Article
Clinical Neurology
Francesco Cavallieri, Carla Budriesi, Annalisa Gessani, Sara Contardi, Valentina Fioravanti, Elisa Menozzi, Serge Pinto, Elena Moro, Franco Valzania, Francesca Antonelli
Summary: The study demonstrates that levodopa has a negative effect on speech acoustic parameters in Parkinson's disease patients. The intensity and location of dyskinesia negatively impact speech quality.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Yang Luo, Huiqin Chen, Mingzhen Gui
Summary: This study aimed to predict early levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) using radiomics and machine learning models. The results showed that hybrid models combining radiomics features and clinical features had good performance in predicting early LID in PD.
Article
Neurosciences
Melina P. Bordone, Ana Damianich, Alejandra Bernardi, Tomas Eidelman, Sara Sanz-Blasco, Oscar S. Gershanik, M. Elena Avale, Juan E. Ferrario
Summary: The study aimed to alleviate levodopa-induced dyskinesia in Parkinson's disease by reducing Fyn expression. Preadministration of miRNA-Fyn was effective in reducing LID, while post-L-DOPA delivery of miRNA-Fyn was less effective in reverting established dyskinesia. The findings suggest that early blocking of Fyn activity may be a more efficient therapeutic approach.
Article
Neurosciences
Matthias Loehle, Alexander Bremer, Florin Gandor, Jonathan Timpka, Per Odin, Georg Ebersbach, Alexander Storch
Summary: This study compared the validity of motor state quantification between the Parkinson's disease (PD) home diary and direct clinical observation in fluctuating PD patients. The results showed that the home diary inadequately reflects actual motor states compared to direct clinical observation.
NPJ PARKINSONS DISEASE
(2022)
Review
Neurosciences
Nayoung Kwak, Jinyoung Park, Hye-Young Kang, Myung-Jun Lee, Jae Kyung Suh, Hankil Lee
Summary: The results of the study indicate that as an adjuvant therapy to levodopa, opicapone can reduce dyskinesias and prolong the symptom-free on-time in patients with Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Cell Biology
Rob Powers, Maryam Etezadi-Amoli, Edith M. Arnold, Sara Kianian, Irida Mance, Maxsim Gibiansky, Dan Trietsch, Alexander Singh Alvarado, James D. Kretlow, Todd M. Herrington, Salima Brillman, Nengchun Huang, Peter T. Lin, Hung A. Pham, Adeeti Ullal
Summary: The Motor fluctuations Monitor for Parkinson's Disease (MM4PD) is an ambulatory monitoring system that tracks fluctuations in resting tremor and dyskinesia, correlated to clinical evaluations and expert ratings. It has potential to support patient-clinician communication and medication adjustments.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ana Gabrielle Bispo, Caio S. Silva, Camille Sena-dos-Santos, Dafne Dalledone Moura, Brenda Hanae Bentes Koshimoto, Bruno Lopes Santos-Lobato, Andrea Ribeiro-dos-Santos, Giovanna C. Cavalcante
Summary: Mitophagy dysfunction caused by gene mutations is associated with the development of Parkinson's Disease (PD). However, the association between the variants of mitophagy-related genes and the treatment with levodopa (LD) in PD patients has not been well explored. This study investigated the association of 14 variants of the PRKN gene with LD treatment in PD patients. The results suggest that while age at onset of symptoms, duration of PD, and LD treatment and dosage can influence the occurrence of dyskinesia, the investigated PRKN variants did not show a significant association.
Review
Pharmacology & Pharmacy
Peter Kempster, Andrew Ma
Summary: A large proportion of drugs for neurological disorders are derived from naturally occurring compounds, especially plant alkaloids. The treatment of Parkinson's disease has strong botanical origins, with plant-derived substances playing a significant role. The interaction between plant compounds and animal dopaminergic systems has deep evolutionary roots.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Asha Kishore, Praveen James, Parvathy Rajeswari, Gangadhara Sarma, Syam Krishnan, Sabine Meunier, Traian Popa
Summary: Depotentiation mechanisms of heterosynaptic plasticity are preserved in Parkinson's disease patients, indicating the potential for reversing abnormal brain plasticity. Cerebellar stimulation enhances heterosynaptic plasticity in both dyskinetic and non-dyskinetic PD patients, suggesting a possible therapeutic target for improving motor symptoms.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Pharmacology & Pharmacy
Ritam Bandopadhyay, Nainshi Mishra, Ruhi Rana, Gagandeep Kaur, Mohammed M. Ghoneim, Sultan Alshehri, Gulam Mustafa, Javed Ahmad, Nabil. A. Alhakamy, Awanish Mishra
Summary: This study focuses on the recent updates in molecular mechanisms and therapeutic approaches for the effective management of levodopa-induced dyskinesia (LID) in Parkinson's disease patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Matthias Loehle, Jonathan Timpka, Alexander Bremer, Hamid Khodakarami, Florin Gandor, Malcom Horne, Georg Ebersbach, Per Odin, Alexander Storch
Summary: This study examined the accuracy of a wearable accelerometer-based digital Parkinson's Motor Diary in measuring motor states of advanced Parkinson's disease. The results showed moderate validity of the device in measuring Off and Dyskinetic state, but limited temporal agreement with the clinical observer diary data.
