Article
Clinical Neurology
Keitaro Ogaki, Hiroaki Fujita, Narihiro Nozawa, Tomohiko Shiina, Hirotaka Sakuramoto, Keisuke Suzuki
Summary: The study aimed to identify the contributors to sleep disturbances, including insomnia, restless legs syndrome, rapid eye movement sleep behavior disorder (RBD), sleep-disordered breathing, nocturnal akinesia and excessive daytime sleepiness (EDS), in patients with Parkinson's disease (PD). The results showed that autonomic symptoms were associated with sleep disturbances or EDS, and depressive and RBD symptoms in addition to autonomic symptoms were associated with both sleep disturbances and EDS in patients with PD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Yezhou Li, Jing Wang, Lirong Ji, Chaohong Cheng, Tong Su, Shuqing Wu, Fei Han, Daniel J. Cox, Erlei Wang, Rui Chen
Summary: This study aims to investigate the effects of excessive daytime sleepiness on cortical thickness in patients with obstructive sleep apnoea. It was found that the cortical thickness was significantly thinner in the sleepiness group, particularly in the left temporal, frontal, and parietal lobe, and bilateral pre- and postcentral gyri. There was a significant negative correlation between the cortical thickness and the Epworth Sleepiness Scale score.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Anatilde Trindade, Catarina Custodio, Jorge Cabral, Telma Lopes, Vera Martins, Margarida Aguiar, Ines Goncalves, Sofia Furtado
Summary: This study aimed to compare the adherence to positive airway pressure (PAP) therapy between patients with or without excessive daytime sleepiness (EDS) in different severities of obstructive sleep apnea (OSA). The results showed that there were differences in adherence between patients with different severities of OSA but without EDS. However, there was no difference in adherence between patients with or without EDS, regardless of the severity.
Article
Clinical Neurology
Jean-Christophe Corvol, Jean-Philippe Azulay, Bjorn Bosse, Yves Dauvilliers, Luc Defebvre, Fabian Klostermann, Norbert Kovacs, David Maltete, William G. Ondo, Rajesh Pahwa, Werner Rein, Stephane Thobois, Martin Valis, Aleksandar Videnovic, Olivier Rascol
Summary: The study of THN102 in PD patients with EDS showed that the 200/2 dose demonstrated efficacy and good tolerability, supporting further development. On the other hand, the 200/18 dose did not show significant improvement.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Henrik Holtstrand Hjalm, Erik Thunstrom, Helena Glantz, Martin Karlsson, Yeliz Celik, Yuksel Peker
Summary: There is an independent and dose-response relationship between the severity of obstructive sleep apnea (OSA) and prevalent atrial fibrillation (AF), especially among individuals without excessive daytime sleepiness (EDS).
Article
Behavioral Sciences
Yuan Shen, Haicun Shi, JianGuo Zhong, PingLei Pan, ShuFang Wang, MingZhu Chen, ZhiPeng Chen, ChunFeng Liu
Summary: This study aimed to explore the factors correlated with excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD). The findings revealed that fatigue and respiratory-related microarousal index were independent risk factors for EDS in PD patients. Fragmented sleep and pathological abnormalities of the central nervous system resulting in changes in arousal are speculated to be major influencing factors of EDS in PD.
BRAIN AND BEHAVIOR
(2023)
Article
Biology
Helena Martynowicz, Rafal Poreba, Tomasz Wieczorek, Zygmunt Domagala, Robert Skomro, Anna Wojakowska, Sylwia Winiewska, Piotr Macek, Grzegorz Mazur, Pawel Gac
Summary: The aim of this study was to examine the sleep patterns and daytime sleepiness in patients with erectile dysfunction. The researchers studied 280 patients, with 107 of them reporting erectile dysfunction, and 173 without a history of erectile dysfunction serving as the control group. The results showed that patients with erectile dysfunction had altered sleep architecture, lower oxygen saturation levels, and increased daytime sleepiness compared to the control group.
