Article
Multidisciplinary Sciences
Jafar Ganjipour Sales, Hamed Behniafar, Mohammadreza Bazavar, Mojtaba Varshochi, Abbas Majdi Seghinsara
Summary: Echinococcosis is a rare zoonotic parasitic infection caused by the larval stage of Echinococcus species, with osseous cysts being even rarer and typically found in the sacral region. Surgical removal and chemotherapy are essential for treatment, with pathological examination playing a crucial role in confirming the diagnosis.
Article
Veterinary Sciences
Davide De Biase, Francesco Prisco, Paola Pepe, Antonio Bosco, Giuseppe Piegari, Ilaria d'Aquino, Valeria Russo, Serenella Papparella, Maria Paola Maurelli, Laura Rinaldi, Orlando Paciello
Summary: This study examined the inflammatory phenotype of sheep livers infected with cystic echinococcosis through macroscopic assessment, histopathological analysis, and molecular analysis. The livers were classified into three groups: normal liver, liver with fertile hydatid cysts, and liver with sterile hydatid cysts. The results showed that macrophages play a predominant role in the immune response to cystic echinococcosis, with a dominance of Th2 immunity and an immunomodulatory role of IL-10 and TGF-beta.
VETERINARY SCIENCES
(2023)
Article
Medicine, General & Internal
Bei Zhang, Li Zhang, Hongli Zhou, Junwei Tian, Jiping Wang
Summary: This report presents a rare case of a primary isolated thoracic vertebral hydatid cyst with compressive myelopathy. The patient showed slow but measurable progress after surgical excision. While relatively rare in non-pastoral areas, this condition may be considered as a potential etiology of atypical spinal compression.
Article
Infectious Diseases
Qiyu Jia, Shuo Wu, Jian Guo, Abudusalamu Alimujiang, Hao Zheng, Jun Zhang, Yingbo Wang, Zengru Xie, Chuang Ma
Summary: This case report presents a rare case of giant muscle hydatid in the lower extremity, with neurological symptoms as the initial manifestation. It highlights the importance of considering hydatid disease when diagnosing soft tissue masses in muscles, particularly in endemic areas, as patients may present with atypical symptoms.
BMC INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Tiange Li, Yunfei Ling, Yongjun Qian
Summary: A 48-year-old female presented with intermittent chest pain and was found to have a cyst located at the interventricular septum. The diagnosis of cardiac hydatid disease was suspected based on medical history, imaging examination, and serological results. The cyst was successfully removed, and pathological biopsy confirmed the infection of Echinococcus granulosus. The patient recovered well without complications.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Article
Agriculture, Dairy & Animal Science
Sakandar Khan, Jo Cable, Muhammad Younus, Muhammad Imran Rashid, Frank Hailer, Haroon Akbar
Summary: Cystic echinococcosis is a global parasitic disease that affects food animals and humans. The disease has negative impacts on food production, socio-economics, and animal welfare. In this study, a potential candidate antigen, iEg67 kDa crude antigen, was identified and tested for ELISA kit development to improve the diagnostic accuracy for cystic echinococcosis in cattle and buffalo.
Article
Parasitology
Guilherme Brzoskowski dos Santos, Edileuza Danieli da Silva, Eduardo Shigueo Kitano, Maria Eduarda Battistella, Karina Mariante Monteiro, Jeferson Camargo de Lima, Henrique Bunselmeyer Ferreira, Solange Maria de Toledo Serrano, Arnaldo Zaha
Summary: This study investigated the protein content of the hydatid fluid compartment in E. granulosus and E. ortleppi pulmonary bovine cysts and compared their molecular arsenal at the host-parasite interface. The results showed a predominance of parasite proteins compared to host proteins in the hydatid fluid samples. Functional analysis revealed important molecular functions and processes that are active in pulmonary cystic echinococcosis.
