Review
Medicine, General & Internal
Giacomo Garone, Federica Graziola, Melissa Grasso, Alessandro Capuano
Summary: Acute-onset movement disorders (MDs) are increasingly recognized as neurological emergencies in both adults and children, with a wide range of possible causes and challenging diagnostic work-up. The key to treatment lies in recognizing the underlying disorder and the diagnostic approach relies on defining the overall clinical syndrome and recognizing the prominent MD phenomenology.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Kamble Jayaprakash Harsha, E. Joshy, Rangenahalli Vasudev Aravinda, Rangareddy Poornima
Summary: This case report describes a unique case of pregabalin abuse leading to symptoms mimicking encephalitis. The initial response to methylprednisolone followed by symptom recurrence, as well as parenchymal changes on MRI, raised suspicion of autoimmune encephalitis. The patient recovered completely upon cessation of pregabalin abuse.
Review
Clinical Neurology
Sophie Tasseel-Ponche, Arnaud Delafontaine, Olivier Godefroy, Alain P. Yelnik, Pierre-Louis Doutrellot, Charline Duchossoy, Marie Hyra, Thibaud Sader, Momar Diouf
Summary: This study conducted a meta-analysis on gait disorders and walking speed in stroke patients, exploring the association with balance, cognitive disorders, and autonomy. Results showed that at the sub-acute stroke stage, patients' walking speed was lower than the general population and significantly below the level required for safe independent walking.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Haikun Song, Cen Wang, Chenggang Zhu, Ziying Wang, Huiya Yang, Peng Wu, Xiaotian Cui, Juan Botas, Yongjun Dang, Yu Ding, Yiyan Fei, Boxun Lu
Summary: Chemical binders targeting mutant huntingtin protein (mHTT) have the potential to inhibit Huntington's disease (HD) by destabilizing the protein through enhancing its polyubiquitination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Public, Environmental & Occupational Health
Irmeli Lindstrom, Jussi Lantto, Kirsi Karvala, Satu Soini, Katriina Ylinen, Hille Suojalehto, Katri Suuronen
Summary: Occupations such as industrial operators, metal and machinery workers, and construction workers are most commonly affected by irritant-induced asthma (IIA). Accidents are the main cause of acute IIA, while subacute IIA often develops in industrial operators working under poor work hygiene conditions. Airborne strong acids or bases are the most important causative agents of both acute and subacute IIA.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Clinical Neurology
Emma A. Honkanen, Jaana Roenkae, Eero Pekkonen, Juho Aaltonen, Maija Koivu, Olli Eskola, Hazem Eldebakey, Jens Volkmann, Valtteri Kaasinen, Martin M. Reich, Juho Joutsa
Summary: Deep brain stimulation (DBS) of the globus pallidus interna (GPi) can significantly improve symptoms of cervical dystonia. This study used brain metabolic imaging to investigate the effects of GPi-DBS on brain metabolism in cervical dystonia. The results showed that GPi-DBS increases metabolic activity at the stimulation site and is related to modulation of specific networks. The study also found a strong correlation between stimulation amplitude and metabolic activity.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Clinical Neurology
Hui Wu, Spyridon Siafis, Dongfang Wang, Angelika Burschinski, Johannes Schneider-Thoma, Josef Priller, John M. Davis, Stefan Leucht
Summary: This study investigated the relationship between antipsychotic doses and the risk of akathisia. The results showed that the risk of akathisia increased with higher doses in most antipsychotics, except for a few drugs like Sertindole and Quetiapine, where the risk was negligible at all examined doses.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Eva Ntanasi, Maria Maraki, Mary Yannakoulia, Maria Stamelou, Georgia Xiromerisiou, Mary H. Kosmidis, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Antonios Gargalionis, Kostas Patas, Stylianos Chatzipanagiotou, Socrates Charisis, Leonidas Stefanis, Nikolaos Scarmeas
Summary: The study found an association between frailty and prodromal PD and PD, suggesting that frailty may impact the likelihood of older individuals developing these conditions, and indicating common characteristics or underlying mechanisms among them.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Clinical Neurology
Grace A. Bailey, Emily K. Hubbard, Alfonso Fasano, Marina A. J. Tijssen, Timothy Lynch, Kirstie N. Anderson, Kathryn J. Peall
Summary: Sleep and circadian rhythm disturbances are central features of many movement disorders, with implications for early disease detection. Medication for motor symptoms can impact sleep, highlighting the importance of addressing sleep disturbances for improved quality of life. Shared underlying mechanisms between motor and sleep pathophysiology warrant further investigation for better understanding and management of movement disorders.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Souvik Dubey, Subhankar Chatterjee, Ritwik Ghosh, Elan D. Louis, Avijit Hazra, Samya Sengupta, Shambaditya Das, Abhirup Banerjee, Alak Pandit, Biman Kanti Ray, Julian Benito-Leon
Summary: This is the largest clinical series investigating the frequency and clinical-radiological characteristics of patients with diabetes mellitus who experience acute onset movement disorders. Nearly one third of the patients had nonchoreic and nonballistic movements.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Grace A. Bailey, Anna Rawlings, Fatemeh Torabi, William Owen Pickrell, Kathryn J. Peall
Summary: This study reveals a higher rate of psychiatric diagnoses and prescriptions in individuals diagnosed with idiopathic dystonia compared to controls. There may be a bidirectional relationship between idiopathic dystonia and psychiatric disorders, particularly mood disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Suzanne H. Bongers, Na Chen, Erinke van Grinsven, Selma van Staveren, Marwan Hassani, Roy Spijkerman, Lilian Hesselink, Adele T. Lo Tam Loi, Corneli van Aalst, Guus P. Leijte, Matthijs Kox, Peter Pickkers, Falco Hietbrink, Luke P. H. Leenen, Leo Koenderman, Nienke Vrisekoop
Summary: Neutrophil phenotypes exhibit changes in disease states, with acute inflammation showing more heterogeneity and chronic inflammation not leading to increases in specific neutrophil subsets. The dynamics of neutrophil subsets in various inflammatory conditions contribute to our understanding of the role of neutrophils in health and disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Katerina Roma, Salman Mohammed, Blake Sieck, Katrina Naik, Shahid Wahid
Summary: Alternative medicine supplements, such as kratoms, have become a significant cause of liver injury in the US. Reports of adverse events linked to kratom use are increasing, including liver injury, organ dysfunction, and even death. The need for increased regulation and public awareness of the risks associated with kratom is emphasized.
JOURNAL OF HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Jafari-Garageshlaghi, Fatemeh Hashtarkhani, Hamid Soraya, Hassan Malekinejad
Summary: This study aimed to investigate the hepato- and cardioprotective effects of quercetin (QCN) on aluminum phosphide (ALP) intoxication. The results showed that QCN reduced ALP-induced hepatic and cardiac damage, improved ECG abnormalities and arrhythmias, and attenuated oxidative/nitrosative stress and histopathological injuries.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Psychiatry
Guy Chouinard, Fiammetta Cosci, Virginie-Anne Chouinard, Larry Alphs
Summary: This article introduces the ESRS and ESRS-A as valid tools for measuring drug-induced movement disorders, highlighting their value in clinical research and clinics.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2023)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)