Article
Biotechnology & Applied Microbiology
Neil D. Young, Andreas J. Stroehlein, Liina Kinkar, Tao Wang, Woon-Mok Sohn, Bill C. H. Chang, Parwinder Kaur, David Weisz, Olga Dudchenko, Erez Lieberman Aiden, Pasi K. Korhonen, Robin B. Gasser
Summary: The Chinese liver fluke causes the disease clonorchiasis, affecting millions of people in various regions. Chronic clonorchiasis can lead to cholangitis and even cholangiocarcinoma. Control of the disease in endemic regions is difficult due to the risk of drug resistance, underscoring the need for new interventions. By using advanced DNA sequencing and informatics, a high-quality reference genome for C. sinensis was constructed, which can expedite molecular investigations and aid in the discovery of new interventions for this neglected disease complex.
Article
Infectious Diseases
Xiaoying Xie, Zhanshuai Wu, Yuhong Wu, Jing Liu, Xinyuan Chen, Xiaoqian Shi, Caiheng Wei, Jiasheng Li, Jiahui Lv, Qing Li, Lili Tang, Shanshan He, Tingzheng Zhan, Zeli Tang
Summary: Clonorchis sinensis and its derivatives have potential therapeutic value for inflammatory bowel disease. The study shows that cysteine protease and adult crude antigen of Clonorchis sinensis can alleviate acute colitis, with cysteine protease being more effective. Cysteine protease improves colonic inflammation mainly by activating innate immunity and regulating the expression of cytokines.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Tingzheng Zhan, Yuhong Wu, Xueling Deng, Qing Li, Yu Chen, Jiahui Lv, Jilong Wang, Shitao Li, Zhanshuai Wu, Dengyu Liu, Zeli Tang
Summary: This study revealed that the most severe symptoms in mice infected with C. sinensis occurred at 5 weeks post-infection. Moreover, multi-omics analysis uncovered predominant molecular events related to fibrosis changes in the liver. This study not only enhances our understanding of clonorchiasis progression but also provides valuable insights into the molecular-level interaction mechanism between C. sinensis and its host liver.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Chao Yan, Jing Wu, Na Xu, Jing Li, Qian-Yang Zhou, Hui-Min Yang, Xiao-Dan Cheng, Ji-Xin Liu, Xin Dong, Stephane Koda, Bei-Bei Zhang, Qian Yu, Jia-Xu Chen, Ren-Xian Tang, Kui-Yang Zheng
Summary: This study found that TLR4 deficiency exacerbates biliary injuries and peribiliary fibrosis caused by C. sinensis in C57BL/10 strain mice, which is contributed by augmenting type 2 immune responses and decreasing pro-inflammatory responses.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Cell Biology
Stephane Koda, Xing-Quan Zhu, Kui-Yang Zheng, Chao Yan
Summary: This review explores and analyzes the immunological mechanisms involved in the pathogenicity of Clonorchis sinensis, highlighting the different mechanisms by which the parasite interacts with its host to induce immune responses. These findings provide insights for the development of an effective vaccine against C. sinensis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Infectious Diseases
Men-Bao Qian, Chang-Hai Zhou, Hui-Hui Zhu, Ying-Dan Chen, Xiao-Nong Zhou
Summary: The study modeled the cost yield of different treatment strategies against clonorchiasis, finding that in areas with a prevalence over 10%, selective chemotherapy for adult men was the most cost-effective approach. Treatments varied in terms of cost effectiveness and utility depending on endemic levels and populations.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Immunology
Yu Jeong Lee, Moon-Ju Kim, Sungsin Jo, So-Hee Jin, Pu-Reum Park, Kijeong Park, Ho-Chun Song, Jahae Kim, Ji-Young Kim, Seung Cheol Shim, Tae-Hwan Kim, Sung-Jong Hong, Hyundeok Kang, Tae-Jong Kim, Eun Jeong Won
Summary: Helminth infections and their components have the potential to modulate immune responses. Clonorchis sinensis-derived protein (CSp) was found to protect against ankylosing spondylitis (AS) by reducing inflammatory cytokine-producing cells and new bone formation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Archana K. Reddy, Melony Chakrabarty, Ying Liu, Stuart H. Cohen, Archana H. Maniar
