident memory T cells playing a crucial role in their function. The composition of fatty acids in the skin is linked to the functions of epidermal T cells and may affect the severity of psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Etienne Daguindau, Cecile Chague, Philippe Saas
M S-MEDECINE SCIENCES
(2023)
Editorial Material
Immunology
Philippe Saas, Guo-Chang Fan
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Maxime Samson, Coraline Genet, Marc Corbera-Bellalta, Helene Greigert, Georgina Espigol-Frigole, Claire Gerard, Claudie Cladiere, Roser Alba-Rovira, Marion Ciudad, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Georges Tarris, Laurent Martin, Philippe Saas, Sylvain Audia, Bernard Bonnotte, Maria C. Cid
Summary: This study evaluated the effect of Human Monocyte-derived Suppressor Cells (HuMoSC) on inflammation and vascular remodeling in Giant Cell Arteritis (GCA) treatment. The results showed that HuMoSCs or their supernatant could decrease vascular inflammation and remodeling, which may address the unmet need in GCA treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Eleonora Sosa Cuevas, Philippe Saas, Caroline Aspord
Summary: Immunotherapies using immune checkpoint blockers have shown clinical success in melanoma, but some patients still relapse or do not respond. Dendritic cells (DCs) play a key role in immune responses and their understanding is important for developing effective immunotherapies. This review provides an overview of DC diversity, their role in melanoma pathophysiology and clinical outcomes, tumor-induced DC subversion mechanisms, and DC-based therapeutic developments.
Article
Immunology
Emilie Gaiffe, Mathilde Colladant, Maxime Desmaret, Jamal Bamoulid, Franck Leroux, Caroline Laheurte, Sophie Brouard, Magali Giral, Philippe Saas, Cecile Courivaud, Nicolas Degauque, Didier Ducloux
Summary: Unsupervised hierarchical clustering analysis was performed on pre-transplant immunological phenotype in 1113 renal transplant recipients, identifying three immune profiles correlated with clinical phenotypes. The memory immune cluster was associated with older age and diabetes, while the activated immune cluster was associated with younger age and previous exposure to CMV. Both were associated with an increased risk of acute rejection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Emilie Gaiffe, Dewi Vernerey, Laurent Bardiaux, Franck Leroux, Aurelia Meurisse, Jamal Bamoulid, Cecile Courivaud, Philippe Saas, Marc Hazzan, Pierre Tiberghien, Didier Ducloux
Summary: A longer storage duration of red blood cells (RBC) was associated with a decreased risk of transplant failure among patients who received kidney transplants and RBC transfusions. Preferential use of RBC with longer storage duration might improve kidney graft survival following transplant and transfusion.
Article
Rheumatology
Sophie Hecquet, Perle Totoson, Helene Martin, Marie-Paule Algros, Philippe Saas, Jean-Paul Pais-de-Barros, Alban Atchon, Benoit Valot, Didier Hocquet, Maude Tournier, Clement Prati, Daniel Wendling, Celine Demougeot, Frank Verhoeven
Summary: Intestinal inflammation and alterations of the intestinal barrier are not the consequence of joint damage, and intestinal changes occurred in the absence of bacterial translocation.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Immunology
Camille Niveau, Eleonora Sosa Cuevas, Benoit Roubinet, Mylene Pezet, Michel Thepaut, Stephane Mouret, Julie Charles, Franck Fieschi, Ludovic Landemarre, Laurence Chaperot, Philippe Saas, Caroline Aspord
Summary: Dendritic cell subsets play a crucial role in shaping anti-tumour immunity. The study found that melanoma tumour cells display aberrant glycan motifs which can be sensed by dendritic cells through specific receptors. This interaction may lead to abnormal immune responses. The study suggests that targeting the glycan/receptor axis could be a promising strategy for improving cancer immunotherapy.
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
