Markers of inflammation in prevalent and incident Parkinson's disease in the Cardiovascular Health Study

Background: Studies demonstrate existence of inflammation in prevalent Parkinson's disease (PD). We assessed associations of baseline levels of inflammatory markers with prevalent PD at baseline (1989) and incident PD identified over 13 years of follow-up of the Cardiovascular Health Study. Methods: Blood samples at baseline were measured for fibrinogen, interleukin-6, tumor necrosis factor-alpha, C-reactive protein, albumin, and white blood cells. The analysis included 60 prevalent and 154 incident PD cases. Results: Risk of prevalent PD was significantly higher per doubling of IL-6 among women (odds ratio [OR] = 1.5, 95% confidence interval [CI]: 1.0, 2.4) and WBC among men (OR: 2.4, 95% Cl: 1.2, 4.9) in multivariate models. Risk of incident PD was not associated with higher levels of any biomarker after adjusting for age, smoking, African American race, and history of diabetes. Inverse associations with incident PD were observed per doubling of C-reactive protein (OR = 0.9; 95% Cl: 0.8, 1.0) and of fibrinogen among women (OR = 0.4; 95% Cl: 0.2, 0.8). Conclusions: Although inflammation exists in PD, it may not represent an etiologic factor. Our findings suggest the need for larger studies that measure inflammatory markers before PD onset. Published by Elsevier Ltd.