Article
Clinical Neurology
Galit Kleiner, Hubert H. Fernandez, Kelvin L. Chou, Alfonso Fasano, Kevin R. Duque, Diana Hengartner, Albie Law, Adam Margolius, Yu-Yan Poon, Michel Saenz Farret, Philip Saleh, Joaquin A. Vizcarra, Glenn T. Stebbins, Alberto J. Espay
Summary: The study validated a final version of a 27-item self-administered NoMoFA questionnaire, capable of effectively capturing both static and fluctuating non-motor symptoms in Parkinson's disease patients. The questionnaire showed good internal consistency, test-retest reliability, and concurrent validity, and underwent item reduction through a Delphi process, resulting in high acceptability.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Parisa Farzanehfar, Holly Woodrow, Malcolm Horne
Summary: The study found that a high proportion of patients with Parkinson's disease experience motor and non-motor function wearing off, with severity correlated to factors such as disease duration, baseline MDS-UPDRS (motor component), Percent Time in Bradykinesia, Levodopa Equivalent Daily Dose, frequency of Levodopa doses, and age of onset. Patients with more severe wearing off experienced worse motor and non-motor symptoms, resulting in lower quality of life. Quality of life significantly improved in patients with Parkinson's disease when wearing off was treated.
JOURNAL OF NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Remi Morimoto, Mutsumi Iijima, Yasuyuki Okuma, Keisuke Suzuki, Fumihito Yoshii, Shigeru Nogawa, Takashi Osada, Kazuo Kitagawa
Summary: This study investigated the factors associated with non-motor symptoms (NMS) in patients with Parkinson's disease (PD). The results showed that NMS severity was higher in older adults, those with longer disease duration, subjective and objective motor function impairments, and rapid eye movement sleep behavior disorder (RBD). Sex-based differences were also observed, with higher levels of anxiety in female patients and higher levels of daytime sleepiness, urinary problems, and RBD in male patients.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Parisa Farzanehfar, Holly Woodrow, Malcolm Horne
Summary: Sensor measurement plays a crucial role in identifying and managing fluctuations in bradykinesia of Parkinson's Disease, helping to improve treatment outcomes and quality of life for patients, as well as assisting healthcare professionals in making therapeutic decisions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Stuart H. Isaacson, Daniel Kremens, Yasar Torres-Yaghi, Fabrizio Stocchi, Angelo Antonini
Summary: This article reviews the contribution of delays in time to ON to total daily OFF time in Parkinson's disease patients and emphasizes the importance of measuring and adequately addressing delays in time to ON.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Mariana Fernandes, Mariangela Pierantozzi, Alessandro Stefani, Carlo Cattaneo, Erminio A. Bonizzoni, Rocco Cerroni, Nicola Biagio Mercuri, Claudio Liguori
Summary: This study found a high prevalence of NMS in PD patients with motor fluctuations, with psychiatric disorders being more frequent in older patients and those with a longer PD diagnosis duration, while sleep problems were more common in younger patients with a shorter disease duration.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Diego Santos-Garcia, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Ester Suarez Castro, Hector Canfield, Cristina Martinez Miro, Silvia Jesus, Miquel Aguilar, Pau Pastor, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez-Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Marta Blazquez Estrada, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Oriol de Fabregues, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. Lopez Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: This study found that the development of motor fluctuations (MF) in patients with Parkinson's disease (PD) is associated with an increase in non-motor symptoms (NMS) burden after a 2-year follow-up.
