Review
Medicine, General & Internal
Paloma Moreta-de-Esteban, Patricia Martin-Casas, Rosa Maria Ortiz-Gutierrez, Sofia Straudi, Roberto Cano-de-la-Cuerda
Summary: Resting tremor is a common motor manifestation in Parkinson's disease (PD) patients. Mobile applications using the measurement components of smartphones show potential for objectively assessing resting tremor in PD, but validation studies are lacking. This systematic review identified 13 apps in mobile markets for assessing resting tremor in PD, meeting an average of 85.09% of the recommendations for medical mobile app development.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Luciano Brinck Peres, Bruno Coelho Calil, Ana Paula Sousa Paixao Barroso da Silva, Valdeci Carlos Dionisio, Marcus Fraga Vieira, Adriano de Oliveira Andrade, Adriano Alves Pereira
Summary: Parkinson's disease is a neurological disorder that affects the motor system and has a significant impact on the individual's quality of life. This study proposed a method based on inertial sensor recordings to differentiate individuals with PD from healthy groups, showing promising results for the accurate diagnosis and classification of PD patients.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Chemistry, Analytical
Christina van der Linden, Thea Berger, Gregor A. Brandt, Joshua N. Strelow, Hannah Jergas, Juan Carlos Baldermann, Veerle Visser-Vandewalle, Gereon R. Fink, Michael T. Barbe, Jan Niklas Petry-Schmelzer, Till A. Dembek
Summary: Clinical rating scales for tremor have limitations, and reliable quantitative approaches are needed. This study investigated the use of accelerometry metrics to objectively classify tremor amplitude and compared them to clinical ratings. The results showed that accelerometry can reliably quantify tremor amplitude, with finger-worn accelerometry performing slightly better.
Article
Clinical Neurology
Michiel F. Dirkx, James M. Shine, Rick C. Helmich
Summary: Fluctuations in cerebral integration and arousal drive spontaneous fluctuations in PD rest tremor. Increasing cerebral integration and enhanced arousal amplify PD tremor activity. Attenuating enhanced cerebral integration may reduce tremor in PD.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Asma Channa, Oana Cramariuc, Madeha Memon, Nirvana Popescu, Nadia Mammone, Giuseppe Ruggeri
Summary: Resting tremor refers to a complete repose of a body part that often dampens or subsides entirely with action. The most common cause of resting tremors is idiopathic Parkinson's disease (PD). This study analyzed the severity of an imbalanced dataset of PD patients and found that the oversampling method performed better than undersampling and hybrid sampling techniques.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Yuke Zhong, Hang Liu, Guohui Liu, Yi Liang, Chengcheng Dai, Lili Zhao, Hongyu Lai, Lijuan Mo, Changhong Tan, Fen Deng, Xi Liu, Lifen Chen
Summary: This study used diffusion tensor imaging (DTI) to investigate white matter alterations in the cerebrum and cerebellum in Parkinson's disease patients with resting tremor. The results showed better white matter integrity in the cerebrum and cerebellum, suggesting a potential association between white matter and resting tremor in this disease.
Article
Chemistry, Analytical
Luis Sigcha, Ignacio Pavon, Nelson Costa, Susana Costa, Miguel Gago, Pedro Arezes, Juan Manuel Lopez, Guillermo De Arcas
Summary: A novel approach using smartwatches and multitask classification models can accurately assess resting tremor in Parkinson's disease patients without interfering with their daily lives. Results show high agreement with clinical assessments, indicating the potential for early-stage disease monitoring and improvement of Parkinson's disease clinical evaluation.
Article
Medicine, General & Internal
Basilio Vescio, Rita Nistico, Antonio Augimeri, Andrea Quattrone, Marianna Crasa, Aldo Quattrone
Summary: This study developed a new low-cost, wearable mobile device called mu EMG for the automated and quantitative characterization of resting tremor patterns in ambulatory clinical settings. The results showed good agreement with standard EMG and demonstrated that tremor analysis using mu EMG is easy to perform and operator-independent for routine clinical practice.
Review
Clinical Neurology
Michiel F. Dirkx, Matteo Bologna
Summary: This article reviews the dysfunctional network underlying tremor in PD, discusses the oscillations and synchronization changes in two central motor circuits, and emphasizes the pathophysiological consequences of the abnormal interaction between the two systems.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yina Lan, Xinyun Liu, ChunYu Yin, Jinhao Lyu, Xiaoxaio Ma, Zhiqiang Cui, Xuemei Li, Xin Lou
Summary: This study examined spontaneous brain activity patterns in different subtypes of Parkinson's disease (tremor dominant and postural instability gait difficulty). The results showed that patients with postural instability gait difficulty had increased activity in certain regions of the brain, suggesting a compensatory mechanism for altered motor function. In contrast, patients with tremor dominant had lower activity levels in certain regions. These findings provide insights into the neural mechanisms underlying different subtypes of Parkinson's disease.
