Journal
PARKINSONISM & RELATED DISORDERS
Volume 15, Issue -, Pages S43-S45Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1353-8020(09)70012-4
Keywords
Parkin; Gene therapy; AAV; alpha-Synuclein
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The search for genetic mutations responsible for familial forms of Parkinson's disease (PD) hits identified several penes and loci. Mutations in the parkin gene are linked to autosomal recessive juvenile parkinsonism. The genetic Forms of PD are uncommon, but gene therapy targeting alpha-synuclein. Parkin. or other pathways may be also applicable for idiopathic PD. Intriguingly. several Studies suggest that parkin (gene therapy could be useful in a Subset of PD patients with Mutations in the alpha-synuclein gene. Furthermore, if parkin overexpression call correct neuronal degeneration in the substantia nigra and striatum, it Might be a potentially effective therapy for alpha-synucleinopathy. (c) 2008 Elsevier Ltd. All rights reserved.
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