Journal
PATHOLOGIE BIOLOGIE
Volume 62, Issue 1, Pages 34-37Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.patbio.2013.10.003
Keywords
Copy number variation; Family-based association study; Genetics; Psoriasis; Gene interaction
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Funding
- Tunisian Ministry of Scientific and Technological Research
- Development of Competencies (Laboratory of Genetics, Immunology and Human Pathologies and Research Unit on Study of Hereditary Keratinization Disorders) [UR24/04]
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Background. - Recently, it has been shown that a deletion in the late cornified envelope (LCE) gene cluster (LCE3C_LCE3B-del) is associated with susceptibility to psoriasis in European and Asian populations. However, no study of this deletion has been performed in the North African population. The aim of the present study was to investigate whether this deletion is associated with familial psoriasis in Tunisian population. Methods. - A total of 34 patients and 55 healthy individuals were recruited from 7 multiplex families and a PCR assay was used to determine the association of this deletion. Its effect on susceptibility to psoriasis was assessed using the PDT program. Results. - We failed to detect any evidence of association between LCE3C_LCE3B-del and psoriasis in Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus. Conclusions. - These findings indicate that the LCE3C_LCE3B-del does not contribute in a major way to psoriasis susceptibility in Tunisian families. (C) 2013 Elsevier Masson SAS. All rights reserved.
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