Article
Clinical Neurology
Dejan Georgiev, Marusa Mencinger, Robert Rajnar, Polona Music, Mitja Benedicic, Dusan Flisar, Roman Bosnjak, Jan Mehrkens, Zvezdan Pirtosek, Kai Boetzel, Maja Trost
Summary: A four-year longitudinal study found that bilateral stimulation of the subthalamic nucleus has beneficial effects on non-motor symptoms in patients with advanced Parkinson's disease, but may not be effective in all domains. Further research with larger cohorts and longer follow-up is needed to better understand the long-term effects of this treatment.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Nico Golfre Andreasi, Luigi Michele Romito, Roberta Telese, Roberto Cilia, Antonio Emanuele Elia, Alessio Novelli, Giovanni Tringali, Giuseppe Messina, Vincenzo Levi, Grazia Devigili, Sara Rinaldo, Angelo Amato Franzini, Roberto Eleopra
Summary: STN-DBS has a long-lasting effect on motor complications in both male and female PD patients, but there may be slight differences in certain aspects that require further investigation.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Hana Brozova, Isabelle Barnaure, Evzen Ruzicka, Jan Stochl, Ron Alterman, Michele Tagliati
Summary: The study aimed to compare the short and long-term effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on gait dysfunction and other cardinal symptoms of Parkinson's disease (PD). The results showed that short-term improvement of gait abnormalities appears to significantly decline after 5 years of STN DBS in PD patients, while effectiveness for other symptoms remains stable. This suggests that non-dopaminergic mechanisms or deleterious effects of high frequency STN stimulation might play a role in the decline of gait function over time.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Galit Kleiner, Hubert H. Fernandez, Kelvin L. Chou, Alfonso Fasano, Kevin R. Duque, Diana Hengartner, Albie Law, Adam Margolius, Yu-Yan Poon, Michel Saenz Farret, Philip Saleh, Joaquin A. Vizcarra, Glenn T. Stebbins, Alberto J. Espay
Summary: The study validated a final version of a 27-item self-administered NoMoFA questionnaire, capable of effectively capturing both static and fluctuating non-motor symptoms in Parkinson's disease patients. The questionnaire showed good internal consistency, test-retest reliability, and concurrent validity, and underwent item reduction through a Delphi process, resulting in high acceptability.
MOVEMENT DISORDERS
(2021)
Article
Health Care Sciences & Services
Matteo Carpi, Mariangela Pierantozzi, Stefano Cofano, Mariana Fernandes, Rocco Cerroni, Francesca De Cillis, Nicola Biagio Mercuri, Alessandro Stefani, Claudio Liguori
Summary: This observational study investigates the presence of non-motor symptoms (NMS) and non-motor fluctuations (NMF) in Parkinson's disease (PD) patients using the Non-Motor Fluctuation Assessment questionnaire (NoMoFa). The study finds that NMF are frequently reported by mild-to-moderate PD patients and are associated with an increased number of NMS. The study emphasizes the importance of understanding the clinical role of NMS and NMF in the management of PD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Bowen Chang, Chen Ni, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang, Chaoshi Niu
Summary: This study investigated the relationship between uric acid levels and improvement of motor symptoms in patients with Parkinson's disease after subthalamic nucleus deep brain stimulation. The results showed a non-linear correlation between uric acid levels and motor symptom improvement.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Maria Antonietta Volonte, Giacomo Clarizio, Sebastiano Galantucci, Pietro Giuseppe Scamarcia, Rosalinda Cardamone, Lina Raffaella Barzaghi, Monica Falautano, Pietro Mortini, Giancarlo Comi, Massimo Filippi
Summary: This study evaluated the long-term effectiveness of STN-DBS treatment on advanced PD patients over a span of 14 years. Results showed significant improvement in tremor, rigidity, and daily dopaminergic dose, but no lasting effect on axial symptoms and cognitive functions. STN-DBS remains an effective therapy for advanced PD patients, extending the period of acceptable quality of life despite disease progression.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Matteo Conti, Alessandro Stefani, Roberta Bovenzi, Rocco Cerroni, Elena Garasto, Fabio Placidi, Claudio Liguori, Tommaso Schirinzi, Nicola B. Mercuri, Mariangela Pierantozzi
Summary: In this study, the short-term effects of subthalamic nucleus deep-brain stimulation (STN-DBS) on beta-band cortical functional connectivity (FC) were investigated in Parkinson's disease (PD) patients. The results showed that PD patients exhibited widespread cortical hyperconnectivity in beta bands, and STN-DBS could acutely reduce beta FC primarily in cortical regions involved in basal ganglia-cortical circuits.
Article
Clinical Neurology
Eleonora Del Prete, Emmanuelle Schmitt, Sara Meoni, Valerie Fraix, Anna Castrioto, Pierre Pelissier, Roberto Ceravolo, Elena Moro
Summary: This study investigates the relationship between motor fluctuations (MFs) and neuropsychiatric fluctuations (NMFs) in Parkinson's disease (PD). The findings suggest that NMFs only temporarily match the OFF MFs in PD patients. The study emphasizes the need to further investigate the associations between non-motor and motor symptoms in PD patients to better manage NMFs.
NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Annalisa Gessani, Francesco Cavallieri, Valentina Fioravanti, Isabella Campanini, Andrea Merlo, Giulia Di Rauso, Benedetta Damiano, Sara Scaltriti, Elisa Bardi, Maria Giulia Corni, Francesca Antonelli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Alessandro Fraternali, Annibale Versari, Giuseppe Biagini, Valerie Fraix, Serge Pinto, Elena Moro, Carla Budriesi, Franco Valzania
Summary: This study aimed to evaluate the long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on speech in advanced Parkinson's Disease (PD) patients. The results showed that speech intelligibility stayed at the same level as preoperative values in the long-term follow-up. However, there was a significant acute improvement of speech intelligibility in the postoperative assessment.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
John R. Younce, Meghan C. Campbell, Tamara Hershey, Aaron B. Tanenbaum, Mikhail Milchenko, Mwiza Ushe, Morvarid Karimi, Samer D. Tabbal, Albert E. Kim, Abraham Z. Snyder, Joel S. Perlmutter, Scott A. Norris
Summary: Resting-state functional connectivity MRI may predict motor response to subthalamic nucleus deep brain stimulation, with stronger connectivity between the left subthalamic nucleus and ipsilateral internal globus pallidus correlating with greater improvement in postsurgical motor outcomes. The integrity of pallidal-subthalamic nucleus circuits may be critical to motor benefits from deep brain stimulation.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Asra Askari, Brandon J. Zhu, Xiru Lyu, Kelvin L. Chou, Parag G. Patil
Summary: The study found that STN DBS has differential effects on rigidity in upper and lower extremities in patients with Parkinson's disease. However, there was no significant difference in tremor or bradykinesia between the upper and lower extremities. Even though there were slight differences in the maximal-effect loci for stimulation between the upper and lower extremities, they were not statistically resolved.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Chemistry, Medicinal
Giovanni Abbruzzese, Paolo Barone, Leonardo Lopiano, Fabrizio Stocchi
Summary: Safinamide is a recently approved drug for fluctuating Parkinson's patients with a unique dual mechanism of action. Research suggests it can improve motor functions and fluctuations, as well as some non-motor symptoms, benefiting patients' quality of life.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Medicine, General & Internal
Diego Santos-Garcia, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Ester Suarez Castro, Hector Canfield, Cristina Martinez Miro, Silvia Jesus, Miquel Aguilar, Pau Pastor, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez-Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Marta Blazquez Estrada, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Oriol de Fabregues, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. Lopez Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: This study found that the development of motor fluctuations (MF) in patients with Parkinson's disease (PD) is associated with an increase in non-motor symptoms (NMS) burden after a 2-year follow-up.
Article
Geriatrics & Gerontology
Yan Qu, Tingting Zhang, Yunyan Duo, Liling Chen, Xiaohong Li
Summary: This study aims to investigate the value of the Parkinson's KinetiGraph (PKG) in identifying and quantitatively assessing motor complications in the Chinese PD population and its correlation with clinical assessments. The study found that PKG has a significant correlation with clinical assessment, high sensitivity, and high specificity, providing an objective and quantitative method for identifying and assessing motor complications in Parkinson's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Letter
Clinical Neurology
M. O. Iridoy, P. Clavero, T. Cabada, M. E. Erro
Article
Neurosciences
Lianne M. Reus, Bogdan Pasaniuc, Danielle Posthuma, Toni Boltz, Yolande A. L. Pijnenburg, Roel A. Ophoff
Summary: Using a transcriptome-wide association study approach, novel candidate genes associated with FTD were identified, with most significant associations observed in the dorsolateral prefrontal cortex. In addition to SEC22B, the 17q21.31 inversion locus also showed significant associations.