Article
Health Care Sciences & Services
Matteo Carpi, Mariangela Pierantozzi, Stefano Cofano, Mariana Fernandes, Rocco Cerroni, Francesca De Cillis, Nicola Biagio Mercuri, Alessandro Stefani, Claudio Liguori
Summary: This observational study investigates the presence of non-motor symptoms (NMS) and non-motor fluctuations (NMF) in Parkinson's disease (PD) patients using the Non-Motor Fluctuation Assessment questionnaire (NoMoFa). The study finds that NMF are frequently reported by mild-to-moderate PD patients and are associated with an increased number of NMS. The study emphasizes the importance of understanding the clinical role of NMS and NMF in the management of PD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Si-Chun Gu, Qing Ye, Chang-De Wang, Shao-Rong Zhao, Jie Zhou, Chen Gao, Yu Zhang, Zhen-Guo Liu, Can-Xing Yuan
Summary: Pingchan granule (PCG) has a long-lasting and extensive symptomatic efficacy for both motor and non-motor symptoms of Parkinson's disease (PD) with good tolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
C. Warren Olanow, Werner Poewe, Olivier Rascol, Fabrizio Stocchi
Summary: Levodopa is the most effective therapy for Parkinson's disease, but chronic treatment can lead to OFF episodes, causing disability and emotional issues for patients. There are currently three on-demand therapies available for OFF episodes, including subcutaneous injection of apomorphine, sublingual apomorphine film, and inhaled levodopa.
MOVEMENT DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Frank C. Church
Summary: Parkinson's disease is a progressive neurodegenerative disorder that mainly affects older adults. Treatment options include rehabilitation, therapy, restorative programs, maintenance with complementary and alternative medicine, and surgery as a last resort. Currently, there is no cure for PD and the focus is on slowing disease progression and improving quality of life for patients.
Review
Clinical Neurology
Margherita Fabbri, Raquel Barbosa, Olivier Rascol
Summary: Motor fluctuations (MF) are a troublesome disease feature for patients with Parkinson's disease (PD) due to the increasing impairment in responsiveness to dopaminergic drug treatments. MF are characterized by the loss of a stable response to levodopa over the day and night, and they normally appear after a few years of treatment with levodopa. The management of MF includes various treatment options such as new compounds, on-demand therapies, and advanced therapies. The choice of treatment depends on physician opinion, patient preference, caregiver availability, and public health systems and socio-economic environment.
NEUROLOGY AND THERAPY
(2023)
Article
Clinical Neurology
Eleonora Del Prete, Emmanuelle Schmitt, Sara Meoni, Valerie Fraix, Anna Castrioto, Pierre Pelissier, Roberto Ceravolo, Elena Moro
Summary: This study investigates the relationship between motor fluctuations (MFs) and neuropsychiatric fluctuations (NMFs) in Parkinson's disease (PD). The findings suggest that NMFs only temporarily match the OFF MFs in PD patients. The study emphasizes the need to further investigate the associations between non-motor and motor symptoms in PD patients to better manage NMFs.
NEUROLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Diego Santos-Garcia, Ariadna Laguna, Jorge Hernandez-Vara, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Maria Cristina Iniguez-Alvarado, Iago Garcia Diaz, Silvia Jesus, Maria Teresa Boungiorno, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso G. Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Menendez Gonzalez, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. Lopez M. Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: This study analyzed sex difference manifestations in Spanish patients with Parkinson's disease (PD) and found important differences. Symptoms such as depression, fatigue, and pain were more frequent and/or severe in females, while symptoms such as hypomimia, speech problems, rigidity, and hypersexuality were more noted in males. Women received a lower levodopa equivalent daily dose and had worse perception of quality of life. After two years of follow-up, the NMS burden increased more significantly in males, while the functional capacity was more impaired in females.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Asako Kakimoto, Miki Kawazoe, Kanako Kurihara, Takayasu Mishima, Yoshio Tsuboi
Summary: Long-term levodopa treatment in patients with Parkinson's disease often causes motor fluctuations, which can affect their quality of life. This study found that Parkinson's disease patients with non-motor fluctuations had a lower quality of life compared to those with only motor fluctuations or no fluctuations.
