Article
Medical Laboratory Technology
Chiu-Che Feng, Ci-Wen Chang, Zhi-Yi Lien, Jinun-An Lin, Tzu-Ting Chen, Su-Peng Yeh
Summary: The Polybrene method is a cost-effective alternative to the DTT-IAT in overcoming anti-CD38 interference, especially for populations with a high prevalence of anti-M and anti-Mi(a) antibodies. However, both methods have a low detection sensitivity for anti-K.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Psychology, Experimental
Francois Maquestiaux, Eric Ruthruff
Summary: The study found that as individuals age, they tend to rely more on central attention to carry out tasks, even when those tasks do not require it. Older adults showed larger age differences in dual-task performance in IM tasks compared to younger adults.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
(2021)
Article
Management
Bo Chen, Nicholas G. Hall
Summary: Project management plays a crucial role in global economic activities, but is often affected by Parkinson's Law, resulting in high project failure rates and success rates below 40%. Research using mechanism design and game theory addresses incentive issues in project management, proposing incentive schemes that can eliminate or mitigate Parkinson's Law.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Weixing Zhang, Juan Du, Tonghe Zhu, Ruilan Wang
Summary: In this research, a SiO2 nanosphere-coated PTFE catheter (PTFE-SiO2) with enhanced antibacterial and excellent mechanical properties was prepared via dopamine as a graft bridge. The microscopic morphology results show that the nanospheres are uniformly dispersed on the surface of the catheter. The physicochemical characterization confirmed that PTFE-SiO2 had reliable bending resistance properties, superhydrophobicity, and cytocompatibility and could inhibit thrombosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Hematology
Ye Zhou, Leiyu Chen, Tianshu Jiang, Liangfeng Fan, Hang Lei, Yuqing Wang, Hasiyati Heililahong, Jianqing Mi, Danxin Du, Tianhong Miao, Rong Xia, Xuefeng Wang, Dong Xiang, Xiaohong Cai, Xiaofeng Tang
Summary: The study found that treating RBCs with 2-ME or using the Polybrene method can eliminate DARA interference with antibody screening or cross-matching, although the K antigen is denatured during treatment. This suggests that 2-ME-based IATs or the Polybrene method could be viable alternatives to DTT-based IATs for mitigating DARA interference.
Article
Chemistry, Physical
Bianca-Iulia Ciubotaru, Mirela-Fernanda Zaltariov, Codrin Tugui, Irina -Elena Stoleru, Dragos Peptanariu, George -Theodor Stiubianu, Nicoleta Vornicu, Maria Cazacu
Summary: Silicones are a significant class of synthetic biomaterials that require cross-linking to become stand-alone objects. They can be cross-linked through chemical or physical processes and exhibit unique characteristics in terms of structure and surface properties. The suitability of these materials as biomaterials has been evaluated through various tests, including stability, surface analysis, biocidal activity, adhesion, and cell compatibility.
SURFACES AND INTERFACES
(2022)
Article
Hematology
Craig Tauscher, Sheila Moldenhauer, Sandra Bryant, Margaret DiGuardo, Eapen K. Jacob
Summary: The study aimed to evaluate RBC utilization and alloimmunization in patients receiving Dara, showing that these patients did not have a higher incidence of alloantibody formation following RBC transfusion compared to similar patient populations.
Article
Medical Laboratory Technology
Anna Feldman, Adrian M. Duek, Mathilda Mandel-Benado, Liz A. Cohen, Daniel R. Feldman, Merav Leiba
Summary: This study aimed to provide a DARAEx((R)) protocol for application with the Grifols platform in patients treated with daratumumab. By introducing a modified protocol (AssutaBB protocol), the study successfully provided antibody screen results for all samples, offering a wider choice for detection under daratumumab treatment.
CLINICAL LABORATORY
(2022)
Article
Medical Laboratory Technology
Anna Feldman, Adrian M. Duek, Mathilda Mandel-Benado, Liz A. Cohen, Daniel R. Feldman, Merav Leiba
Summary: This study provides a DARAEx (R) protocol for application with the Grifols platform, allowing the use of a more widespread platform in daratumumab-treated patients.
CLINICAL LABORATORY
(2022)
Article
Chemistry, Applied
Shuangquan Wu, Biao Chen, Qifa Ye
Summary: In this study, chitin/zeolite composite nanofibrous microspheres (CZ) were developed as efficient and specific blood ammonia adsorbent for the treatment of hyperammonemia. The CZ exhibited rapid and good affinity for ammonia in both aqueous solution and hyperammonemia plasma. It also demonstrated good compatibility with cells and blood components, making it a potential candidate for clinical use.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Physics, Multidisciplinary
C. A. Escobar, A. Martin-Ruiz, A. M. Escobar-Ruiz, Roman Linares
Summary: In this study, we investigate the influence of spontaneous Lorentz symmetry breaking on gravitational quantum states of ultracold neutrons within the scalar sector of the standard-model extension framework. By analyzing high-precision data from GRANIT and qBounce experiments, we are able to set bounds on the symmetry breaking parameters. The derived effective Hamiltonian describes the neutron's motion in a gravitational field with an effective gravitational constant controlled by the Lorentz-violating parameters. Additionally, we consider the gravity-induced interference pattern in a COW-type experiment for the first time and establish an upper bound for the parameters.