Summary: Clonorchis sinensis, a trematode prevalent in East Asia, can cause hepatobiliary infection and, in rare cases, eosinophilic pneumonia. The infection is usually acquired through ingestion of raw or undercooked fish containing the encysted larval form of the parasite. Treatment with prednisone and praziquantel can lead to improvement in patients with pulmonary clonorchiasis.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Biochemistry & Molecular Biology
Bao Zheng, Zhiyan Gao, Liumei Liang, Yunyu Lu, Yongting Kong, Wanting Chen, Keying Lin, Wanqi Chen, Jingying Mai, Yanwen Li, Changling Ma
Summary: The study revealed that CsESPs can induce autophagy in hepatic stellate cells, thus participating in the pathogenesis of hepatic fibrosis.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Parasitology
Yuhong Wu, Xueling Deng, Zhanshuai Wu, Dengyu Liu, Xiaoyin Fu, Lili Tang, Shanshan He, Jiahui Lv, Jilong Wang, Qing Li, Tingzheng Zhan, Zeli Tang
Summary: This study revealed that acute inflammatory injury was rapidly triggered by initial infection by Clonorchis sinensis juveniles in the host, accompanied by the enrichment of detoxification, inflammation, fibrosis, tumor and metabolism-related pathways in the liver, which provides a new perspective for the early intervention and therapy of clonorchiasis.
PARASITES & VECTORS
(2023)
Article
Immunology
Su Han, Xiaoli Zhang, Jian Ding, Xiang Li, Xueli Zhang, Xu Jiang, Shanshan Duan, Beibei Sun, Xinyi Hu, Yannan Gao
Summary: This study used UHPLC-QTOF-MS to analyze the serum metabolites of rats infected with Clonorchis sinensis. It was found that levels of phosphatidylcholines, glycerophosphocholine, and choline in the serum significantly changed, indicating shifts in lipid metabolism. Significant changes were also observed in amino acids and phosphatidylcholines. In conclusion, C. sinensis infection causes significant alterations in rat serum metabolism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Lu Zhang, Xiaohao Wang, Jing Zhang, Zhongrong Wang, Dachuan Cai
Summary: We report a rare case of co-infection with hepatitis E viruses, Clonorchis sinensis, and Escherichia coli. The patient was hospitalized due to fatigue, jaundice, and nausea. Laboratory tests confirmed the presence of hepatitis E virus, Clonorchis sinensis, and Escherichia coli. Treatment with praziquantel, imipenem, and hepatoprotective drugs was effective in relieving the clinical symptoms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Jong-In Chang, Keol Lee, Dongwuk Kim, Ju- Yang, Jae Keun Park, Kyu Choi, Soo Hoon Kang, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Seon Mee Park, Joo Kyung Park
Summary: CS infection is a major risk factor for CCA, with CACC patients being diagnosed at a younger age, having a higher male to female ratio, residing more in CS-endemic areas, and having poorer survival rates among patients under 64 years old compared to non-CACC patients.
FRONTIERS IN MEDICINE
(2021)
Article
Parasitology
Yang-Yuan Qiu, Qiao-Cheng Chang, Jun-Feng Gao, Ming-Jia Bao, Hai-Tao Luo, Jin-Ho Song, Sung-Jong Hong, Rui-Feng Mao, Yun-Yi Sun, Ying-Yu Chen, Ming-Yuan Liu, Chun-Ren Wang, Xiao-Lei Liu
Summary: This study investigated the metabolic changes in rabbits during Clonorchis sinensis infection using a plasma metabolomics approach, and identified potential biomarkers for the diagnosis of clonorchiasis. The findings provide new insights into the pathogenesis of clonorchiasis and may contribute to the development of effective diagnostic methods in the future.
PARASITES & VECTORS
(2022)
Article
Microbiology
Jung-Mi Kang, Huong Giang Le, Byoung-Kuk Na, Won Gi Yoo
Summary: This study investigated the pH-dependent structural alterations and functional changes in CsCatD2 through molecular dynamics simulations, showing that acidic pH induced conformational transitions and enhanced stabilization of the enzyme-inhibitor complex, while neutral pH hindered enzyme accessibility to the active site. These findings can provide valuable insights for designing inhibitors targeting parasitic CatD.
