Article
Neurosciences
Haydeh Payami, Gwendolyn Cohen, Charles F. Murchison, Timothy R. Sampson, David G. Standaert, Zachary D. Wallen
Summary: Parkinson's disease is a rapidly growing neurological disorder with no known prevention methods. While intrinsic risk factors like age, sex, and genetics cannot be avoided, environmental factors can. This study suggests that repeated blows to the head in sports/combat may be a potential new risk factor. Approximately 23% of Parkinson's disease cases in females and 30% in males could be attributed to pesticide/herbicide exposure, military-related chemical exposures, and repeated blows to the head, highlighting the potential for prevention.
NPJ PARKINSONS DISEASE
(2023)
Review
Neurosciences
Jianjun Xu, Etsuko Minobe, Masaki Kameyama
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor dysfunction, and its exact causes are still unknown. Risk factors for PD include aging, genetic mutations, environmental factors, and gender. Endoplasmic reticulum stress, excessive reactive oxygen species production, and impaired autophagy have been linked to neuronal death in the substantia nigra pars compacta in PD. Dysregulation of Ca2+ handling may mediate risk factor-related PD pathogenesis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Pierre-Emmanuel Sugier, Elise A. Lucotte, Cloe Domenighetti, Matthew H. Law, Mark M. Iles, Kevin Brown, Christopher Amos, James D. McKay, Rayjean J. Hung, Mojgan Karimi, Delphine Bacq-Daian, Anne Boland-Auge, Robert Olaso, Jean-francois Deleuze, Fabienne Lesueur, Evgenia Ostroumova, Ausrele Kesminiene, Florent de Vathaire, Pascal Guenel, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Patrick May, Dheeraj R. Bobbili, Milena Radivojkov-Blagojevic, Peter Lichtner, Andrew B. Singleton, Dena G. Hernandez, Connor Edsall, George D. Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E. Lang, Sulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugenie Mutez, Kathrin Brockmann, Angela B. Deutschlaender, Georges M. Hadjigeorgiou, Efthimios Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Pierre Kolber, Bart P. C. van de Warrenburg, Bastiaan R. Bloem, Jan Aasly, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J. Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Pau Pastor, Monica Diez-Fairen, Karin Wirdefeldt, Nancy Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Emil Ygland Roedstroem, Carl E. Clarke, Karen E. Morrison, Manuela Tan, Dimitri Krainc, Lena F. Burbulla, Matt J. Farrer, Rejko Kruger, Thomas Gasser, Manu Sharma, Therese Truong, Alexis Elbaz
Summary: By using genome-wide association studies, this study found that Parkinson's disease (PD) is genetically correlated with melanoma and prostate cancer, while it is inversely correlated with ovarian cancer. These findings suggest that pleiotropic genes contribute to the association between PD and specific cancers.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Tarek Antar, Huw R. Morris, Faraz Faghri, Hampton L. Leonard, Mike A. Nalls, Andrew B. Singleton, Hirotaka Iwaki
Summary: The study identified potential risk factors for depression in Parkinson's disease patients, highlighting the importance of adjusting for multiple covariates when analyzing risk factors for depression. Risk factors included probable REM sleep behavior disorder (pRBD), age, duration of diagnosis, impairment in daily activities, mild constipation, and antidepressant use. Cox regression model found pRBD, impairment in daily activities, hyposmia, and mild constipation to be longitudinal predictors of sustained depressive symptoms.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Luis M. Garcia-Marin, Paula Reyes-Perez, Santiago Diaz-Torres, Alejandra Medina-Rivera, Nicholas G. Martin, Brittany L. Mitchell, Miguel E. Renteria
Summary: This study reveals the genetic correlations between Parkinson's disease (PD) and brain structure volumes, and identifies potential genetic variants and pathways involved. The findings suggest that genetic variations influencing brain structure volumes, possibly during early stages, can affect the risk of developing PD later in life.
