Review
Immunology
Cindy S. Chu, Marie Stolbrink, Daniel Stolady, Makoto Saito, Candy Beau, Kan Choun, Tha Gay Wah, Ne Mu, Klay Htoo, Be Nu, Arunrot Keereevijit, Jacher Wiladpaingern, Verena Carrara, Aung Pyae Phyo, Khin Maung Lwin, Christine Luxemburger, Stephane Proux, Prakaykaew Charunwatthana, Rose McGready, Nicholas J. White, Francois Nosten
Summary: This study reviewed all malaria cases managed by the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016. The results showed that Plasmodium falciparum and Plasmodium vivax malaria had higher incidence and mortality rates in this area compared to areas of low seasonal malaria transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Marina L. S. Santos, Roney S. Coimbra, Tais N. Sousa, Luiz F. F. Guimaraes, Matheus S. Gomes, Laurence R. Amaral, Dhelio B. Pereira, Cor J. F. Fontes, Ibrahim Hawwari, Bernardo S. Franklin, Luzia H. Carvalho
Summary: Severe thrombocytopenia is a key factor in the morbidity of Plasmodium vivax, and the analysis of inflammatory mediators and their regulatory miRNAs has provided insights into the mechanisms underlying PvST. IL-10 and IL-8 are identified as central mediators in PvST, and IL-10 plays a critical role in P. vivax-mediated thrombocytopenia according to supervised machine learning.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Leen Vandermosten, Fran Prenen, Balotin Fogang, Pauline Dagneau de Richecour, Sofie Knoops, Christiane Josiane Donkeu, Cathy Doric Piemba Nguefack, Jean-Voisin Taguebue, Paul Koki Ndombo, Bart Ghesquiere, Lawrence Ayong, Philippe E. Van den Steen
Summary: This study investigated the response of adrenal hormones in children with different types of malaria in Cameroon. The study found that patients with clinical malaria had increased cortisol levels but decreased sensitivity to adrenal hormones, which may contribute to the severity of the disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Omnia Fathelrhman Abdelwhab, Arwa Elaagip, Musab M. Albsheer, Ayman Ahmed, Giacomo Maria Paganotti, Muzamil Mahdi Abdel Hamid
Summary: This study identified P. vivax infections in Anopheles mosquitoes collected from Central and Eastern Sudan. An. arabiensis was the most abundant vector across all study areas, with An. funestus being recorded for the first time in New Halfa, Eastern Sudan. The documented Anopheles species are implicated in Pvcsp allele diversity, suggesting a need for large-scale surveys to identify the vectors of P. vivax malaria and understand their role in disease transmission dynamics.
Review
Infectious Diseases
Loick P. Kojom Foko, Aditi Arya, Amit Sharma, Vineeta Singh
Summary: This study conducted a systematic review and meta-analysis of Indian literature on severe vivax malaria, providing evidence for P. vivax as the etiologic agent of severe malaria leading to deaths in some cases. Further research is needed on SVM in pregnancy, SVM in drug resistance, and correlations with cytoadherence in disease severity due to P. vivax.
JOURNAL OF INFECTION
(2021)
Article
Immunology
Maelle Le Goff, Eric Kendjo, Marc Thellier, Renaud Piarroux, Pierre Yves Boelle, Stephane Jaureguiberry
Summary: This study analyzed the impact of chemoprophylaxis on the outcomes of Plasmodium vivax and Plasmodium ovale infections in civilian travelers. It found that travelers using blood-stage drugs were at a higher risk of delayed-onset illness. This calls for new chemoprophylaxis acting on liver stages.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Suelen Queiroz Diniz, Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, Dhelio Batista Pereira, Mauro Shugiro Tada, Luis Carlos Crocco Afonso, Markus Kohlhoff, Carlos Leomar Zani, Ricardo Tostes Gazzinelli, Fabiano Oliveira, Lis Ribeiro Antonelli
Summary: This study reveals that monocytes in patients with malaria produce high levels of inflammatory cytokines and also have a regulatory role through specific receptors, suggesting a dual role of monocytes in malaria.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Mohd Amirul Fitri A. Rahim, Mohd Bakhtiar Munajat, Nor Diyana Dian, Mohd Ikhwan Mukmin Seri Rakna, Wathiqah Wahid, Nuraffini Ghazali, Noor Wanie Hassan, Siti Nor Azreen Abdul Manap, Muhd Rafiq Mohd Kasri, Ahmad Imran Mohamed, Emelia Osman, Sriwipa Chuangchaiya, Inke Nadia D. Lubis, Paul C. S. Divis, Akira Kaneko, Kevin K. A. Tetteh, Zulkarnain Md Idris
Summary: Malaria control in Malaysia has made significant progress, but there is still a need to determine malaria exposure and transmission patterns in high-risk populations. This study used a serological method to measure the transmission levels of Plasmodium falciparum and Plasmodium vivax among indigenous communities. The findings showed a higher level of P. falciparum transmission and an association between living in a specific area and malaria infection. This approach can be an important tool for monitoring and surveillance in low malaria transmission settings.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biology
Tobias Mourier, Denise Anete Madureira de Alvarenga, Abhinav Kaushik, Anielle de Pina-Costa, Olga Douvropoulou, Qingtian Guan, Francisco J. Guzman-Vega, Sarah Forrester, Filipe Vieira Santos de Abreu, Cesare Bianco Junior, Julio Cesar de Souza Junior, Silvia Bahadian Moreira, Zelinda Maria Braga Hirano, Alcides Pissinatti, Maria de Fatima Ferreira-da-Cruz, Ricardo Lourenco de Oliveira, Stefan T. Arold, Daniel C. Jeffares, Patricia Brasil, Cristiana Ferreira Alves de Brito, Richard Culleton, Claudio Tadeu Daniel-Ribeiro, Arnab Pain
Summary: Plasmodium simium, a malaria parasite of non-human primates, likely originated in South America from Plasmodium vivax and has recently acquired the ability to infect humans. Genetic analysis suggests that specific gene deletions in P. simium, especially in the Duffy-binding protein 1 (DBP1), may play a role in its ability to invade human red blood cells, leading to recent zoonotic infections.