Review
Pharmacology & Pharmacy
Md Hafiz Uddin, Jeffrey A. Zonder, Asfar S. Azmi
DRUG DISCOVERY TODAY
(2020)
Correction
Oncology
Asfar S. Azmi, Mohammed H. Uddin, Ramzi M. Mohammad
Summary: An erratum for this paper has been published and can be viewed at the provided link.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Md Hafiz Uddin, Yiwei Li, Husain Yar Khan, Irfana Muqbil, Amro Aboukameel, Rachel E. Sexton, Shriya Reddy, Yosef Landesman, Trinayan Kashyap, Asfar S. Azmi, Elisabeth Heath
Summary: The combination of KPT-8602 with PARP inhibitors has shown therapeutic potential for the treatment of mCRPC, with synergistic effects and superior induction of apoptosis compared to single agent treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Gabriel B. Mpilla, Md Hafiz Uddin, Mohammed N. Al-Hallak, Amro Aboukameel, Yiwei Li, Steve H. Kim, Rafic Beydoun, Gregory Dyson, Erkan Baloglu, William T. Senapedis, Yosef Landesman, Kay-Uwe Wagner, Nerissa T. Viola, Bassel F. El-Rayes, Philip A. Philip, Ramzi M. Mohammad, Asfar S. Azmi
Summary: The study highlights the need for more effective targeted approaches to sensitize PNETs to everolimus for better treatment outcomes. The dual inhibitor KPT-9274 targeting PAK4-NAMPT, when combined with everolimus, showed promising results in inhibiting PNET growth and formation.
MOLECULAR CANCER THERAPEUTICS
(2021)
Review
Oncology
Md. Hafiz Uddin, Mohammed Najeeb Al-Hallak, Philip A. Philip, Ramzi M. Mohammad, Nerissa Viola, Kay-Uwe Wagner, Asfar S. Azmi
Summary: Pancreatic cancer is the fourth leading cause of cancer death in the United States, with PDAC accounting for over 90% of cases and a low survival rate. MiRNAs have been identified as sensitive biomarkers in pancreatic cancer and are found in stable forms within exosomes. Further research on exosomal miRNAs is necessary for improved diagnostic, prognostic, and therapeutic strategies.
Article
Oncology
Husain Yar Khan, Md. Hafiz Uddin, Suresh Kumar Balasubramanian, Noor Sulaiman, Marium Iqbal, Mahmoud Chaker, Amro Aboukameel, Yiwei Li, William Senapedis, Erkan Baloglu, Ramzi M. Mohammad, Jeffrey Zonder, Asfar S. Azmi
Summary: Targeting PAK4 and NAMPT using the small molecule inhibitor KPT-9274 can inhibit cell proliferation, deplete energy, and induce apoptosis in various NHL subtypes. KPT-9274 treatment shows potent anti-tumor effects in experimental models, suggesting its potential as a novel therapy for NHL.
Article
Parasitology
Yan Jin, Seungman Cha, Youngjin Kim, Hamdan Mustafa Hamdan, Mousab Siddig Elhag, Hassan Ahmed Hassan Ahmed Ismail, Keon Hoon Lee, Sung-Tae Hong
Summary: This study reveals a significant association between the parents' occupation and schistosomiasis among students, with children of farmers being at a higher risk of infection. The findings suggest that schistosomiasis is a disease linked to poverty, and children of farmers are identified as a high-risk group.
KOREAN JOURNAL OF PARASITOLOGY
(2022)
Article
Biology
Hassan Ahmed Hassan Ahmed Ismail, Seungman Cha, Yan Jin, Sung-Tae Hong
Summary: Despite repeated mass drug administration interventions, the prevalence of schistosomiasis remains high in certain areas due to reinfection. A community-based survey in Sudan revealed that individuals without latrines in their households or with open defecation had a higher risk of schistosomiasis infection. Installing improved latrines and eliminating open defecation should be emphasized in schistosomiasis elimination projects in high-transmission areas.