NPJ PARKINSONS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Jana Tchekalarova, Rumiana Tzoneva
Summary: Aging and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are linked by common features like mitochondrial dysfunction and protein aggregation. The rising costs of caring for elderly patients with these diseases is a major issue in today's demographic crisis. Oxidative stress and imbalanced antioxidant defense system play crucial roles in age-related neurodegeneration, and diminished melatonin release with aging further increases susceptibility to these diseases. Understanding the underlying mechanisms and melatonin's role is important for developing precise treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Paraskevi P. Chairta, Andreas Hadjisavvas, Andrea N. Georgiou, Maria A. Loizidou, Kristia Yiangou, Christiana A. Demetriou, Yiolanda P. Christou, Marios Pantziaris, Kyriaki Michailidou, Eleni Zamba-Papanicolaou
Summary: The study revealed an association between genetic and environmental factors with Parkinson's disease. The combination of a 12-SNPs PRS and seven other independent lifestyle/environmental factors was identified as the most predictive model for Parkinson's disease in the population studied.
Article
Clinical Neurology
Zhirong Wan, Xuemei Wang, Huizi Ma, Zhan Wang, Tao Feng
Summary: This study investigated the risk factors and correlation between motor complications and sex hormone levels in female Parkinson's disease (PD) patients. The results showed that female PD patients had a higher incidence of motor complications. Younger age of onset and higher Hoehn-Yahr (H&Y) stage were identified as risk factors for the wearing-off phenomenon, and younger age of onset was a risk factor for dyskinesia in female PD patients. There may also be a correlation between the occurrence of motor complications and sex hormone levels in female PD patients, but further confirmation is needed.
NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Kyum-Yil Kwon, Suyeon Park, Eun Ji Lee, Mina Lee, Hyunjin Ju
Summary: The study revealed that fall-related risk factors in patients with early Parkinson's disease (PD) were highly associated with gastrointestinal dysautonomia.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Yuhei Kanaya, Kodai Kume, Hiroyuki Morino, Ryosuke Ohsawa, Takashi Kurashige, Masaki Kamada, Tsuyoshi Torii, Yuishin Izumi, Hirofumi Maruyama, Hideshi Kawakami
Summary: Parkinson's disease (PD) is influenced by a combination of genetic and environmental factors. Studies on the genetic risk factors in Japanese PD patients are limited, but it was found that early-onset PD patients have more genetic risk factors and PRKN and LRRK2 are the major genetic factors in Japanese PD patients.
JOURNAL OF HUMAN GENETICS
(2021)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Shusaku Omoto, Hidetomo Murakami, Tomotaka Shiraishi, Keiko Bono, Tadashi Umehara, Yasuyuki Iguchi
Summary: Minor hallucinations (MHs) are common in Parkinson's disease (PD), and patients with MHs can have different clinical characteristics depending on when the hallucinations appear. Understanding these differences is important for clinical diagnosis and treatment.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Alessandra Nicoletti, Antonina Luca, Roberta Baschi, Calogero Edoardo Cicero, Giovanni Mostile, Marco Davi, Giuseppe La Bianca, Vincenzo Restivo, Mario Zappia, Roberto Monastero
Summary: This study found that hypertension is the most important modifiable risk factor for PD-MCI in PD patients, increasing the risk of the disease about four times. Additionally, the presence of cognitive impairment at baseline and a severe burden of white matter lesions were identified as the strongest predictors of PDD.
JOURNAL OF NEUROLOGY
(2021)
Review
Psychology, Multidisciplinary
Paulina Gonzalez-Latapi, Ece Bayram, Irene Litvan, Connie Marras
Summary: Cognitive impairment is a common non-motor symptom in Parkinson's Disease, with risk factors including protein accumulation, oxidative stress, and genetic factors. However, conflicting evidence and methodological issues exist in studies on influencing factors.
BEHAVIORAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Wenhua Ren, Yumeng Qi, Yan Liu, Yayun Yan, Xiaoqi Zheng, Shuxian Jin, Ying Chang
Summary: This study determined the prevalence of impulse control disorder (ICD) in Parkinson's disease (PD) patients in northern China and analyzed the associated risk factors. The results showed that ICD was associated with disease duration, motor symptoms, dyskinesia, depression, REM sleep behavior disorder (RBD), and cognitive decline. Multiple ICDs were related to coffee history, motor symptoms, dyskinesia, depression, apathy, and RBD. The prediction model demonstrated good performance.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
