Article
Surgery
Kasiemobi E. Pulliam, Bernadin Joseph, Amy T. Makley, Charles C. Caldwell, Alex B. Lentsch, Michael D. Goodman, Timothy A. Pritts
Summary: A novel storage solution for packed red blood cells was developed, which mitigated the storage lesion and inflammatory response after resuscitation. This solution shows promise in improving the storage quality and reducing harm after massive transfusion.
Article
Immunology
Maria Sebti, Camille Petit-Hoang, Btissam Chami, Etienne Audureau, Catherine Cordonnier-Jourdin, Muriel Paul, Franck Pourcine, Philippe Grimbert, Clement Ourghanlian, Marie Matignon
Summary: This study compared the impact of anti-thymocyte globulins (ATGs) on hematological parameters in kidney transplant recipients. The results showed that ATG-F was associated with a higher need for red blood cell transfusions and early thrombocytopenia compared to Thymo. However, there was no difference in the incidence of rejection, infections, or the prevalence of antibodies between the two groups.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Stacey Uter, Hyun Hyung An, Grace E. Linder, Stephan Kadauke, Deborah Sesok-Pizzini, Haewon C. Kim, David F. Friedman, Stella T. Chou
Summary: The study successfully reduced the number of red blood cell units required by patients undergoing chronic red cell exchange during the COVID-19 pandemic by implementing two measures, maintaining pretransfusion HbS% target goals and minimizing iron accumulation.
Article
Obstetrics & Gynecology
Anne Brynolf, Anna Sandstrom, Gustaf Edgren
Summary: The risk of recurrent maternal red-cell transfusion in delivery is higher for women with a history of red-cell transfusion in previous deliveries. In contrast, women without a history of red-cell transfusion are less likely to require transfusion during delivery.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Jeffrey L. Carson, Simon J. Stanworth, Gordon Guyatt, Stacey Valentine, Jane Dennis, Sara Bakhtary, Claudia S. Cohn, Allan Dubon, Brenda J. Grossman, Gaurav K. Gupta, Aaron S. Hess, Jessica L. Jacobson, Lewis J. Kaplan, Yulia Lin, Ryan A. Metcalf, Colin H. Murphy, Katerina Pavenski, Micah T. Prochaska, Jay S. Raval, Eric Salazar, Nabiha H. Saifee, Aaron A. R. Tobian, Cynthia So-Osman, Jonathan Waters, Erica M. Wood, Nicole D. Zantek, Monica B. Pagano
Summary: This study provides recommendations for the use of red blood cell transfusion in adults and children. Based on the evidence from randomized controlled trials, it is suggested that restrictive transfusion thresholds do not have adverse effects on patient-important outcomes for most patient populations. Therefore, transfusion may be considered when the hemoglobin concentration is less than 7 g/dL.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Veterinary Sciences
S. L. Blois, H. Marshall, A. C. G. Abrams-Ogg, A. M. Bersenas, K. Ruotsalo, G. Monteith
Summary: This study aimed to compare the accuracy of gel-based and laboratory-based crossmatch testing, and describe the incidence of major crossmatch incompatibility in cats. There was poor agreement between the two testing methods, and previously-transfused cats had higher rates of incompatibility. History of previous transfusion was identified as the main risk factor for incompatibility in cats.
VETERINARY JOURNAL
(2021)
Article
Medicine, General & Internal
Sondos Zayed, Timothy K. Nguyen, Cindy Lin, Gabriel Boldt, Sushil Beriwal, Carien L. Creutzberg, Mitchell Kamrava, Lucas C. Mendez, Vikram Velker, Corinne Doll, Amandeep Taggar, Eric Leung, David P. D'Souza
Summary: This study aimed to develop consensus statements to guide PRBC transfusion practices in patients with cervical cancer receiving curative-intent RT with EBRT and brachytherapy, using an international Delphi consensus method. Through the consensus, a hemoglobin transfusion target of 9 g/dL or more and less than 12 g/dL was endorsed for patients who receive a PRBC transfusion.