PARASITES & VECTORS
(2022)
Article
Oncology
Edgardo Berriel, Teresa Freire, Carolina Chiale, Ernesto Rodriguez, Gabriel Moron, Gabriel Fernandez-Grana, Martina Crispo, Nora Berois, Eduardo Osinaga
Summary: Echinococcus granulosus, a cestode parasite, can inhibit colon cancer growth, and also show anti-tumor activity against LL/2 lung cancer in mice by inducing antigen-specific immune responses and activating NK1.1(+) cells. This suggests that HCF vaccination can evoke an integrated anti-tumor immune response, involving both innate and adaptive components, providing novel insights into the relationship between HCF vaccination and tumor growth.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Clinical Neurology
Hatim Belfquih, Mohamed Amine Azami, Ali Akhaddar
Summary: Posterior fossa localization of hydatid cysts is rare, usually in the cerebellum; we report a case in the cerebellopontine cistern, the sixth in the literature; successful removal of the cyst, unexpected nature of the cyst preoperatively.
WORLD NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Muhammad Ashraf, Shakeel Ahmed, Shahryar Ahmad, Ashar Ahmad
Summary: This article reports the surgical treatment process of a giant hydatid cyst in the brain of a 10-year-old male child. The patient recovered uneventfully after the surgery, and follow-up CT scans confirmed complete resolution of the disease.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Review
Medicine, General & Internal
Sultan Abdulwadoud Alshoabi, Abdulaziz H. Alkalady, Khaled M. Almas, Abdullatif O. Magram, Ali K. Algaberi, Amal A. Alareqi, Abdullgabbar M. Hamid, Fahad H. Alhazmi, Abdulaziz A. Qurashi, Osamah M. Abdulaal, Khalid M. Aloufi, Walaa M. Alsharif, Kamal D. Alsultan, Awatif M. Omer, Awadia Gareeballah
Summary: Hydatid cysts, caused by Echinococcus granulosus, are commonly transmitted from animals to humans through the fecal-oral route. They primarily affect the liver (75%) and lung (15%), and can impact various organs. Medical imaging plays a crucial role in diagnosis, with ultrasound being the preferred method for differentiation and evaluation. CT and MRI are used in cases where ultrasound is unsuitable, providing additional information such as calcification and biliary communication, or neural involvement and cyst wall defects, respectively.
Article
Cell Biology
Mojdeh Khosravi, Hanieh Mohammad Rahimi, Abdoreza Nazari, Kaveh Baghaei, Hamid Asadzadeh Aghdaei, Shabnam Shahrokh, Meysam Sharifdini, Ana Claudia Torrecilhas, Fatemeh Mehryab, Hamed Mirjalali, Faezeh Shekari, Mohammad Reza Zali
Summary: This study investigates the communication between extracellular vesicles (EVs) derived from hydatid cyst fluid (HCF) and host cells. EVs were successfully isolated and characterized as spherical shape with a size distribution of 130.6 nm. The expression levels of pro-inflammatory cytokine genes (IL1 & UBeta;, IL15, and IL8) were initially upregulated after 3 hours and then decreased, while IL13 gene expression showed upregulation. An increase in the level of IL-10 was observed after 24 hours. These findings suggest that HCF-derived EVs may modulate immune responses by exerting time-dependent anti-inflammatory effects.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Parasitology
Unal Bakal, Figen Celik, Sami Simsek, Harun Kaya Kesik, Seyma Gunyakti Kilinc
Summary: This study investigated the genetic variation of hydatid cyst isolates obtained from pediatric cases in eastern Turkey, finding that 16 samples matched E. granulosus s.s. and one sample was identified as E. canadensis for the first time. High haplotype diversity and low nucleotide diversity were observed in the E. granulosus s.s. sequences.
Article
Parasitology
Shuying Wang, Donghui Jiang, Feifei Huang, Yayun Qian, Meitao Qi, Huihui Li, Xiaoli Wang, Zhi Wang, Kaigui Wang, Yin Wang, Pengfei Du, Bin Zhan, Rui Zhou, Liang Chu, Xiaodi Yang
Summary: EgCF demonstrates therapeutic effects on sepsis by inhibiting pro-inflammatory cytokine production and inducing regulatory cytokines. The anti-inflammatory effect of EgCF is possibly achieved through macrophage polarization from pro-inflammatory M1 to regulatory M2 phenotype to reduce excessive inflammation and subsequent multi-organ damage of sepsis. The role of EgCF in regulating macrophage polarization may be carried out by inhibiting the TLR2/MyD88 signaling pathway.