Article
Medicine, General & Internal
Samuel Odarkwei Blankson, Lauriane Rietmeyer, Patrick Tettey, Liliane Dikroh, Bernard Tornyigah, Rafiou Adamou, Azizath Moussiliou, Caroline Padounou, Annick Amoussou, Benedicta Ayiedu Mensah, Maroufou J. J. Alao, Gordon Awandare, Nicaise Tuikue Ndam, Christian Roussilhon, Rachida Tahar
Summary: This study evaluated the levels of plasma soluble neopterin in severe malaria patients and assessed its prognostic accuracy. The results showed that neopterin levels were higher in patients with severe malarial anemia and in patients who died from the disease. Plasma neopterin levels may serve as a potential biomarker for predicting fatality in severe falciparum malaria patients.
Article
Biotechnology & Applied Microbiology
Jack Adderley, Christian Doerig
Summary: This study fills gaps in the kinomes of Plasmodium falciparum and Plasmodium vivax, highlighting their similarities and differences for target selection. It also identifies kinases that are not suitable targets for drug discovery due to their high similarity with human counterparts.
Editorial Material
Infectious Diseases
Fang Huang, Li Zhang, Zhi-Gui Xia
Summary: This article highlights China's practices and experience in targeting vivax malaria control and elimination, including radical cure strategies, comprehensive but adaptive strategies, mass drug administration, and case-/focus-centered surveillance and response systems. After nearly 70 years of effort, China was certified as a malaria-free country in June 2021.
INFECTIOUS DISEASES OF POVERTY
(2023)
Review
Nutrition & Dietetics
Kwuntida Uthaisar Kotepui, Aongart Mahittikorn, Polrat Wilairatana, Frederick Ramirez Masangkay, Manas Kotepui
Summary: This study aimed to synthesize the evidence on the association between blood calcium levels and malaria severity. Thematic synthesis showed reduced calcium levels in malaria patients, but meta-analysis showed no significant difference in calcium levels between different groups of participants. Regional and age-related variations may influence these outcomes.
Article
Microbiology
Giulia Chiopris, Stefano Maccario, Tawaddud Hassan Eisa Artaiga, Abdalrhman Ibrahim Mohamed, Manuela Valenti, Susanna Esposito
Summary: Sickle cell disease is the most common genetic disease in sub-Saharan Africa, with symptoms usually appearing in early childhood. Patients with SCD are at risk of malaria in endemic countries, and guidelines recommend antimalarial chemoprophylaxis. Hydroxyurea is considered a safe and effective treatment for SCD, although its impact on malaria incidence and severity still needs further demonstration.
Review
Infectious Diseases
Myriam Drysdale, Lionel Tan, Ana Martin, Isabelle Borghini Fuhrer, Stephan Duparc, Hema Sharma
Summary: Plasmodium vivax is the most common type of malaria in certain regions and affects mainly children. Treatment for radical cure, which prevents relapse, is challenging due to limited diagnostic tests, potential side effects in patients with G6PD deficiency, and lack of pediatric formulations. Future efforts should focus on improving access to curative treatments for infants and children, as well as research and control initiatives for P. vivax in this population.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Public, Environmental & Occupational Health
Saeed M. Omar, Imad R. Musa, Osman E. Osman, Ishag Adam
Article
Obstetrics & Gynecology
Duria A. Rayis, Imad R. Musa, Ahmad Al-Shafei, Abdelmarouf H. Moheldein, Ola A. El-Gendy, Ishag Adam
Summary: A study conducted in Khartoum, Sudan revealed a high prevalence of gestational diabetes mellitus (GDM), particularly among women with high haemoglobin levels in early pregnancy. High haemoglobin levels were identified as the only factor associated with GDM, suggesting its potential use as a marker for detecting and possibly preventing GDM.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Health Care Sciences & Services
Saeed M. Omar, Imad R. Musa, Sami E. Salah, Mohammed M. Elnur, Osama Al-Wutayd, Ishag Adam
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2020)
Article
Cardiac & Cardiovascular Systems
Omer Abdelbagi, Imad R. Musa, Shaza M. Musa, Salim A. ALtigani, Ishag Adam
Summary: The study revealed a high prevalence of hypertension among patients with diabetes mellitus. Older age, male gender, employment, duration of diabetes, diabetic foot, underweight, and obesity were significant predictors of hypertension among patients with diabetes mellitus.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Psychiatry
Saeed M. Omar, Imad R. Musa, Maysoon B. Idrees, Ishag Adam
Summary: The study found a high prevalence of depression among Sudanese patients with T2DM, with significant associations between depression and rural residence, unemployment, co-morbidity, and obesity.
