Article
Agriculture, Multidisciplinary
Peiyuan Li, Sha Zhang, Hui Song, Stanislav Seydou Traore, Jiangtao Li, David Raubenheimer, Zhenwei Cui, Guangning Kou
Summary: Naringin can promote the transition of skeletal muscle fibers from fast-twitch to slow-twitch through the AdipoR1 signaling pathway, improving exercise endurance and muscle fiber deficiencies related diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Hiroaki Wake, Wataru Ogawa, Yu Hirata, Yoshihisa Tachibana, Takahiro Niikura, Kana Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro Adachi, Koji Shibasaki
Summary: This study reveals that the upregulation of KLF15 and IL-6, as well as the decrease in intracellular Ca2+ concentration, are involved in muscle atrophy induced by immobility. This finding has been validated in both mouse models and human samples.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Xiang Ma, Yusuke Takahashi, Wenjing Wu, Jianglei Chen, Marcus Dehdarani, Wentao Liang, Young-Hwa Shin, Siribhinya Benyajati, Jian-xing Ma
Summary: The study suggests that sVLDLR plays an anti-fibrotic role in neovascular age-related macular degeneration (nAMD) by inhibiting the Wnt signaling pathway. Additionally, in human RPE cells, Wnt and TGF-beta signaling synergistically promote fibrosis.
Article
Endocrinology & Metabolism
Wentao Liang, Li Huang, Xiang Ma, Lijie Dong, Rui Cheng, Marcus Dehdarani, Dimitrios Karamichos, Jian-Xing Ma
Summary: This study found that overexpression of kallistatin in diabetic patients contributes to delayed corneal wound healing by inhibiting the canonical Wnt signaling. Additionally, it was discovered that kallistatin suppresses the activation of Wnt signaling and delays wound healing in the cornea.
Article
Physiology
Spyridon Methenitis, T. Nomikos, T. Mpampoulis, E. Kontou, E. Evangelidou, C. Papadopoulos, G. Papadimas, G. Terzis
Summary: This study investigated the association between muscle fiber composition, body composition, and resting glycemic-lipidemic blood profiles in young healthy females. The results showed that increased type IIx and low Type I, IIa %CSAs were associated with poorer body composition and glycemic-lipidemic profiles. The contribution of muscle fiber %CSA on health status seems to be comparable to that of nutrition and body composition.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jing Yue, Wei Xu, Li Xiang, Shao-juan Chen, Xin-yuan Li, Qian Yang, Ruo-nan Zhang, Xin Bao, Yan Wang, MagdaleenaNaemi Mbadhi, Yun Liu, Lu-yuan Yao, Long Chen, Xiao-ying Zhao, Chang-qing Hu, Jing-xuan Zhang, Hong-tao Zheng, Yan Wu, Shi-You Chen, Shan Li, Jing Lv, Liu-liu Shi, Jun-ming Tang
Summary: This study found that excessive sympathetic activity has an impact on myoblast differentiation, fusion, and myofiber types. Continuous single-dose isoprenaline exposure significantly reduced myotube size and delayed myoblast differentiation/fusion. Overexpression of NFATc1 or NFATc2 mitigated the inhibitory effects of isoprenaline on myoblast differentiation/fusion and myotube size. Knockdown of NFATc4 worsened the effects of isoprenaline on myoblast fusion and myotube size. The inhibition of myoblast differentiation/fusion and myotube size by isoprenaline was mediated through the NFAT-MyoG-MEF2C signaling pathway.