FRONTIERS IN NEUROLOGY
(2023)
Meeting Abstract
Neurosciences
Harald Murck, Lisa Lehr, Maxim Zavarotnyy, Daniela Jezova, Tilo Kircher
BIOLOGICAL PSYCHIATRY
(2019)
Meeting Abstract
Neurosciences
Harald Murck, Benjamin Luerweg, Johannes Hahn, Matthias Braunisch, Daniela Jezova, Andreas Jansen, Tilo Kircher
BIOLOGICAL PSYCHIATRY
(2019)
Article
Psychiatry
Harald Murck, Benjamin Luerweg, Johannes Hahn, Matthias Braunisch, Daniela Jezova, Maxim Zavorotnyy, Carsten Konrad, Andreas Jansen, Tilo Kircher
Summary: Brain morphology and endocrine parameters were found to be associated with treatment outcome in depressed patients. Non-responders tended to have larger ventricular volume and smaller central white matter structures.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2021)
Review
Immunology
Harald Murck
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Clinical Neurology
Maureen Schmitter-Edgecombe, Courtney McAlister, David Greeley
Summary: This study found that both the PD-MCI and MCI groups performed more poorly on overall IADL measures compared to HOAs. However, on the direct-observation measure, the PD-MCI group took longer and made more inefficient and irrelevant/off-task errors, while the MCI group made more omission and substitution errors. Cognitive and motor abilities had varying impacts on the everyday task difficulties of these two groups.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2022)
Article
Nutrition & Dietetics
Daniela Jezova, Peter Karailiev, Lucia Karailievova, Agnesa Puhova, Harald Murck
Summary: The study introduced the concept that Glycyrrhiza glabra extract might reduce the entry point for SARS-CoV-2, ACE2. Results showed a significant decrease in ACE2 gene and protein expression in the small intestine of rats fed with the extract, suggesting a potential therapeutic target for COVID-19 prevention.
Article
Psychiatry
Jan Terock, Anke Hannemann, Johanna Klinger-Koenig, Deborah Janowitz, Hans J. Grabe, Harald Murck
Summary: Childhood trauma is associated with alterations in the renin-angiotensin-aldosterone system, leading to changes in plasma aldosterone concentrations and blood pressure. These neurobiological markers may increase the risk for psychiatric disorders, especially major depression.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Jan Engelmann, Harald Murck, Stefanie Wagner, Lea Zillich, Fabian Streit, David P. Herzog, Dieter F. Braus, Andre Tadic, Klaus Lieb, Marianne B. Muller
Summary: This study investigated the predictive value of peripheral markers related to the mineralocorticoid receptor (MR) for the outcome of antidepressant treatment. The results showed that patients with more severe depression had lower blood pressure, lower K+ levels, and higher Na+/K+ ratios. These biomarkers obtained in routine clinical settings may be useful for risk stratification in early stages of depression treatment.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Review
Endocrinology & Metabolism
Harald Murck, Lisa Lehr, Daniela Jezova
Summary: An abundance of knowledge has been collected on neuroendocrine parameters in major depression, with the hypothalamic-pituitary-adrenocortical (HPA) axis and its regulation of cortisol receiving extensive study. However, attempts to pharmacologically target the HPA axis for treating major depression have been unsuccessful. This review focuses on the role of aldosterone, released by adrenocorticotropic hormone and angiotensin, and the mineralocorticoid receptor (MR) in depression. Depressed patients, especially those with atypical depression, show signs of central hyperactivation of the aldosterone sensitive MR, potentially due to reactive aldosterone release induced by low blood pressure and low peripheral MR sensitivity.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Victoria K. Karschney, David R. Greeley
AMERICAN HEALTH AND DRUG BENEFITS
(2020)
Meeting Abstract
Clinical Neurology
Aaron Koenig, Harald Murck, Yingchun Luo, Irena Webster, Michael Quirk, Steve Kanes, James Doherty
Meeting Abstract
Clinical Neurology
Aaron Koenig, Harald Murck, Jason Berlin, Yingchun Luo, Sigui Li, Brandon Farley, David Nguyen, Irena Webster, Michael Quirk, Stephen Kanes, James Doherty
Meeting Abstract
Neurosciences
Harald Murck, Lisa Lehr, Maxim Zavorotny
BIOLOGICAL PSYCHIATRY
(2020)
Meeting Abstract
Neurosciences
Aaron Koenig, Harald Murck, Yingchun Luo, Irena Webster, Michael Quirk, Stephen Kanes, James Doherty
NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Neurosciences
Harald Murck, Aaron Koenig, Jason Berlin, Yingchun Luo, Sigui Li, Brandon Farley, David Nguyen, Irena Webster, Michael Quirk, Stephen Kanes, James Doherty
NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
