Article
Biodiversity Conservation
F. Mauduit, A. Segarra, M. Mandic, A. E. Todgham, M. R. Baerwald, A. D. Schreier, N. A. Fangue, R. E. Connon
Summary: This study found that two parasites infect juvenile Chinook salmon in key areas of the Sacramento River in California, affecting their body weight and immune responses, reducing their chances of migration success. However, hypoxia and thermal tolerance were not affected by infection, indicating that salmon can still cope with environmental stressors.
CONSERVATION PHYSIOLOGY
(2022)
Article
Horticulture
Teresa Rosmaninho, Manuel Mota, Maria L. Inacio, Jonathan D. Eisenback, Carlos Gutierrez-Gutierrez
Summary: By using morphological and molecular analysis, nine populations of Paratylenchus spp. were successfully identified in vineyards, with six species parasitizing grapevines for the first time, highlighting the significance for further research and management strategies.
Article
Fisheries
Magnus Lauringson, Ilkka Nousiainen, Siim Kahar, Oksana Burimski, Riho Gross, Tanel Kaart, Anti Vasemagi
Summary: Global climate change is impacting the abundance and spread of parasites, leading to variation in host-parasite interactions and relationships between different host species. The study on myxozoan endoparasite Tetracapsuloides bryosalmonae in wild brown trout and Atlantic salmon reveals that the speed of parasite proliferation, rather than the absolute number of parasites in the host kidney, plays a critical role in interspecific variation in PKD susceptibility. Therefore, temporal perspective is useful for understanding host defense mechanisms and the impacts of climate change on wildlife.
JOURNAL OF FISH DISEASES
(2021)
Article
Multidisciplinary Sciences
Kristen Homel, Julie D. Alexander
Summary: Anthropogenic activities in the Columbia River Basin have negatively affected the habitat and population of salmon species, with the presence of the parasite C. shasta potentially limiting the recovery of chum salmon.
Article
Biodiversity Conservation
Yuwei Wang, Arthur L. Bass, Scott G. Hinch, Shaorong Li, Emiliano Di Cicco, Karia H. Kaukinen, Hugh Ferguson, Tobi J. Ming, David A. Patterson, Kristina M. Miller
Summary: This study examined the physiological response of Chinook salmon during their first ocean year and identified multiple infectious agents associated with it. Pathological changes may only manifest in the presence of environmental stressors, hence it is important to gain context from field observations. The study provides evidence that the molecular activation of viral disease response and the lesions observed during the development of PRV-related disease are also observed in wild juvenile Chinook salmon.
CONSERVATION PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
O. Gervais, A. Barria, A. Papadopoulou, R. L. Gratacap, B. Hillestad, A. E. Tinch, S. A. M. Martin, D. Robledo, R. D. Houston
Summary: The study found that the heritability of ISAV resistance is moderate with a polygenic architecture, but a significant quantitative trait locus was detected on chromosome 13. A mild up-regulation of the interferon pathway characterizes the response to the virus in heart samples from this population of Atlantic salmon, and candidate genes showing differential expression between samples with high and low breeding values for resistance were identified.
Article
Multidisciplinary Sciences
Paula Clemente, Javier Calvo-Garrido, Sarah F. Pearce, Florian A. Schober, Megumi Shigematsu, Stefan J. Siira, Isabelle Laine, Henrik Spahr, Christian Steinmetzger, Katja Petzold, Yohei Kirino, Rolf Wibom, Oliver Rackham, Aleksandra Filipovska, Joanna Rorbach, Christoph Freyer, Anna Wredenberg
Summary: Using Drosophila and mouse models, this study demonstrates that non-canonical RNA processing in mammalian mitochondria results in the formation of 3' phosphates, which are hydrolyzed by the phosphatase activity of the carbon catabolite repressor 4 domain-containing family member ANGEL2. The findings also suggest the involvement of the FAST kinase domain-containing protein family in the generation of these 3' phosphates.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Antonio Casuso, Valentina Valenzuela-Munoz, Cristian Gallardo-Escarate
Summary: This study evaluated the effects of two recombinant antigens on the transcriptome profiling of Atlantic salmon during a sea lice infestation. Dual RNA-seq analysis revealed vaccine-dependent gene patterns in both the host and the pathogen. The study demonstrated the potential of two proteins as lice vaccines for the salmon industry.
