Article
Microbiology
Anna Stanicka, Lukasz Migdalski, Katarzyna Szopieray, Anna Cichy, Lukasz Jermacz, Paola Lombardo, Elzbieta Zbikowska
Summary: The research explores the potential of alien species as diluents for bird schistosome cercariae, highlighting the positive impact of increased biodiversity in reducing parasitic infections in aquatic environments. Furthermore, the study underscores the importance of determining the most effective diluent to enhance protection measures against swimmer's itch in bathing areas.
Article
Microbiology
Nathaniel J. Anderson, Curtis L. Blankespoor, Randall J. DeJong
Summary: A new type of schistosome called avian schistosomatid sp. C (ASC) was found to cause milder swimmer's itch symptoms compared to Trichobilharzia stagnicolae. ASC showed lower penetration frequency into human skin compared to T. stagnicolae. Limited experiments showed that ASC exhibited penetration behavior when placed on the esophageal tissue of its known host, Canada goose.
Article
Physics, Multidisciplinary
Danish Iqbal, Syed Mohd Danish Rizvi, Md Tabish Rehman, M. Salman Khan, Abdulaziz Bin Dukhyil, Mohamed F. AlAjmi, Bader Mohammed Alshehri, Saeed Banawas, Qamar Zia, Mohammed Alsaweed, Yahya Madkhali, Suliman A. Alsagaby, Wael Alturaiki
Summary: This study used molecular docking and dynamics approaches to investigate potential treatments for neurodegenerative disorders such as Alzheimer's disease. The results showed that Soyasapogenol B, a pentacyclic triterpenoid, effectively bound to multiple target proteins involved in these disorders, making it a promising natural inducer.
Article
Chemistry, Medicinal
Anindra Sharma, Anand K. Agrahari, Sanchayita Rajkhowa, Vinod K. Tiwari
Summary: This review summarizes the recent innovation of triazole-appended hybrids with in vitro and in vivo antitubercular activity. By analyzing the structure-activity relationship, it aims to assist medicinal chemists in exploring triazole scaffolds for the rational design of potent drug candidates with improved efficacy, selectivity, and minimal toxicity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Plant Sciences
Kobra Ziyaei, Fatemeh Abdi, Majid Mokhtari, Mohammad Ali Daneshmehr, Zahra Ataie
Summary: Phycocyanin, a protein compound with antidiabetic properties, can be used as a nutraceutical. Animal studies showed that phycocyanin positively affected biochemical parameters related to diabetes, such as increased fasting insulin serum and decreased fasting blood glucose. Cellular studies demonstrated that phycocyanin exerted its antidiabetic effect through various molecular pathways. Overall, targeting these pathways by phycocyanin may offer benefits in the management of diabetes.
Article
Agriculture, Multidisciplinary
Kho Swen Jack, Mohd Razip Bin Asaruddin, Showkat Ahmad Bhawani
Summary: The study showed that monolaurin has strong interactions with the COX-2 protein, disrupting its function through significant hydrogen bonds and hydrophobic interactions with amino acid residues in the target protein's active site. This suggests potential for monolaurin as a promising anti-inflammatory agent.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Ashok Kumar Mandal, Samrat Paudel, Anisha Pandey, Parasmani Yadav, Prateek Pathak, Maria Grishina, Mariusz Jaremko, Abdul-Hamid Emwas, Habibullah Khalilullah, Amita Verma
Summary: The study investigated the antioxidant and anticancer activities of Psidium guajava L. essential oil, demonstrating its potential therapeutic value against breast cancer. The bioactive compounds in the oil showed promising properties in inhibiting tumor growth and exhibited drug likeness properties according to ADME analysis, suggesting their potential for novel drug discovery.
Article
Genetics & Heredity
Jaciara Neves Sousa, Lorena dos Reis Pereira Queiroz, Alfredo Mauricio Batista de Paula, Andre Luiz Sena Guimaraes, Caroline Honaiser Lescano, Charles Martins Aguilar, Ivan Pires de Oliveira, Sergio Henrique Sousa Santos
Summary: Studies have shown that gallic acid (GA) has the potential to promote weight loss and improve glycemic parameters. This study investigated the activating potential of GA on Sestrin using molecular docking. The results revealed that specific amino acids play a crucial role in stabilizing GA and activating SESN2, similar to the interaction that allows leucine to activate SESN2. Therefore, the anti-obesity property of GA may be achieved through the activation of Sestrin.