Article
Medicine, General & Internal
Senta Jorinde Raasveld, Sanne de Bruin, Merijn C. Reuland, Claudia Van den Oord, Jimmy Schenk, Cecile Aubron, Jan Bakker, Maurizio Cecconi, Aarne Feldheiser, Jens Meier, Marcella C. A. Mueller, Thomas W. L. Scheeren, Zoe Mcquilten, Andrew Flint, Tarikul Hamid, Michael Piagnerelli, Tina Tomic Mahecic, Jan Benes, Lene Russell, Hernan Aguirre-Bermeo, Konstantina Triantafyllopoulou, Vasiliki Chantziara, Mohan Gurjar, Sheila Nainan Myatra, Vincenzo Pota, Muhammed Elhadi, Ryszard Gawda, Mafalda Mourisco, Marcus Lance, Vojislava Neskovic, Matej Podbregar, Juan V. Llau, Manual Quintana-Diaz, Maria Cronhjort, Carmen A. Pfortmueller, Nihan Yapici, Nathan D. Nielsen, Akshay Shah, Harm-Jan de Grooth, Alexander P. J. Vlaar, InPUT Study Grp
Summary: Red blood cell transfusion was common among patients admitted to the intensive care unit (ICU) between 2019 and 2022, with high variability in transfusion practices across centers.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Hematology
Eric A. Gehrie, Bipin N. Savani, Garrett S. Booth
Summary: Advancements in laboratory testing, pathogen reduction, and donor qualification have significantly reduced the risk of infection from blood transfusions. However, the prevention and recognition of hemolytic reactions, particularly due to donor-recipient incompatibility, have seen little recent progress. The article discusses the role of compatibility testing and transfusion practices in acute hemolysis, emphasizing clinical scenarios with increased risk and outlining initial clinical management for severe hemolytic reactions.
Article
Immunology
Rebekka Mispelbaum, Sandra Tessa Hattenhauer, Peter Brossart, Annkristin Heine
Summary: This study demonstrates that administration of red blood cell transfusion during immunotherapy, but not before, negatively affects response rates. The findings suggest a need for restrictive transfusion management in patients undergoing immunotherapy to optimize response rates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physiology
Pierre Raeven, Gerhard Hagn, Laura Niederstaetter, Jonas Brugger, Sophia Bayer-Blauensteiner, Christoph Domenig, Konrad Hoetzenecker, Martin Posch, Gerda Leitner, Christopher Gerner, David M. M. Baron
Summary: This study analyzed the changes in the levels of eicosanoids in the plasma of postoperative ICU patients before and after transfusion. The results showed that the levels of these substances increased in the stored red blood cell component and were widely present in the plasma before transfusion. This study demonstrates the importance of further research on the role of eicosanoids in transfusion-related immunomodulation.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Physiology
Timothy J. McMahon, Cole C. Darrow, Brooke A. Hoehn, Hongmei Zhu
Summary: Metabolic homeostasis in animals relies on the evolved mechanisms of how red blood cell hemoglobin senses oxygen needs and responds accordingly. The dynamic control of ATP production and antioxidant systems within the RBC helps adapt to physiological and pathophysiological stresses. Impairments in the ability of RBCs to adapt to the metabolic environment can occur in various diseases and conditions, but emerging therapies may offer clinical interventions to optimize or correct RBC function via metabolite delivery mechanisms.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Ordono Alonso-Tunon, Manuel Bertomeu-Cornejo, Isabel Castillo-Cantero, Jose Miguel Borrego-Dominguez, Emilio Garcia-Cabrera, Luis Bejar-Prado, Angel Vilches-Arenas
Summary: The objective of this study was to develop a simple prediction model to determine the risk of blood transfusion in cardiac surgery. By studying the data of patients who underwent cardiac surgery, we identified age, sex, BMI, perioperative hemoglobin level, and type of surgery as predictors of transfusion risk. We developed a predictive model that showed good discriminatory ability in predicting the risk of transfusion in cardiac surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Gagan Mathur, Matthew B. Wilkinson, Eddie R. Island, Jay E. Menitove, Lowell Tilzer
Summary: This case highlights the importance of knowing a patient's antibody history and emphasizes the need for a national registry of RBC antibodies to improve patient safety and outcomes.
Article
Critical Care Medicine
Seyed Hamid Salehi, Maziar Daniali, Paniz Motaghi, Mahnoush Momeni
Summary: A study on adjusting transfusion thresholds for burn patients found that a more restrictive transfusion strategy significantly reduces the number of transfusions without increasing complications or mortality rates, while also saving costs and reducing infection rates.