EUROPEAN PHYSICAL JOURNAL PLUS
(2022)
Article
Biophysics
Zhonghua Xue, Xiaojing Sun, Hang Li, Mujahid Iqbal, Yachen Hou, Zi Jin, Jingan Li
Summary: This study successfully obtained two kinds of sulfonated hyaluronic acid (S-HA) with higher sulfur content. Through a series of cell experiments, it was found that the S-HA with higher sulfur content not only possessed stronger ability in promoting endothelial cell growth and migration, regulating smooth muscle cell phenotype, but also had stronger anti-inflammatory function. Furthermore, all the S-HA molecules are highly compatible with blood.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Electrical & Electronic
Andreas Bendicks, Michael Gerten, Stephan Frei
Summary: Active electromagnetic interference (EMI) cancellation is a promising solution to reduce the size of passive filters. This study applies this cancellation method to the common-mode EMI of a three-phase motor inverter, successfully suppressing approximately 2.4 million harmonics. The characteristics and challenges of the overall system are discussed.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2022)
Article
Pediatrics
John F. Morehous, Cynthia White, William B. Brinkman, Dominick J. DeBlasio, Allison Reyner, Julie Kleiman, Srikant B. Iyer
Summary: The research team successfully implemented a process to improve preventive care for children through multidisciplinary collaboration and quality improvement methods, increasing the closure rate of preventive care gaps.
Article
Oncology
Kristine A. Frerichs, Christie P. M. Verkleij, Meletios A. Dimopoulos, Jhon A. Marin Soto, Sonja Zweegman, Mary H. Young, Kathryn J. Newhall, Tuna Mutis, Niels W. C. J. van de Donk
Summary: Daratumumab, a CD38-targeting antibody, shows significant activity in multiple myeloma but resistance often develops. The addition of the PD-L1 checkpoint inhibitor durvalumab at the time of daratumumab failure did not reverse daratumumab-resistance. This suggests that PD-L1 co-targeting may not be sufficient to overcome daratumumab-resistance.
Article
Pharmacology & Pharmacy
Benjamin Hohlfelder, Daniel Kelly, Minh Hoang, Kevin E. Anger, Katelyn W. Sylvester, Richard M. Kaufman, Jean M. Connors
Summary: This study retrospectively analyzed the monitoring strategies for anticoagulation management in adult ECMO patients. The results showed that monitoring of anti-Xa and aPTT were more closely correlated with UFH dosing.
AMERICAN JOURNAL OF THERAPEUTICS
(2022)
Editorial Material
Hematology
Richard Kaufman
Article
Hematology
Candace C. Fuller, Vinod E. Nambudiri, Caren Spencer-Smith, Lesley H. Curtis, Mayura Shinde, Austin Cosgrove, Margaret Johnson, Jason Hickok, Stacey Honda, Heba Ismail, Richard Max Kaufman, Adee Kennedy, Karla M. Miller, David J. Mohlman, Russell E. Poland, Robert Rosofsky, Kimberly Smith, Salim R. Surani, Meghan A. Baker
Summary: In a validation study within a large hospital system, low positive predictive values were observed for TRALI ICD-9-CM diagnosis codes as verified by medical records, possibly due to inconsistent code use, incomplete records, or other factors. Medical record confirmation may be necessary for accurately identifying TRALI cases identified through diagnosis codes.
Article
Hematology
Nancy M. Dunbar, Meghan Delaney, Michael F. Murphy, Monica B. Pagano, Nabiha Huq Saifee, Jansen Seheult, Mark Yazer, Richard M. Kaufman
Summary: The study found that WBIT errors are more common in emergency departments compared to inpatient wards and outpatient clinics, and that electronic positive patient identification systems may have a greater impact on reducing WBIT errors in emergency departments relative to other clinical areas.
Review
Hematology
Jensyn Cone Sullivan, Melanie Oliveira, Dana Elliott, Richard M. Kaufman
Article
Hematology
Nancy M. Dunbar, Richard M. Kaufman
Summary: In this study, a total of 331 wrong blood in tube (WBIT) errors were compiled from 36 centers in 11 countries, with most errors detected through pretransfusion sample testing. The most common contributing factors to WBIT errors were protocol violations and slips/lapses. The conclusion emphasizes the need for sample collection processes to be designed to minimize error opportunities and for staff to be educated on the critical importance of protocol compliance for patient safety.