NPJ DIGITAL MEDICINE
(2023)
Review
Neurosciences
Ivan Castela, Ledia F. Hernandez
Summary: The study reviews the dopamine replacement therapy with L-DOPA commonly used in the treatment of Parkinson's disease, focusing on the role of the striatal direct and indirect pathways in the pathological motor consequences. It discusses how alterations in the efferent circuitry of the striatum and changes in synaptic plasticity and firing patterns can contribute to dyskinesia development. Recent findings suggest that an imbalance in the activity between both striatal pathways is sufficient to cause dyskinesia in both rodent and primate models of Parkinson's disease.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Danny Spampinato, Esin Avci, John Rothwell, Lorenzo Rocchi
Summary: Cerebellar transcranial alternating current stimulation (tACS) can specifically enhance cerebellar motor cortex (M1) inhibition, particularly during the application of 5Hz tACS. The effects of 5Hz tACS appear to be site-specific and do not induce long-lasting effects.
Article
Neurosciences
Nayron Medeiros Soares, Gabriela Magalhaes Pereira, Ana Carolina Leonardi Dutra, Nathalie Ribeiro Artigas, Julia Schneider Krimberg, Bruno Elkfury Monticelli, Artur Francisco Schumacher-Schuh, Rosa Maria Martins de Almeida, Carlos Roberto de Mello Rieder
Summary: This study investigated the relationship between serum uric acid (UA) levels and levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) patients, as well as the associations between UA levels and clinical features of PD. The results showed that the dyskinesia group had lower serum UA levels compared to the no dyskinesia group, which was also observed in both men and women. Multivariate analysis demonstrated that lower UA levels were significantly associated with the presence of dyskinesia. Additional analysis revealed that serum UA levels were inversely correlated with depressive symptoms, disease duration, MDS-UPDRS IV, and time spent with dyskinesia, while positively correlated with age at onset of PD symptoms.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Review
Health Care Sciences & Services
Anirudha S. Chandrabhatla, I. Jonathan Pomeraniec, Alexander Ksendzovsky
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor impairments. Researchers have developed in-home automated methods to monitor PD symptoms using technology and machine learning algorithms. Significant progress has been made in monitoring PD motor symptoms over the past five decades.
NPJ DIGITAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Luca Filippi, Agostino Chiaravalloti, Pietro Basile, Orazio Schillaci, Oreste Bagni
Summary: Prostate cancer is one of the most common tumors in males and a major cause of death in Western countries. When standard treatment fails, novel therapies have dramatically improved the prognosis of advanced prostate cancer. However, there is a need for imaging biomarkers to assess treatment response and personalize therapeutic approaches.
CURRENT MOLECULAR MEDICINE
(2022)
Review
Pathology
Luca Filippi, Orazio Schillaci, Barbara Palumbo
Summary: Molecular neuroimaging with Tau-PET is an intriguing tool for the in vivo detection and monitoring of neuropathological hallmarks associated with CTE. Novel tracers, such as TSPO-ligands, hold promise for understanding the complex mechanisms leading from brain injury to symptomatic CTE.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Neurosciences
Elias Paolo Casula, Gaetano Tieri, Lorenzo Rocchi, Rachele Pezzetta, Michele Maiella, Enea Francesco Pavone, Salvatore Maria Aglioti, Giacomo Koch
Summary: Immersive virtual reality can lead to a strong feeling of embodiment over artificial body parts, but the neural mechanisms behind this phenomenon are not yet fully understood. By tracking real-time brain dynamics, researchers found that observing virtual body parts is associated with a rapid decrease in cortical activity in the hand region of the primary motor cortex, as well as rapid changes in activity within a fronto-parietal circuit. These findings suggest that changes in bodily representations are supported by dynamic interactions within a highly plastic network.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Nicoletta Urbano, Manuel Scimeca, Elena Bonanno, Orazio Schillaci
Summary: This pilot study evaluated the capability of a digital autoradiography system to perform biodistribution evaluation of [F-18] choline in a xenograft mouse model of prostate cancer. The results showed that the system could accurately assess the biodistribution of the radiopharmaceutical and demonstrate tumor-specific uptake. Immunohistochemical analysis also confirmed a strong correlation between [F-18] choline uptake and tumor proliferation index.