BIOLOGICAL PSYCHIATRY
(2021)
Editorial Material
Clinical Neurology
Oihana Errea, Maria Cruz Rodriguez-Oroz
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Monica Diez-Fairen, Gabrielle Houle, Sara Ortega-Cubero, Sara Bandres-Ciga, Ignacio Alvarez, Maria Carcel, Laura Ibanez, Maria Victoria Fernandez, John P. Budde, Jean-Remi Trotta, Raul Tonda, Jessica X. Chong, Michael J. Bamshad, Deborah A. Nickerson, Miquel Aguilar, Juan P. Tartari, Alexandre Gironell, Elena Garcia-Martin, Jose A. G. Agundez, Hortensia Alonso-Navarro, Felix Javier Jimenez-Jimenez, Manel Fernandez, Francesc Valldeoriola, Maria Jose Marti, Eduard Tolosa, Francisco Coria, Maria A. Pastor, Carles Vilarino-Guell, Alex Rajput, Patrick A. Dion, Carlos Cruchaga, Guy A. Rouleau, Pau Pastor
Summary: Through whole exome sequencing and case-control association testing, several candidate genes related to ET, especially MMP10, were identified. Further research is needed to elucidate the genetic mechanisms of ET.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Shenghong He, Fahd Baig, Abteen Mostofi, Alek Pogosyan, Jean Debarros, Alexander L. Green, Tipu Z. Aziz, Erlick Pereira, Peter Brown, Huiling Tan
Summary: The study proposed an innovative approach for essential tremor treatment by detecting tremor-provoking movements and delivering stimulation in real-time, achieving effective therapeutic outcomes. Results showed a high percentage of stimulation time when tremors were triggered, with tremor suppression achieved while conserving energy.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Pedro David Delgado-Lopez, Antonio Montalvo-Afonso, Javier Martin-Alonso, Vicente Martin-Velasco, Jose Manuel Castilla-Diez, Ana Maria Galacho-Harriero, Sara Ortega-Cubero, Antonio Sanchez-Rodriguez, Antonio Rodriguez-Salazar
Summary: The study found that the majority of incidentally found meningiomas remained untreated over the first 4 years of follow-up, with a considerable proportion of tumors growing but showing minimal symptoms. The treatment-related morbidity was very low in the incidental meningioma group.
ACTA NEUROCHIRURGICA
(2021)
Editorial Material
Clinical Neurology
Wolf-Julian Neumann, Maria C. Rodriguez-Oroz
MOVEMENT DISORDERS
(2021)
Review
Clinical Neurology
Antonio Martin-Bastida, Manuel Delgado-Alvarado, Irene Navalpotro-Gomez, Maria Cruz Rodriguez-Oroz
Summary: Dementia, mild cognitive impairment, and neuropsychiatric symptoms are common non-motor symptoms of Parkinson's disease. Neuroimaging studies play a critical role in early diagnosis, monitoring, and understanding the pathophysiology of cognitive and neuropsychiatric symptoms associated with PD. This literature review provides an update on the latest neuroimaging findings for assessing cognitive dysfunction and impulse control disorders in PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neuroimaging
Teresa Esteban-Penalba, Pedro M. Paz-Alonso, Irene Navalpotro-Gomez, Maria C. Rodriguez-Oroz
Summary: Our findings indicate that PD patients with ICD completed the inhibition task correctly, showing altered engagement of inhibitory and attentional areas. During proactive inhibition they showed bilateral hyperactivation of two inhibitory regions, while during restrained inhibition they showed additional involvement of attentional areas responsible for alerting and orienting.
NEUROIMAGE-CLINICAL
(2021)
Meeting Abstract
Clinical Neurology
J. Carte-Garcia, A. Gorospe, I. Aviles, A. Martin-Bastida, O. Parras, A. Arcadi, M. Fernandez, L. Gonzalez, J. Guridi, M. C. Rodriguez-Oroz
MOVEMENT DISORDERS
(2021)
Meeting Abstract
Clinical Neurology
T. Esteban-Penalba, P. Paz-Alonso, I. Navalpotro-Gomez, M. Rodriguez-Oroz
MOVEMENT DISORDERS
(2021)
Meeting Abstract
Clinical Neurology
I. Aviles-Olmos, A. Martin-Bastida, A. Gorospe-Osinalde, J. Carte-Garcia, P. Manrique, A. Arcadi, O. Parras, M. Fernandez-Martinez, L. Armengou-Garcia, L. Gonzalez-Quarante, J. Guridi, M. C. Rodriguez-Oroz
MOVEMENT DISORDERS
(2021)
Meeting Abstract
Clinical Neurology
S. Basaia, F. Agosta, I. Diez Palacio, E. Bueicheku, F. d'Oleire Uquillas, M. Delgado-Alvarado, C. Caballero-Gaudes, M. Rodriguez-Oroz, T. Stojkovic, V. Kostic, M. Filippi, J. Sepulcre
MOVEMENT DISORDERS
(2021)
Review
Psychology, Multidisciplinary
Angela Milan-Tomas, Marta Fernandez-Matarrubia, Maria Cruz Rodriguez-Oroz
Summary: Lewy body dementias (LBDs) comprise dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), sharing neuropathological features. Updated diagnostic criteria now include biomarker information, with the major clinical distinction being the time interval of dementia onset relative to parkinsonism.
BEHAVIORAL SCIENCES
(2021)
Article
Clinical Neurology
Elena Cacho-Asenjo, Cristina Honorato-Cia, Jorge M. Nunez-Cordoba, Miguel Fernandez-Martinez, Lain H. Gonzalez-Quarante, Iciar Aviles-Olmos, Maria Aranzazu Gorospe, Alfredo Panadero, Maria Cruz Rodriguez-Oroz, Jorge Guridi, Antonio Martinez-Simon
Summary: Headache was associated with skull density ratio and thickness, while nausea was related to sex. Women had higher odds of experiencing nausea compared to men. Dexmedetomidine did not reduce headache or nausea, but increased the number and duration of sonications.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