PARASITES & VECTORS
(2023)
Article
Parasitology
Kourosh Cheraghipour, Marjan Beiranvand, Masoomeh Zivdari, Sana Amiri, Leila Masoori, Morteza Nourmohammadi, Ali Safar Maken Ali, Saber Abbaszadeh, Kobra Moradpour, Abdolrazagh Marzban
Summary: This study evaluated the efficacy of methanolic extract of P. longum against protoscolices of hydatid cyst in vitro, showing that 50 mg/ml concentration had the highest lethality. The IC50 value was found to be about 20 mg/ml after 60 minutes of exposure to PLM extract. Valuable findings were obtained for the first time about the scolicidal activity of P. longum, indicating the need for further studies in this field.
EXPERIMENTAL PARASITOLOGY
(2021)
Editorial Material
Veterinary Sciences
Sandra Lapsina, Martina Stirn, Marilisa Novacco, Claudia Cueni, Marina L. Meli, Regina Hofmann-Lehmann, Barbara Riond
VETERINARY CLINICAL PATHOLOGY
(2023)
Article
Virology
Evelyn Kuhlmeier, Tatjana Chan, Julia Klaus, Benita Pineroli, Esther Geisser, Regina Hofmann-Lehmann, Marina L. Meli
Summary: The study in Switzerland found that active SARS-CoV-2 infections were not prevalent in stray cats, supporting the importance of monitoring susceptible animal species in the One Health approach to combat the COVID-19 pandemic effectively.
Article
Infectious Diseases
John M. Hoppe, Louise U. Fueessl, Katrin Hartmann, Regina Hofmann-Lehmann, Alexander Graf, Stefan Krebs, Helmut Blum, Irina Badell, Oliver T. Keppler, Maximilian Muenchhoff
Summary: This study reports a case of a COVID-19 patient who discovered that his dog exhibited respiratory symptoms shortly before his own infection. The dog tested positive for SARS-CoV-2 and genomic sequencing revealed two separate lineages of the virus in both the dog and the patient's samples. The timeline suggests dog-to-human transmission, although direct transmission is highly unlikely due to the genetic distance between the dog and the patient.
Article
Virology
Evelyn Kuhlmeier, Tatjana Chan, Cecilia Valenzuela Agui, Barbara Willi, Aline Wolfensberger, Christian Beisel, Ivan Topolsky, Niko Beerenwinkel, Tanja Stadler, Sarah Jones, Grace Tyson, Margaret J. Hosie, Katja Reitt, Julia Huttl, Marina L. Meli, Regina Hofmann-Lehmann
Summary: This study aims to investigate SARS-CoV-2 infections in companion animals in close contact with COVID-19-positive owners, with a focus on the Delta variant. The results show that 11 cats and 3 dogs in 9 COVID-19-positive households tested positive for the SARS-CoV-2 Delta variant. NGS data identified SNPs in the viral sequences of companion animals that occur at a higher frequency than in viral sequences of humans, as well as SNPs exclusively found in the animals investigated in this study.
Article
Veterinary Sciences
Nadja S. Sieber-Ruckstuhl, Livia Harburger, Natalie Hofer, Claudia Kummerle, Claudia Mueller, Barbara Riond, Regina Hofmann-Lehmann, Claudia E. Reusch, Felicitas S. Boretti
Summary: This study described 11 cats with primary hypoadrenocorticism (PH) and focused on long-term treatment. The study found that the doses of desoxycorticosterone pivalate and prednisolone used in cats were higher than what is currently used in dogs. Furthermore, adrenal glands smaller than 2.7 mm on ultrasonography can be suggestive of PH.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Virology
Mark E. Westman, Juliana Giselbrecht, Jacqueline M. Norris, Richard Malik, Jennifer Green, Elle Burton-Bradley, Ashley Cheang, Theres Meili, Marina L. Meli, Katrin Hartmann, Regina Hofmann-Lehmann
Summary: This study evaluated the field performance of a new rapid point-of-care test kit in determining different feline leukemia virus (FeLV) infection outcomes, as well as its performance in detecting feline immunodeficiency virus (FIV) infection status. The results showed that the test kit was unable to accurately determine different FeLV infection outcomes in field samples and improvements are needed.
Article
Virology
Sandra Felten, Ute Klein-Richers, Stefan Unterer, Michele Bergmann, Yury Zablotski, Regina Hofmann-Lehmann, Katrin Hartmann
Summary: This study aimed to describe the shedding patterns of feline coronavirus (FCoV) in catteries and analyze risk factors for high-intensity shedding or non-shedding. The proportion of high-intensity shedders and non-shedding cats was higher than previously reported, possibly due to housing conditions, genetic susceptibility, or differences in the study period. Certain breeds had a higher risk of high-intensity shedding, and individual hygiene procedures may have influenced FCoV shedding frequency. Smaller group sizes were protective against FCoV shedding.