Article
Clinical Neurology
Gianpaolo Maggi, Carmine Vitale, Francesco Cerciello, Gabriella Santangelo
Summary: Sleep disorders are common in Parkinson's disease and have variable prevalence rates. They are multifactorial in etiology, resulting from degenerative processes, drug interactions, and clinical features. A meta-analytic study found that RBD had a prevalence of 46% and was associated with older age, lower education, longer disease duration, higher medication doses, and more severe symptoms. EDS had a prevalence of 35% and was associated with older age, longer disease duration, more severe symptoms, higher medication doses, and reduced autonomy. Insomnia was reported in 44% of patients and was related to longer disease duration, higher medication doses, and more severe depression. Sleep disorders are associated with a more severe clinical phenotype of Parkinson's disease, and further research is needed to understand their underlying mechanisms and develop targeted therapies.
SLEEP MEDICINE REVIEWS
(2023)
Review
Clinical Neurology
Fei Feng, YingYing Cai, YanBing Hou, Ruwei Ou, Zheng Jiang, HuiFang Shang
Summary: The study found that approximately one-third of patients with Parkinson's disease (PD) had excessive daytime sleepiness (EDS), which may be associated with the severity of the disease, depression symptoms, male sex, and medication.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Sijie Cai, Zhiqiang Li, Jing Wang, Qiaojun Wang, Rui Chen
Summary: The aim of this study was to investigate the impact of excessive daytime sleepiness (EDS) on cognitive function among young and middle-aged Chinese patients with obstructive sleep apnea (OSA). The results showed that patients with moderate to severe OSA had cognitive dysfunction, specifically impaired delayed recall. Excessive daytime sleepiness was significantly associated with cognitive dysfunction in this population.
SLEEP AND BREATHING
(2023)
Article
Multidisciplinary Sciences
Changxiu Ma, Ying Zhang, Jiuyu Liu, Gengyun Sun
Summary: The study evaluated the new parameter AHT% for assessing nocturnal hypoxaemia and excessive daytime sleepiness in patients with obstructive sleep apnoea, comparing it with the traditional AHI. Results showed that AHT% was superior to AHI in predicting excessive daytime sleepiness and better reflected the clinical characteristics of patients with obstructive sleep apnoea.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Ying Huang, Sidan Du, Durong Chen, Yao Qin, Jing Cui, Hongjuan Han, Xiaoyan Ge, Wenlin Bai, Xinnan Zhang, Hongmei Yu
Summary: This study found that excessive daytime sleepiness (EDS) can affect the activities of daily living (ADL) in Parkinson's disease (PD) patients through autonomic dysfunction. As the disease progresses, EDS and autonomic dysfunction worsen while ADL decreases in PD patients. The severity of EDS symptoms is positively associated with the severity of autonomic dysfunction symptoms, leading to a decrease in ADL. Autonomic dysfunction partially mediates the relationship between EDS and ADL, indicating a longitudinal mediation effect.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Simon J. Schreiner, Esther Werth, Leonie Ballmer, Philipp O. Valko, Kai M. Schubert, Lukas L. Imbach, Christian R. Baumann, Angelina Maric, Heide Baumann-Vogel
Summary: This study found that excessive daytime sleepiness (EDS) in Parkinson disease (PD) is associated with nocturnal sleep disturbance, as indicated by reduced overnight slow-wave activity (SWA) decline and reduced spindle frequency activity.
Article
Medicine, General & Internal
Michael A. Grandner, Jae S. Min, Ragy Saad, Eileen B. Leary, Lev Eldemir, Danielle Hyman
Summary: Approximately 1 billion people worldwide have obstructive sleep apnea (OSA) and experience excessive daytime sleepiness (EDS), which has negative impacts on their health, behavioral choices, and lifestyle. This study reveals that people with OSA and EDS have higher rates of anxiety, depression, insomnia, and impairments in daytime functioning. EDS also prevents physical activity and influences dietary choices.
POSTGRADUATE MEDICINE
(2023)
Article
Clinical Neurology
Ming Liu, Ya-Jun Luo, Han-Ying Gu, Yi-Ming Wang, Man-Hua Liu, Kai Li, Jiao Li, Sheng Zhuang, Yun Shen, Hong Jin, Jing Chen, Cheng-Jie Mao, Chun-Feng Liu
Summary: Gender and age at onset have an impact on excessive daytime sleepiness and night-time sleep quality in Parkinson's disease patients. Depression is a common risk factor for both EDS and poor sleep quality in PD patients. More attention is needed for sleep disorders in male late-onset PD patients.
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)