SCIENTIFIC REPORTS
(2023)
Article
Geriatrics & Gerontology
Yuhei Mizunoe, Masaki Kobayashi, Hiroki Saito, Akifumi Goto, Ryota Migitaka, Kumi Miura, Naoyuki Okita, Yuka Sudo, Ryoma Tagawa, Miki Yoshida, Ai Umemori, Yoshimi Nakagawa, Hitoshi Shimano, Yoshikazu Higami
Summary: Research indicates that aging leads to muscle atrophy, but long-term caloric restriction can reduce this age-related muscle decline.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Immunology
Joseph E. Rupert, Ashok Narasimhan, Daenique H. A. Jengelley, Yanlin Jiang, Jianguo Liu, Ernie Au, Libbie M. Silverman, George Sandusky, Andrea Bonetto, Sha Cao, Xiaoyu Lu, Thomas M. O'Connell, Yunlong Liu, Leonidas G. Koniaris, Teresa A. Zimmers
Summary: The study revealed that most patients with pancreatic adenocarcinoma suffer from cachexia, which is mainly due to tissue crosstalk mediated via IL-6 signaling affecting muscle and adipocytes, providing targetable mechanisms for cachexia treatment.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Prech Uapinyoying, Marshall Hogarth, Surajit Battacharya, Davi A. G. Mazala, Karuna Panchapakesan, Carsten G. Bonnemann, Jyoti K. Jaiswal
Summary: The research revealed significant transcriptional similarity between FAPs and MeSCs, confirming PDGFRα as a suitable marker for FAPs and identifying extracellular proteolysis as a new function of FAPs. Additionally, decreased FAP-mediated Wnt signaling may be a potential driver of FAP dysfunction in dysferlinopathic muscles. Furthermore, analysis of FAPs in dystrophin-deficient muscles showed a relationship between muscle pathology and alteration in FAP gene expression.
Article
Agriculture, Dairy & Animal Science
Luke K. Fuerniss, Bradley J. Johnson
Summary: This study validated a semi-automated workflow that can efficiently and objectively identify the type and measure the size of muscle fibers compared to a manual technique. The semi-automated workflow is six times faster than the manual workflow and yields similar results. This study demonstrates the efficiency and objectivity of the semi-automated workflow in imaging, classifying, and measuring muscle fibers.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Geriatrics & Gerontology
Navneet N. Lal, Jon Cornwall, Philip W. Sheard
Summary: Age-related loss of skeletal muscle mass in mice is mainly due to fiber shortening rather than fiber loss, with alterations in muscle morphology playing a significant role in muscle wasting. Tendon length and pennation angle remain consistent across the lifespan, while changes in connective tissue selectively impact muscle structure.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Chen Duan, Cong Yin, Zewei Ma, Fan Li, Fenglin Zhang, Qiang Yang, Mingfa Lin, Shengchun Feng, Canjun Zhu, Lina Wang, Xiaotong Zhu, Ping Gao, Qingyan Jiang, Gang Shu, Songbo Wang
Summary: The study found that the t10, c12-CLA isomer enhances exercise endurance and promotes the formation of oxidative skeletal muscle fiber type in mice through increased TLR4 signaling.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Lu Xiang, Zhiqing Huang, Xiaoling Chen, Gang Jia, Guangmang Liu, Hua Zhao
Summary: The study reveals that leucine promotes muscle fiber type transformation from fast-twitch to slow-twitch through the AdipoQ signaling pathway. This is achieved by increasing the expression of slow muscle markers and decreasing the expression of fast muscle markers. Leucine plays a significant role in regulating muscle fiber type transformation.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Tertius A. Kohn, Megan J. Anley, S'thandiwe N. Magwaza, Luqmaan Adamson, Louw C. Hoffman, Tertius S. Brand
Summary: This study analyzed muscle fiber type, fiber cross-sectional area, enzyme activities, and glycogen content in four muscles of 24 ostriches. The results showed similar proportions of type I and II fibers in all muscles, with the smallest fibers in the iliotibialis cranialis muscle. Citrate synthase activity was highest in the iliotibialis cranialis muscle and similar in the other muscles. 3-hydroxyacetyl Co A dehydrogenase activities were low in all muscles, indicating poor beta-oxidation. The iliotibialis cranialis muscle also had the lowest phosphofructokinase activity. Glycogen content varied within each muscle. These findings suggest that the ostrich muscles have low fat oxidation capacity and glycogen content, which could affect meat quality attributes.