CURRENT RADIOPHARMACEUTICALS
(2022)
Article
Neurosciences
Lucia Mencarelli, Lucia Monti, Sara Romanella, Francesco Neri, Giacomo Koch, Ricardo Salvador, Giulio Ruffini, Giulia Sprugnoli, Simone Rossi, Emiliano Santarnecchi
Summary: This study found that stimulating the left and right DLPFC with 40 Hz tACS can increase blood oxygenation level-dependent activity in the targeted DLPFCs and surrounding areas according to biophysical modeling. However, off-target effects on visual cortices, SMA, left subgenual cingulate, and right superior temporal gyrus were also observed.
Article
Clinical Neurology
Giacomo Koch, Elias Paolo Casula, Sonia Bonni, Ilaria Borghi, Martina Assogna, Marilena Minei, Maria Concetta Pellicciari, Caterina Motta, Alessia D'Acunto, Francesco Porrazzini, Michele Maiella, Clarissa Ferrari, Carlo Caltagirone, Emiliano Santarnecchi, Marco Bozzali, Alessandro Martorana
Summary: In a 24-week trial, repetitive transcranial magnetic stimulation of the precuneus was found to slow down cognitive and functional decline in patients with Alzheimer's disease. The study suggests that targeting the default mode network could be a novel therapeutic approach for Alzheimer's disease patients.
Editorial Material
Engineering, Biomedical
Luca Filippi, Antonia Dimitrakopoulou-Strauss, Laura Evangelista, Orazio Schillaci
EXPERT REVIEW OF MEDICAL DEVICES
(2022)
Letter
Clinical Neurology
Giacomo Koch, Alessandro Martorana
Editorial Material
Engineering, Biomedical
Luca Filippi
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Review
Oncology
Laura Evangelista, Viviana Frantellizzi, Orazio Schillaci, Luca Filippi
Summary: This study reviewed the application of radiolabeled-FAPI in patients with pancreatic cancer, discussing its advantages, disadvantages, and future prospects, especially in the field of theragnostic. A literature search was performed in PubMed, EBSCO, and EMBASE databases, and 21 studies were selected for comprehensive analysis. The results showed that FAPI could better detect pancreatic malignant lesions, but further prospective studies are needed to validate its effectiveness.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Review
Pathology
Luca Filippi, Luca Urso, Francesco Bianconi, Barbara Palumbo, Maria Cristina Marzola, Laura Evangelista, Orazio Schillaci
Summary: In the past decade, two new radionuclide-based therapies, (223)Radichloride and radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA), have been approved for the management of castrate-resistant prostate cancer (PCa). This article illustrates the basic principles of PCa molecular imaging, with a focus on the combined use of diagnosis and therapy for response prediction and assessment. Radiomics, an emerging discipline based on quantitative features extracted from medical images, is also discussed for its potential in this field.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Review
Gastroenterology & Hepatology
Luca Filippi, Laura Evangelista, Orazio Schillaci
Summary: TARE with Y-90-labeled microspheres and ICIs has been effectively used for the treatment of advanced HCC and hepatic metastases. The potential synergy between Y-90-microspheres and ICIs in integrated therapeutic regimens is of great interest.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Clinical Neurology
Matilde Bruno, Chiara Giuseppina Bonomi, Francesco Ricci, Martina Gaia Di Donna, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana, Caterina Motta
Summary: This study investigated the relationship between BBB permeability and neuroinflammation in AD patients. The findings suggest that different neuroinflammatory profiles can be associated with different levels of BBB permeability in AD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Oncology
Luca Filippi, Orazio Schillaci
Summary: The study by Duan et al. introduces a promising molecular imaging technique that could aid in patient selection for EV therapy and the development of targeted drugs for UC. It also highlights the potential of LAFOV PET/CT in enhancing imaging precision and expanding future therapeutic possibilities for UC.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Article
Engineering, Biomedical
Luca Filippi, Oreste Bagni, Orazio Schillaci
Summary: Digital PET/CT with F-18-FACBC was evaluated in patients with early castration-resistant prostate cancer, and it was found that F-18-FACBC dPET/CT can detect M1 metastasis in 33.3% of patients, significantly impacting clinical management.
EXPERT REVIEW OF MEDICAL DEVICES
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