Article
Biochemistry & Molecular Biology
Kiran Lokhande, Neelu Nawani, Swamy K. Venkateswara, Sarika Pawar
Summary: The recent outbreak of SARS-CoV-2 has led to a global pandemic with significant threats to human health and the economy. Researchers are searching for potential drugs to combat this virus, and plant-derived bioflavonoids from Rhus succedanea have shown promise as antiviral compounds. Specifically, bioflavonoids from Rhus succedanea have been found to interact with the SARS-CoV-2 Mpro protease, a key enzyme in viral replication. Computational methods have identified specific bioflavonoids, such as Amentoflavone and Agathisflavone, that exhibit strong interaction with the catalytic residues of Mpro. Molecular dynamic simulations further support the stability and potential of these bioflavonoids as inhibitors of SARS-CoV-2. This research provides a valuable starting point for further experimental studies and drug development.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Manal Y. Sameeh, Manal M. Khowdiary, Hisham S. Nassar, Mahmoud M. Abdelall, Suliman A. Alderhami, Ahmed A. Elhenawy
Summary: This study aimed to synthesize safe antihyperglycemic derivatives with a thiazolidinedione fragment. The authors used spectral data to discuss the interaction between the derivatives and the biological receptor. They evaluated the effects of the derivatives on alpha-amylase inhibition and radical scavenging ability. Compound 6 exhibited the highest potency and radical scavenging ability. In vivo studies showed that compounds 6 and 11 significantly reduced blood glucose levels. All compounds showed normal values for tested biochemical parameters and had good oral bioavailability without observed carcinogenesis effects.
Article
Chemistry, Physical
Rizal Irfandi, Santi Santi, Indah Raya, Ahyar Ahmad, Ahmad Fudholi, Dewi Ratih Tirto Sari, Prihantono
Summary: This study characterized the synthetic Zn(II)Prolinedithiocarbamate and determined its anti-cancer activity in vitro and in silico. The results suggest that the Zn(II)Prolinedithiocarbamate complex may have potential pharmacological activity against MCF-7 cell line.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Mohammed M. Ghoneim, Rasha Hamed Al-Serwi, Mohamed El-Sherbiny, El-sayed M. El-ghaly, Amal E. Hamad, Mohamed A. Abdelgawad, Ehab A. Ragab, Sarah Bukhari, Khulud Bukhari, Khaled Elokely, Manal A. Nael
Summary: In the search for a new anti-MRSA lead compound, emodin was identified as a potential candidate due to its effectiveness against methicillin-resistant Staphylococcus aureus. The study focused on emodin's interactions with alpha-hemolysin, a key enzyme in Staphylococcus infections. Molecular dynamics simulations were used to identify and investigate possible ligand binding pockets, leading to the discovery of three potential sites. Site 1 showed the most stable binding, while sites 2 and 3 exhibited fluctuating or unstable binding. This study sheds light on the interaction types, binding mode, and key amino acids involved in ligand binding, providing valuable insights for the design of effective anti-MRSA agents.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Qingrong Li, Qiang Ma, Jibing Cheng, Xi Zhou, Wenjie Pu, Xiaowu Zhong, Xiaolan Guo
Summary: DHA, a derivative of artemisinin developed in China, exhibits anticancer activities and enhances the efficacy of chemotherapy, targeted therapy, and radiotherapy. The mechanisms of DHA on different tumors vary, highlighting the potential for DHA as a sensitizer for cancer therapy.
ONCOTARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
S. Nanjundaswamy, S. Bindhu, R. R. Arun Renganathan, S. Nagashree, C. S. Karthik, P. Mallu, V. Ravishankar Rai
Summary: This study synthesized compounds with anti-MRSA activity and validated their antibacterial activity through molecular docking and molecular dynamics simulations. The results showed that certain compounds exhibited high antibacterial activity and had good interactions with the target protein.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Energy & Fuels
Timur Ildarovich Yunusov, Lyutsia Faritovna Davletshina, Lyubov Abdulaevna Magadova, Mikhail Alexandrovich Silin
Summary: The application of chelating agents in enhanced oil recovery (EOR) and well stimulation is growing rapidly. However, chelating agents have drawbacks, including high interfacial tension (IFT). This paper investigates the interaction between a chelating agent (ethylenediaminetetraacetic acid, EDTA) and anionic and cationic surfactants (sodium dodecyl sulfate, SDS and dodecyl trimethynlammonium bromide, DTAB) through experimental and theoretical methods. The results show that the addition of chelating agents decreases IFT and lowers the critical micelle concentration of surfactants, indicating a salting-out effect. Molecular dynamics simulations reveal closer packing of the surfactant layer and decreased hydration of head groups, with specific attractive interactions observed with SDS. These findings can be useful for selecting appropriate fluids for real-field operations.