Article
Biochemistry & Molecular Biology
Xiang Ma, Yusuke Takahashi, Wenjing Wu, Wentao Liang, Jianglei Chen, Dibyendu Chakraborty, Yangxiong Li, Yanhong Du, Siribhinya Benyajati, Jian-Xing Ma
Summary: This study demonstrates that ADAM17 is responsible for shedding the soluble ectodomain of VLDLR in human retinal pigment epithelium cells, which plays anti-inflammatory and anti-angiogenic roles through inhibition of Wnt signaling. Inhibition of ADAM17 reduces sVLDLR levels in ocular tissues, suggesting it as a potential therapeutic target for disorders associated with dysregulation of Wnt signaling.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Behavioral Sciences
Megumi Nonaka, Shuichiro Neshige, Hidetada Yamada, Haruka Ishibashi, Yoshiko Takebayashi, Masahiro Nakamori, Shiro Aoki, Yu Yamazaki, Takeo Shishido, Dai Agari, Kazuhide Ochi, Koji Iida, Hirofumi Maruyama
Summary: This study aimed to investigate the seizure outcomes in epilepsy patients following SARS-CoV2 mRNA vaccination. The study found that 5.7% of the vaccinated patients experienced seizure worsening, which mostly occurred within 48 hours after vaccination but was not sustained. Patients with seizure worsening were significantly associated with focal impaired awareness seizures, high seizure frequency, and drug-resistant epilepsy. Nationwide survey data confirmed a very low incidence rate of self-reported seizure worsening. Therefore, there is little evidence to suggest that worsening seizures discourage current and future vaccinations.
EPILEPSY & BEHAVIOR
(2023)
Article
Medicine, General & Internal
Tomoaki Watanabe, Masahiro Nakamori, Kenichi Ishikawa, Atsuko Motoda, Shuichiro Neshige, Shotaro Yamamoto, Kento Katahira, Toru Higaki, Hiroki Ueno, Takahiro Iizuka, Hirofumi Maruyama
Summary: C-NORSE is a neurologic emergency condition characterized by refractory status epilepticus (RSE) of unknown cause. Brain atrophy in patients with C-NORSE is usually irreversible, but a 33-year-old woman showed recovery of brain atrophy after treatment, along with improved cognitive function.
Article
Genetics & Heredity
Takashi Kurashige, Hiroyuki Morino, Hiroki Ueno, Tomomi Murao, Tomoaki Watanabe, Takao Hinoi, Ichizo Nishino, Tsuyoshi Torii, Hirofumi Maruyama
Summary: This study investigated clinical manifestations in 31 FSHD1 patients and 30 non-affected individuals. The results showed that gastrointestinal cancers, specifically gastric and colorectal cancers, increased after the age of 40 in FSHD1 patients and were more frequent compared to non-affected individuals, but were not dependent on D4Z4 repeat number.
JOURNAL OF HUMAN GENETICS
(2023)
Article
Clinical Neurology
Shuichiro Neshige, Shiro Aoki, Tomohisa Nezu, Masahiro Nakamori, Yu Yamazaki, Tomohiko Ohshita, Hirofumi Maruyama
Summary: This study found that patients with Parkinson's disease are less likely to be diagnosed with colds compared to patients with other common brain diseases. This may be due to the protective resistance provided by alpha-synuclein against viral infections, which is activated by chronic inflammation in non-advanced Parkinson's disease patients.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Takamichi Sugimoto, Katsumi Kurokawa, Hiroyuki Naito, Tomoyuki Kono, Eiichi Nomura, Hirofumi Maruyama
Summary: The study aims to evaluate the influence of upper limb symptoms on the results of electromyography and nerve conduction studies. The results showed that ALS patients with upper limb symptoms had a higher proportion of abnormal results in electromyography and nerve conduction studies.