Article
Chemistry, Multidisciplinary
Shen Yan, Ziang Lu, Wei Yang, Jinglei Xu, Yafen Wang, Wei Xiong, Rongjie Zhu, Linao Ren, Zhaoxin Chen, Qi Wei, Song-mei Liu, Tian Feng, Bifeng Yuan, Xiaocheng Weng, Yuhao Du, Xiang Zhou
Summary: The substance N-4-Acetylcytidine (ac(4)C) has been found to have impacts on various cellular and biological processes. To gain a mechanistic understanding of ac(4)C's roles in biology and disease, researchers have developed a new method called FAM-seq, which detects ac(4)C in RNA without using antibodies. By applying FAM-seq, the researchers successfully mapped the distribution of ac(4)C in human cell lines and found its important role in regulating chemotherapy drug resistance in chronic myeloid leukemia. This study suggests that understanding ac(4)C modification could enhance drug development and combination therapy in cancer treatment.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Immunology
Natasha A. Botwright, Amin R. Mohamed, Joel Slinger, Paula C. Lima, James W. Wynne
Summary: Through studying the pathogenesis of amoebic gill disease in Atlantic salmon, the localized and systemic immune responses of the host and parasite were identified, along with transcription factors and gene networks significantly altered in disease states. This dual transcriptomic study provides novel molecular insights into the pathology of AGD, offering alternative theories for future research and improved management strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Ceren Erguden Gurbuz, Songul Bayram Delibas, Aylin Ozgen Alpaydin, Ayca Arzu Sayiner, Soykan Ozkoc
Summary: This study investigated the gene polymorphisms in Pneumocystis jirovecii isolates in Western Turkey and surrounding areas, revealing important genetic information related to the fungus infection. The presence of gene mutations associated with potential drug resistance in this community was also identified for the first time, warranting further research on the possible effects of genotypes on disease prognosis.
Article
Microbiology
Claudia Wylezich, Dirk Hoeper
Summary: The article reviews the past use of ribosomal sequences to address scientific and diagnostic questions, highlighting different sequencing approaches and introducing meta-ribosomalomics as an unbiased method. It elaborates on prerequisites, benefits, drawbacks, and future perspectives, comparing them with other sequencing approaches.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Mariam Jaafar, Julia Contreras, Carine Dominique, Sara Martin-Villanueva, Regine Capeyrou, Patrice Vitali, Olga Rodriguez-Galan, Carmen Velasco, Odile Humbert, Nicholas J. Watkins, Eduardo Villalobo, Katherine E. Bohnsack, Markus T. Bohnsack, Yves Henry, Raghida Abou Merhi, Jesus de la Cruz, Anthony K. Henras
Summary: This study investigates the functions of box C/D snoRNP snR190 and helicase Dbp7 in eukaryotic ribosome biogenesis. The snR190 snoRNA acts as an RNA chaperone to assist in structuring 25S rRNA, while Dbp7 is crucial for facilitating remodeling events in the peptidyl transferase center region of 25S rRNAs. The molecular events underlying the assembly and maturation of early pre-60S particles during eukaryotic ribosome synthesis are complex and not well understood.
NATURE COMMUNICATIONS
(2021)
Article
Veterinary Sciences
Ehab Kotb Elmahallawy, Ahmed Gareh, Akram Abu-Okail, Pamela C. Koster, Alejandro Dashti, Jamal Asseri, Asmaa Aboelabbas Gouda, Murad A. Mubaraki, Sara Abdel-Aal Mohamed, Yasser M. Mohamed, Ehssan Ahmed Hassan, Mohamed Elgendy, Carolina Hernandez-Castro, Begona Bailo, David Gonzalez-Barrio, Lihua Xiao, David Carmena
Summary: This study investigated the occurrence, genetic diversity, and zoonotic potential of common diarrhea-causing enteric protist parasites in household dogs and cats in Egypt. The results showed that the prevalence rates of Cryptosporidium spp. and Giardia duodenalis were high in dogs and cats in Egypt, posing a potential risk to public health.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Limnology
Joanna Gauthier, David Walsh, Daniel T. Selbie, Alyssa Bourgeois, Katherine Griffiths, Isabelle Domaizon, Irene Gregory-Eaves
Summary: Paleolimnological studies rely on bioindicators like diatoms and cladocerans deposited in sediments. DNA-based approaches are expanding taxonomic diversity for investigation, but calibration work is needed. This study assessed congruence between morphological and DNA-based approaches in sediment trap samples, identifying potential bioindicators of environmental variations. Diatom morphology showed significant correlations with genetic analyses, while crustaceans showed weaker correlations. Intracellular DNA reads correlated more strongly with diatom morphology, while extracellular DNA reads correlated more strongly with crustacean morphology, indicating the effectiveness of DNA-based approaches in tracking community dynamics for successful paleolimnological studies.
LIMNOLOGY AND OCEANOGRAPHY
(2021)
Article
Fisheries
Amy Long, Kyle A. Garver, Simon R. M. Jones
JOURNAL OF AQUATIC ANIMAL HEALTH
(2019)
Article
Fisheries
Simon R. M. Jones, Amy Long
DISEASES OF AQUATIC ORGANISMS
(2019)
Article
Fisheries
Amy Long, Kyle A. Garver, Simon R. M. Jones
JOURNAL OF FISH DISEASES
(2019)
Article
Fisheries
Simon R. M. Jones, Amy Long, Christine MacWilliams, Mark Polinski, Kyle Garver
JOURNAL OF FISH DISEASES
(2020)
Article
Fisheries
Simon R. M. Jones, Hanna Ahonen, Jouni Taskinen
DISEASES OF AQUATIC ORGANISMS
(2020)
Article
Fisheries
Amy Long, Aidan Goodall, Simon R. M. Jones
Summary: The study developed a reproducible immersion challenge model to induce salmonid rickettsial septicaemia and found that sockeye salmon are less susceptible to P. salmonis compared to Atlantic and pink salmon, while Atlantic salmon had a higher bacterial shedding post-immersion. Skin lesions were observed in infected fish, suggesting skin as the primary entry point for P. salmonis during the immersion challenge.