Article
Environmental Sciences
Tahereh Davoodi, Ali Khamesipour, Saeed Shahabi, Fatemeh Gholizadeh, Daniel Pourkamal, Gholamreza Hatam
Summary: This study investigated the molecular identification and geographical distribution of anthroponotic and zoonotic cutaneous leishmaniasis in southern Iran, revealing that ACL was only detected in Shiraz city, while ZCL was observed in both Shiraz and most counties of Fars Province. Additionally, the district 8 of Shiraz municipality showed the highest number of CL infections, suggesting the need for further attention.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Immunology
Narjes Yektaeian, Abdorrasoul Malekpour, Amir Atapour, Tahereh Davoodi, Gholamreza Hatam
Summary: Toxoplasma gondii is a protozoan parasite causing toxoplasmosis, transmitted through various routes and infecting warm-blooded animals. DNA vaccines are considered as a successful approach against the parasite, inducing suitable immune response and protection.
MICROBIAL PATHOGENESIS
(2021)
Article
Infectious Diseases
Mohammad Amin Ghatee, Koorosh Nikaein, Omid Rajaie, Walter Robert Taylor, Mehdi Karamian
Summary: This study investigated the impact of nomadic tribes on the epidemiology of Cutaneous Leishmaniasis (CL) in southwestern Iran and found that living in areas around nomadic travel routes significantly increased the incidence of CL. Additionally, irrigated farm areas were the only land cover type within nomadic travel routes that had a significant impact on CL.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Neurosciences
Abolfazl Alipour, Gholamreza Hatam, Hassan Seradj
Summary: Microtubules may not be crucial for learning behavior in Paramecium caudatum, suggesting the need for further investigation into the hypothesis of microtubular information processing.
BASIC AND CLINICAL NEUROSCIENCE
(2022)
Article
Environmental Sciences
Seyed Mohammad Jafar Nazemosadat, Reza Shafiei, Habib Ghaedamini, Mohsen Najjari, Zahra Nazemosadat-Arsanjani, Gholamreza Hatam
Summary: This study provides a comprehensive analysis of the relationship between malaria and climate in the southeast region of Iran. The findings indicate that the infection rate varies by season, and malaria in rural areas is more climate-related. Additionally, the outbreak of Plasmodium falciparum/P. vivax occurs during autumn/summer, with opposite relationships between patient numbers and dry/wet years in summer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Genetics & Heredity
Neda Pirbonyeh, Amir Emami, Fatemeh Javanmardi, Afagh Moattari, Gholam Reza Hatam, Abdollah Bazargani
Summary: This study found a relatively high prevalence of Shiga toxin-producing E. coli in HIV patients, highlighting the threat of infectious agents as a cause of diarrhea in immunocompromised patients who must be careful about infectious control.
Article
Immunology
Masood Ziaee, Mohammad Amin Ghatee, Walter Robert Taylor, Mehdi Karamian
Summary: This study describes a family cluster of L. major infection, where the family members traveled to an endemic area and were treated differently, with two patients being hospitalized due to disease progression. Genotyping of the parasite gene revealed that the infecting strain was the same as one found in a tourist who visited North African countries. It is hypothesized that the host immune response may have been reduced in the hospitalized patients.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Review
Parasitology
Morteza Shams, Laya Shamsi, Amirhosein Yousefi, Alireza Sadrebazzaz, Ali Asghari, Behnam Mohammadi-Ghalehbin, Saeed Shahabi, Gholamreza Hatam
Summary: This study provides a global estimate of Blastocystis infection and subtype distribution in dogs and cats, finding that cats have a slightly higher infection rate than dogs, while dogs have higher subtype diversity. Dogs and cats are both involved in zoonotic transmission of various Blastocystis subtypes. More comprehensive studies are needed to elucidate the true epidemiology and subtype distribution of Blastocystis in dogs and cats.