Article
Medicine, General & Internal
Hae Kyung Cho, Moo-Song Lee, Sung-Tae Hong
Summary: This article analyzes the citation patterns of articles published in the Journal of Korean Medical Science (JKMS) from 2011 to 2020. The results show that most articles are cited within 5 years of publication, with a noncitation rate of 1.4%. The study suggests that inviting review articles in clinical sciences, research reports on hot medical topics, and nationwide database analyses may attract more author interest and citations.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Oncology
Husain Yar Khan, Misako Nagasaka, Yiwei Li, Amro Aboukameel, Md. Hafiz Uddin, Rachel Sexton, Sahar Bannoura, Yousef Mzannar, Mohammed Najeeb Al-Hallak, Steve Kim, Rafic Beydoun, Yosef Landesman, Hirva Mamdani, Dipesh Uprety, Philip A. Philip, Ramzi M. Mohammad, Anthony F. Shields, Asfar S. Azmi
Summary: The XPO1 inhibitor can enhance the anticancer activity of KRAS G12C inhibitors in preclinical cancer models. The combination treatment synergistically inhibits the proliferation of KRAS G12C mutant cancer cells and reduces tumor burden, leading to improved survival in vivo.
CANCER RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Jong-Min Kim, Jin-Hong Yoo, Hae Kyung Cho, Sung-Tae Hong
Summary: During the COVID-19 pandemic, publications on the disease have increased worldwide. Korean researchers contributed to a small percentage of global publications on COVID-19, with the Journal of Korean Medical Science (JKMS) publishing the most articles on the disease in Korea.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Correction
Medicine, General & Internal
Sung-Tae Hong
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Review
Oncology
Asfar S. Azmi, Mohammed H. Uddin, Ramzi M. Mohammad
Summary: XPO1 plays a crucial role in cellular homeostasis and cancer development, with its inhibitor selinexor clinically validated and approved for multiple myeloma and diffuse large B cell lymphoma treatment.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Md Hafiz Uddin, Boyun Kim, Untack Cho, Asfar S. Azmi, Yong Sang Song
Review
Oncology
Rachel E. Sexton, Mohammed Najeeb Al Hallak, Md. Hafiz Uddin, Maria Diab, Asfar S. Azmi
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2020)
Article
Parasitology
Kiswendsida Thierry Guiguemde, Patindoilba Marcel Sawadogo, Adama Zida, Apollinaire Kima, Roland Windtare Bougma, Mamadou Serme, Ibrahim Sangare, Clarisse Bougouma, Sanata Bamba
Summary: This study assessed the transmission of onchocerciasis in the Cascades region of Burkina Faso and found that the resumption of ivermectin treatment has significantly reduced the prevalence of the disease since 2011.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
K. D. Steffen, M. L. Gos, J. M. Unzaga, M. C. Venturini, R. O. Ariasc, G. More
Summary: The dynamics of anti-T. gondii antibodies and seroconversion in naturally infected goats from the last third of pregnancy to 100 days of lactation were evaluated, and their relationship with hematological and dehydration parameters was examined. The results showed that seroconversion occurred in goats of different physiological states and ages, and it was not related to hydration status.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Maho Kotake, Yuho Watanabe, Naoki Itoh, Tomoyoshi Yoshinaga
Summary: This study examined the effects of light exposure on the theront excystment circadian rhythm in Cryptocaryon irritans. The results showed that light reception is essential for circadian rhythm entrainment and both light duration and temperature have an impact on the entrainment of circadian rhythm.
PARASITOLOGY INTERNATIONAL
(2024)
Review
Parasitology
Olivier Ndogo Eteme, Ernestine Nkwengoua Zondegoumba, Yasmin Saegusa Tadayozzi, Jessica Aparecida Serafim, Wendell Queiroz Leite, Mariane de Freitas Genari Severino, Eduardo Festozo Vicente
Summary: The high mortality rate caused by parasitic worms on their hosts is a major concern. Current drugs on the market are often toxic with numerous side effects, necessitating the search for new, more potent molecules. Medicinal plants have been found to contain a wide range of novel molecules that can effectively combat different types of helminths. This review provides an overview of the methods, activities, and mechanisms of action of cyclic peptides, specifically cyclotides, for treating helminthic infections.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Lucas de Assis Silva Andrade, Carlos Nei Ortuzar-Ferreira, Mariana de Souza Oliveira, Sergian Vianna Cardozo, Viviane Moreira de Lima, Bruno Pereira Berto
Summary: A new species of Isospora Schneider, 1881 has been identified from V. chivi in Southeastern Brazil. Morphological and molecular analyses confirmed the identity of this new species.
PARASITOLOGY INTERNATIONAL
(2024)