JOURNAL OF FISH DISEASES
(2021)
Article
Ecology
James P. Losee, Simon R. M. Jones, Caitlin A. E. McKinstry, William N. Batts, Paul K. Hershberger
Article
Multidisciplinary Sciences
Amy Long, Simon R. M. Jones
Summary: Salmonid rickettsial septicemia is an emergent disease caused by Piscirickettsia salmonis in marine-farmed salmonids. The study found species-specific patterns of bacterial shedding and pathogenesis, as well as correlations between physiological parameters and bacterial burden in different fish species. The timing and magnitude of bacterial shedding in infected fish align with mortality, providing insights for pathogen transmission models.
Article
Virology
Amy Long, Francis LeBlanc, Jean-Rene Arseneau, Nellie Gagne, Katja Einer-Jensen, Jan Lovy, Mark Polinski, Simon Jones, Kyle A. Garver
Summary: This study identified viruses resembling both CTV and CTV-2 in salmonids in eastern and western Canada. The Canadian CTV isolates were divided into two genotypes (CTV-1 and CTV-2) within the Piscihepevirus genus, with a missing ORF3 counterpart in their genomes. The in vitro replication of a CTV-2 isolate resulted in cytopathic effects similar to CTV, with unique dilation of the endoplasmic reticulum lumen.
Article
Microbiology
Simon R. M. Jones, Derek Price
Summary: This study investigated the occurrence of amoebic gill disease in farmed Atlantic salmon in British Columbia, Canada, and found distinct spatial and temporal patterns. The results showed a significant relationship between seawater temperature and gill scores, indicating temperature as a major risk factor.
Article
Fisheries
Simon R. M. Jones, Amy Long
Summary: Kudoa thyrsites is a parasite that infects marine fish and can cause a degradation of fillet quality in farmed Atlantic salmon. This study found that exposure to deeper-sourced seawater led to a higher prevalence and severity of K. thyrsites infections in Atlantic salmon. Additionally, fish held in tanks supplied with deep-sourced seawater had a higher infection rate compared to those in surface net-pens.
DISEASES OF AQUATIC ORGANISMS
(2022)
Article
Parasitology
Simon R. M. Jones, Jessica C. C. Low, Aidan Goodall
Summary: This study confirmed the presence of the Parvicapsula pseudobranchicola parasite in Pacific salmon and described its host range and geographical distribution. Infection caused pathological changes, but the impact on the health of wild Pacific salmon and the distribution and abundance of infective actinospores remain important areas of research.
PARASITES & VECTORS
(2023)
Article
Microbiology
Vimbai Irene Machimbirike, Ignacio Vasquez, Trung Cao, Joy Chukwu-Osazuwa, Oluwatoyin Onireti, Cristopher Segovia, Pongsak Khunrae, Triwit Rattanarojpong, Marije Booman, Simon Jones, Manuel Soto-Davila, Brian Dixon, Javier Santander
Summary: This study investigates the genetic differences and evolution of the most common fish pathogen Vibrio anguillarum serotype O1. The O1 strain has two chromosomes and two typical plasmids. Furthermore, the O1 strain displays resistance to colistin sulphate, which differs from the O2 serotype and may be attributed to the ugd gene. The study also reveals that the genetic heterogeneity in the O-antigen biosynthesis gene cluster is characterized by the absence or presence of unique genes, which could result in differences in immune evasion mechanisms among serotypes.
Article
Fisheries
E. Ghanizadeh-Kazerouni, J. M. Wilson, S. R. M. Jones, C. J. Brauner
Summary: This study investigated the regenerative capability of gill tissue in Atlantic salmon. The results showed that approximately 38% of the resected gill filament length regenerated after 20 weeks. The regeneration percentage varied significantly among individuals but was not correlated with initial body size, condition factor, or overall fish growth rate. Immunohistochemistry showed increased cell proliferation at the filament tip shortly after resection, followed by the appearance of ionocytes, chemoreceptive neuroepithelial cells, and nerve fibers.
Article
Immunology
Laura M. Braden, Karina J. Rasmussen, Sara L. Purcell, Lauren Ellis, Amelia Mahony, Steven Cho, Shona K. Whyte, Simon R. M. Jones, Mark D. Fast
INFECTION AND IMMUNITY
(2018)