Journal
PARASITOLOGY
Volume 137, Issue 9, Pages 1315-1331Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0031182009991843
Keywords
acetate and succinate excretion; acetate:succinate CoA-transferase; Entamoeba histolytica; Fasciola hepatica; fumarate reductase; Giardia lamblia; reductive TCA cycle; Trichomonas vaginalis; Trypanosoma brucei
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Funding
- CNRS
- Universite Victor Segalen Bordeaux 2
- Fondation pour la Recherche Medicale
- Agence Nationale de la Recherche (ANR) [NIETABOTRYP, SysTryp]
- University of Munich
- Deutsche Forschungsgemeinschaft
- Franco-Bavarian University Cooperation Center (BFFIZ/CCUFBU)
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Parasites that often grow anaerobically in their hosts have adopted a fermentative strategy relying on the production of partially oxidized end products, including lactate, glycerol, ethanol, succinate and acetate. This review focuses on recent progress in understanding acetate production in protist parasites, such as amoebae, diplomonads, trichomonads, trypanosomatids and in the metazoan parasites helminths, as well as the succinate production pathway(s) present in some of them. We also describe the unconventional organisation of the tricarboxylic acid cycle associated with the fermentative strategy adopted by the procyclic trypanosomes, which may resemble the probable structure of the primordial TcA cycle in prokaryotes.
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