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Kodai Kume, Takashi Kurashige, Keiko Muguruma, Hiroyuki Morino, Yui Tada, Mai Kikumoto, Tatsuo Miyamoto, Silvia Natsuko Akutsu, Yukiko Matsuda, Shinya Matsuura, Masahiro Nakamori, Ayumi Nishiyama, Rumiko Izumi, Tetsuya Niihori, Masashi Ogasawara, Nobuyuki Eura, Tamaki Kato, Mamoru Yokomura, Yoshiaki Nakayama, Hidefumi Ito, Masataka Nakamura, Kayoko Saito, Yuichi Riku, Yasushi Iwasaki, Hirofumi Maruyama, Yoko Aoki, Ichizo Nishino, Yuishin Izumi, Masashi Aoki, Hideshi Kawakami
Summary: In this study, it was found that repeat expansion in LRP12 causes both ALS and OPDM, with the length of the repeat determining the specific phenotype. The presence of phosphorylated TDP-43 in iPS cell-derived motor neurons in LRP12-ALS replicated the pathological hallmark of ALS. Additionally, distinct differences in RNA foci and Muscleblind-like 1 aggregates were observed between LRP12-ALS and LRP12-OPDM.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Clinical Neurology
Megumi Takenaka, Masahiro Nakamori, Rouyi Ishikawa, Shiro Aoki, Hirofumi Maruyama
Summary: Vaccination for COVID-19 is beneficial but can lead to neurological complications. We present a case of a 25-year-old Japanese man who developed acute encephalopathy following the second dose of the vaccine. He had been receiving nivolumab for cancer treatment. The patient had a high fever, confusion, and positive anti-myelin oligodendrocyte glycoproteins. Abnormal signal intensity was observed in the brain, and the diagnosis of autoimmune encephalitis was made. Intravenous methylprednisolone was initiated with rapid improvement of symptoms.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Behavioral Sciences
Yoshiko Takebayashi, Shuichiro Neshige, Takeo Shishido, Yuki Hayashi, Akiko Segawa, Masahiro Nakamori, Tomohisa Nezu, Shiro Aoki, Yu Yamazaki, Hiroki Ueno, Tomohiko Ohshita, Koji Iida, Hirofumi Maruyama
Summary: The study aimed to investigate the incidence and risk factors for paradoxical effects of levetiracetam (LEV) in people with epilepsy (PWE) and evaluate the usefulness of electroencephalography (EEG) in predicting these effects. The results showed that the incidence of paradoxical LEV effects was 5.2% and was significantly associated with high LEV dose, high seizure frequency, temporal lobe epilepsy, and abnormal EEG signals (REDs). The occurrence of REDs in EEG was identified as an independent factor associated with the paradoxical effects of LEV.
EPILEPSY & BEHAVIOR
(2023)
Article
Medicine, Research & Experimental
Masahiro Nakamori, Megumi Toko, Hidetada Yamada, Yuki Hayashi, Kohei Yoshikawa, Mineka Yoshikawa, Toshikazu Nagasaki, Aya Hiraoka, Yoshitaka Shimizu, Yukio Mikami, Hirofumi Maruyama
Summary: This study aims to evaluate the effectiveness of percutaneous neck interferential current stimulation in enhancing swallowing function in patients with Parkinson's disease. The intervention will be conducted twice a week for 8 weeks, and evaluations will be performed every 4 weeks using novel instruments. This study will provide insights into dysphagia in patients with Parkinson's disease and the usefulness of percutaneous neck interferential current stimulation.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Article
Peripheral Vascular Disease
Teppei Kamimura, Shiro Aoki, Tomohisa Nezu, Futoshi Eto, Yuji Shiga, Masahiro Nakamori, Eiji Imamura, Tatsuya Mizoue, Shinichi Wakabayashi, Hirofumi Maruyama
Summary: This study examined the relationship between carotid wall shear stress (WSS) and cerebral small vessel disease (SVD). The results showed a correlation between carotid WSS and SVD scores, particularly with enlarged perivascular space (EPVS) > 10. Lower WSS was also associated with executive dysfunction.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Clinical Neurology
Mai Kikumoto, Takashi Kurashige, Tomohiko Ohshita, Kodai Kume, Osamu Kikumoto, Tomohisa Nezu, Shiro Aoki, Kazuhide Ochi, Hiroyuki Morino, Eiichi Nomura, Hiroshi Yamashita, Mayumi Kaneko, Hirofumi Maruyama, Hideshi Kawakami
Summary: Pontine autosomal dominant microangiopathy and leukoencephalopathy is a hereditary cerebral small vessel disease caused by pathogenic variants in COL4A1 3' UTR. The appearance of multiple oval small infarctions in the pons resembling raisin bread, known as the 'raisin bread sign', is a characteristic radiological feature of this disease. The discovery of this sign has important implications for accurate diagnosis and evaluation of patients with undetermined juvenile cerebral vascular disorder.
BRAIN COMMUNICATIONS
(2023)