Article
Medicine, General & Internal
Omer M. Abdelbagi, Imad R. Musa, Salim A. Altigani, Abdelrhaman Osman, Ishag Adam
Summary: This study revealed a high prevalence of diabetic foot among patients with diabetes in Nahr an Nil State, Sudan. Factors such as older age, type 2 diabetes, duration of diabetes, family history of diabetes, hypertension, and obesity were associated with diabetic foot.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Medical Laboratory Technology
Imad R. Musa, Saeed M. Omar, Manal E. Sharif, Abdel B. A. Ahmed, Ishag Adam
Summary: Diabetes mellitus (DM) is a chronic metabolic disorder that is increasing globally and associated with chronic complications. Glycosylated haemoglobin (HbA(1c)) is the gold standard for monitoring glycaemic control, but measurements are relatively expensive. A cross-sectional study was conducted to evaluate the agreement between calculated and measured HbA(1c) levels, which showed a significant correlation but lack of agreement between the two.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Pediatrics
Mohammed Ahmed A. Ahmed, Imad R. Musa, Hyder M. Mahgoub, Abdullah Al-Nafeesah, Osama Al-Wutayd, Ishag Adam
Summary: This study investigated the morbidity, mortality, and outcomes of children admitted to Gadarif Hospital in Sudan. The results showed that communicable diseases were the main causes of hospital admissions for children, with a mortality rate of 5.7%.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Saeed M. Omar, Imad R. Musa, Omer Abdelbagi, Manal E. Sharif, Ishag Adam
Summary: This study found a high prevalence of newly diagnosed hypertension and a positive association between HbA1c levels and newly diagnosed hypertension.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Endocrinology & Metabolism
Saeed M. Omar, Imad R. Musa, Maysoon B. Idrees, Omer Abdelbagi, Ishag Adam
Summary: There is a high prevalence of erectile dysfunction (ED) among patients with type 2 diabetes mellitus (T2DM) in eastern Sudan. Age, duration of DM, and cholesterol levels are positively associated with ED.
BMC ENDOCRINE DISORDERS
(2022)
Article
Medicine, General & Internal
Saeed M. Omar, Osama S. Osman, Gasim Gasim, Ishag Adam
Summary: This study investigated the causes, trends of admission, and mortality among adult patients in Gadarif Hospital in Eastern Sudan. The data showed a high rate of admissions and mortality for both communicable and non-communicable diseases compared to other African countries. Cardiovascular diseases, snakebites, and visceral leishmaniasis were the most common causes of admission, while cardiovascular diseases, neurological diseases, and sepsis were the leading causes of inpatient mortality.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Imad R. Musa, Saeed M. Omar, Ishag Adam
Summary: This study compared mid-upper arm circumference (MUAC) with body mass index (BMI) and proposed MUAC cut-off points for underweight and obesity among Sudanese adults. The results suggest that MUAC cut-offs can be used for community-based screening of underweight and obesity.
Article
Endocrinology & Metabolism
Hussain Alyousif, Ishag Adam, Naser A. Alamin, Mona A. Sid Ahmed, Ayat Al Saeed, Abdulmuhsen Hussein Hassoni, Imad R. Musa
Summary: This study evaluated the prevalence and associated predictors for thyroid nodule Bethesda III-VI in eastern Saudi Arabia. The results showed that the thyroid ultrasound report for TI-RADS was significantly associated with the outcome of thyroid FNAC. This suggests that it can be a reliable tool in the absence of molecular testing for thyroid cancer.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Medical Laboratory Technology
Bahaeldin Hassan, Duria A. Rayis, Imad R. Musa, Reem Eltayeb, Nadiah ALhabardi, Ishag Adam
Summary: This study found no significant differences in blood groups and other hematological parameters between women with and without gestational diabetes mellitus (GDM) in early pregnancy.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2021)
Article
Endocrinology & Metabolism
Saeed M. Omar, Imad R. Musa, Amir ElSouli, Ishag Adam
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2019)