Article
Engineering, Biomedical
Junjie Li, Huaiyu Zhu, Jiaxiang Li, Haotian Wang, Bo Wang, Wei Luo, Yun Pan
Summary: This study proposes a wearable system for assessing upper limb tremor and differentiating between Parkinson's disease and essential tremor. The system collects tremor data from the wrist and fingers simultaneously and extracts multi-segment features to perform the differential diagnosis using support vector machine classifiers. The system demonstrated high accuracy in diagnosing Parkinson's disease versus essential tremor in real-world settings.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Clinical Neurology
Mario Stanziano, Nico Golfre Andreasi, Giuseppe Messina, Sara Rinaldo, Sara Palermo, Mattia Verri, Greta Demichelis, Jean Paul Medina, Francesco Ghielmetti, Salvatore Bonvegna, Anna Nigri, Giulia Frazzetta, Ludovico D'Incerti, Giovanni Tringali, Francesco DiMeco, Roberto Eleopra, Maria Grazia Bruzzone
Summary: Magnetic resonance-guided high-intensity focused ultrasound is a non-invasive alternative treatment for tremor. This study found that the treatment modulated resting state functional connectivity within the tremor network and these changes were associated with clinical outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Patrick M. Fisher, Simon S. Albrechtsen, Vardan Nersesjan, Moshgan Amiri, Daniel Kondziella
Summary: This study investigates the functional connectivity of a middle-aged man after hemispherectomy, revealing increased between-network connectivity in the preserved hemisphere. This suggests that the brain can reorganize its connections to restore consciousness and cognitive functions after the loss of one hemisphere.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Rita Nistico, Andrea Quattrone, Marianna Crasa, Marida De Maria, Basilio Vescio, Aldo Quattrone
Summary: This study compared the electrophysiological features of rest tremor (RT) across different positions in tremor-dominant Parkinson's disease (PD) and essential tremor plus (ET with RT, rET) patients. The findings showed that RT was present in all PD and rET patients in the hand-hanging position, and supine and standing RT were more common in PD patients. However, only the RT pattern was significantly different between PD and rET patients in all positions.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Sahar Yassine, Ute Gschwandtner, Manon Auffret, Joan Duprez, Marc Verin, Peter Fuhr, Mahmoud Hassan
Summary: In this study, different sub-phenotypes of Parkinson's disease (PD) were identified based on electrophysiological profiles obtained from resting-state electroencephalography (RS-EEG). These sub-phenotypes showed distinct disruptions in various brain networks and were predictive of disease outcome. EEG features were also able to predict cognitive evolution of PD patients. The identification of these novel PD subtypes based on electrical brain activity signatures has important clinical implications and can support the development of brain-based therapeutic strategies.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Jae-Myung Kim, Seung-Han Lee, Soo Hyun Cho, Kyung Wook Kang, Kang-Ho Choi, Tai-Seung Nam, Joon-Tae Kim, Seong-Min Choi, Man-Seok Park, Byeong C. Kim, Myeong-Kyu Kim
Summary: Isolated central positional vertigo due to cerebellar infarction is often difficult to differentiate from benign paroxysmal positional vertigo. This study aimed to evaluate whether vascular risk factors and serum vitamin D level can differentiate between positional vertigo types. Results showed that the proportion of men and atrial fibrillation were higher in the CPV group, and the serum vitamin D levels were below the normal range in both groups.
NEUROLOGICAL SCIENCES
(2021)
Letter
Clinical Neurology
Jae-Myung Kim, Kyung Wook Kang, Hyong-Ho Cho, Man-Seok Park, Seung-Han Lee
JOURNAL OF CLINICAL NEUROLOGY
(2022)
Article
Medicine, General & Internal
Jae-Myung Kim, Kyung Wook Kang, Hyunsoo Kim, Seung-Han Lee, Tae-Sun Kim, Man-Seok Park
Summary: This case report describes a rare but possible cause of septic cavernous sinus thrombosis (SCST), which is minor head trauma. Early recognition and prompt treatment are essential for improving outcomes.
Review
Clinical Neurology
Seung-Han Lee, Jae-Myung Kim, Ji-Soo Kim
Summary: The medial longitudinal fasciculus is a crucial structure for eye movement, and lesions can result in internuclear ophthalmoplegia and other ocular motor abnormalities. Recognizing these abnormalities aids in detecting and localizing brainstem lesions.
NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Joon-Tae Kim, Nu Ri Kim, Su Hoon Choi, Seungwon Oh, Man-Seok Park, Seung-Han Lee, Byeong C. Kim, Jonghyun Choi, Min Soo Kim
Summary: Clustering stroke patients with similar characteristics is crucial for predicting subsequent vascular outcome events. This study compared different clustering methods and found that a deep neural network-based model (DLC-Kuiper UB model) showed the best performance in achieving a distinct distribution of 1-year vascular events among different clusters of ischemic stroke patients.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Jae-Myung Kim, Seung-Han Lee, Hyo-Jung Kim, Ji-Soo Kim
Summary: This article discusses the emerging and controversial syndromes of BPPV, as well as atypical nystagmus based on the involved canal and persistent geotropic positional nystagmus. These topics contribute to a better understanding of the pathomechanisms of BPPV and differentiation from central vertigo and nystagmus.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Hyo-Jung Kim, Ji-Soo Kim, Kwang-Dong Choi, Seo-Young Choi, Seung-Han Lee, Ileok Jung, Jae Han Park
Summary: This study aimed to determine the efficacy of a web-based diagnosis and treatment for recurrent BPPV. The randomized controlled trial found that the web-based system could effectively diagnose and treat recurrent BPPV, highlighting its potential role in telemedicine for vestibular disorders.
Article
Clinical Neurology
Seung-Han Lee, Jae-Myung Kim, Joon-Tae Kim, Alexander Andrea Tarnutzer
Summary: This study retrospectively analyzed 6 patients with isolated (hemi)nodular strokes and conducted comprehensive neuro-otological assessments. The study found that the patients had normal horizontal and vertical vestibulo-ocular reflex (aVOR) function but exhibited various ocular motor abnormalities and postural control issues.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
You-Ri Kang, Tai-Seung Nam, Jae-Myung Kim, Kyung Wook Kang, Seung-Han Lee, Seong-Min Choi, Myeong-Kyu Kim
Summary: Alexander disease (AxD) is a rare autosomal dominant astrogliopathy caused by mutations in the gene encoding for glial fibrillary acidic protein. AxD is divided into two clinical subtypes: type I and type II AxD. Type II AxD usually manifests in the second decade of life or later, and its radiologic features include tadpole-like appearance of the brainstem, ventricular garlands, and pial signal changes along the brainstem. Recently, eye-spot signs in the anterior medulla oblongata (MO) have been reported in patients with elderly-onset AxD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
You-Ri Kang, Tai-Seung Nam, Jae-Myung Kim, Kyung Wook Kang, Seong-Min Choi, Seung-Han Lee, Byeong C. Kim, Myeong-Kyu Kim
Summary: This study retrospectively analyzed the clinical phenotype of 6 patients with SPG11-HSP. It found that the core feature was progressive spastic paraplegia, accompanied by pseudobulbar dysarthria, intellectual disability, bladder dysfunction, and overweight. Additional symptoms included upper limbs rigidity and sensory axonopathy. The disease progression was associated with worsening of PVWM signal abnormalities, ventricular widening, and extension of the thin corpus callosum.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Jae-Myung Kim, Tai-Seung Nam, Seong-Min Choi, Byeong C. Kim, Seung-Han Lee
Summary: The diagnosis of spinocerebellar ataxia (SCA) currently relies on genetic testing. This study evaluated the vestibulo-ocular reflex (VOR) parameters of different SCA subtypes and found that the VOR patterns varied among subtypes, providing potential value for differential diagnosis.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Hyo-Jung Kim, Ji-Soo Kim, Kwang-Dong Choi, Seo-Young Choi, Seung-Han Lee, Ileok Jung, Jae Han Park
Summary: This study aimed to evaluate the efficacy of a web-based diagnosis and treatment for recurrent benign paroxysmal positional vertigo (BPPV). The study found that using a web-based system for diagnosis and treatment can effectively alleviate the symptoms of recurrent BPPV, and it has significant implications for telemedicine in the field of vestibular disorders.
Article
Medicine, General & Internal
You-Ri Kang, Tai-Seung Nam, Byeong C. Kim, Jae-Myung Kim, Soo Hyun Cho, Kyung Wook Kang, Kang-Ho Choi, Joon-Tae Kim, Seong-Min Choi, Seung-Han Lee, Man-Seok Park, Myeong-Kyu Kim
Summary: This study investigated the clinical, laboratory, and radiological features of meningitis after lumbar epidural steroid injection (M-ESI) without accompanying spinal infection. Seven patients with M-ESI were identified and all presented with headache and fever. Cerebrospinal fluid analysis showed abnormalities and radiologic findings included sulcal hyperintensity and pneumocephalus. Symptoms improved quickly with treatment and no neurological sequelae were observed.
Meeting Abstract
Clinical Neurology
You-Ri Kang, Jae-Myung Kim, Seung-Han Lee, Joon-Tae Kim
Meeting Abstract
Clinical Neurology
You-Ri Kang, Kyung Wook Kang, Jae-Myung Kim, Seung-Han Lee, Tai-Seung Nam
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