Editorial Material
Hematology
Richard M. Kaufman
Article
Microbiology
Nicole Tolan, Amy C. Sherman, Guohai Zhou, Katherine G. Nabel, Michael Desjardins, Stacy Melanson, Sanjat Kanjilal, Serina Moheed, John Kupelian, Richard M. Kaufman, Edward T. Ryan, Regina C. LaRocque, John A. Branda, Anand S. Dighe, Jonathan Abraham, Lindsey R. Baden, Richelle C. Charles, Sarah E. Turbett
Summary: The use of anti-S antibody assays as surrogate measurements of SARS-CoV-2 vaccine induced immunity is important. This study evaluated a commercially available assay and found good correlation between anti-S and neutralizing antibodies, but this correlation was influenced by vaccine type and viral variant.
MICROBIOLOGY SPECTRUM
(2022)
Article
Hematology
Fleur Aung, Jeff Spencer, David Potter, Thuy-Dung Pham, Naheed Farooqui, Kathryn R. Platt, Raja Zayat, Melanie Oliveira, Robin Smeland-Wagman, Eric Petersen, Richard M. Kaufman
Summary: The study evaluated a new anti-idiotype antibody's ability to neutralize DARA in vitro and eliminate anti-CD38 interference. Results showed that a 1:1 ratio of anti-DARA to DARA successfully eliminated interference in IATs and allowed detection of other alloantibodies. This new approach provides a promising solution for blood compatibility testing in patients receiving anti-CD38 therapy.
Article
Hematology
Wen Lu, Mark Yazer, Na Li, Alyssa Ziman, Silvano Wendel, Hongying Tang, Hamilton Tsang, Kjell Titlestad, Suzanne R. Thibodeaux, Andrew W. Shih, Jessica L. Poisson, Tho Pham, Suchi Pandey, Monica B. Pagano, Hua Shan, Mike Murphy, Colin Murphy, Mariana Lorenzi Savioli, Jose Mauro Kutner, Aaron S. Hess, Magali J. Fontaine, Roberta Fachini, Nancy M. Dunbar, Richard M. Kaufman
Summary: During the COVID-19 pandemic in 2020, there were sufficient inventories of red blood cells (RBCs) and platelets (PLTs). The first wave of cases was associated with a significant decrease in patient care activities, leading to excess supplies and increased product outdating of RBCs and PLTs.
Article
Hematology
Lauren E. Merz, Charlotte M. Story, Miriam A. Osei, Katherine Jolley, Siyang Ren, Hae Soo Park, Revital Yefidoff Freedman, Donna Neuberg, Robin Smeland-Wagman, Richard M. Kaufman, Maureen O. Achebe
Summary: Many individuals of African descent have lower ANC due to the Duffy-null phenotype. This study found that 66.7% of self-identified Black individuals have the Duffy-null phenotype and there is a significant difference in ANCs between Duffy-null and Duffy non-null individuals. The Duffy-null phenotype is clinically insignificant, but appropriate reference ranges should be developed to avoid systemic racism.
Article
Surgery
Abigail Joseph, Cody J. Murray, Natasha D. Novikov, Randall W. Velliquette, Sunitha Vege, Justin B. L. Halls, Helen H. Mah, Jamie L. Dellagatta, Edward Comeau, Maria Aguad, Richard M. Kaufman, Martin L. Olsson, Indira Guleria, Sean R. Stowell, Edgar L. Milford, Annika K. Hult, Melissa Y. Yeung, Connie M. Westhoff, Cathi L. Murphey, William J. Lane
Summary: ABO compatibility is crucial for kidney transplantation, especially for blood group B candidates who often experience longer waitlist times. This study compares the accuracy of lectin and genotyping testing methods for ABO subtyping, and suggests that genotyping can identify more A2 donors than lectin testing, providing increased transplant opportunities for group B candidates and potentially reducing wait times.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Hematology
Brody Foy, Jonathan Stefely, Pavan K. Bendapudi, Robert P. Hasserjian, Hanny Al-Samkari, Abner Louissaint, Megan J. Fitzpatrick, Bailey Hutchison, Christopher Mow, Julia Collins, Hasmukh P. Patel, Chhaya Patel, Nikita Patel, Samantha Ho, Richard M. Kaufman, Walter Dzik, John M. Higgins, Robert S. Makar
Meeting Abstract
Health Care Sciences & Services
Oreofe Odejide, Scott Huntington, Susan Lysaght Hurley, Richard Kaufman, Eleanor Shi, Kimberly Johnson, James Tulsky, Gregory Abel
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Hematology
Jingcheng Zhao, Erin Gabriel, Rut Norda, Petter Hoglund, Lindsey Baden, Beatrice A. Diedrich, Per Marits, Sara L. Enoksson, John M. Gansner, Richard Kaufman, Paul W. Dickman, Gustaf Edgren
Summary: Frequent plateletpheresis donations using an LRS chamber were found to be associated with CD4+ T-cell lymphopenia and an increased risk of infections. Monitoring T-lymphocyte counts in frequent platelet donors and conducting future investigations on long-term donor health are recommended.