Article
Geriatrics & Gerontology
Ritesh A. Ramdhani, Jeremy Watts, Myriam Kline, Toni Fitzpatrick, Martin Niethammer, Anahita Khojandi
Summary: This study investigated the effects of high-frequency and low-frequency STN-DBS on spatiotemporal gait kinematics in patients with advanced Parkinson's disease. It was found that high-frequency STN-DBS significantly improved trunk and lumbar kinematics.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Clinical Neurology
Dejan Georgiev, Sanja Roskar, Anja Cus, Leonora Wilkinson, Marjan Jahanshahi
Summary: This study examined the acute effects of STN-DBS on proactive interference (PI) and retroactive interference (RI) during verbal learning in Parkinson's disease patients. The results showed that stimulation increased PI but had no effect on RI, indicating a role of STN in inhibitory control during memory encoding or recall.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Maria Antonietta Volonte, Giacomo Clarizio, Sebastiano Galantucci, Pietro Giuseppe Scamarcia, Rosalinda Cardamone, Lina Raffaella Barzaghi, Monica Falautano, Pietro Mortini, Giancarlo Comi, Massimo Filippi
Summary: This study evaluated the long-term effectiveness of STN-DBS treatment on advanced PD patients over a span of 14 years. Results showed significant improvement in tremor, rigidity, and daily dopaminergic dose, but no lasting effect on axial symptoms and cognitive functions. STN-DBS remains an effective therapy for advanced PD patients, extending the period of acceptable quality of life despite disease progression.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Asra Askari, Brandon J. Zhu, Xiru Lyu, Kelvin L. Chou, Parag G. Patil
Summary: The study found that STN DBS has differential effects on rigidity in upper and lower extremities in patients with Parkinson's disease. However, there was no significant difference in tremor or bradykinesia between the upper and lower extremities. Even though there were slight differences in the maximal-effect loci for stimulation between the upper and lower extremities, they were not statistically resolved.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Jing Wei, Zhifan Zou, Jiping Li, Yuqing Zhang
Summary: Deep-brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for motor symptoms of advanced Parkinson's disease (PD). This study aimed to investigate the local field potential (LFP) distribution patterns in dorsomedial and dorsolateral subparts of STN. The results showed weaker gamma oscillations and coherence in the dorsomedial part compared to the dorsolateral part, indicating the potential of targeting the dorsomedial STN for DBS in PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Roxanne Lofredi, Cem-Georg Auernig, Siobhan Ewert, Friederike Irmen, Leon A. Steiner, Ute Scheller, Bernadette C. M. van Wijk, Simon Oxenford, Andrea A. Kuhn, Andreas Horn
Summary: Lead-DBS is a reliable and easy-to-use software tool for precise localization of deep brain stimulation electrodes. This study investigates the differences introduced by different raters and imaging types in the manual refinement process of electrode localization using Lead-DBS. The results show similar outcomes for all users, with an increase in variability when using postoperative MRI and standard space normalization. These findings contribute to the understanding of Lead-DBS and its potential use in formal training and imaging research in the field of deep brain stimulation.
Article
Neurosciences
Bowen Chang, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang, Chaoshi Niu
Summary: This study reported a case of a PD patient who significantly improved symptoms after undergoing bilateral globus pallidus interna combined with subthalamic nucleus variable frequency DBS treatment, exploring a new approach for treating dystonia disorders.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Zhitong Zeng, Linbin Wang, Weikun Shi, Lu Xu, Zhengyu Lin, Xinmeng Xu, Peng Huang, Yixin Pan, Zhonglue Chen, Yun Ling, Kang Ren, Chencheng Zhang, Bomin Sun, Dianyou Li
Summary: This study found that subthalamic nucleus (STN) deep brain stimulation (DBS) is more effective than unilateral globus pallidus interna (GPi) DBS in treating motor symptoms. STN DBS improves symptoms on both sides of the body, while GPi DBS mainly affects the contralateral side.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Rachel K. Spooner, Bahne H. Bahners, Alfons Schnitzler, Esther Florin
Summary: Research shows that optimal contact orientations in subthalamic deep brain stimulation can lead to larger cortical responses and smoother hand movements in patients with Parkinson's disease. These findings have clinical implications for optimizing DBS parameter settings to alleviate motor symptoms.
NPJ PARKINSONS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Giulia Di Rauso, Francesco Cavallieri, Isabella Campanini, Annalisa Gessani, Valentina Fioravanti, Alberto Feletti, Benedetta Damiano, Sara Scaltriti, Elisa Bardi, Maria Giulia Corni, Francesca Antonelli, Vittorio Rispoli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Annette Puzzolante, Jessica Rossi, Stefano Meletti, Giuseppe Biagini, Giacomo Pavesi, Valerie Fraix, Mirco Lusuardi, Alessandro Fraternali, Annibale Versari, Carla Budriesi, Elena Moro, Andrea Merlo, Franco Valzania
Summary: This study evaluated the long-term effects of STN-DBS on freezing of gait (FOG) in advanced Parkinson's Disease (PD). The results showed that FOG significantly improved in the on-stimulation/off-medication condition compared to the off-stimulation/off-medication condition, highlighting the possible beneficial long-term effects of STN-DBS on FOG.
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Fabian J. David, Yessenia M. Rivera, Tara K. Entezar, Rishabh Arora, Quentin H. Drane, Miranda J. Munoz, Joshua M. Rosenow, Sepehr B. Sani, Gian D. Pal, Leonard Verhagen-Metman, Daniel M. Corcos
Summary: This study investigated the effects of encoding type, medication, and subthalamic nucleus deep brain stimulation (STN-DBS) on memory-guided movements in Parkinson's disease (PD). The findings revealed that encoding type influenced reaching performance and deficits in PD, medication had differential effects depending on the encoding type, and STN-DBS was superior to medication in increasing amplitude and velocity. The study provides valuable insights into the understanding of memory-guided movements in PD and the effects of different treatments.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Anika Frank, Jonas Bendig, Inaki Schniewind, Witold H. Polanski, Stephan B. Sobottka, Heinz Reichmann, Katja Akgun, Tjalf Ziemssen, Lisa Klingelhoefer, Bjorn H. Falkenburger
Summary: This study found that deep brain stimulation surgery may be associated with neuronal damage, but stimulation itself does not have an impact.
SCIENTIFIC REPORTS
(2022)
Review
Neurosciences
Faisal Alosaimi, Jackson Tyler Boonstra, Sonny Tan, Yasin Temel, Ali Jahanshahi
Summary: DBS is a successful paradigm for treating movement disorders, but its specific mechanisms and effects on neurotransmitter dynamics are still not fully understood. This review discusses the role of neurotransmitter dynamics in mediating DBS effects in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)