Article
Virology
Evelyn Kuhlmeier, Tatjana Chan, Marina L. Meli, Barbara Willi, Aline Wolfensberger, Katja Reitt, Julia Huttl, Sarah Jones, Grace Tyson, Margaret J. Hosie, Yury Zablotski, Regina Hofmann-Lehmann
Summary: A higher prevalence of SARS-CoV-2 infections in animals from Swiss COVID-19 households was found, with 21.7% of animals testing positive. Factors such as outdoor access and hygiene practices were significantly associated with infection rates in cats. The study highlights the importance of monitoring and identifying risk factors for SARS-CoV-2 in companion animals.
Article
Cell Biology
Sophia Jenni, Odette Ludwig-Peisker, Vidhya Jagannathan, Sandra Lapsina, Martina Stirn, Regina Hofmann-Lehmann, Nikolay Bogdanov, Nelli Schetle, Urs Giger, Tosso Leeb, Anna Bogdanova
Summary: This study describes the clinical, pathophysiological, and molecular genetic features of a cat with hereditary methemoglobinemia. Genetic analyses revealed a single homozygous base exchange in the CYB5R3 gene, resulting in a splice defect and expression of two mutant CYB5R3 transcripts. The affected cat showed characteristics such as increased red blood cell fragility and deformability, glutathione overload, and morphological alterations typical for stress erythropoiesis associated with methemoglobinemia.
Article
Veterinary Sciences
Katharina Zwicklbauer, Daniela Krentz, Michele Bergmann, Sandra Felten, Roswitha Dorsch, Andrea Fischer, Regina Hofmann-Lehmann, Marina L. Meli, Andrea M. Spiri, Martin Alberer, Laura Kolberg, Kaspar Matiasek, Yury Zablotski, Ulrich von Both, Katrin Hartmann
Summary: This study aims to evaluate the long-term outcome in cats successfully treated with GS-441524 for FIP. The results showed that the treatment was effective in both short-term and long-term, with no relapse during the 1-year follow-up.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2023)
Review
Virology
Severine Tasker, Diane D. Addie, Herman Egberink, Regina Hofmann-Lehmann, Margaret J. Hosie, Uwe Truyen, Sandor Belak, Corine Boucraut-Baralon, Tadeusz Frymus, Albert Lloret, Fulvio Marsilio, Maria Grazia Pennisi, Etienne Thiry, Karin Moestl, Katrin Hartmann
Summary: Feline coronavirus (FCoV) is a common virus in cats that is primarily transmitted faeco-orally. While most infections do not cause clinical signs, a small proportion of infected cats develop feline infectious peritonitis (FIP), which is most frequently seen in cats under two years old. Cats with FIP typically present with fever, anorexia, weight loss, and effusions.
Review
Virology
Katrin Hartmann, Herman Egberink, Karin Moestl, Diane D. Addie, Sandor Belak, Corine Boucraut-Baralon, Tadeusz Frymus, Albert Lloret, Regina Hofmann-Lehmann, Fulvio Marsilio, Maria Grazia Pennisi, Severine Tasker, Etienne Thiry, Uwe Truyen, Margaret J. Hosie
Summary: Vaccine-associated adverse events (VAAEs), such as feline injection-site sarcomas (FISSs), are rare but can be severe. The European Advisory Board on Cat Diseases (ABCD) provides a comprehensive review on VAAEs in cats, summarizing existing knowledge and filling gaps with expert opinions. The causes of VAAEs include immune reactions, local reactions, administration errors, and manufacturing failures. FISS, the most severe VAAE, can occur after vaccinations or other injections. It is important to understand and minimize the risks associated with vaccination.
Article
Virology
Juliana Giselbrecht, Stephanie Jaehne, Michele Bergmann, Marina L. Meli, Benita Pineroli, Eva Boenzli, Svenja Teichmann-Knorrn, Yury Zablotski, Maria-Grazia Pennisi, Nicolas Layachi, Rodrigo Serra, Stefano Bo, Regina Hofmann-Lehmann, Katrin Hartmann
Summary: This study investigated the prevalence of different outcomes of FeLV infection in cats in four European countries. The results showed that the prevalence of FeLV infection is still high in Italy and Portugal, while it is lower in Germany and France. In conclusion, FeLV infection still has a high prevalence, especially in Southern European countries.