PARASITES & VECTORS
(2022)
Article
Multidisciplinary Sciences
Sama Rashidi, Seyed Nooreddin Faraji, Amirreza Javadi Mamaghani, Saeid Hatam, Bahram Kazemi, Peyman Bemani, Seyyed Javad Seyyed Tabaei, Gholamreza Hatam
Summary: Leishmaniasis, especially Cutaneous Leishmania (CL), is a major infectious disease worldwide. This study aims to design a new multi-epitope DNA vaccine using immune bioinformatics to effectively control the disease. Multiple antigens were selected and their MHC-I epitopes were used to construct the vaccine. The designed vaccine showed high stability and antigenicity, making it a suitable model for further animal and human studies.
SCIENTIFIC REPORTS
(2022)
Article
Veterinary Sciences
Mahdi Fakhar, Majid Derakhshani-nia, Shaban Gohardehi, Mehdi Karamian, Hajar Ziaei Hezarjaribi, Mehdi Mohebali, Behnaz Akhoundi, Mitra Sharbatkhori
Summary: The aim of this study was to determine the Leishmania species infecting domestic dogs in Golestan Province, Iran. The results showed that 7% of the dogs tested positive for antibodies and 25% tested positive for Leishmania spp. DNA by PCR, with most of the dogs being asymptomatic. PCR testing also revealed a significantly higher infection rate in male dogs compared to female dogs. Additionally, a new emerging agent for Leishmania infection was identified.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Parasitology
Narjes Yektaeian, Shahrokh Zare, Amir Hosein Radfar, Gholamreza Hatam
Summary: This study evaluated the role of superparamagnetic iron oxide nanoparticles (SPIONs) in cell culture for tracking labeled Leishmania major in fibroblasts. The results showed that SPIONs can accurately and rapidly label Leishmania parasites invaded into fibroblasts. These findings can provide new insights into the diagnosis, pathogenesis, and treatment of cutaneous leishmaniasis.
JOURNAL OF PARASITOLOGY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Neda Moradian, Gholamreza Hatam, Azadeh Hamedi, Ardalan Pasdaran
Summary: This study evaluated the antileishmanial potential of Carex pendula Huds. methanolic extract and its fractions against Leishmania major cutaneous infection. The ethyl acetate fraction showed the best activity, with an IC50 = 1.627 +/- 0.211 mg/mL. Nine chemical compounds, including flavonols, flavanonols, and flavan derivatives, were identified in this fraction. The in vivo and in vitro experiments confirmed the considerable antileishmanial activity of the ethyl acetate fraction.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Parasitology
Hamid Mahmoodpour, Adel Spotin, Gholam Reza Hatam, Ali Pourmahdi Ghaemmaghami, Seyed Mahmoud Sadjjadi
Summary: This study aimed to investigate the activity and safety of hydroalcoholic extracts of E. microtheca against E. granulosus in vitro and ex vivo. The results showed that the prepared extracts exhibited strong protoscolicidal effects in both in vitro and ex vivo tests.
EXPERIMENTAL PARASITOLOGY
(2023)
Review
Immunology
Seyed Nooreddin Faraji, Mohamad Javad Raee, Seyed Mohamad Ali Hashemi, Gholamreza Daryabor, Reza Tabrizi, Fateme Sadat Dashti, Emad Behboudi, Kamran Heidarnejad, Peyman Nowrouzi-Sohrabi, Gholamreza Hatam
Summary: This study systematically reviewed clinical and experimental research on the interaction targets between SARS-CoV-2 and human cell entry. The results showed that the spike protein of SARS-CoV-2 mainly interacts with the ACE2 receptor and TMPRSS family. The findings provide important insights into the pathogenesis of SARS-CoV-2 and the development of comprehensive therapeutic approaches.
EUROPEAN JOURNAL OF INFLAMMATION
(2022)
Article
Infectious Diseases
Zahra Hashemizadeh, Gholamreza Hatam, Javad Fathi, Fatemeh Aminazadeh, Hossein Hosseini-Nave, Mahtab Hadadi, Nafiseh Hosseinzadeh Shakib, Sodeh Kholdiv, Abdollah Bazargani
Summary: This study investigated the molecular typing and frequency of carbapenem resistance genes in carbapenem-resistant Acinetobacter baumannii bacteria collected from patients in Shiraz, Iran. The results showed that transposable elements played a significant role in the development of resistance genes and resistance to carbapenems.
INFECTION AND CHEMOTHERAPY
(2022)