Review
Virology
Maria Grazia Pennisi, Sandor Belak, Severine Tasker, Diane D. Addie, Corine Boucraut-Baralon, Herman Egberink, Tadeusz Frymus, Katrin Hartmann, Regina Hofmann-Lehmann, Albert Lloret, Fulvio Marsilio, Etienne Thiry, Uwe Truyen, Karin Moestl, Margaret J. Hosie
Summary: Feline morbillivirus (FeMV) is a virus associated with feline chronic kidney disease (CKD) and has a worldwide distribution. The genetic diversity of FeMV is extensive, but its clinical relevance is still unknown. There is conflicting evidence regarding the association between FeMV infection and renal disease. Higher viral loads are found in urine and are associated with renal TIN lesions.
Article
Veterinary Sciences
Sandra Kampf, Simone Fenk, Ankie Van Cromvoirt, Nikolay Bogdanov, Sonja Hartnack, Martina Stirn, Regina Hofmann-Lehmann, Iris Margaret Reichler, Anna Bogdanova
Summary: This study compared selected blood parameters between brachycephalic and non-brachycephalic dogs, aiming to explore the possibility of developing a blood test for grading the severity of brachycephalic obstructive airway syndrome (BOAS) in the future. The results showed that brachycephalic dogs exhibited alterations in blood cells and metabolism, including higher reticulocyte counts, abundance of immature reticulocytes, mean corpuscular hemoglobin concentration, and lower levels of intracellular reduced glutathione, as well as increased plasma lactate. These findings may serve as potential objective indicators for BOAS.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Parasitology
Kiswendsida Thierry Guiguemde, Patindoilba Marcel Sawadogo, Adama Zida, Apollinaire Kima, Roland Windtare Bougma, Mamadou Serme, Ibrahim Sangare, Clarisse Bougouma, Sanata Bamba
Summary: This study assessed the transmission of onchocerciasis in the Cascades region of Burkina Faso and found that the resumption of ivermectin treatment has significantly reduced the prevalence of the disease since 2011.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
K. D. Steffen, M. L. Gos, J. M. Unzaga, M. C. Venturini, R. O. Ariasc, G. More
Summary: The dynamics of anti-T. gondii antibodies and seroconversion in naturally infected goats from the last third of pregnancy to 100 days of lactation were evaluated, and their relationship with hematological and dehydration parameters was examined. The results showed that seroconversion occurred in goats of different physiological states and ages, and it was not related to hydration status.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Maho Kotake, Yuho Watanabe, Naoki Itoh, Tomoyoshi Yoshinaga
Summary: This study examined the effects of light exposure on the theront excystment circadian rhythm in Cryptocaryon irritans. The results showed that light reception is essential for circadian rhythm entrainment and both light duration and temperature have an impact on the entrainment of circadian rhythm.
PARASITOLOGY INTERNATIONAL
(2024)
Review
Parasitology
Olivier Ndogo Eteme, Ernestine Nkwengoua Zondegoumba, Yasmin Saegusa Tadayozzi, Jessica Aparecida Serafim, Wendell Queiroz Leite, Mariane de Freitas Genari Severino, Eduardo Festozo Vicente
Summary: The high mortality rate caused by parasitic worms on their hosts is a major concern. Current drugs on the market are often toxic with numerous side effects, necessitating the search for new, more potent molecules. Medicinal plants have been found to contain a wide range of novel molecules that can effectively combat different types of helminths. This review provides an overview of the methods, activities, and mechanisms of action of cyclic peptides, specifically cyclotides, for treating helminthic infections.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Lucas de Assis Silva Andrade, Carlos Nei Ortuzar-Ferreira, Mariana de Souza Oliveira, Sergian Vianna Cardozo, Viviane Moreira de Lima, Bruno Pereira Berto
Summary: A new species of Isospora Schneider, 1881 has been identified from V. chivi in Southeastern Brazil. Morphological and molecular analyses confirmed the identity of this new species.
PARASITOLOGY INTERNATIONAL
(2024)
